IGF系统与雌性哺乳动物生殖
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摘要
胰岛素样生长因子(insulin-like growth factor,IGF)是一类多肽类生长因子。IGF-I、IGF-II以及各自受体和胰岛素生长因子结合蛋白(IGF-binding proteins,IGFBPs)构成了IGF系统。IGF系统在多个组织器官中均有表达,具有调节动物生殖,细胞增殖和凋亡等方面的功能。本文综述了IGF系统在雌性动物生殖激素分泌、卵泡闭锁、胚胎和胎盘发育等方面的作用,为进一步研究IGF系统对动物生殖的调控提供参考。
引文
1 Dubey PK,Nath A,Chandra V,et al.Expression of mRNAencoding IGF-I,IGF-II,type-I,and II IGF-receptors and IGF-binding proteins-1-4 during ovarian follicular development in buffalo(Bubalus bubalis).Anim Biotechnol,2015,2681~91.
2 Rodriguez FM,Gareis NC,Hein GJ,et al.Role of components of the insulin-like growth factor system in the early stages of ovarian follicular persistence in cattle.J Comp Pathol,2017,157201~214.
3 Wolfe A,Divall S,Wu S.The regulation of reproductive neuroendocrine function by insulin and insulin-like growth factor-1(IGF-1).Front Neuroendocrinol,2014,35558~572.
4 Kashyap MK.Role of insulin-like growth factor-binding proteins in the pathophysiology and tumorigenesis of gastroesophageal cancers.Tumour Biol,2015,368247~8257.
5 Clemmons DR.Use of mutagenesis to probe IGF-binding protein structure/function relationships.Endocr Rev,2001,22800.
6 Firth SM,Baxter RC.Cellular actions of the insulin-like growth factor binding proteins.Endocr Rev,2002,23824~854.
7 Duan C,Xu Q.Roles of insulin-like growth factor(IGF)binding proteins in regulating IGF actions.Gen Comp Endocr,2005,14244~52.
8胡世福,夏伟,朱长虹.P38αMAPK在雌性生殖系统中的研究进展.国际生殖健康/计划生育杂志,2015,164~68.
9姚海蓉,刘永杰,李旭丽,等.不同卵巢反应中IGF-1、IG-FBP-1表达与IVF结局的关系.宁夏医学杂志,2017,39961~964.
10 Adesanya OO,Zhou J,Bondy CA.Cellular localization and sex steroid regulation of insulin-like growth factor binding protein messenger ribonucleic acids in the primate myometrium.J Clin Endocr Metab,1996,812495.
11叶希平,赵倩,陈晓蓉,等.胰岛素样生长因子结合蛋白-4(IGFBP-4)与生殖相关的研究进展.铜陵职业技术学院学报,2017,1642~44.
12 Zhou J,Wang J,Penny D,et al.Insulin-like growth factor binding protein 4 expression parallels luteinizing hormone receptor expression and follicular luteinization in the primate ovary.Biol Reprod,2003,6922~29.
13 Mazerbourg S,Ooergaard MT,Oxvig C,et al.Pregnancyassociated plasma protein-A(PAPP-A)in ovine,bovine,porcine,and equine ovarian follicles:involvement in IGFbinding protein-4 proteolytic degradation and mRNA expression during follicular development.Endocrinology,2001,1425243~5253.
14 Monget P,Oxvig C.PAPP-A and the IGF system.Annales d'endocrinologie,2016,7790~96.
15 Singh J,Paul A,Thakur N,et al.Localization of IGF proteins in various stages of ovarian follicular development and modulatory role of IGF-I on granulosa cell steroid production in water buffalo(Bubalus bubalis).Anim Reprod Sci,2015,15831~52.
16 Duan C,Ren H,Gao S.Insulin-like growth factors(IG-Fs),IGF receptors,and IGF-binding proteins:roles in skeletal muscle growth and differentiation.Gen Comp Endocr,2010,167344~351.
17 Wathes DC,Reynolds TS,Robinson RS,et al.Role of the insulin-like growth factor system in uterine function and placental development in ruminants.J Dairy Sci,1998,811778~1789.
18范新阳,苗永旺.牛科物种类胰岛素生长因子结合蛋白3的研究进展.黑龙江畜牧兽医,2017,1353~56.
