CD147表达与结直肠癌关系的国内外研究进展
摘要
<正>结直肠癌(colorectal cancer,CRC)是常见的消化道恶性肿瘤,也是我国五大常见癌症之一。在1987—2015年,中国结直肠癌发病率整体呈上升趋势[1],除此之外,世界结直肠癌发病死亡比例也呈逐年上升趋势,总体趋势为男性高于女性[2]。大部分CRC患者最终会发生远处转移,而化疗是转移癌患者基本的治疗手段,但由于肿瘤的耐药性往往导致晚期化疗效果欠佳,为此早期诊断对结直肠癌的治
引文
[1]刘晓雪,宇传华,周薇,等.中国近30年间结直肠癌死亡趋势分析[J].中国癌症杂志,2018,23(3):177-183.
[2]Siegel R L,Miller K D,Fedewa S A,et al. Colorectal cancer statistics,2017[J]. CA Cancer J Clin,2017,67(3):177-193.
[3]Kaname T,Miyauchi T,Kuwano A,et al. Mapping basigin(BSG),a member of the immunoglobulin superfamily,to19p13.3[J]. Cytogenet Cell Genet,1993,64(3-4):195-197.
[4]Zhu R,Zhang C G,Liu Y,et al. CD147 monoclonal antibody mediated by chitosan nanoparticles loaded with alphahederin enhances antineoplastic activity and cellular uptake in liver cancer cells[J]. Sci Rep,2015,5:17904.
[5]Han Y H,Gao B,Huang J H,et al. Expression of CD147,PCNA,VEGF,MMPs and their clinical significance in the giant cell tumor of bones[J]. Int J Clin Exp Pathol,2015,8(7):8446-8452.
[6]Nagashima S,Sakurai K,Suzuki S,et al. CD147 expression in non-invasive and invasive breast carcinoma][J]. Gan To Kagaku Ryoho,2014,41(10):1267-1269.
[7]Shen L,Dong X,Yu M,et al. Beta3GnT8 promotes gastric cancer invasion by regulating the glycosylation of CD147[J].J Cancer,2017,8(2):314-322.
[8]Zheng H C,Gong B C. CD147 expression was positively linked to aggressiveness and worse prognosis of gastric cancer:a meta and bioinformatics analysis[J]. Oncotarget,2017,8(52):90358-90370.
[9]Hu C,Dong X,Wu J,et al. CD147 overexpression may serve as a promising diagnostic and prognostic marker for gastric cancer:evidence from original research and literature[J]. Oncotarget,2017,8(19):30888-30899.
[10]Zhou Y,Wu B,Li J H,et al. Rab22a enhances CD147 recycling and is required for lung cancer cell migration and invasion[J]. Exp Cell Res,2017,357(1):9-16.
[11]Zhang X,Tian T,Zhang X,et al. Elevated CD147 expression is associated with shorter overall survival in non-small cell lung cancer[J]. Oncotarget,2017,8(23):37673-37680.
[12]Zheng H C,Wang W,Xu X Y,et al. Up-regulated EMMPRIN/CD147 protein expression might play a role in colorectal carcinogenesis and its subsequent progression without an alteration of its glycosylation and mRNA level[J]. J Cancer Res Clin Oncol,2011,137(4):585-596.
[13]郭梅梅,卢宁,黄建国,等.结直肠癌中CD147和CK20的表达及其临床意义[J].现代肿瘤医学,2013,21(5):1062-1065.
[14]陈娟,卢宁,黄建国,等. CD147和MMP-9在结直肠癌组织中的表达及临床意义[J].临床肿瘤学杂志,2013,18(11):982-985.
[15]Zheng H C,Wang W,Xu X Y,et al. Up-regulated EMMPRIN/CD147 protein expression might play a role in colorectal carcinogenesis and its subsequent progression without an alteration of its glycosylation and mRNA level[J]. J Cancer Res Clin Oncol,2011,137(4):585-596.
[16]Xu T,Zhou M,Peng L,et al. Upregulation of CD147 promotes cell invasion,epithelial-to-mesenchymal transition and activates MAPK/ERK signaling pathway in colorectal cancer[J]. Int J Clin Exp Pathol,2014,7(11):7432-7441.
[17]周明良. CD147上调表达与结肠癌耐药及肿瘤侵袭转移的关系及机制研究[D].济南:山东大学,2015.
[18]Willms A,Muller C,Julich H,et al. Tumour-associated circulating microparticles:A novel liquid biopsy tool for screening and therapy monitoring of colorectal carcinoma and other epithelial neoplasia[J]. Oncotarget,2016,7(21):30867-30875.
[19]张香梅,何常,张维元,等.结直肠癌中CD147、MMP-1表达及其临床病理意义[J].诊断病理学杂志,2008,15(2):124-126.
[20]金勇. CD147表达与结直肠癌临床病理因素及预后研究[D].蚌埠:蚌埠医学院,2016.
[21]Ferro S,Azevedo-silva J,Casal M,et al. Characterization of acetate transport in colorectal cancer cells and potential therapeutic implications[J]. Oncotarget,2016,7(43):70639-70653.
