复杂腹腔感染患者中甲状腺功能改变与低蛋白血症的相关性分析
摘要
<正>腹腔感染是外科常见的危重症,通常可以分为单纯腹腔感染和复杂腹腔感染两类,一般认为复杂腹腔感染累及多个器官,易造成弥漫性腹膜炎,需要感染源控制联合抗生素治疗,并且预后往往不良~([1])。在腹腔感染中经常发现甲状腺功能的改变,通常表现为T3降低,T4正常或者降低,而TSH正常~([2]),这种非甲状腺疾病引起的甲状腺功能异常的状态被称为非甲状腺病态综合征(NTIS)或正常甲状腺病
引文
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[15]Pacelli F,Doglietto GB,Alfieri S,et al.Prognosis in intra-abdominal infections.Multivariate analysis on 604patients[J].Archives of Surgery,1996,131(6):641.
[16]Zhou B,Ren J,Han G,et al.Dynamics of albumin synthetic response to intra-abdominal abscess in patients with gastrointestinal fistula[J].Surgical Infections,2014,15(2):111.
[17]黎介寿.首选肠内营养的合理性[J].肠外与肠内营养,2013,20(6):321.
[2]Akcay I,Okoh AK,Yalav O,et al.The prognostic value of procalcitonin,CRP and thyroid hormones in secondary peritonitis:a single-center prospective study[J].TJTES,2014,20(5):343.
[3]De Groot LJ.Dangerous dogmas in medicine:the nonthyroidal illness syndrome[J].J Clin Endocrinol Metab,1999,84(1):151.
[4]Han G,Ren J,Liu S,et al.Nonthyroidal illness syndrome in enterocutaneous fistulas[J].American Journal of Surgery,2013,206(3):386.
[5]McClave SA,Taylor BE,Martindale RG,et al.Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient:Society of Critical Care Medicine(SC-CM)and American Society for Parenteral and Enteral Nutrition(A.S.P.E.N.)[J].JPEN,2016,40(2):159.
[6]任建安.当前腹腔感染诊治的难题与对策[J].中华胃肠外科杂志,2011,14(7):483.
[7]Oppenheimer JH,Squef R,Surks MI,et al.Binding of thyroxine by serum proteins evaluated by equilibrum dialysis and electrophoretic techniques.alterations in nonthyroidal illness[J].Journal of Clinical Investigation,1963,42(11):1769.
[8]Chopra IJ.Euthyroid Sick Syndrome:Is It a Misnomer?[J].JClin Endocr Metab,2013,82(2):329.
[9]Van dBG.Dynamic neuroendocrine responses to critical illness[J].Frontiers in Neuroendocrinology,2002,23(4):370.
[10]Palazzo MG,Suter PM.Thyroid hormone receptor expression in“sick euthyroid”syndrome[J].Lancet,1990,335(8690):662.
[11]Boelen A,Kwakkel J,Fliers E.Beyond low plasma T3:local thyroid hormone metabolism during inflammation and infection[J].Endocrine Reviews,2011,32(5):670.
[12]Boelen A,Platvoetter Schiphorst MC,Wiersinga WM.Immunoneutralization of interleukin-1,tumor necrosis factor,interleukin-6or interferon does not prevent the LPS-induced sick euthyroid syndrome in mice[J].Journal of Endocrinology,1997,153(1):115.
[13]Vincent JL,Navickis RJ,Wilkes MM.Morbidity in hospitalized patients receiving human albumin:a meta-analysis of randomized,controlled trials[J].Critical Care Medicine,2004,32(10):2029.
[14]Gibbs J,Cull W,Henderson W,et al.Preoperative serum albumin level as a predictor of operative mortality and morbidity:results from the National VA Surgical Risk Study[J].Arch Surg,1999,134(1):36.
[15]Pacelli F,Doglietto GB,Alfieri S,et al.Prognosis in intra-abdominal infections.Multivariate analysis on 604patients[J].Archives of Surgery,1996,131(6):641.
[16]Zhou B,Ren J,Han G,et al.Dynamics of albumin synthetic response to intra-abdominal abscess in patients with gastrointestinal fistula[J].Surgical Infections,2014,15(2):111.
[17]黎介寿.首选肠内营养的合理性[J].肠外与肠内营养,2013,20(6):321.