19 Mishra SR,Thakur N,Somal A,et al.Expression and localization of angiopoietin family in buffalo ovarian follicles during different stages of development and modulatory role of angiopoietins on steroidogenesis and survival of cultured buffalo granulosa cells.Theriogenology,2016,861818~1833.
20 Chakravarthi V,Kona S,Kumar AV,et al.Quantitative expression of antiapoptotic and proapoptotic genes in sheep ovarian follicles grown in vivo or cultured in vitro.Theriogenology,2015,83590~595.
21 Srividya D,Praveen Chakravarthi V,Kona S,et al.Expression of kit ligand and insulin-like growth factor binding protein 3 during in vivo or in vitro development of ovarian follicles in sheep.Repro Domest Anima,2017,52661~671.
22 Valleh MV,Tahmoorespur M,Joupari MD,et al.Paternal breed effects on expression of IGF-II,BAK1 and BCL2-L1in bovine preimplantation embryos.Zygote,2015,23712~721.
23 Damerill I,Biggar KK,Abu Shehab M,et al.Hypoxia increases IGFBP-1 phosphorylation mediated by m TOR inhibition.Mol Endocrinol,2016,30201~216.
24 Oxvig C.The role of PAPP-A in the IGF system:location,location,location.J Cell Commun Signal,2015,9177~187.
25 Meyerholz MM,Mense K,Lietzau M,et al.Serum IG-FBP4 concentration decreased in dairy heifers towards day 18 of pregnancy.J Vet Sci,2015,16413~421.
26 De Brun V,Meikle A,Casal A,et al.Periconceptional undernutrition modifies endocrine profiles and hepatic gene expression in sheep.J Anim Physiol An A,2015,99710~718.
27 Salih DA,Tripathi G,Holding C,et al.Insulin-like growth factor-binding protein 5(Igfbp5)compromises survival,growth,muscle development,and fertility in mice.P Natl Acad Sci USA,2004,1014314~4319.
28 Wood TL,Rogler LE,Czick ME,et al.Selective alterations in organ sizes in mice with a targeted disruption of the insulin-like growth factor binding protein-2 gene.Mol Endocrinol,2000,141472~1482.
29 Mense K,Heidekorn-Dettmer J,Wirthgen E,et al.Increased concentrations of insulin-like growth factor binding protein(IGFBP)-2,IGFBP-3,and IGFBP-4 are associated with fetal mortality in pregnant cows.Front Endocrinol(Lausanne),2018,9310.
30 Hoeflich A,Reyer A,Ohde D,et al.Dissociation of somatic growth,time of sexual maturity,and life expectancy by overexpression of an RGD-deficient IGFBP-2 variant in female transgenic mice.Aging cell,2016,15111~117.
2 Rodriguez FM,Gareis NC,Hein GJ,et al.Role of components of the insulin-like growth factor system in the early stages of ovarian follicular persistence in cattle.J Comp Pathol,2017,157201~214.
3 Wolfe A,Divall S,Wu S.The regulation of reproductive neuroendocrine function by insulin and insulin-like growth factor-1(IGF-1).Front Neuroendocrinol,2014,35558~572.
4 Kashyap MK.Role of insulin-like growth factor-binding proteins in the pathophysiology and tumorigenesis of gastroesophageal cancers.Tumour Biol,2015,368247~8257.
5 Clemmons DR.Use of mutagenesis to probe IGF-binding protein structure/function relationships.Endocr Rev,2001,22800.
6 Firth SM,Baxter RC.Cellular actions of the insulin-like growth factor binding proteins.Endocr Rev,2002,23824~854.
7 Duan C,Xu Q.Roles of insulin-like growth factor(IGF)binding proteins in regulating IGF actions.Gen Comp Endocr,2005,14244~52.
8胡世福,夏伟,朱长虹.P38αMAPK在雌性生殖系统中的研究进展.国际生殖健康/计划生育杂志,2015,164~68.
9姚海蓉,刘永杰,李旭丽,等.不同卵巢反应中IGF-1、IG-FBP-1表达与IVF结局的关系.宁夏医学杂志,2017,39961~964.
10 Adesanya OO,Zhou J,Bondy CA.Cellular localization and sex steroid regulation of insulin-like growth factor binding protein messenger ribonucleic acids in the primate myometrium.J Clin Endocr Metab,1996,812495.