[22]Chen J,Pan Y,He B,et al. Inhibition of CD147 expression by RNA interference reduces proliferation,invasion and increases chemosensitivity in cancer stem cell-like HT-29 cells[J]. Int J Oncol,2015,47(4):1476-1484.
[23]Zhu S,Chu D,Zhang Y,et al. EMMPRIN/CD147 expression is associated with disease-free survival of patients with colorectal cancer[J]. Med Oncol,2013,30(1):369.
[24]Li R,Pan Y,He B,et al. Downregulation of CD147 expression by RNA interference inhibits HT29 cell proliferation,invasion and tumorigenicity in vitro and in vivo[J].Int J Oncol,2013,43(6):1885-1894.
[25]张欢.β3GnT2、β3GnT8介导的CD147糖基化在结肠癌细胞SW620侵袭和转移中的作用及其机制[D].苏州:苏州大学,2017.
[26]Ni J,Jiang Z,Shen L,et al.Beta3GnT8 regulates the metastatic potential of colorectal carcinoma cells by altering the glycosylation of CD147[J]. Oncol Rep,2014,31(4):1795-1801.
[27]李瑞. RNA干扰抑制CD147表达对人结直肠癌细胞HT29增殖、侵袭和致瘤能力的影响[D].南京:南京师范大学,2014.
[28]张敏,张晨光,丁卫.外泌体及其在肿瘤诊疗中的意义[J].生理科学进展,2014,45(5):372-378.
[29]Yoshioka Y,Kosaka N,Konishi Y,et al. Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen[J]. Nat Commun,2014,5:3591.
[30]Tian X,Ye C,Yang Y,et al. Expression of CD147 and matrix metalloproteinase-11 in colorectal cancer and their relationship to clinicopathological features[J]. J Transl Med,2015,13:337.
[31]唐志鹏. RNAi CD147溶瘤腺病毒对结直肠癌的靶向治疗作用及机制研究[D].南京:南京医科大学,2012.
[32]Ismail R,Allaudin Z N,Abdullah R,et al. Combination of VP3 and CD147-knockdown enhance apoptosis and tumor growth delay index in colorectal tumor allograft[J]. BMC Cancer,2016,16:461.
[33]Stenzinger A,Wittschieber D,von Winterfeld M,et al.High extracellular matrix metalloproteinase inducer/CD147expression is strongly and independently associated with poor prognosis in colorectal cancer[J]. Hum Pathol,2012,43(9):1471-1481.
[34]彭利盼. MiR-492调控CD147表达对结肠癌细胞LS174T奧沙利铂耐药性的影响的研究[D].济南:山东大学,2015.
[35]董晓霞,邱力,骆志国,等.衣霉素逆转CD147介导的结肠癌细胞株SW620/5-FU耐药性的实验研究[J].湖北医药学院学报,2015,34(5):432-435.
[2]Siegel R L,Miller K D,Fedewa S A,et al. Colorectal cancer statistics,2017[J]. CA Cancer J Clin,2017,67(3):177-193.
[3]Kaname T,Miyauchi T,Kuwano A,et al. Mapping basigin(BSG),a member of the immunoglobulin superfamily,to19p13.3[J]. Cytogenet Cell Genet,1993,64(3-4):195-197.
[4]Zhu R,Zhang C G,Liu Y,et al. CD147 monoclonal antibody mediated by chitosan nanoparticles loaded with alphahederin enhances antineoplastic activity and cellular uptake in liver cancer cells[J]. Sci Rep,2015,5:17904.
[5]Han Y H,Gao B,Huang J H,et al. Expression of CD147,PCNA,VEGF,MMPs and their clinical significance in the giant cell tumor of bones[J]. Int J Clin Exp Pathol,2015,8(7):8446-8452.
[6]Nagashima S,Sakurai K,Suzuki S,et al. CD147 expression in non-invasive and invasive breast carcinoma][J]. Gan To Kagaku Ryoho,2014,41(10):1267-1269.
[7]Shen L,Dong X,Yu M,et al. Beta3GnT8 promotes gastric cancer invasion by regulating the glycosylation of CD147[J].J Cancer,2017,8(2):314-322.
[8]Zheng H C,Gong B C. CD147 expression was positively linked to aggressiveness and worse prognosis of gastric cancer:a meta and bioinformatics analysis[J]. Oncotarget,2017,8(52):90358-90370.
[9]Hu C,Dong X,Wu J,et al. CD147 overexpression may serve as a promising diagnostic and prognostic marker for gastric cancer:evidence from original research and literature[J]. Oncotarget,2017,8(19):30888-30899.
[10]Zhou Y,Wu B,Li J H,et al. Rab22a enhances CD147 recycling and is required for lung cancer cell migration and invasion[J]. Exp Cell Res,2017,357(1):9-16.
[11]Zhang X,Tian T,Zhang X,et al. Elevated CD147 expression is associated with shorter overall survival in non-small cell lung cancer[J]. Oncotarget,2017,8(23):37673-37680.
