HBV相关肝病患者血清抵抗素水平及其与肝病进展的关系
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摘要
目的:探讨HBV相关肝病患者血清抵抗素水平和肝脏疾病进展的关系。方法:收集十堰市太和医院感染科2015年至2017年住院治疗的慢性乙型肝炎患者134例,乙型肝炎肝硬化59例,乙型肝炎肝衰竭63例,收集其血清标本及临床资料。ELISA检测其血清抵抗素水平。分析血清抵抗素水平与疾病临床阶段和部分生化指标的关系。结果:HBV相关肝病患者抵抗素水平明显高于健康对照组(P<0.01)。肝硬化患者血清抵抗素水平和AST、TBil水平呈正相关,R值分别为0.4357,0.8742。结论:抵抗素参与肝纤维化过程,也促进肝脏炎症的进展。
Objective:To explore the serum resistin level and the relationship with progression of HBV-related liver disease.Methods:Total of 134 patients with hepatitis B,59 patients with liver cirrhosis of hepatitis B and 63 patients with HBV-related liver failure,who hospitalized in Department of Infectious Diseases of Shiyan taihe hospital were choosed from 2015 to 2017.The serum samples and clinical data were collected.The resistin level of the serum samples were detected by ELISA.The relationship between resistin level and clinical stages and partial biochemical index were analyzed.Results:The level of resistin in patients with HBV-related liver disease was higher than healthy control group(P<0.01).The level of resistin in patients with LC was positively correlated with AST and TBIL,the R value were 0.4357,0.8742 respectively.Conclusion:Rsistin participated in the process of liver fibrosis,also promote the progress of inflammation in liver disease.
Objective:To explore the serum resistin level and the relationship with progression of HBV-related liver disease.Methods:Total of 134 patients with hepatitis B,59 patients with liver cirrhosis of hepatitis B and 63 patients with HBV-related liver failure,who hospitalized in Department of Infectious Diseases of Shiyan taihe hospital were choosed from 2015 to 2017.The serum samples and clinical data were collected.The resistin level of the serum samples were detected by ELISA.The relationship between resistin level and clinical stages and partial biochemical index were analyzed.Results:The level of resistin in patients with HBV-related liver disease was higher than healthy control group(P<0.01).The level of resistin in patients with LC was positively correlated with AST and TBIL,the R value were 0.4357,0.8742 respectively.Conclusion:Rsistin participated in the process of liver fibrosis,also promote the progress of inflammation in liver disease.
引文
[1] Steppan CM,Bailey ST,Bhat S,et al.The hormone resistin links obesity to diabetes[J].Nature, 2001,409(6818):307-312.
[2] Szalowska E,Elferink MG,Hoek A,et al.Resistin is more abundant in liver than adipose tissue and is not up-regulated by lipopolysaccharide[J].J Clin Endocrinol Metab,2009,94(8):3051-3057.
[3] 陈思娇,都镇先,张海燕,等.2型糖尿病患者血清抵抗素水平与血糖和炎症因子的关系[J].中华内分泌代谢杂志,2006,22(2):151-153.
[4] Kakizaki S,Sohara N,Yamazaki Y,et al..Elevated plasma resistin concentrations in patients with liver cirrhosis[J].Journal of Gastroenterology and Hepatology,2006,78(19):74-81.
[5] 吴佩娴,蓝薇,张帆,等.非酒精性脂肪性肝病中抵抗素和肝纤维化的关系[J].中国医师杂志,2014,19(4):482-484.
[6] Bertolani C,Sancho-Bru P,Failli P,et al.Resistin as an intrahepatic cytokine:overexpression during chronic injury and induction of proinflammatory actions in hepatic stellate cells[J].Am J Pathol,2006,169(6):2042-2053.
[7] Durazzo M,Belci P,Niro G,et al.Variations of serum levels of adiponectin and resistin in chronic viral hepatitis[J].J Endocrinol Invest,2013,36(8):600-605.
[8] Bostrom EA,Ekstedt M,Kechagias S,et al.Resistin is Associated with Breach of Tolerance and Anti-nuclear Antibodies in Patients with Hepatobiliary Inflammation[J].Scandinavian Journal of Immunology,2011,74(5):463-470.
[2] Szalowska E,Elferink MG,Hoek A,et al.Resistin is more abundant in liver than adipose tissue and is not up-regulated by lipopolysaccharide[J].J Clin Endocrinol Metab,2009,94(8):3051-3057.
[3] 陈思娇,都镇先,张海燕,等.2型糖尿病患者血清抵抗素水平与血糖和炎症因子的关系[J].中华内分泌代谢杂志,2006,22(2):151-153.
[4] Kakizaki S,Sohara N,Yamazaki Y,et al..Elevated plasma resistin concentrations in patients with liver cirrhosis[J].Journal of Gastroenterology and Hepatology,2006,78(19):74-81.
[5] 吴佩娴,蓝薇,张帆,等.非酒精性脂肪性肝病中抵抗素和肝纤维化的关系[J].中国医师杂志,2014,19(4):482-484.
[6] Bertolani C,Sancho-Bru P,Failli P,et al.Resistin as an intrahepatic cytokine:overexpression during chronic injury and induction of proinflammatory actions in hepatic stellate cells[J].Am J Pathol,2006,169(6):2042-2053.
[7] Durazzo M,Belci P,Niro G,et al.Variations of serum levels of adiponectin and resistin in chronic viral hepatitis[J].J Endocrinol Invest,2013,36(8):600-605.
[8] Bostrom EA,Ekstedt M,Kechagias S,et al.Resistin is Associated with Breach of Tolerance and Anti-nuclear Antibodies in Patients with Hepatobiliary Inflammation[J].Scandinavian Journal of Immunology,2011,74(5):463-470.