穿透素3在肺部疾病诊疗中的研究进展
|
摘要
穿透素3是首个被发现的长正五聚蛋白,是先天性免疫中体液免疫的重要组成部分,通过病原体识别、补体激活、调理作用、白细胞募集及糖基化依赖的炎性调节等在免疫系统中发挥着重要作用。穿透素-3在多种疾病的炎症调控中发挥重要作用,尤其是肺部疾病,可作为一种诊断疾病的新型生物学标志物。穿透素-3通过参与多种生理及病理过程,与多种肺部疾病的发生与发展密切相关,其可用于肺部疾病的诊断、评定疾病的活动性和严重性、疗效检测、判断预后等。穿透素3还可能是某些肺部疾病的保护因素。
Pentraxin-3 is the first long positive pentameric protein discovered,an important component of humoral immunity in innate immunity,which plays an important role through pathogen recognition,complement activation,opsonization,leukocyte recruitment,and glycosylation-dependent inflammation in the immune system. Pentraxin-3 also plays an important role in the regulation of inflammation in a variety of diseases,especially lung diseases,and can be used as a new biological marker for diagnosis. Through its participation in a variety of physiological and pathological processes,pentraxin-3 is closely related to the occurrence and development of various lung diseases. It can be used for the diagnosis of lung diseases,assessing the activity and severity of the disease,detecting the efficacy,and judging the prognosis. It may also be a protective factor for certain lung diseases.
Pentraxin-3 is the first long positive pentameric protein discovered,an important component of humoral immunity in innate immunity,which plays an important role through pathogen recognition,complement activation,opsonization,leukocyte recruitment,and glycosylation-dependent inflammation in the immune system. Pentraxin-3 also plays an important role in the regulation of inflammation in a variety of diseases,especially lung diseases,and can be used as a new biological marker for diagnosis. Through its participation in a variety of physiological and pathological processes,pentraxin-3 is closely related to the occurrence and development of various lung diseases. It can be used for the diagnosis of lung diseases,assessing the activity and severity of the disease,detecting the efficacy,and judging the prognosis. It may also be a protective factor for certain lung diseases.
引文
[1]谢京,张静波.正五聚蛋白3在炎症及自身免疫中的作用[J].中国病理生理杂志,2013,29(4):752-756.
[2]柯荟,张静,瞿介明.正五聚素的监测在肺部疾病中的应用进展[J].中国呼吸与危重监护杂志,2013,12(2):211-214.
[3]Magrini E,Mantovani A,Garlanda C.The dual complexity of PTX3 in health and disease:A balancing act?[J].Trends Mol Med,2016,22(6):497-510.
[4]Inforzato A,Rivieccio V,Morreale AP,et al.Structural characterization of PTX3 disulfide bond network and its multimeric status in cumulus matrix organization[J].J Biol Chem,2008,283(15):10147-10161.
[5]Balhara J,Koussih L,Zhang J,et al.Pentraxin 3:An immunoregulator in the lungs[J].Front Immunol,2013,4:127.
[6]Daigo K,Inforzato A,Barajon I,et al.Pentraxins in the activation and regulation of innate immunity[J].Immunol Rev,2016,274(1):202-217.
[7]Wang H,Atkins SJ,Fernando R,et al.Pentraxin-3 is a TSH-inducible protein in human fibrocytes and orbital fibroblasts[J].Endocrinology,2015,156(11):4336-4344.
[8]Qin S,Chen X,Gao M,et al.Prenatal exposure to lipopolysaccharide induces PTX3 expression and results in obesity in mouse offspring[J].Inflammation,2017,40(6):1847-1861.
[9]Garlanda C,Jaillon S,Doni A,et al.PTX3,a humoral pattern recognition molecule at the interface between microbe and matrix recognition[J].Curr Opin Immunol,2016,38:39-44.
[10]Ying TH,Lee CH,Chiou HL,et al.Knockdown of Pentraxin 3suppresses tumorigenicity and metastasis of human cervical cancer cells[J].Sci Rep,2016,6:29385.
[11]Kim MJ,Lee HS,Sol IS,et al.Sputum pentraxin 3 as a candidate to assess airway inflammation and remodeling in childhood asthma[J].Medicine(Baltimore),2016,95(51):e5677.
