基于口腔微生态论结肠炎-癌转化的中医药干预
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摘要
结肠炎-癌转化是炎性肠病长期持续并向癌症演进的动态过程,近期研究表明口腔微生态与炎性肠病、结肠癌发生发展关系密切。中医药调控口腔微生态效果显著、干预结肠炎-癌转化临床证据丰富,但前人鲜有将口腔微生态作为中医药干预结肠炎-癌转化研究切入点。文章结合口腔微生态最新研究进展及中医药干预口腔微生态与肠道微生态相关研究,发现口腔微生态具有反映结肠炎-癌动态演进、监测治疗反馈的作用。在此基础上,探讨口腔微生态对中医药干预结肠炎-癌转化疗效评估的重要作用,为结肠癌的早期检测、治疗及疗效评价提供新的观察窗口,丰富中医肿瘤防治的临证手段。
Colitis-cancer transformation is a dynamic process in which inflammatory bowel disease continues for a long time and evolves into cancer. Recent studies have shown that oral microecology is closely related to the development of inflammatory bowel disease and colon cancer. Traditional Chinese medicine has a significant effect on regulating oral microecology, and it is rich in clinical evidence for intervention of colitis-cancer transformation. However, the predecessors rarely use oral micro-ecology as a breakthrough point for Chinese medicine intervention in colitis-cancer transformation research. In this paper, combined with the latest research progress of oral micro-ecology and the intervention of traditional Chinese medicine intervention in oral micro-ecology and intestinal micro-ecology, it is found that oral micro-ecology has the effect of reflecting the dynamic evolution of colitis-cancer and monitoring and treatment feedback. On this basis, the important role of oral micro-ecology in the evaluation of the effect of traditional Chinese medicine on colitis-cancer transformation is explored, which provids a new observation window for the early detection, treatment and evaluation of colon cancer, and enriches the clinical evidence of TCM cancer prevention and treatment.
Colitis-cancer transformation is a dynamic process in which inflammatory bowel disease continues for a long time and evolves into cancer. Recent studies have shown that oral microecology is closely related to the development of inflammatory bowel disease and colon cancer. Traditional Chinese medicine has a significant effect on regulating oral microecology, and it is rich in clinical evidence for intervention of colitis-cancer transformation. However, the predecessors rarely use oral micro-ecology as a breakthrough point for Chinese medicine intervention in colitis-cancer transformation research. In this paper, combined with the latest research progress of oral micro-ecology and the intervention of traditional Chinese medicine intervention in oral micro-ecology and intestinal micro-ecology, it is found that oral micro-ecology has the effect of reflecting the dynamic evolution of colitis-cancer and monitoring and treatment feedback. On this basis, the important role of oral micro-ecology in the evaluation of the effect of traditional Chinese medicine on colitis-cancer transformation is explored, which provids a new observation window for the early detection, treatment and evaluation of colon cancer, and enriches the clinical evidence of TCM cancer prevention and treatment.
引文
[1]周学东,徐健,施文元.人类口腔微生物组学研究:现状、挑战及机遇.微生物学报,2017,57(6):806-821,792