[12]Zheng H C,Wang W,Xu X Y,et al. Up-regulated EMMPRIN/CD147 protein expression might play a role in colorectal carcinogenesis and its subsequent progression without an alteration of its glycosylation and mRNA level[J]. J Cancer Res Clin Oncol,2011,137(4):585-596.
[13]郭梅梅,卢宁,黄建国,等.结直肠癌中CD147和CK20的表达及其临床意义[J].现代肿瘤医学,2013,21(5):1062-1065.
[14]陈娟,卢宁,黄建国,等. CD147和MMP-9在结直肠癌组织中的表达及临床意义[J].临床肿瘤学杂志,2013,18(11):982-985.
[15]Zheng H C,Wang W,Xu X Y,et al. Up-regulated EMMPRIN/CD147 protein expression might play a role in colorectal carcinogenesis and its subsequent progression without an alteration of its glycosylation and mRNA level[J]. J Cancer Res Clin Oncol,2011,137(4):585-596.
[16]Xu T,Zhou M,Peng L,et al. Upregulation of CD147 promotes cell invasion,epithelial-to-mesenchymal transition and activates MAPK/ERK signaling pathway in colorectal cancer[J]. Int J Clin Exp Pathol,2014,7(11):7432-7441.
[17]周明良. CD147上调表达与结肠癌耐药及肿瘤侵袭转移的关系及机制研究[D].济南:山东大学,2015.
[18]Willms A,Muller C,Julich H,et al. Tumour-associated circulating microparticles:A novel liquid biopsy tool for screening and therapy monitoring of colorectal carcinoma and other epithelial neoplasia[J]. Oncotarget,2016,7(21):30867-30875.
[19]张香梅,何常,张维元,等.结直肠癌中CD147、MMP-1表达及其临床病理意义[J].诊断病理学杂志,2008,15(2):124-126.
[20]金勇. CD147表达与结直肠癌临床病理因素及预后研究[D].蚌埠:蚌埠医学院,2016.
[21]Ferro S,Azevedo-silva J,Casal M,et al. Characterization of acetate transport in colorectal cancer cells and potential therapeutic implications[J]. Oncotarget,2016,7(43):70639-70653.
[22]Chen J,Pan Y,He B,et al. Inhibition of CD147 expression by RNA interference reduces proliferation,invasion and increases chemosensitivity in cancer stem cell-like HT-29 cells[J]. Int J Oncol,2015,47(4):1476-1484.
[23]Zhu S,Chu D,Zhang Y,et al. EMMPRIN/CD147 expression is associated with disease-free survival of patients with colorectal cancer[J]. Med Oncol,2013,30(1):369.
[24]Li R,Pan Y,He B,et al. Downregulation of CD147 expression by RNA interference inhibits HT29 cell proliferation,invasion and tumorigenicity in vitro and in vivo[J].Int J Oncol,2013,43(6):1885-1894.
[25]张欢.β3GnT2、β3GnT8介导的CD147糖基化在结肠癌细胞SW620侵袭和转移中的作用及其机制[D].苏州:苏州大学,2017.
[26]Ni J,Jiang Z,Shen L,et al.Beta3GnT8 regulates the metastatic potential of colorectal carcinoma cells by altering the glycosylation of CD147[J]. Oncol Rep,2014,31(4):1795-1801.
[27]李瑞. RNA干扰抑制CD147表达对人结直肠癌细胞HT29增殖、侵袭和致瘤能力的影响[D].南京:南京师范大学,2014.
[28]张敏,张晨光,丁卫.外泌体及其在肿瘤诊疗中的意义[J].生理科学进展,2014,45(5):372-378.
[29]Yoshioka Y,Kosaka N,Konishi Y,et al. Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen[J]. Nat Commun,2014,5:3591.
[30]Tian X,Ye C,Yang Y,et al. Expression of CD147 and matrix metalloproteinase-11 in colorectal cancer and their relationship to clinicopathological features[J]. J Transl Med,2015,13:337.
[31]唐志鹏. RNAi CD147溶瘤腺病毒对结直肠癌的靶向治疗作用及机制研究[D].南京:南京医科大学,2012.
[32]Ismail R,Allaudin Z N,Abdullah R,et al. Combination of VP3 and CD147-knockdown enhance apoptosis and tumor growth delay index in colorectal tumor allograft[J]. BMC Cancer,2016,16:461.
[33]Stenzinger A,Wittschieber D,von Winterfeld M,et al.High extracellular matrix metalloproteinase inducer/CD147expression is strongly and independently associated with poor prognosis in colorectal cancer[J]. Hum Pathol,2012,43(9):1471-1481.
[34]彭利盼. MiR-492调控CD147表达对结肠癌细胞LS174T奧沙利铂耐药性的影响的研究[D].济南:山东大学,2015.
[35]董晓霞,邱力,骆志国,等.衣霉素逆转CD147介导的结肠癌细胞株SW620/5-FU耐药性的实验研究[J].湖北医药学院学报,2015,34(5):432-435.