[12]Kardas F,Akin L,Kurtoglu S,et al.Plasma Pentraxin 3 as a biomarker of metabolic syndrome[J].Indian J Pediatr,2015,82(1):35-38.
[13]Bottazzi B,Doni A,Garlanda C,et al.An integrated view of humoral innate immunity:Pentraxins as a paradigm[J].Annu Rev Immunol,2010,28:157-183.
[14]Doni A,Musso T,Morone D,et al.An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode[J].J Exp Med,2015,212(6):905-925.
[15]Jaillon S,Moalli F,Ragnarsdottir B,et al.The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection[J].Immunity,2014,40(4):621-632.
[16]Di Virgilio F.A commentary on"PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer"[J].Front Oncol,2015,5:118.
[17]Mauri T,Coppadoro A,Bombino M,et al.Alveolar pentraxin 3 as an early marker of microbiologically confirmed pneumonia:Athreshold-finding prospective observational study[J].Crit Care,2014,18(5):562.
[18]Lin Q,Fu F,Shen L,et al.Pentraxin 3 in the assessment of ventilator-associated pneumonia:An early marker of severity[J].Heart Lung,2013,42(2):139-145.
[19]Kao SJ,Yang HW,Tsao SM,et al.Plasma long pentraxin 3(PTX3)concentration is a novel marker of disease activity in patients with community-acquired pneumonia[J].Clin Chem Lab Med,2013,51(4):907-913.
[20]Yeo CD,Kim JW,Cho MR,et al.Pleural fluid pentraxin-3 for the differential diagnosis of pleural effusions[J].Tuberc Respir Dis(Seoul),2013,75(6):244-249.
[21]Mantovani A.Pentraxin-3 in COPD:Innocent bystander or amplifier?[J].Eur Respir J,2012,39(4):79579-79576.
[22]Schwingel FL,Pizzichini E,Kleveston T,et al.Pentraxin 3 sputum levels differ in patients with chronic obstructive pulmonary disease vs asthma[J].Ann Allergy Asthma Immunol,2015,115(6):485-489.
[23]Kurt OK,Tosun M,Kurt EB,et al.Pentraxin 3 as a novel biomarker of inflammation in chronic obstructive pulmonary disease[J].Inflammation,2015,38(1):89-93.
[24]Blandin Knight S,Crosbie PA,Balata H,et al.Progress and prospects of early detection in lung cancer[J].Open Biol,2017,7(9).pii:170070.
[25]Zhang D,Ren WH,Gao Y,et al.Clinical significance and prognostic value of pentraxin-3 as serologic biomarker for lung cancer[J].Asian Pac J Cancer Prev,2013,14(7):4215-4221.
[26]Infante M,Allavena P,Garlanda C,et al.Prognostic and diagnostic potential of local and circulating levels of pentraxin 3 in lung cancer patients[J].Int J Cancer,2016,138(4):983-991.
[27]Liu C,Yao Y,Wang W.Pentraxin-3 as a prognostic marker in patients with small-cell lung cancer[J].Med Oncol,2014,31(10):207.
[28]Hu FQ,Qiao T,Xie X,et al.Knockdown of the inflammatory factor pentraxin-3 suppresses growth and invasion of lung adenocarcinoma through the AKT and NF-kappa B pathways[J].J Biol Regul Homeost Agents,2014,28(4):649-657.
[29]Takeda N,Asai K,Ijiri N,et al.Pentraxin-3 as a biomarker for febrile neutropenia in patients with lung cancer[J].Osaka City Med J,2015,61(1):43-52.
[30]An J,Park SH,Ko IG,et al.Polydeoxyribonucleotide ameliorates lipopolysaccharide-induced lung injury by inhibiting apoptotic cell death in rats[J].Int J Mol Sci,2017,18(9).pii:E1847.
[31]Han B,Haitsma JJ,Zhang Y,et al.Long pentraxin PTX3 deficiency worsens LPS-induced acute lung injury[J].Intensive Care Med,2011,37(2):334-342.
[32]He X,Han B,Bai X,et al.PTX3 as a potential biomarker of acute lung injury:Supporting evidence from animal experimentation[J].Intensive Care Med,2010,36(2):356-364.