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[6]李燕,何金枝,肖丽英,周学东.口腔微生物组与疾病.国际口腔医学杂志,2014,41(1):118-122
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[10]武娜,刘玉兰,朱元民.结直肠癌患者肠道微生物多样性的研究进展.中华临床医师杂志,2014,8(22):4069-4072
[11]Segata N,Haake S K,Mannon P,et al.Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces,tonsils,throat and stool samples.Genome Biol,2012,13:42
[12]曲芬,虎世升.细菌对人类的挑战.传染病信息,2003,16(1):9-10
[13]秦小燕.魏曦:奠基我国微生态学.湘潮(上半月),2015(7):35-38
[14]闫志安.三两三诀要.中华中医药杂志,2017,32(10):23
[15]彭鑫.《伤寒论》阳明、太阴病证与肠道微生态及人体反应性关系研究.北京:北京中医药大学,2008
[16]WENG Jin-long.Function of microorganisms in tongue coating in oral malodor.Int J Oral Med,2013(5):625-628
[17]刘庆,岳小强,凌昌全.舌诊现代化研究的回顾与展望.中西医结合学报,2003(1):66-70
[18]孙远岭,奚政君,祝明杰,等.运脾治疗对脾虚大鼠免疫功能的影响.中国中医药信息杂志,2005,12(12):27-28
[19]邵铁娟,李海昌,谢志军,等.基于脾主运化理论探讨脾虚湿困与肠道菌群紊乱的关系.中华中医药杂志,2014,29(12):3762-3765
[20]吴国琳,余国友,卢雯雯等.肠道微生态的中医本质探讨.中华中医药学刊,2015,11(33):2586-2588
[21]Rogler G.Chronic ulcerative colitis and colorectal cancer.Cancer letters,2014,345(2):235-241
[22]Christos Polytarchou Verspaget, Dimitrios Iliopoulos.MicroRNA214is associated with progression of ulcerative colitis, and inhibition redu-ces development of colitis and colitis-associated cancer in mice.Gastroenterology,2015,149(4):981-992
[23]唐岸柳.非可控性结肠炎癌变过程的转录组动态变化及其分子机制研究.长沙:中南大学,2012
[24]丁一娟,于皆平,罗和生,等.186例溃疡性结肠炎结肠镜检查的评价和分析.中国内镜杂志,2005,11(9):930-931,934
[25]Abraham C,Medzhitov R.Interactions between the host innate immune system and microbes in inflammatory bowel disease.Gastroenterology,2011,140(6):1729-1737
[26]Cao Xuetao.Intestinal inflammation induced by oral bacteria.Science,2017,358:308-309
[27]Koji Atarashi,Masahira Hattori,Kenya Honda.Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation.Science,2017,358:359-365
[28]Burkhardt Flemer,Paul W O’Toole.The oral microbiota in colorectal cancer is distinctive and predictive.Gut,2017,8:1-10
[29]Kostic A D,gevers D,Pedamallu C S,et al.Genomic analysis identies association of Fusobacterium with colorectal carcinoma.Genome Res,2012,22:292-298
[30]江学良,权启镇,王志奎.溃疡性结肠炎的诊断、分型及疗效标准.世界华人消化杂志,2000(3):332-334
[31]杨小波.溃疡性结肠炎中医辨治理论模型的重构与初步确证.广州:广州中医药大学,2006
[32]Gagnière J,Raisch J,Veziant J,et al.Gut microbiota imbalance and colorectal cancer.World journal of Gastroenterology,2016,22(2):501-518
[33]金赟,武建毅,冯煜.四君子汤对化疗的结直肠癌术后肝转移患者口腔黏膜细胞凋亡率及肠道屏障功能的影响.上海中医药大学学报,2013,27(4):35-38
[34]刘素琴.四君子汤加减加中药雾化吸入治疗鼻咽癌放疗后口腔溃疡疗效观察.北京:中华中医药学会耳鼻喉科分会第十六次全国学术交流会论文摘要,2010:2
[35]廉南,曹均告,严清明.加味痛泻要方对溃疡性结肠炎癌变干预作用的研究(附:116例病例报告).成都中医药大学学报,2003,26(2):1-2
[36]廉南,曹均告,严明清,等.加味痛泻要方防治溃疡性结肠炎复发的临床研究(附:124例病例报告).成都中医药大学学报,2002,25(2):1-3
[37]车宇薇,王燕一.宏基因组学在口腔微生物研究中的应用进展.中华老年口腔医学杂志,2015,13(4):249-252
[38]He J,Li Y,Cao Y,et al.The oral microbiome diversity and its relation to human diseases.Folia Microbiol(Praha),2015,60(1):69-80
[2]黄适,滕飞,杨芳,朱鹏飞,苏晓泉,马波,徐健.基于微生物组的口腔“亚健康状态”检测.生命科学,2017:1-9
[3]葛阳,程磊,周学东.口腔微生物与肿瘤关系的研究进展.华西口腔医学杂志,2014,32(5):527-531
[4]施文元,周学东.人体口腔微生物群的相互作用.华西口腔医学杂志,2010,28(1):1-4
[5]薛晶,肖丽英,周学东.人体口腔微生物组研究最新进展.华西口腔医学杂志,2010,28(1):5-8
