Joining actions: crosstalk between intermediate filaments and actin orchestrates cellular physical dynamics and signaling
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摘要
Many key cellular functions are regulated by the interplay of three distinct cytoskeletal networks, made of actin filaments,microtubules, and intermediate filaments(IFs), which is a hitherto poorly investigated area of research. However, there are growing evidence in the last few years showing that the IFs cooperate with actin filaments to exhibit strongly coupled functions.This review recapitulates our current knowledge on how the crosstalk between IFs and actin filaments modulates the migration properties, mechano-responsiveness and signaling transduction of cells, from both biophysical and biochemical point of view.
Many key cellular functions are regulated by the interplay of three distinct cytoskeletal networks, made of actin filaments,microtubules, and intermediate filaments(IFs), which is a hitherto poorly investigated area of research. However, there are growing evidence in the last few years showing that the IFs cooperate with actin filaments to exhibit strongly coupled functions.This review recapitulates our current knowledge on how the crosstalk between IFs and actin filaments modulates the migration properties, mechano-responsiveness and signaling transduction of cells, from both biophysical and biochemical point of view.
Many key cellular functions are regulated by the interplay of three distinct cytoskeletal networks, made of actin filaments,microtubules, and intermediate filaments(IFs), which is a hitherto poorly investigated area of research. However, there are growing evidence in the last few years showing that the IFs cooperate with actin filaments to exhibit strongly coupled functions.This review recapitulates our current knowledge on how the crosstalk between IFs and actin filaments modulates the migration properties, mechano-responsiveness and signaling transduction of cells, from both biophysical and biochemical point of view.
引文
Buxboim,A.,Swift,J.,Irianto,J.,Spinler,K.R.,Dingal,P.C.D.P.,Athirasala,A.,Kao,Y.R.C.,Cho,S.,Harada,T.,Shin,J.W.,et al.(2014).Matrix elasticity regulates lamin-A,C phosphorylation and turnover with feedback to actomyosin.Curr Biol 24,1909-1917.
Chang,L.,and Goldman,R.D.(2004).Intermediate filaments mediate cytoskeletal crosstalk.Nat Rev Mol Cell Biol 5,601-613.
Cheng,F.,and Eriksson,J.E.Intermediate filaments and the regulation of cell motility during regeneration and wound healing.Cold Spring Harb Perspect Biol 2017,9.
Cleary,R.A.,Wang,R.,Waqar,O.,Singer,H.A.,and Tang,D.D.(2014).Role of c-Abl tyrosine kinase in smooth muscle cell migration.Am JPhysiol Cell Physiol 306,C753-C761.
De Pascalis,C.,Pérez-González,C.,Seetharaman,S.,Bo?da,B.,Vianay,B.,Burute,M.,Leduc,C.,Borghi,N.,Trepat,X.,and EtienneManneville,S.(2018).Intermediate filaments control collective migration by restricting traction forces and sustaining cell-cell contacts.J Cell Biol 217,3031-3044.
Deng,M.,Mohanan,S.,Polyak,E.,and Chacko,S.(2007).Caldesmon is necessary for maintaining the actin and intermediate filaments in cultured bladder smooth muscle cells.Cell Motil Cytoskel 64,951-965.
Dupin,I.,Camand,E.,and Etienne-Manneville,S.(2009).Classical cadherins control nucleus and centrosome position and cell polarity.JCell Biol 185,779-786.
Dupin,I.,Sakamoto,Y.,and Etienne-Manneville,S.(2011).Cytoplasmic intermediate filaments mediate actin-driven positioning of the nucleus.JCell Sci 124,865-872.
Eckes,B.,Dogic,D.,Colucci-Guyon,E.,Wang,N.,Maniotis,A.,Ingber,D.,Merckling,A.,Langa,F.,Aumailley,M.,Delouvee,A.,Koteliansky,V.,Babinet,C.,and Krieg,T.(1998).Impaired mechanical stability,migration and contractile capacity in vimentin-deficient fibroblasts.JCell Sci 111(Pt 13),1897-1907.
Esue,O.,Carson,A.A.,Tseng,Y.,and Wirtz,D.(2006).A direct interaction between actin and vimentin filaments mediated by the tail domain of vimentin.J Biol Chem 281,30393-30399.
