人端粒酶逆转录酶在宫颈癌及其癌前病变中的研究进展
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摘要
人端粒酶逆转录酶(h TERT)与癌症的发生发展息息相关。h TERT在宫颈癌及其癌前病变中的作用也已被广泛研究,主要涉及h TERT表达变化与宫颈癌前病变程度的关系以及h TERT表达水平作为宫颈癌诊断和预后的可行性等方面。h TERT在宫颈癌的诊断、预后及治疗中具有极为重要的临床价值。
Human telomerase reverse transcriptase( h TERT) is closely related to the occurrence and development of cancer.The role of h TERT in cervical cancer and precancerous lesions has been widely studied,mainly involving the relationship of the change of h TERT expression and the degree of precancerous lesions and the feasibility of the expression of h TERT as the diagnosis and prognosis of cervical cancer,etc. h TERT plays an important role in the diagnosis,prognosis and treatment of cervical cancer.
Human telomerase reverse transcriptase( h TERT) is closely related to the occurrence and development of cancer.The role of h TERT in cervical cancer and precancerous lesions has been widely studied,mainly involving the relationship of the change of h TERT expression and the degree of precancerous lesions and the feasibility of the expression of h TERT as the diagnosis and prognosis of cervical cancer,etc. h TERT plays an important role in the diagnosis,prognosis and treatment of cervical cancer.
引文
[1]Kawano M,Mabuchi S,Matsumoto Y,et al.The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer[J/OL].Sci Rep,2015[2016-10-11].https://www.ncbi.nlm.nih.gov/pubmed-/26666576.
[2]Kurmyshkina OV,Kovchur PI,Volkova TO.“Drawing”a molecular portrait of CIN and cervical cancer:a review of genomewide molecular profiling data[J].Asian Pac J Cancer Prev,2015,16(11):4477-4487.
[3]Daniel M,Peek GW,Tollefsbol TO.Regulation of the human catalytic subunit of telomerase(h TERT)[J].Gene,2012,498(2):135-146.
[4]Wang BH,He MF,Chao A,et al.Cervical cancer screening among adult women in China,2010[J].Oncologist,2015,20(6):627-634.
[5]Wang JR,Andrae B,Sundstrom K,et al.Risk of invasive cervical cancer after atypical glandular cells in cervical screening:nationwide cohort study[J/OL].BMJ,2016[2016-10-11].https://www.ncbi.nlm.nih.gov/pubmed/26869597.
[6]Yamazaki H,Todo Y,Okamoto K,et al.Pretreatment risk factors for parametrial involvement in FIGO stage IB1 cervical cancer[J].J Gynecol Oncol,2015,26(4):255-261.
[7]Kang YJ,O'Connell DL,Lotocki R,et al.Effect of changes in treatment practice on survival for cervical cancer:results from a population-based study in Manitoba,Canada[J/OL].Bmc Cancer,2015[2016-10-11].http://europepmc.org/articles/PMC4-580014.
[8]Sherman SM,Lane EL.Awareness of risk factors for breast,lung and cervical cancer in a UK student population[J].J Cancer Educ,2015,30(4):660-663.
[9]Lorin L,Bertaut A,Hudry D,et al.About invasive cervical cancer:a French population based study between 1998 and 2010[J/OL].Eur J Obstet Gynecol Reprod Biol,2015[2016-10-11].http://europepmc.org/abstract/MED/26004674.
[10]徐庆华,朱宝生.端粒、端粒酶及h TERT/h TERC基因的研究进展[J].分子诊断与治疗杂志,2012,4(4):267-273.
[11]Lee YK,Chung HH,Kim JW,et al.Expression of phosphorylated Akt and h TERT is associated with prognosis of epithelial ovarian carcinoma[J].Int J Clin Exp Pathol,2015,8(11):14971-14976.
[12]Bryce LA,Morrison N,Hoare SF,et al.Mapping of the gene for the human telomerase reverse transcriptase,h TERT,to chromosome 5p15.33 by fluorescence in situ hybridization[J].Neoplasia,2000,2(3):197-201.
