转基因动物安全评价浅谈
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摘要
转基因技术飞速发展给人类带来巨大经济效益的同时,其安全性也值得我们深入思考。而作为第一个被FDA批准上市的转基因动物三文鱼掀起轩然大波,关于转基因动物是否安全的问题愈演愈烈。从转基因动物安全评价知识方面及最新进展进行了简要的分析,以期让人们了解转基因动物安全知识的同时,能够了解转基因食品的知识以及安全性,从而在生活中对转基因食品有自己的判断。在此基础上,借助第一个转基因动物三文鱼上市的成功经验,以对我国转基因产品的申报及安全上市提供一些方向性意见。
引文
[1]ZHOU C,WANG J W,HUANG K L,et al.A 90-day safety study in Sprague-Dawley rats fed milk powder containing recombinant human lactoferrin(rhLF)derived from transgenic cloned cattle[J].Drug and chemical toxicology,2011,34(4):359-368．
[2]卢军锋，李晓，杨公社，等．我国转基因动物及其安全性评价发展现状[J]．中国兽医杂志，2018,54(2):62-64．
[3]谭德凡．我国转基因食品安全的法律保障[J]．湖南科技学院学报，2011,32(2):135-137．
[4]HAYES A W,DAYAN A D,HALL W C,et al.A review of mammalian carcinogenicity study design and potential effects of alternate test procedures on the safety evaluation of food ingredients[J].Regulatory toxicology and pharmacology,2011,60(1Suppl):S1-34．
[5]CAO S S,XU W T,LUO Y B,et al.Metabonomics study of transgenic Bacillus thuringiensis rice(T2A-1)meal in a 90-day dietary toxicity study in rats[J].Mol Biosyst,2011,7(1):2304-2310．
[6]CLIVE J.Global status of commercialized Biotech/GM crops in2017:Biotech crop adoption surges as economic benefits accumulate in 22 years[R].ISAAA Briefs,2017．
[7]JOHNSON S R.Quantification of the impacts on US agriculture of biotechnology-derived crops planted in 2006[R].Washington D C:National Centre for Food and Agricultural Policy,2008
[8]WANG D Y,WANG D Y.Implications of US GMO Salmon approved for commercial food use[J].Chinese science bulletin,2016,61(3):289-295．
[9]YANG P,WANG J,GONG G,et al.Cattle mammary bioreactor generated by a novel procedure of transgenic cloning for largeScale production of functional human lactoferrin[J].PLoS ONE,2008,3(10):e3453
[10]WU X,OU Y H,DUAN B,et al.Production of cloned transgen-ic cow expressing omega-3fatty acids[J].Transgenic research,2012,21(3):537-543．
[11]WANG X,YU H,LEI A,et al.Generation of gene-modified goats targeting MSTN and FGF5 via zygote injection of CRISPR/Cas9 system[J].Scientific reports,2015,5:13878．
[12]ZENG F,LI Z,ZHU Q,et al.Production of functional human nerve growth factor from the saliva of transgenic mice by using salivary glands as bioreactors[J].Scientific reports,2017,7:41270．
[13]FDA.FDA has determined that the AquAdvantage Salmon is as safe to eat as Non-GESalmon[EB/OL].https：//www.fda.gov/For Consumers/ConsumerUpdates/ucm472487.htm,2015-11-19．
[14]王大元．美国转基因三文鱼商业化的启示[J]．科学通报，2016,61(3):289-295．
[15]HARLANDER S K.Safety assessments and public concern for genetically modified food products:The American view[J].Toxicologic pathology,2002,30(1):132-134．
[16]MCLEAN M.CVM uses seven-step process to evaluate safety,effectiveness of GE animals[J].FDA Veterinarian,2008,23:5-8．
[17]宋欢，王坤立，许文涛，等．转基因食品安全性评价研究进展[J]．食品科学，2014,35(15):295-303．
[18]农业部农业转基因生物安全管理办公室.农业转基因生物安全管理法规[Z].2010．
[19]卢军锋，李晓，杨公社，等．我国转基因动物及其安全性评价发展现状[J]．中国兽医杂志，2018,54(2):62-64．
[20]MURRAY J D,MAGA E A.Is there a risk from not using GE animals?[J].Transgenic Res,2010,19(3):357-361．
[21]WILLIAMS N.Bold call for more GM animals[J].Curr Biol,2001,11(12):R451.