Etienne-Manneville,S.(2018).Cytoplasmic intermediate filaments in cell biology.Ann Rev Cell Dev Biol 34,1-28.
Folker,E.S.,Ostlund,C.,Luxton,G.W.,Worman,H.J.,and Gundersen,G.G.(2011).Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement.Proc Natl Acad Sci USA 108,131-136.
Fujiwara,S.,Ohashi,K.,Mashiko,T.,Kondo,H.,and Mizuno,K.(2016).Interplay between Solo and keratin filaments is crucial for mechanical force-induced stress fiber reinforcement.Mol Biol Cell 27,954-966.
Gan,Z.,Ding,L.,Burckhardt,C.J.,Lowery,J.,Zaritsky,A.,Sitterley,K.,Mota,A.,Costigliola,N.,Starker,C.G.,Voytas,D.F.,et al.(2016).Vimentin intermediate filaments template microtubule networks to enhance persistence in cell polarity and directed migration.Cell Syst 3,500-501.
Gerashchenko,M.V.,Chernoivanenko,I.S.,Moldaver,M.V.,and Minin,A.A.(2009).Dynein is a motor for nuclear rotation while vimentin IFs is a“brake”.Cell Biol Int 33,1057-1064.
Green,K.J.,Talian,J.C.,and Goldman,R.D.(1986).Relationship between intermediate filaments and microfilaments in cultured fibroblasts:evidence for common foci during cell spreading.Cell Motil Cytoskel6,406-418.
Green,K.J.,Geiger,B.,Jones,J.C.,Talian,J.C.,and Goldman,R.D.(1987).The relationship between intermediate filaments and microfilaments before and during the formation of desmosomes and adherens-type junctions in mouse epidermal keratinocytes.J Cell Biol104,1389-1402.
Gregor,M.,Osmanagic-Myers,S.,Burgstaller,G.,Wolfram,M.,Fischer,I.,Walko,G.,Resch,G.P.,J?rgl,A.,Herrmann,H.,and Wiche,G.(2014).Mechanosensing through focal adhesion-anchored intermediate filaments.FASEB J 28,715-729.
Gyoeva,F.K.,and Gelfand,V.I.(1991).Coalignment of vimentin intermediate filaments with microtubules depends on kinesin.Nature353,445-448.
Havel,L.S.,Kline,E.R.,Salgueiro,A.M.,and Marcus,A.I.(2015).Vimentin regulates lung cancer cell adhesion through a VAV2-Rac1pathway to control focal adhesion kinase activity.Oncogene 34,1979-1990.
Helfand,B.T.,Chang,L.,and Goldman,R.D.(2004).Intermediate filaments are dynamic and motile elements of cellular architecture.JCell Sci 117,133-141.
Helfand,B.T.,Mendez,M.G.,Murthy,S.N.P.,Shumaker,D.K.,Grin,B.,Mahammad,S.,Aebi,U.,Wedig,T.,Wu,Y.I.,Hahn,K.M.,et al.(2011).Vimentin organization modulates the formation of lamellipodia.Mol Biol Cell 22,1274-1289.
Helfand,B.T.,Mikami,A.,Vallee,R.B.,and Goldman,R.D.(2002).Arequirement for cytoplasmic dynein and dynactin in intermediate filament network assembly and organization.J Cell Biol 157,795-806.
Hesse,M.,Magin,T.M.,and Weber,K.(2001).Genes for intermediate filament proteins and the draft sequence of the human genome:novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18.J Cell Sci 114,2569-2575.
Holaska,J.M.,Kowalski,A.K.,and Wilson,K.L.(2004).Emerin caps the pointed end of actin filaments:evidence for an actin cortical network at the nuclear inner membrane.PLoS Biol 2,e231.
Ivaska,J.,Pallari,H.M.,Nevo,J.,and Eriksson,J.E.(2007).Novel functions of vimentin in cell adhesion,migration,and signaling.Exp Cell Res 313,2050-2062.
Janmey,P.A.,Euteneuer,U.,Traub,P.,and Schliwa,M.(1991).Viscoelastic properties of vimentin compared with other filamentous biopolymer networks.J Cell Biol 113,155-160.
Jiu,Y.,Lehtim?ki,J.,Tojkander,S.,Cheng,F.,J??linoja,H.,Liu,X.,Varjosalo,M.,Eriksson,J.E.,and Lappalainen,P.(2015).Bidirectional interplay between vimentin intermediate filaments and contractile actin stress fibers.Cell Rep 11,1511-1518.
