摘要
按2015年版《中国药典》四部中的微生物限度检查法对磷酸左奥硝唑酯二钠进行方法适用性验证。采用平皿法测定需氧菌、霉菌和酵母菌总数,采用常规法检查控制菌。所用方法可用于磷酸左奥硝唑酯二钠的微生物限度检查。
According to the Chinese Pharmacopeia( 2015 Edition the forth version),the methods of microbial limit test for(s)-Ornidazol disodium phosphate were verified. A plate method was used in the total aerobic microbial,yeast and mouldcount,and the direct inoculation method was used for the detection of the( s)-Ornidazol disodium phosphate. The verifiedmethods in this study can be used to detect the microbial limit of( s)-Ornidazol disodium phosphate.
引文
[1] Scott FI,Osterman MT. MedicaL management of Crohndisease[J]. Clin Colonrectal Surg,2013,26:67-74.
[2]谢莉,赵书文,陈佳,等. HPLC测定奥硝唑注射液中的有关物质[J].华西药学杂志,2012,27(4):441-442.
[3]何学军,徐樱珠,丁亚军,等.注射用左旋奥硝唑磷酸酯二钠对小鼠神经系统的影响[J].华西药学杂志,2016,31(3):259-261.
[4]赵亚男,吴佩,孙华,等.左奥硝唑剂量递增志愿者耐受性及药动学研究[J].中国药学杂志,2011,46(6):454-457.