基因多态技术在溃疡性结肠炎个体化针刺治疗中的可行性分析
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摘要
近年来,基因多态性技术在疾病个体化治疗中的应用普遍,人类白细胞抗原(HLA)基因多态性标志物的筛选是目前溃疡性结肠炎(UC)的研究热点之一,通过分析目前UC的针刺和中药诊疗规范化方案以及HLA基因多态性及针刺在该方向的研究成果,在目前形成的UC规范化诊疗方案基础上,评估和筛选HLA基因多态性标志物在UC针刺个体化治疗中的重要性,为进一步个体化治疗方案的建立提供理论和科学依据。
In recent years, gene polymorphism technology has been widely used in individualized treatment of diseases. Screening of human leukocyte antigen(HLA) gene polymorphism markers is one of the research hotspots in ulcerative colitis. By analyzing the current standardized scheme of diagnosis and treatment of ulcerative colitis(UC) by acupuncture and traditional Chinese medicine, as well as HLA gene polymorphism and acupuncture research in this direction. Based on the current standardized diagnosis and treatment program for UC, the importance of HLA gene polymorphism markers in individualized acupuncture treatment for UC was evaluated and screened, which provided theoretical and scientific basis for further individualized treatment.
In recent years, gene polymorphism technology has been widely used in individualized treatment of diseases. Screening of human leukocyte antigen(HLA) gene polymorphism markers is one of the research hotspots in ulcerative colitis. By analyzing the current standardized scheme of diagnosis and treatment of ulcerative colitis(UC) by acupuncture and traditional Chinese medicine, as well as HLA gene polymorphism and acupuncture research in this direction. Based on the current standardized diagnosis and treatment program for UC, the importance of HLA gene polymorphism markers in individualized acupuncture treatment for UC was evaluated and screened, which provided theoretical and scientific basis for further individualized treatment.
引文
[1]张声生,沈洪,郑凯,等.溃疡性结肠炎中医诊疗专家共识意见(2017).中华中医药杂志,2017,32(8):3585-3589
[2]Ungaro R,Mehandru S,Allen P B,et al.Ulcerative colitis.Lancet,2017,389(10080):1756-1770
[3]Molodecky N A,Soon I S,Rabi D M,et al.Increasing incidence and prevalence of the inflammatory bowel diseases with time,based on systematic review.Gastroenterology,2012,142(1):e46-e54,e30
[4]Kornbluth A,Sachar D B.Ulcerative colitis practice guidelines in adults:American College of Gastroenterology,Practice Parameters Committee.AM J Gastroenterol,2010,105(3):501-523,524
[5]Kornbluth A,Sachar D B.Ulcerative colitis practice guidelines in adults(update):American College of Gastroenterology,Practice Parameters Committee.AM J Gastroenterol,2004,99(7):1371-1385
[6]Torres J,Colombel J F.Genetics and phenotypes in inflammatory bowel disease.Lancet,2016,387(10014):98-100
[7]Ordas I,Eckmann L,Talamini M,et al.Ulcerative colitis.Lancet,2012,380(9853):1606-1619
[8]Baumgart D C,Carding S R.Inflammatory bowel disease:cause and immunobiology.Lancet,2007,369(9573):1627-1640
[9]Chikata T,Murakoshi H,Koyanagi M,et al.Control of HIV-1 by an HLA-B*52:01-C*12:02 Protective Haplotype.J Infect Dis,2017,216(11):1415-1424
[10]Arimura Y,Isshiki H,Onodera K,et al.Characteristics of Japanese inflammatory bowel disease susceptibility loci.J Gastroenterol,2014,49(8):1217-1230
[11]Biemond I,Burnham W R,D’Amaro J,et al.HLA-A and-B antigens in inflammatory bowel disease.Gut,1986,27(8):934-941
[12]Habeeb M A,Rajalingam R,Dhar A,et al.HLA association and occurrence of autoantibodies in Asian-Indian patients with ulcerative colitis.Am J Gastroenterol,1997,92(5):772-776