Jiu,Y.,Per?nen,J.,Schaible,N.,Cheng,F.,Eriksson,J.E.,Krishnan,R.,and Lappalainen,P.(2017).Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA.J Cell Sci 130,892-902.
Lanier,M.H.,Kim,T.,and Cooper,J.A.(2015).CARMIL2 is a novel molecular connection between vimentin and actin essential for cell migration and invadopodia formation.Mol Biol Cell 26,4577-4588.
Leduc,C.,and Etienne-Manneville,S.(2015).Intermediate filaments in cell migration and invasion:the unusual suspects.Curr Opin Cell Biol32,102-112.
Li,J.,Wang,R.,Gannon,O.J.,Rezey,A.C.,Jiang,S.,Gerlach,B.D.,Liao,G.,and Tang,D.D.(2016).Polo-like kinase 1 regulates vimentin phosphorylation at Ser-56 and contraction in smooth muscle.J Biol Chem 291,23693-23703.
Li,Q.F.,Spinelli,A.M.,Wang,R.,Anfinogenova,Y.,Singer,H.A.,and Tang,D.D.(2006).Critical role of vimentin phosphorylation at Ser-56by p21-activated kinase in vimentin cytoskeleton signaling.J Biol Chem 281,34716-34724.
Liao,G.,and Gundersen,G.G.(1998).Kinesin is a candidate for crossbridging microtubules and intermediate filaments.Selective binding of kinesin to detyrosinated tubulin and vimentin.J Biol Chem 273,9797-9803.
Liovic,M.,Mogensen,M.M.,and Prescott,A.R.Lane,E.B.,(2003).Observation of keratin particles showing fast bidirectional movement colocalized with microtubules.J Cell Sci 116,1417-1427.
Lobrinus,J.A.,Janzer,R.C.,Kuntzer,T.,Matthieu,J.M.,Pfend,G.,Goy,J.J.,and Bogousslavsky,J.(1998).Familial cardiomyopathy and distal myopathy with abnormal desmin accumulation and migration.Neuromusc Dis 8,77-86.
Luxton,G.W.G.,Gomes,E.R.,Folker,E.S.,Vintinner,E.,and Gundersen,G.G.(2010).Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement.Science 329,956-959.
Mendez,M.G.,Restle,D.,and Janmey,P.A.(2014).Vimentin enhances cell elastic behavior and protects against compressive stress.Biophys J 107,314-323.
Osmanagic-Myers,S.,Dechat,T.,and Foisner,R.(2015).Lamins at the crossroads of mechanosignaling.Genes Dev 29,225-237.
Pallari,H.M.,and Eriksson,J.E.(2006).Intermediate filaments as signaling platforms.Sci STKE 2006,pe53.
Pollard,T.D.,and Borisy,G.G.(2003).Cellular motility driven by assembly and disassembly of actin filaments.Cell 112,453-465.
Prahlad,V.,Yoon,M.,Moir,R.D.,Vale,R.D.,and Goldman,R.D.(1998).Rapid movements of vimentin on microtubule tracks:kinesindependent assembly of intermediate filament networks.J Cell Biol143,159-170.
Rao,M.V.,Engle,L.J.,Mohan,P.S.,Yuan,A.,Qiu,D.,Cataldo,A.,Hassinger,L.,Jacobsen,S.,Lee,V.M.Y.,Andreadis,A.,et al.(2002).Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density.J Cell Biol 159,279-290.
Sharma,P.,Bolten,Z.T.,Wagner,D.R.,and Hsieh,A.H.(2017).Deformability of human mesenchymal stem cells is dependent on vimentin intermediate filaments.Ann Biomed Eng 45,1365-1374.
Sjuve,R.,Arner,A.,Li,Z.,Mies,B.,Paulin,D.,Schmittner,M.,and Small,J.V.(1998).Mechanical alterations in smooth muscle from mice lacking desmin.J Musc Res Cell Motil 19,415-429.
Sullivan,T.,Escalante-Alcalde,D.,Bhatt,H.,Anver,M.,Bhat,N.,Nagashima,K.,Stewart,C.L.,and Burke,B.(1999).Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy.J Cell Biol 147,913-920.