[13]Zou MX,Lv GH,Li J,et al.Upregulated human telomerase reverse transcriptase(h TERT)expression is associated with spinal chordoma growth,invasion and poor prognosis[J].Am J Transl Res,2016,8(2):516-529.
[14]Kuranaga N,Shinomiya N,Mochizuki H.Long-term cultivation of colorectal carcinoma cells with anti-cancer drugs induces drug resistance and telomere elongation:an in vitro study[J/OL].BMC Cancer,2001[2016-10-11].http://europepmc.org/articles/PMC37545.
[15]La SH,Kim SJ,Kang HG,et al.Ablation of human telomerase reverse transcriptase(h TERT)induces cellular senescence in gastric cancer through a galectin-3 dependent mechanism[J].Oncotarget,2016,21(11):131-132.
[16]Ping B,Tsuno S,Wang X,et al.Comparative study of(1)(8)F-FDG-PET/CT imaging and serum h TERT mRNA quantification in cancer diagnosis[J].Cancer Med,2015,4(10):1603-1611.
[17]Gong L,Xu Y,Hu YQ,et al.h TERT gene polymorphism correlates with the risk and the prognosis of thyroid cancer[J].Cancer Biomark,2016,17(2):195-204.
[18]Qin Y,Tang B,Hu CJ,et al.An h TERT/ZEB1 complex directly regulates E-cadherin to promote epithelial-to-mesenchymal transition(EMT)in colorectal cancer[J].Oncotarget,2016,7(1):351-361.
[19]王莉,党裔武,莫小亮,等.宫颈病变中h TERC基因扩增与h TERT蛋白表达的关系及意义[J].诊断病理学杂志,2014,21(9:)561-564.
[20]莫小亮,罗殿中,党裔武,等.不同程度宫颈病变组织中端粒酶催化亚单位的表达与临床病理特征的关系[J].中国妇幼保健,2013,28(26):4363-4366.
[21]吕彩凤,江黎珠,陈鸿雁.HPV16/18E6、cyclin D1、h TERT在喉癌组织中的表达及意义[J].重庆医科大学学报,2010,35(4):515-518.
[22]Zhu DJ,Ye M,Zhang W.E6/E7 oncoproteins of high risk HPV-16 upregulate MT1-MMP,MMP-2 and MMP-9 and promote the migration of cervical cancer cells[J].Int J Clin Exp Med Patho,2015,8(5):4981-4989.
[23]Zhao Q,Zhai YX,Liu HQ,et al.MicroRNA-491-5p suppresses cervical cancer cell growth by targeting h TERT[J].Oncol Rep,2015,34(2):979-986.
[24]Zhou Y,Xu F,Tao F,et al.GRIM-19 restores cervical cancer cell senescence by repressing h TERT transcription[J].J Int Cyt Res,2016,36(8):506-515.
[25]Yan P,Benhattar J,Seelentag W,et al.Immunohistochemical localization of h TERT protein in human tissues[J].Histochem Cell Biol,2004,121(5):391-397.
[26]王崇宇,刘苗生.h TERT、PCNA在宫颈癌组织中表达及临床病理分析[J].齐齐哈尔医学院学报,2008,29(20):2459-2460.
[27]Mc Kenna DJ,Doherty BA,Downes CS,et al.Use of the cometFISH assay to compare DNA damage and repair in p53 and h TERT genes following ionizing radiation[J/OL].PLo S One,2012[2016-10-10].http://pubmedcentralcanada.ca/pmcc/articles/PMC3492288/.
[28]张淑婷,张江宇,罗喜平.宫颈癌脱落细胞人端粒酶逆转录酶mRNA表达临床意义的探讨[J].中华肿瘤防治杂志,2011,18(10):784-787.
[29]袁羡,王国玉,倪晶,等.特异性h TERT-siRNA介导RNAi在Hela细胞中的实验研究[J].中华实用诊断与治疗杂志,2011,25(4):350-354.
[30]莫小亮,罗殿中,莫凌昭,等.人端粒酶逆转录酶基因shRNA慢病毒表达载体的构建及其病毒包装鉴定[J].中国妇幼保健,2014,29(4):580-585.
