葫芦[8]脲主客体包合物特性及对金属离子键合常数测定
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摘要
利用核磁共振、紫外-可见光谱、荧光发射光谱等检测手段,研究了葫芦[8]脲与一种双咪唑盐(C1)客体的包合模式。并以包合物为荧光探针测定了几种金属离子与葫芦[8]脲的键合常数。结果显示葫芦[8]脲与双咪唑盐C1以3∶1的比例形成包合物。核磁和紫外检测结果显示葫芦[8]脲优先结合双咪唑盐C1上新铜试剂基团,当其摩尔浓度超过C1后,葫芦[8]脲逐渐结合蒽基团。荧光滴定实验表明,葫芦[8]脲的加入显著增强了双咪唑盐C1的荧光强度。当葫芦[8]脲摩尔浓度为C1的4倍时,客体C1的荧光增强幅度达5倍。进一步的研究发现,金属离子与双咪唑盐C1竞争结合葫芦[8]脲造成葫芦[8]脲-C1包合物的荧光猝灭。Job’s plot曲线确定了金属离子与葫芦[8]脲的结合模式为1∶1和1∶2共存。通过荧光滴定,测定了Na~+、K~+、Ca~(2+)、Mg~(2+)、Cu~(2+)、Mn~(2+)、Cd~(2+)、Fe~(3+)8种金属离子与葫芦[8]脲的键合常数,其中Fe~(3+)与葫芦[8]脲的键合常数高达4.3×10~8(mol/L)~(-2)。
The host-guest interaction between a bisimidazolium salt(C1)and cucurbit[8]uril(CB[8])was investigated in aqueous solution by UV-Vis,fluorescence spectroscopic techniques,and ~1H NMR.The results showed that CB[8]formed a 3∶1(3CB[8]·C1)inclusion complex with C1.NMR and UV-Vis results showed that CB[8]firstly bound the neocuproine group,and gradually bound the anthracene group.When more than 1.0equivalent,the addition of CB[8]could significantly enhance the fluorescence intensity of C1.When the concentration of CB[8]was 4times of C1,the fluorescence intensity of C1increased by 5times.Further investigation displayed that C1could not bind metal ions in aqueous solution.However,the inclusion complex of C1with CB[8]could be used as a fluorescent probe since metal ions compete with C1to bind with CB[8],causing the fluorescence quenching of C1.Eight metal ions(Na~+,K~+,Ca~(2+),Mg~(2+),Cu~(2+),Mn~(2+),Cd~(2+),Fe~(3+))were selected to check their binding with CB[8]and Fe~(3+)showed the strongest binding affinity with CB[8](K=4.3×10~8(mol/L)~(-2)).
The host-guest interaction between a bisimidazolium salt(C1)and cucurbit[8]uril(CB[8])was investigated in aqueous solution by UV-Vis,fluorescence spectroscopic techniques,and ~1H NMR.The results showed that CB[8]formed a 3∶1(3CB[8]·C1)inclusion complex with C1.NMR and UV-Vis results showed that CB[8]firstly bound the neocuproine group,and gradually bound the anthracene group.When more than 1.0equivalent,the addition of CB[8]could significantly enhance the fluorescence intensity of C1.When the concentration of CB[8]was 4times of C1,the fluorescence intensity of C1increased by 5times.Further investigation displayed that C1could not bind metal ions in aqueous solution.However,the inclusion complex of C1with CB[8]could be used as a fluorescent probe since metal ions compete with C1to bind with CB[8],causing the fluorescence quenching of C1.Eight metal ions(Na~+,K~+,Ca~(2+),Mg~(2+),Cu~(2+),Mn~(2+),Cd~(2+),Fe~(3+))were selected to check their binding with CB[8]and Fe~(3+)showed the strongest binding affinity with CB[8](K=4.3×10~8(mol/L)~(-2)).
引文
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[6] Day A I,Blanch R J,Arnold A P,et al.Angewandte Chemie International Edition,2002,41(2):275.
[7] Liu S M,Zavalij P Y,Isaacs L.Journal of the American Chemical Society,2005,127(48):16798.
[8] Cheng X J,Liang L L,Chen K,et al.Angewandte Chemie,2013,52(28):7252.
[9] Masson E,Ling X X,Joseph R,et al.RSC Advances,2012,2(4):1213.
[10]Yang X R,Liu F B,Zhao Z Y,et al.Chinese Chemical Letters,2018,doi.org/10.1016/j.cclet.2018,1:32.
[11]Ni X L,Xiao X,Cong H,et al.Chemical Society Reviews,2013,42(24):9480.
[12]Hoffmann R,Knoche W,Fenn C,et al.Journal of the Chemical Society,Faraday Transactions,1994,90(11):161.
[13]Kumar R,Sandhu S,Singh P,et al.Chemical Record,2017,17(4):441.
[14]Busschaert N,Caltagirone C,Van R W,et al.Chemical Reviews,2015,115(15):8038.
[15]Chellappan K,Singh N J,Hwang I C,et al.Angewandte Chemie,2010,117(19):2959.
[16]Xu Z C,Kim S,Lee K H,et al.Tetrahedron Letters,2007,48(22):3797.
[17]Liu Q X,Song H B,Xu F B,et al.Journal of Chemical Research,2003,(7):445.
[18]Wang K,Cui J H,Xing S Y,et al.Chemical Communications,2017,53(54):7517.
[19]Wang R,Yuan L,Macartney D H.Chemical Communications,2006,27(27):2908.
[20]Li S,Wyman I W,Wang C,et al.The Journal of Organic Chemistry,2016,81(19):9494.
[21]Ganguly A,Ghosh S,Guchhait N.The Journal of Physical Chemistry B,2016,120(19):4421.
[22]Yang C,Mori T,Origane Y,et al.Journal of the American Chemical Society,2008,130(27):8574.
[23]Choudhury S D,Mohanty J,Pal H,et al.Journal of the American Chemical Society,2010,132(4):1395.
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[25]Geng Q X,Cong H,Tao Z,et al.Supramolecular Chemistry,2015,28(9-10):784.