Swift,J.,Ivanovska,I.L.,Buxboim,A.,Harada,T.,Dingal,P.C.D.P.,Pinter,J.,Pajerowski,J.D.,Spinler,K.R.,Shin,J.W.,Tewari,M.,et al.(2013).Nuclear lamin-A scales with tissue stiffness and enhances matrixdirected differentiation.Science 341,1240104.
Szeverenyi,I.,Cassidy,A.J.,Chung,C.W.,Lee,B.T.K.,Common,J.E.A.,Ogg,S.C.,Chen,H.,Sim,S.Y.,Goh,W.L.P.,Ng,K.W.,et al.(2008).The Human Intermediate Filament Database:comprehensive information on a gene family involved in many human diseases.Hum Mutat 29,351-360.
Tang,D.D.(2008).Intermediate filaments in smooth muscle.Am J Physiol Cell Physiol 294,C869-C878.
Tang,D.D.,and Anfinogenova,Y.(2008).Physiologic properties and regulation of the actin cytoskeleton in vascular smooth muscle.JCardiovasc Pharmacol Ther 13,130-140.
Tang,D.D.(2009).p130 Crk-associated substrate(CAS)in vascular smooth muscle.J Cardiovasc Pharmacol Ther 14,89-98.
Tang,D.D.(2015).Critical role of actin-associated proteins in smooth muscle contraction,cell proliferation,airway hyperresponsiveness and airway remodeling.Respir Res 16,134.
Tang,D.D.,and Gerlach,B.D.(2017).The roles and regulation of the actin cytoskeleton,intermediate filaments and microtubules in smooth muscle cell migration.Respir Res 18,54.
Wang,R.,Li,Q.,and Tang,D.D.(2006).Role of vimentin in smooth muscle force development.Am J Physiol Cell Physiol 291,C483-C489.
Wang,R.,Li,Q.F.,Anfinogenova,Y.,and Tang,D.D.(2007).Dissociation of Crk-associated substrate from the vimentin network is regulated by p21-activated kinase on ACh activation of airway smooth muscle.Am JPhysiol Lung Cell Mol Physiol 292,L240-L248.
Weber,K.L.,and Bement,W.M.(2002).F-actin serves as a template for cytokeratin organization in cell free extracts.J Cell Sci 115,1373-1382.
Whipple,R.A.,Balzer,E.M.,Cho,E.H.,Matrone,M.A.,Yoon,J.R.,and Martin,S.S.(2008).Vimentin filaments support extension of tubulinbased microtentacles in detached breast tumor cells.Cancer Res 68,5678-5688.
Yoon,K.H.,Yoon,M.,Moir,R.D.,Khuon,S.,Flitney,F.W.,and Goldman,R.D.(2001).Insights into the dynamic properties of keratin intermediate filaments in living epithelial cells.J Cell Biol 153,503-516.
Yoon,M.,Moir,R.D.,Prahlad,V.,and Goldman,R.D.(1998).Motile properties of vimentin intermediate filament networks in living cells.JCell Biol 143,147-157.
Zastrow,M.S.,Vlcek,S.,and Wilson,K.L.(2004).Proteins that bind A-type lamins:integrating isolated clues.J Cell Sci 117,979-987.
Chang,L.,and Goldman,R.D.(2004).Intermediate filaments mediate cytoskeletal crosstalk.Nat Rev Mol Cell Biol 5,601-613.
Cheng,F.,and Eriksson,J.E.Intermediate filaments and the regulation of cell motility during regeneration and wound healing.Cold Spring Harb Perspect Biol 2017,9.
Cleary,R.A.,Wang,R.,Waqar,O.,Singer,H.A.,and Tang,D.D.(2014).Role of c-Abl tyrosine kinase in smooth muscle cell migration.Am JPhysiol Cell Physiol 306,C753-C761.
De Pascalis,C.,Pérez-González,C.,Seetharaman,S.,Bo?da,B.,Vianay,B.,Burute,M.,Leduc,C.,Borghi,N.,Trepat,X.,and EtienneManneville,S.(2018).Intermediate filaments control collective migration by restricting traction forces and sustaining cell-cell contacts.J Cell Biol 217,3031-3044.
Deng,M.,Mohanan,S.,Polyak,E.,and Chacko,S.(2007).Caldesmon is necessary for maintaining the actin and intermediate filaments in cultured bladder smooth muscle cells.Cell Motil Cytoskel 64,951-965.