[31]王颉,张友忠,冯进波,等.慢病毒介导的h TERT-shRNA联合光动力治疗对宫颈癌细胞Si Ha的影响[J].山东大学学报(医学版),2015,53(1):27-33.
[32]刘颖,高超,蔡晓敏,等.白花蛇舌草对人宫颈癌Hela细胞端粒酶活性及h TERT基因表达的影响[J].肿瘤基础与临床,2010,23(2):103-106.
[33]汪茗,章尧,谢向荣,等.冬凌草甲素通过PI3K/Akt通路诱导MDA-MB-231细胞的凋亡[J].中国临床药理学与治疗学,2013,18(2):161-165.
[34]肖静,黄健玲,蔡林儿.疣毒净治疗HR-HPV感染宫颈病变的研究[J].广东医学,2011,32(15):2036-2039.
[2]Kurmyshkina OV,Kovchur PI,Volkova TO.“Drawing”a molecular portrait of CIN and cervical cancer:a review of genomewide molecular profiling data[J].Asian Pac J Cancer Prev,2015,16(11):4477-4487.
[3]Daniel M,Peek GW,Tollefsbol TO.Regulation of the human catalytic subunit of telomerase(h TERT)[J].Gene,2012,498(2):135-146.
[4]Wang BH,He MF,Chao A,et al.Cervical cancer screening among adult women in China,2010[J].Oncologist,2015,20(6):627-634.
[5]Wang JR,Andrae B,Sundstrom K,et al.Risk of invasive cervical cancer after atypical glandular cells in cervical screening:nationwide cohort study[J/OL].BMJ,2016[2016-10-11].https://www.ncbi.nlm.nih.gov/pubmed/26869597.
[6]Yamazaki H,Todo Y,Okamoto K,et al.Pretreatment risk factors for parametrial involvement in FIGO stage IB1 cervical cancer[J].J Gynecol Oncol,2015,26(4):255-261.
[7]Kang YJ,O'Connell DL,Lotocki R,et al.Effect of changes in treatment practice on survival for cervical cancer:results from a population-based study in Manitoba,Canada[J/OL].Bmc Cancer,2015[2016-10-11].http://europepmc.org/articles/PMC4-580014.
[8]Sherman SM,Lane EL.Awareness of risk factors for breast,lung and cervical cancer in a UK student population[J].J Cancer Educ,2015,30(4):660-663.
[9]Lorin L,Bertaut A,Hudry D,et al.About invasive cervical cancer:a French population based study between 1998 and 2010[J/OL].Eur J Obstet Gynecol Reprod Biol,2015[2016-10-11].http://europepmc.org/abstract/MED/26004674.
[10]徐庆华,朱宝生.端粒、端粒酶及h TERT/h TERC基因的研究进展[J].分子诊断与治疗杂志,2012,4(4):267-273.
[11]Lee YK,Chung HH,Kim JW,et al.Expression of phosphorylated Akt and h TERT is associated with prognosis of epithelial ovarian carcinoma[J].Int J Clin Exp Pathol,2015,8(11):14971-14976.
[12]Bryce LA,Morrison N,Hoare SF,et al.Mapping of the gene for the human telomerase reverse transcriptase,h TERT,to chromosome 5p15.33 by fluorescence in situ hybridization[J].Neoplasia,2000,2(3):197-201.
[13]Zou MX,Lv GH,Li J,et al.Upregulated human telomerase reverse transcriptase(h TERT)expression is associated with spinal chordoma growth,invasion and poor prognosis[J].Am J Transl Res,2016,8(2):516-529.
[14]Kuranaga N,Shinomiya N,Mochizuki H.Long-term cultivation of colorectal carcinoma cells with anti-cancer drugs induces drug resistance and telomere elongation:an in vitro study[J/OL].BMC Cancer,2001[2016-10-11].http://europepmc.org/articles/PMC37545.
[15]La SH,Kim SJ,Kang HG,et al.Ablation of human telomerase reverse transcriptase(h TERT)induces cellular senescence in gastric cancer through a galectin-3 dependent mechanism[J].Oncotarget,2016,21(11):131-132.