[13]Fernandez L,Nunez C,Mendoza J L,et al.A recombined haplotype in the major histocompatibility region contains a cluster of genes conferring high susceptibility to ulcerative colitis in the Spanish population.Inflamm Bowel Dis,2005,11(9):785-791
[14]Fernandez A M,Lopez N G,De la Concha E G,et al.HLA-DR2 gene and Spanish patients with ulcerative colitis.Rev Esp Enferm Dig,1998,90(4):243-249
[15]Lappalainen M,Halme L,Turunen U,et al.Association of IL23R,TNFRSF1A,and HLA-DRB1*0103 allele variants with inflammatory bowel disease phenotypes in the Finnish population.Inflamm Bowel Dis,2008,14(8):1118-1124
[16]Puzanowska B,Prokopowicz D,Ziarko S,et al.The incidence of HLADRB1*0103 in ulcerative colitis patients in north-eastern Poland.Hepatogastroenterology,2003,50(53):1436-1438
[17]Silverberg M S,Mirea L,Bull S B,et al.A population-and familybased study of Canadian families reveals association of HLADRB1*0103 with colonic involvement in inflammatory bowel disease.Inflamm Bowel Dis,2003,9(1):1-9
[18]Lu M,Xia B.Polymorphism of HLA-DRB1 gene shows no strong association with ulcerative colitis in Chinese patients.Int JImmunogenet,2006,33(1):37-40
[19]Sugimura K,Ota M,Matsuzawa J,et al.A close relationship of triplet repeat polymorphism in MHC class I chain-related gene A(MICA)to the disease susceptibility and behavior in ulcerative colitis.Tissue Antigens,2001,57(1):9-14
[20]Ding Y,Xia B,Lu M,et al.MHC class I chain-related gene A-A5.1allele is associated with ulcerative colitis in Chinese population.Clin Exp Immunol,2005,142(1):193-198
[21]Fdez-Morera J L,Rodrigo L,Lopez-Vazquez A,et al.MHC class Ichain-related gene A transmembrane polymorphism modulates the extension of ulcerative colitis.Hum Immunol,2003,64(8):816-822
[22]Shi L W,Gu H,Liu M J,et al.Effect of electroacupuncture and manual acupuncture on colonic inflammatory injury,cytokine levels and cell apoptosis in ulcerative colitis rats.Acupuncture Research,2017,42(1):56-61
[23]Wang C Y,Zeng L L,Geng Y,et al.Effect of electroacupuncture stimulation of‘Guanyuan’(CV4)and‘Zusanli’(ST36)on spleen lymphocytes Treg/Th17 immune balance in ulcerative colitis mice.Acupuncture Research,2016,41(1):55-59
[24]Wu H G,Liu H R,Tan L Y,et al.Electroacupuncture and moxibustion promote neutrophil apoptosis and improve ulcerative colitis in rats.Dig Dis Sci,2007,52(2):379-384
[25]Wu H G,Gong X,Yao L Q,et al.Mechanisms of acupuncture and moxibustion in regulation of epithelial cell apoptosis in rat ulcerative colitis.World J Gastroenterol,2004,10(5):682-688
[26]Ji J,Lu Y,Liu H,et al.Acupuncture and moxibustion for inflammatory bowel diseases:A systematic review and meta-analysis of randomized controlled trials.Evid Based Complement Alternat Med,2013,2013:158352
[2]Ungaro R,Mehandru S,Allen P B,et al.Ulcerative colitis.Lancet,2017,389(10080):1756-1770
[3]Molodecky N A,Soon I S,Rabi D M,et al.Increasing incidence and prevalence of the inflammatory bowel diseases with time,based on systematic review.Gastroenterology,2012,142(1):e46-e54,e30
[4]Kornbluth A,Sachar D B.Ulcerative colitis practice guidelines in adults:American College of Gastroenterology,Practice Parameters Committee.AM J Gastroenterol,2010,105(3):501-523,524
[5]Kornbluth A,Sachar D B.Ulcerative colitis practice guidelines in adults(update):American College of Gastroenterology,Practice Parameters Committee.AM J Gastroenterol,2004,99(7):1371-1385
[6]Torres J,Colombel J F.Genetics and phenotypes in inflammatory bowel disease.Lancet,2016,387(10014):98-100
[7]Ordas I,Eckmann L,Talamini M,et al.Ulcerative colitis.Lancet,2012,380(9853):1606-1619