Dupin,I.,Camand,E.,and Etienne-Manneville,S.(2009).Classical cadherins control nucleus and centrosome position and cell polarity.JCell Biol 185,779-786.
Dupin,I.,Sakamoto,Y.,and Etienne-Manneville,S.(2011).Cytoplasmic intermediate filaments mediate actin-driven positioning of the nucleus.JCell Sci 124,865-872.
Eckes,B.,Dogic,D.,Colucci-Guyon,E.,Wang,N.,Maniotis,A.,Ingber,D.,Merckling,A.,Langa,F.,Aumailley,M.,Delouvee,A.,Koteliansky,V.,Babinet,C.,and Krieg,T.(1998).Impaired mechanical stability,migration and contractile capacity in vimentin-deficient fibroblasts.JCell Sci 111(Pt 13),1897-1907.
Esue,O.,Carson,A.A.,Tseng,Y.,and Wirtz,D.(2006).A direct interaction between actin and vimentin filaments mediated by the tail domain of vimentin.J Biol Chem 281,30393-30399.
Etienne-Manneville,S.(2018).Cytoplasmic intermediate filaments in cell biology.Ann Rev Cell Dev Biol 34,1-28.
Folker,E.S.,Ostlund,C.,Luxton,G.W.,Worman,H.J.,and Gundersen,G.G.(2011).Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement.Proc Natl Acad Sci USA 108,131-136.
Fujiwara,S.,Ohashi,K.,Mashiko,T.,Kondo,H.,and Mizuno,K.(2016).Interplay between Solo and keratin filaments is crucial for mechanical force-induced stress fiber reinforcement.Mol Biol Cell 27,954-966.
Gan,Z.,Ding,L.,Burckhardt,C.J.,Lowery,J.,Zaritsky,A.,Sitterley,K.,Mota,A.,Costigliola,N.,Starker,C.G.,Voytas,D.F.,et al.(2016).Vimentin intermediate filaments template microtubule networks to enhance persistence in cell polarity and directed migration.Cell Syst 3,500-501.
Gerashchenko,M.V.,Chernoivanenko,I.S.,Moldaver,M.V.,and Minin,A.A.(2009).Dynein is a motor for nuclear rotation while vimentin IFs is a“brake”.Cell Biol Int 33,1057-1064.
Green,K.J.,Talian,J.C.,and Goldman,R.D.(1986).Relationship between intermediate filaments and microfilaments in cultured fibroblasts:evidence for common foci during cell spreading.Cell Motil Cytoskel6,406-418.
Green,K.J.,Geiger,B.,Jones,J.C.,Talian,J.C.,and Goldman,R.D.(1987).The relationship between intermediate filaments and microfilaments before and during the formation of desmosomes and adherens-type junctions in mouse epidermal keratinocytes.J Cell Biol104,1389-1402.
Gregor,M.,Osmanagic-Myers,S.,Burgstaller,G.,Wolfram,M.,Fischer,I.,Walko,G.,Resch,G.P.,J?rgl,A.,Herrmann,H.,and Wiche,G.(2014).Mechanosensing through focal adhesion-anchored intermediate filaments.FASEB J 28,715-729.
Gyoeva,F.K.,and Gelfand,V.I.(1991).Coalignment of vimentin intermediate filaments with microtubules depends on kinesin.Nature353,445-448.
Havel,L.S.,Kline,E.R.,Salgueiro,A.M.,and Marcus,A.I.(2015).Vimentin regulates lung cancer cell adhesion through a VAV2-Rac1pathway to control focal adhesion kinase activity.Oncogene 34,1979-1990.
Helfand,B.T.,Chang,L.,and Goldman,R.D.(2004).Intermediate filaments are dynamic and motile elements of cellular architecture.JCell Sci 117,133-141.
Helfand,B.T.,Mendez,M.G.,Murthy,S.N.P.,Shumaker,D.K.,Grin,B.,Mahammad,S.,Aebi,U.,Wedig,T.,Wu,Y.I.,Hahn,K.M.,et al.(2011).Vimentin organization modulates the formation of lamellipodia.Mol Biol Cell 22,1274-1289.
Helfand,B.T.,Mikami,A.,Vallee,R.B.,and Goldman,R.D.(2002).Arequirement for cytoplasmic dynein and dynactin in intermediate filament network assembly and organization.J Cell Biol 157,795-806.
