稀土掺杂近红外二区发光纳米探针及其生物应用（英文）
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摘要
近红外二区(1000–1700 nm)荧光纳米探针可以显著降低穿透组织时的光散射和自荧光效应的影响,从而提高探测深度以及成像分辨率.目前已报道的近红外二区生物探针主要基于有机荧光团、碳纳米管、量子点以及共轭聚合物.稀土离子掺杂纳米晶因其优异的发光性质,被认为是一类极具发展潜力的生物探针.本文从设计高效近红外二区发光的稀土掺杂纳米材料的角度出发,主要介绍了此类稀土纳米探针的基质选择、阳离子掺杂和表面修饰等设计策略的研究进展,及其在无背景生物成像、高灵敏生物检测和温度探测等领域的最新应用.此外,还展望了此类荧光纳米探针面临的挑战以及未来发展趋势.
Luminescent biosensing in the second nearinfrared(NIR-II) region is featured with superior spatial resolution and high penetration depth by virtue of the suppressed scattering of long-wavelength photons. Hitherto, the reported NIR-II nanoprobes are mostly based on carbon nanotubes, organic fluorophores or semiconducting quantum dots. As an alternative, trivalent lanthanide ions(Ln3+) doped nanoparticles have been emerging as a novel class of promising nanoprobes. In this review, we highlight the recent progress in the design of highly efficient Ln3+-doped NIR-II nanoparticles towards their emerging bioapplications, with an emphasis on autofluorescence-free bioimaging, sensitive bioassay, and accurate temperature sensing. Moreover, some efforts and challenges towards this rapidly expanding field are envisioned.
Luminescent biosensing in the second nearinfrared(NIR-II) region is featured with superior spatial resolution and high penetration depth by virtue of the suppressed scattering of long-wavelength photons. Hitherto, the reported NIR-II nanoprobes are mostly based on carbon nanotubes, organic fluorophores or semiconducting quantum dots. As an alternative, trivalent lanthanide ions(Ln3+) doped nanoparticles have been emerging as a novel class of promising nanoprobes. In this review, we highlight the recent progress in the design of highly efficient Ln3+-doped NIR-II nanoparticles towards their emerging bioapplications, with an emphasis on autofluorescence-free bioimaging, sensitive bioassay, and accurate temperature sensing. Moreover, some efforts and challenges towards this rapidly expanding field are envisioned.
引文
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