11叶希平,赵倩,陈晓蓉,等.胰岛素样生长因子结合蛋白-4(IGFBP-4)与生殖相关的研究进展.铜陵职业技术学院学报,2017,1642~44.
12 Zhou J,Wang J,Penny D,et al.Insulin-like growth factor binding protein 4 expression parallels luteinizing hormone receptor expression and follicular luteinization in the primate ovary.Biol Reprod,2003,6922~29.
13 Mazerbourg S,Ooergaard MT,Oxvig C,et al.Pregnancyassociated plasma protein-A(PAPP-A)in ovine,bovine,porcine,and equine ovarian follicles:involvement in IGFbinding protein-4 proteolytic degradation and mRNA expression during follicular development.Endocrinology,2001,1425243~5253.
14 Monget P,Oxvig C.PAPP-A and the IGF system.Annales d'endocrinologie,2016,7790~96.
15 Singh J,Paul A,Thakur N,et al.Localization of IGF proteins in various stages of ovarian follicular development and modulatory role of IGF-I on granulosa cell steroid production in water buffalo(Bubalus bubalis).Anim Reprod Sci,2015,15831~52.
16 Duan C,Ren H,Gao S.Insulin-like growth factors(IG-Fs),IGF receptors,and IGF-binding proteins:roles in skeletal muscle growth and differentiation.Gen Comp Endocr,2010,167344~351.
17 Wathes DC,Reynolds TS,Robinson RS,et al.Role of the insulin-like growth factor system in uterine function and placental development in ruminants.J Dairy Sci,1998,811778~1789.
18范新阳,苗永旺.牛科物种类胰岛素生长因子结合蛋白3的研究进展.黑龙江畜牧兽医,2017,1353~56.
19 Mishra SR,Thakur N,Somal A,et al.Expression and localization of angiopoietin family in buffalo ovarian follicles during different stages of development and modulatory role of angiopoietins on steroidogenesis and survival of cultured buffalo granulosa cells.Theriogenology,2016,861818~1833.
20 Chakravarthi V,Kona S,Kumar AV,et al.Quantitative expression of antiapoptotic and proapoptotic genes in sheep ovarian follicles grown in vivo or cultured in vitro.Theriogenology,2015,83590~595.
21 Srividya D,Praveen Chakravarthi V,Kona S,et al.Expression of kit ligand and insulin-like growth factor binding protein 3 during in vivo or in vitro development of ovarian follicles in sheep.Repro Domest Anima,2017,52661~671.
22 Valleh MV,Tahmoorespur M,Joupari MD,et al.Paternal breed effects on expression of IGF-II,BAK1 and BCL2-L1in bovine preimplantation embryos.Zygote,2015,23712~721.
23 Damerill I,Biggar KK,Abu Shehab M,et al.Hypoxia increases IGFBP-1 phosphorylation mediated by m TOR inhibition.Mol Endocrinol,2016,30201~216.
24 Oxvig C.The role of PAPP-A in the IGF system:location,location,location.J Cell Commun Signal,2015,9177~187.
25 Meyerholz MM,Mense K,Lietzau M,et al.Serum IG-FBP4 concentration decreased in dairy heifers towards day 18 of pregnancy.J Vet Sci,2015,16413~421.
26 De Brun V,Meikle A,Casal A,et al.Periconceptional undernutrition modifies endocrine profiles and hepatic gene expression in sheep.J Anim Physiol An A,2015,99710~718.
27 Salih DA,Tripathi G,Holding C,et al.Insulin-like growth factor-binding protein 5(Igfbp5)compromises survival,growth,muscle development,and fertility in mice.P Natl Acad Sci USA,2004,1014314~4319.
28 Wood TL,Rogler LE,Czick ME,et al.Selective alterations in organ sizes in mice with a targeted disruption of the insulin-like growth factor binding protein-2 gene.Mol Endocrinol,2000,141472~1482.
29 Mense K,Heidekorn-Dettmer J,Wirthgen E,et al.Increased concentrations of insulin-like growth factor binding protein(IGFBP)-2,IGFBP-3,and IGFBP-4 are associated with fetal mortality in pregnant cows.Front Endocrinol(Lausanne),2018,9310.
30 Hoeflich A,Reyer A,Ohde D,et al.Dissociation of somatic growth,time of sexual maturity,and life expectancy by overexpression of an RGD-deficient IGFBP-2 variant in female transgenic mice.Aging cell,2016,15111~117.