Hesse,M.,Magin,T.M.,and Weber,K.(2001).Genes for intermediate filament proteins and the draft sequence of the human genome:novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18.J Cell Sci 114,2569-2575.
Holaska,J.M.,Kowalski,A.K.,and Wilson,K.L.(2004).Emerin caps the pointed end of actin filaments:evidence for an actin cortical network at the nuclear inner membrane.PLoS Biol 2,e231.
Ivaska,J.,Pallari,H.M.,Nevo,J.,and Eriksson,J.E.(2007).Novel functions of vimentin in cell adhesion,migration,and signaling.Exp Cell Res 313,2050-2062.
Janmey,P.A.,Euteneuer,U.,Traub,P.,and Schliwa,M.(1991).Viscoelastic properties of vimentin compared with other filamentous biopolymer networks.J Cell Biol 113,155-160.
Jiu,Y.,Lehtim?ki,J.,Tojkander,S.,Cheng,F.,J??linoja,H.,Liu,X.,Varjosalo,M.,Eriksson,J.E.,and Lappalainen,P.(2015).Bidirectional interplay between vimentin intermediate filaments and contractile actin stress fibers.Cell Rep 11,1511-1518.
Jiu,Y.,Per?nen,J.,Schaible,N.,Cheng,F.,Eriksson,J.E.,Krishnan,R.,and Lappalainen,P.(2017).Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA.J Cell Sci 130,892-902.
Lanier,M.H.,Kim,T.,and Cooper,J.A.(2015).CARMIL2 is a novel molecular connection between vimentin and actin essential for cell migration and invadopodia formation.Mol Biol Cell 26,4577-4588.
Leduc,C.,and Etienne-Manneville,S.(2015).Intermediate filaments in cell migration and invasion:the unusual suspects.Curr Opin Cell Biol32,102-112.
Li,J.,Wang,R.,Gannon,O.J.,Rezey,A.C.,Jiang,S.,Gerlach,B.D.,Liao,G.,and Tang,D.D.(2016).Polo-like kinase 1 regulates vimentin phosphorylation at Ser-56 and contraction in smooth muscle.J Biol Chem 291,23693-23703.
Li,Q.F.,Spinelli,A.M.,Wang,R.,Anfinogenova,Y.,Singer,H.A.,and Tang,D.D.(2006).Critical role of vimentin phosphorylation at Ser-56by p21-activated kinase in vimentin cytoskeleton signaling.J Biol Chem 281,34716-34724.
Liao,G.,and Gundersen,G.G.(1998).Kinesin is a candidate for crossbridging microtubules and intermediate filaments.Selective binding of kinesin to detyrosinated tubulin and vimentin.J Biol Chem 273,9797-9803.
Liovic,M.,Mogensen,M.M.,and Prescott,A.R.Lane,E.B.,(2003).Observation of keratin particles showing fast bidirectional movement colocalized with microtubules.J Cell Sci 116,1417-1427.
Lobrinus,J.A.,Janzer,R.C.,Kuntzer,T.,Matthieu,J.M.,Pfend,G.,Goy,J.J.,and Bogousslavsky,J.(1998).Familial cardiomyopathy and distal myopathy with abnormal desmin accumulation and migration.Neuromusc Dis 8,77-86.
Luxton,G.W.G.,Gomes,E.R.,Folker,E.S.,Vintinner,E.,and Gundersen,G.G.(2010).Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement.Science 329,956-959.
Mendez,M.G.,Restle,D.,and Janmey,P.A.(2014).Vimentin enhances cell elastic behavior and protects against compressive stress.Biophys J 107,314-323.
Osmanagic-Myers,S.,Dechat,T.,and Foisner,R.(2015).Lamins at the crossroads of mechanosignaling.Genes Dev 29,225-237.
Pallari,H.M.,and Eriksson,J.E.(2006).Intermediate filaments as signaling platforms.Sci STKE 2006,pe53.
Pollard,T.D.,and Borisy,G.G.(2003).Cellular motility driven by assembly and disassembly of actin filaments.Cell 112,453-465.
Prahlad,V.,Yoon,M.,Moir,R.D.,Vale,R.D.,and Goldman,R.D.(1998).Rapid movements of vimentin on microtubule tracks:kinesindependent assembly of intermediate filament networks.J Cell Biol143,159-170.