[16]Ping B,Tsuno S,Wang X,et al.Comparative study of(1)(8)F-FDG-PET/CT imaging and serum h TERT mRNA quantification in cancer diagnosis[J].Cancer Med,2015,4(10):1603-1611.
[17]Gong L,Xu Y,Hu YQ,et al.h TERT gene polymorphism correlates with the risk and the prognosis of thyroid cancer[J].Cancer Biomark,2016,17(2):195-204.
[18]Qin Y,Tang B,Hu CJ,et al.An h TERT/ZEB1 complex directly regulates E-cadherin to promote epithelial-to-mesenchymal transition(EMT)in colorectal cancer[J].Oncotarget,2016,7(1):351-361.
[19]王莉,党裔武,莫小亮,等.宫颈病变中h TERC基因扩增与h TERT蛋白表达的关系及意义[J].诊断病理学杂志,2014,21(9:)561-564.
[20]莫小亮,罗殿中,党裔武,等.不同程度宫颈病变组织中端粒酶催化亚单位的表达与临床病理特征的关系[J].中国妇幼保健,2013,28(26):4363-4366.
[21]吕彩凤,江黎珠,陈鸿雁.HPV16/18E6、cyclin D1、h TERT在喉癌组织中的表达及意义[J].重庆医科大学学报,2010,35(4):515-518.
[22]Zhu DJ,Ye M,Zhang W.E6/E7 oncoproteins of high risk HPV-16 upregulate MT1-MMP,MMP-2 and MMP-9 and promote the migration of cervical cancer cells[J].Int J Clin Exp Med Patho,2015,8(5):4981-4989.
[23]Zhao Q,Zhai YX,Liu HQ,et al.MicroRNA-491-5p suppresses cervical cancer cell growth by targeting h TERT[J].Oncol Rep,2015,34(2):979-986.
[24]Zhou Y,Xu F,Tao F,et al.GRIM-19 restores cervical cancer cell senescence by repressing h TERT transcription[J].J Int Cyt Res,2016,36(8):506-515.
[25]Yan P,Benhattar J,Seelentag W,et al.Immunohistochemical localization of h TERT protein in human tissues[J].Histochem Cell Biol,2004,121(5):391-397.
[26]王崇宇,刘苗生.h TERT、PCNA在宫颈癌组织中表达及临床病理分析[J].齐齐哈尔医学院学报,2008,29(20):2459-2460.
[27]Mc Kenna DJ,Doherty BA,Downes CS,et al.Use of the cometFISH assay to compare DNA damage and repair in p53 and h TERT genes following ionizing radiation[J/OL].PLo S One,2012[2016-10-10].http://pubmedcentralcanada.ca/pmcc/articles/PMC3492288/.
[28]张淑婷,张江宇,罗喜平.宫颈癌脱落细胞人端粒酶逆转录酶mRNA表达临床意义的探讨[J].中华肿瘤防治杂志,2011,18(10):784-787.
[29]袁羡,王国玉,倪晶,等.特异性h TERT-siRNA介导RNAi在Hela细胞中的实验研究[J].中华实用诊断与治疗杂志,2011,25(4):350-354.
[30]莫小亮,罗殿中,莫凌昭,等.人端粒酶逆转录酶基因shRNA慢病毒表达载体的构建及其病毒包装鉴定[J].中国妇幼保健,2014,29(4):580-585.
[31]王颉,张友忠,冯进波,等.慢病毒介导的h TERT-shRNA联合光动力治疗对宫颈癌细胞Si Ha的影响[J].山东大学学报(医学版),2015,53(1):27-33.
[32]刘颖,高超,蔡晓敏,等.白花蛇舌草对人宫颈癌Hela细胞端粒酶活性及h TERT基因表达的影响[J].肿瘤基础与临床,2010,23(2):103-106.
[33]汪茗,章尧,谢向荣,等.冬凌草甲素通过PI3K/Akt通路诱导MDA-MB-231细胞的凋亡[J].中国临床药理学与治疗学,2013,18(2):161-165.
[34]肖静,黄健玲,蔡林儿.疣毒净治疗HR-HPV感染宫颈病变的研究[J].广东医学,2011,32(15):2036-2039.