[33]Zeng G,Liu J,Wu N,et al.Lipopolysaccharide challenge induces long pentraxin 3 expression in mice independently from acute lung injury[J].Chin Med Sci J,2015,30(1):7-17.
[34]Han B,Ma X,Zhang J,et al.Protective effects of long pentraxin PTX3 on lung injury in a severe acute respiratory syndrome model in mice[J].Lab Invest,2012,92(9):1285-1296.
[35]Diamond JM,Meyer NJ,Feng R,et al.Variation in PTX3 is associated with primary graft dysfunction after lung transplantation[J].Am J Respir Crit Care Med,2012,186(6):546-552.
[36]Diamond JM,Lederer DJ,Kawut SM,et al.Elevated plasma long pentraxin-3 levels and primary graft dysfunction after lung transplantation for idiopathic pulmonary fibrosis[J].Am J Transplant,2011,11(11):2517-2522.
[37]Kabbani D,Bhaskaran A,Singer LG,et al.Pentraxin 3 levels in bronchoalveolar lavage fluid of lung transplant recipients with invasive aspergillosis[J].J Heart Lung Transplant,2017,36(9):973-979.
[2]柯荟,张静,瞿介明.正五聚素的监测在肺部疾病中的应用进展[J].中国呼吸与危重监护杂志,2013,12(2):211-214.
[3]Magrini E,Mantovani A,Garlanda C.The dual complexity of PTX3 in health and disease:A balancing act?[J].Trends Mol Med,2016,22(6):497-510.
[4]Inforzato A,Rivieccio V,Morreale AP,et al.Structural characterization of PTX3 disulfide bond network and its multimeric status in cumulus matrix organization[J].J Biol Chem,2008,283(15):10147-10161.
[5]Balhara J,Koussih L,Zhang J,et al.Pentraxin 3:An immunoregulator in the lungs[J].Front Immunol,2013,4:127.
[6]Daigo K,Inforzato A,Barajon I,et al.Pentraxins in the activation and regulation of innate immunity[J].Immunol Rev,2016,274(1):202-217.
[7]Wang H,Atkins SJ,Fernando R,et al.Pentraxin-3 is a TSH-inducible protein in human fibrocytes and orbital fibroblasts[J].Endocrinology,2015,156(11):4336-4344.
[8]Qin S,Chen X,Gao M,et al.Prenatal exposure to lipopolysaccharide induces PTX3 expression and results in obesity in mouse offspring[J].Inflammation,2017,40(6):1847-1861.
[9]Garlanda C,Jaillon S,Doni A,et al.PTX3,a humoral pattern recognition molecule at the interface between microbe and matrix recognition[J].Curr Opin Immunol,2016,38:39-44.
[10]Ying TH,Lee CH,Chiou HL,et al.Knockdown of Pentraxin 3suppresses tumorigenicity and metastasis of human cervical cancer cells[J].Sci Rep,2016,6:29385.
[11]Kim MJ,Lee HS,Sol IS,et al.Sputum pentraxin 3 as a candidate to assess airway inflammation and remodeling in childhood asthma[J].Medicine(Baltimore),2016,95(51):e5677.
[12]Kardas F,Akin L,Kurtoglu S,et al.Plasma Pentraxin 3 as a biomarker of metabolic syndrome[J].Indian J Pediatr,2015,82(1):35-38.
[13]Bottazzi B,Doni A,Garlanda C,et al.An integrated view of humoral innate immunity:Pentraxins as a paradigm[J].Annu Rev Immunol,2010,28:157-183.
[14]Doni A,Musso T,Morone D,et al.An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode[J].J Exp Med,2015,212(6):905-925.
[15]Jaillon S,Moalli F,Ragnarsdottir B,et al.The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection[J].Immunity,2014,40(4):621-632.
[16]Di Virgilio F.A commentary on"PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer"[J].Front Oncol,2015,5:118.
[17]Mauri T,Coppadoro A,Bombino M,et al.Alveolar pentraxin 3 as an early marker of microbiologically confirmed pneumonia:Athreshold-finding prospective observational study[J].Crit Care,2014,18(5):562.
[18]Lin Q,Fu F,Shen L,et al.Pentraxin 3 in the assessment of ventilator-associated pneumonia:An early marker of severity[J].Heart Lung,2013,42(2):139-145.