Rao,M.V.,Engle,L.J.,Mohan,P.S.,Yuan,A.,Qiu,D.,Cataldo,A.,Hassinger,L.,Jacobsen,S.,Lee,V.M.Y.,Andreadis,A.,et al.(2002).Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density.J Cell Biol 159,279-290.
Sharma,P.,Bolten,Z.T.,Wagner,D.R.,and Hsieh,A.H.(2017).Deformability of human mesenchymal stem cells is dependent on vimentin intermediate filaments.Ann Biomed Eng 45,1365-1374.
Sjuve,R.,Arner,A.,Li,Z.,Mies,B.,Paulin,D.,Schmittner,M.,and Small,J.V.(1998).Mechanical alterations in smooth muscle from mice lacking desmin.J Musc Res Cell Motil 19,415-429.
Sullivan,T.,Escalante-Alcalde,D.,Bhatt,H.,Anver,M.,Bhat,N.,Nagashima,K.,Stewart,C.L.,and Burke,B.(1999).Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy.J Cell Biol 147,913-920.
Swift,J.,Ivanovska,I.L.,Buxboim,A.,Harada,T.,Dingal,P.C.D.P.,Pinter,J.,Pajerowski,J.D.,Spinler,K.R.,Shin,J.W.,Tewari,M.,et al.(2013).Nuclear lamin-A scales with tissue stiffness and enhances matrixdirected differentiation.Science 341,1240104.
Szeverenyi,I.,Cassidy,A.J.,Chung,C.W.,Lee,B.T.K.,Common,J.E.A.,Ogg,S.C.,Chen,H.,Sim,S.Y.,Goh,W.L.P.,Ng,K.W.,et al.(2008).The Human Intermediate Filament Database:comprehensive information on a gene family involved in many human diseases.Hum Mutat 29,351-360.
Tang,D.D.(2008).Intermediate filaments in smooth muscle.Am J Physiol Cell Physiol 294,C869-C878.
Tang,D.D.,and Anfinogenova,Y.(2008).Physiologic properties and regulation of the actin cytoskeleton in vascular smooth muscle.JCardiovasc Pharmacol Ther 13,130-140.
Tang,D.D.(2009).p130 Crk-associated substrate(CAS)in vascular smooth muscle.J Cardiovasc Pharmacol Ther 14,89-98.
Tang,D.D.(2015).Critical role of actin-associated proteins in smooth muscle contraction,cell proliferation,airway hyperresponsiveness and airway remodeling.Respir Res 16,134.
Tang,D.D.,and Gerlach,B.D.(2017).The roles and regulation of the actin cytoskeleton,intermediate filaments and microtubules in smooth muscle cell migration.Respir Res 18,54.
Wang,R.,Li,Q.,and Tang,D.D.(2006).Role of vimentin in smooth muscle force development.Am J Physiol Cell Physiol 291,C483-C489.
Wang,R.,Li,Q.F.,Anfinogenova,Y.,and Tang,D.D.(2007).Dissociation of Crk-associated substrate from the vimentin network is regulated by p21-activated kinase on ACh activation of airway smooth muscle.Am JPhysiol Lung Cell Mol Physiol 292,L240-L248.
Weber,K.L.,and Bement,W.M.(2002).F-actin serves as a template for cytokeratin organization in cell free extracts.J Cell Sci 115,1373-1382.
Whipple,R.A.,Balzer,E.M.,Cho,E.H.,Matrone,M.A.,Yoon,J.R.,and Martin,S.S.(2008).Vimentin filaments support extension of tubulinbased microtentacles in detached breast tumor cells.Cancer Res 68,5678-5688.
Yoon,K.H.,Yoon,M.,Moir,R.D.,Khuon,S.,Flitney,F.W.,and Goldman,R.D.(2001).Insights into the dynamic properties of keratin intermediate filaments in living epithelial cells.J Cell Biol 153,503-516.
Yoon,M.,Moir,R.D.,Prahlad,V.,and Goldman,R.D.(1998).Motile properties of vimentin intermediate filament networks in living cells.JCell Biol 143,147-157.
Zastrow,M.S.,Vlcek,S.,and Wilson,K.L.(2004).Proteins that bind A-type lamins:integrating isolated clues.J Cell Sci 117,979-987.