[8]Baumgart D C,Carding S R.Inflammatory bowel disease:cause and immunobiology.Lancet,2007,369(9573):1627-1640
[9]Chikata T,Murakoshi H,Koyanagi M,et al.Control of HIV-1 by an HLA-B*52:01-C*12:02 Protective Haplotype.J Infect Dis,2017,216(11):1415-1424
[10]Arimura Y,Isshiki H,Onodera K,et al.Characteristics of Japanese inflammatory bowel disease susceptibility loci.J Gastroenterol,2014,49(8):1217-1230
[11]Biemond I,Burnham W R,D’Amaro J,et al.HLA-A and-B antigens in inflammatory bowel disease.Gut,1986,27(8):934-941
[12]Habeeb M A,Rajalingam R,Dhar A,et al.HLA association and occurrence of autoantibodies in Asian-Indian patients with ulcerative colitis.Am J Gastroenterol,1997,92(5):772-776
[13]Fernandez L,Nunez C,Mendoza J L,et al.A recombined haplotype in the major histocompatibility region contains a cluster of genes conferring high susceptibility to ulcerative colitis in the Spanish population.Inflamm Bowel Dis,2005,11(9):785-791
[14]Fernandez A M,Lopez N G,De la Concha E G,et al.HLA-DR2 gene and Spanish patients with ulcerative colitis.Rev Esp Enferm Dig,1998,90(4):243-249
[15]Lappalainen M,Halme L,Turunen U,et al.Association of IL23R,TNFRSF1A,and HLA-DRB1*0103 allele variants with inflammatory bowel disease phenotypes in the Finnish population.Inflamm Bowel Dis,2008,14(8):1118-1124
[16]Puzanowska B,Prokopowicz D,Ziarko S,et al.The incidence of HLADRB1*0103 in ulcerative colitis patients in north-eastern Poland.Hepatogastroenterology,2003,50(53):1436-1438
[17]Silverberg M S,Mirea L,Bull S B,et al.A population-and familybased study of Canadian families reveals association of HLADRB1*0103 with colonic involvement in inflammatory bowel disease.Inflamm Bowel Dis,2003,9(1):1-9
[18]Lu M,Xia B.Polymorphism of HLA-DRB1 gene shows no strong association with ulcerative colitis in Chinese patients.Int JImmunogenet,2006,33(1):37-40
[19]Sugimura K,Ota M,Matsuzawa J,et al.A close relationship of triplet repeat polymorphism in MHC class I chain-related gene A(MICA)to the disease susceptibility and behavior in ulcerative colitis.Tissue Antigens,2001,57(1):9-14
[20]Ding Y,Xia B,Lu M,et al.MHC class I chain-related gene A-A5.1allele is associated with ulcerative colitis in Chinese population.Clin Exp Immunol,2005,142(1):193-198
[21]Fdez-Morera J L,Rodrigo L,Lopez-Vazquez A,et al.MHC class Ichain-related gene A transmembrane polymorphism modulates the extension of ulcerative colitis.Hum Immunol,2003,64(8):816-822
[22]Shi L W,Gu H,Liu M J,et al.Effect of electroacupuncture and manual acupuncture on colonic inflammatory injury,cytokine levels and cell apoptosis in ulcerative colitis rats.Acupuncture Research,2017,42(1):56-61
[23]Wang C Y,Zeng L L,Geng Y,et al.Effect of electroacupuncture stimulation of‘Guanyuan’(CV4)and‘Zusanli’(ST36)on spleen lymphocytes Treg/Th17 immune balance in ulcerative colitis mice.Acupuncture Research,2016,41(1):55-59
[24]Wu H G,Liu H R,Tan L Y,et al.Electroacupuncture and moxibustion promote neutrophil apoptosis and improve ulcerative colitis in rats.Dig Dis Sci,2007,52(2):379-384
[25]Wu H G,Gong X,Yao L Q,et al.Mechanisms of acupuncture and moxibustion in regulation of epithelial cell apoptosis in rat ulcerative colitis.World J Gastroenterol,2004,10(5):682-688
[26]Ji J,Lu Y,Liu H,et al.Acupuncture and moxibustion for inflammatory bowel diseases:A systematic review and meta-analysis of randomized controlled trials.Evid Based Complement Alternat Med,2013,2013:158352