[6]李燕,何金枝,肖丽英,周学东.口腔微生物组与疾病.国际口腔医学杂志,2014,41(1):118-122
[7]徐欣,何金枝,周学东.口腔微生物群落在口腔与全身疾病预警中的作用.华西口腔医学杂志,2015,33(6):555-560
[8]Gagnière J,Raisch J,Veziant J,et al.Gut microbiota imbalance and colorectal cancer.World Journal of Gastroenterology,2016,22(2):501-518
[9]Heller D,Helmerhorste J,Gower A C,et al.Microbial diversity in the early in vivo-formed dental biolm.Appl Environ Microbiol,2016,82:1881-1888
[10]武娜,刘玉兰,朱元民.结直肠癌患者肠道微生物多样性的研究进展.中华临床医师杂志,2014,8(22):4069-4072
[11]Segata N,Haake S K,Mannon P,et al.Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces,tonsils,throat and stool samples.Genome Biol,2012,13:42
[12]曲芬,虎世升.细菌对人类的挑战.传染病信息,2003,16(1):9-10
[13]秦小燕.魏曦:奠基我国微生态学.湘潮(上半月),2015(7):35-38
[14]闫志安.三两三诀要.中华中医药杂志,2017,32(10):23
[15]彭鑫.《伤寒论》阳明、太阴病证与肠道微生态及人体反应性关系研究.北京:北京中医药大学,2008
[16]WENG Jin-long.Function of microorganisms in tongue coating in oral malodor.Int J Oral Med,2013(5):625-628
[17]刘庆,岳小强,凌昌全.舌诊现代化研究的回顾与展望.中西医结合学报,2003(1):66-70
[18]孙远岭,奚政君,祝明杰,等.运脾治疗对脾虚大鼠免疫功能的影响.中国中医药信息杂志,2005,12(12):27-28
[19]邵铁娟,李海昌,谢志军,等.基于脾主运化理论探讨脾虚湿困与肠道菌群紊乱的关系.中华中医药杂志,2014,29(12):3762-3765
[20]吴国琳,余国友,卢雯雯等.肠道微生态的中医本质探讨.中华中医药学刊,2015,11(33):2586-2588
[21]Rogler G.Chronic ulcerative colitis and colorectal cancer.Cancer letters,2014,345(2):235-241
[22]Christos Polytarchou Verspaget, Dimitrios Iliopoulos.MicroRNA214is associated with progression of ulcerative colitis, and inhibition redu-ces development of colitis and colitis-associated cancer in mice.Gastroenterology,2015,149(4):981-992
[23]唐岸柳.非可控性结肠炎癌变过程的转录组动态变化及其分子机制研究.长沙:中南大学,2012
[24]丁一娟,于皆平,罗和生,等.186例溃疡性结肠炎结肠镜检查的评价和分析.中国内镜杂志,2005,11(9):930-931,934
[25]Abraham C,Medzhitov R.Interactions between the host innate immune system and microbes in inflammatory bowel disease.Gastroenterology,2011,140(6):1729-1737
[26]Cao Xuetao.Intestinal inflammation induced by oral bacteria.Science,2017,358:308-309
[27]Koji Atarashi,Masahira Hattori,Kenya Honda.Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation.Science,2017,358:359-365
[28]Burkhardt Flemer,Paul W O’Toole.The oral microbiota in colorectal cancer is distinctive and predictive.Gut,2017,8:1-10
[29]Kostic A D,gevers D,Pedamallu C S,et al.Genomic analysis identies association of Fusobacterium with colorectal carcinoma.Genome Res,2012,22:292-298
[30]江学良,权启镇,王志奎.溃疡性结肠炎的诊断、分型及疗效标准.世界华人消化杂志,2000(3):332-334
[31]杨小波.溃疡性结肠炎中医辨治理论模型的重构与初步确证.广州:广州中医药大学,2006
[32]Gagnière J,Raisch J,Veziant J,et al.Gut microbiota imbalance and colorectal cancer.World journal of Gastroenterology,2016,22(2):501-518
[33]金赟,武建毅,冯煜.四君子汤对化疗的结直肠癌术后肝转移患者口腔黏膜细胞凋亡率及肠道屏障功能的影响.上海中医药大学学报,2013,27(4):35-38
[34]刘素琴.四君子汤加减加中药雾化吸入治疗鼻咽癌放疗后口腔溃疡疗效观察.北京:中华中医药学会耳鼻喉科分会第十六次全国学术交流会论文摘要,2010:2
[35]廉南,曹均告,严清明.加味痛泻要方对溃疡性结肠炎癌变干预作用的研究(附:116例病例报告).成都中医药大学学报,2003,26(2):1-2
[36]廉南,曹均告,严明清,等.加味痛泻要方防治溃疡性结肠炎复发的临床研究(附:124例病例报告).成都中医药大学学报,2002,25(2):1-3
[37]车宇薇,王燕一.宏基因组学在口腔微生物研究中的应用进展.中华老年口腔医学杂志,2015,13(4):249-252
[38]He J,Li Y,Cao Y,et al.The oral microbiome diversity and its relation to human diseases.Folia Microbiol(Praha),2015,60(1):69-80