[19]Kao SJ,Yang HW,Tsao SM,et al.Plasma long pentraxin 3(PTX3)concentration is a novel marker of disease activity in patients with community-acquired pneumonia[J].Clin Chem Lab Med,2013,51(4):907-913.
[20]Yeo CD,Kim JW,Cho MR,et al.Pleural fluid pentraxin-3 for the differential diagnosis of pleural effusions[J].Tuberc Respir Dis(Seoul),2013,75(6):244-249.
[21]Mantovani A.Pentraxin-3 in COPD:Innocent bystander or amplifier?[J].Eur Respir J,2012,39(4):79579-79576.
[22]Schwingel FL,Pizzichini E,Kleveston T,et al.Pentraxin 3 sputum levels differ in patients with chronic obstructive pulmonary disease vs asthma[J].Ann Allergy Asthma Immunol,2015,115(6):485-489.
[23]Kurt OK,Tosun M,Kurt EB,et al.Pentraxin 3 as a novel biomarker of inflammation in chronic obstructive pulmonary disease[J].Inflammation,2015,38(1):89-93.
[24]Blandin Knight S,Crosbie PA,Balata H,et al.Progress and prospects of early detection in lung cancer[J].Open Biol,2017,7(9).pii:170070.
[25]Zhang D,Ren WH,Gao Y,et al.Clinical significance and prognostic value of pentraxin-3 as serologic biomarker for lung cancer[J].Asian Pac J Cancer Prev,2013,14(7):4215-4221.
[26]Infante M,Allavena P,Garlanda C,et al.Prognostic and diagnostic potential of local and circulating levels of pentraxin 3 in lung cancer patients[J].Int J Cancer,2016,138(4):983-991.
[27]Liu C,Yao Y,Wang W.Pentraxin-3 as a prognostic marker in patients with small-cell lung cancer[J].Med Oncol,2014,31(10):207.
[28]Hu FQ,Qiao T,Xie X,et al.Knockdown of the inflammatory factor pentraxin-3 suppresses growth and invasion of lung adenocarcinoma through the AKT and NF-kappa B pathways[J].J Biol Regul Homeost Agents,2014,28(4):649-657.
[29]Takeda N,Asai K,Ijiri N,et al.Pentraxin-3 as a biomarker for febrile neutropenia in patients with lung cancer[J].Osaka City Med J,2015,61(1):43-52.
[30]An J,Park SH,Ko IG,et al.Polydeoxyribonucleotide ameliorates lipopolysaccharide-induced lung injury by inhibiting apoptotic cell death in rats[J].Int J Mol Sci,2017,18(9).pii:E1847.
[31]Han B,Haitsma JJ,Zhang Y,et al.Long pentraxin PTX3 deficiency worsens LPS-induced acute lung injury[J].Intensive Care Med,2011,37(2):334-342.
[32]He X,Han B,Bai X,et al.PTX3 as a potential biomarker of acute lung injury:Supporting evidence from animal experimentation[J].Intensive Care Med,2010,36(2):356-364.
[33]Zeng G,Liu J,Wu N,et al.Lipopolysaccharide challenge induces long pentraxin 3 expression in mice independently from acute lung injury[J].Chin Med Sci J,2015,30(1):7-17.
[34]Han B,Ma X,Zhang J,et al.Protective effects of long pentraxin PTX3 on lung injury in a severe acute respiratory syndrome model in mice[J].Lab Invest,2012,92(9):1285-1296.
[35]Diamond JM,Meyer NJ,Feng R,et al.Variation in PTX3 is associated with primary graft dysfunction after lung transplantation[J].Am J Respir Crit Care Med,2012,186(6):546-552.
[36]Diamond JM,Lederer DJ,Kawut SM,et al.Elevated plasma long pentraxin-3 levels and primary graft dysfunction after lung transplantation for idiopathic pulmonary fibrosis[J].Am J Transplant,2011,11(11):2517-2522.
[37]Kabbani D,Bhaskaran A,Singer LG,et al.Pentraxin 3 levels in bronchoalveolar lavage fluid of lung transplant recipients with invasive aspergillosis[J].J Heart Lung Transplant,2017,36(9):973-979.