[2]卢军锋，李晓，杨公社，等．我国转基因动物及其安全性评价发展现状[J]．中国兽医杂志，2018,54(2):62-64．
[3]谭德凡．我国转基因食品安全的法律保障[J]．湖南科技学院学报，2011,32(2):135-137．
[4]HAYES A W,DAYAN A D,HALL W C,et al.A review of mammalian carcinogenicity study design and potential effects of alternate test procedures on the safety evaluation of food ingredients[J].Regulatory toxicology and pharmacology,2011,60(1Suppl):S1-34．
[5]CAO S S,XU W T,LUO Y B,et al.Metabonomics study of transgenic Bacillus thuringiensis rice(T2A-1)meal in a 90-day dietary toxicity study in rats[J].Mol Biosyst,2011,7(1):2304-2310．
[6]CLIVE J.Global status of commercialized Biotech/GM crops in2017:Biotech crop adoption surges as economic benefits accumulate in 22 years[R].ISAAA Briefs,2017．
[7]JOHNSON S R.Quantification of the impacts on US agriculture of biotechnology-derived crops planted in 2006[R].Washington D C:National Centre for Food and Agricultural Policy,2008
[8]WANG D Y,WANG D Y.Implications of US GMO Salmon approved for commercial food use[J].Chinese science bulletin,2016,61(3):289-295．
[9]YANG P,WANG J,GONG G,et al.Cattle mammary bioreactor generated by a novel procedure of transgenic cloning for largeScale production of functional human lactoferrin[J].PLoS ONE,2008,3(10):e3453
[10]WU X,OU Y H,DUAN B,et al.Production of cloned transgen-ic cow expressing omega-3fatty acids[J].Transgenic research,2012,21(3):537-543．
[11]WANG X,YU H,LEI A,et al.Generation of gene-modified goats targeting MSTN and FGF5 via zygote injection of CRISPR/Cas9 system[J].Scientific reports,2015,5:13878．
[12]ZENG F,LI Z,ZHU Q,et al.Production of functional human nerve growth factor from the saliva of transgenic mice by using salivary glands as bioreactors[J].Scientific reports,2017,7:41270．
[13]FDA.FDA has determined that the AquAdvantage Salmon is as safe to eat as Non-GESalmon[EB/OL].https：//www.fda.gov/For Consumers/ConsumerUpdates/ucm472487.htm,2015-11-19．
[14]王大元．美国转基因三文鱼商业化的启示[J]．科学通报，2016,61(3):289-295．
[15]HARLANDER S K.Safety assessments and public concern for genetically modified food products:The American view[J].Toxicologic pathology,2002,30(1):132-134．
[16]MCLEAN M.CVM uses seven-step process to evaluate safety,effectiveness of GE animals[J].FDA Veterinarian,2008,23:5-8．
[17]宋欢，王坤立，许文涛，等．转基因食品安全性评价研究进展[J]．食品科学，2014,35(15):295-303．
[18]农业部农业转基因生物安全管理办公室.农业转基因生物安全管理法规[Z].2010．
[19]卢军锋，李晓，杨公社，等．我国转基因动物及其安全性评价发展现状[J]．中国兽医杂志，2018,54(2):62-64．
[20]MURRAY J D,MAGA E A.Is there a risk from not using GE animals?[J].Transgenic Res,2010,19(3):357-361．
[21]WILLIAMS N.Bold call for more GM animals[J].Curr Biol,2001,11(12):R451.