鼻咽癌放疗中顺铂增敏作用和紫杉醇增敏作用的比较
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摘要
目的探讨顺铂和紫杉醇在鼻咽癌放射治疗中的增敏作用和不良反应。方法选取2005年6月～2010年6月于湖南省郴州市第一人民医院肿瘤科首次治疗的102例局部晚期鼻咽癌患者,随机分顺铂增敏组(C组,n=50)与紫杉醇增敏组(P组,n=52)。用药方法:C组顺铂每周用药1次,每次按40 mg/m2剂量用药,用药后1 h内进行放疗,到放疗结束;P组按紫杉醇60 mg/m2药量静脉滴注,每周1次,共用7周。放疗方法:先定制面模固定,采用常规放疗方法。结果治疗后,两组在原发灶及颈部淋巴结退缩方面的差异没有统计学意义(P>0.05)。C组(52.0%)转移率高于P组(28.8%),且差异有统计学意义(P<0.05),而两组在复发率和生存率方面差异无统计学意义(P>0.05)。P组在2、3级口腔黏膜炎、白细胞减少方面较C组明显,并且差异有高度统计学意义(P<0.01)。结论顺铂与紫杉醇在鼻咽癌放射治疗中的增敏作用相似,但顺铂毒副作用相对较小。
Objective To evaluate the radio-sensitization effect and side effect of Cisplatin versus Paclitaxel in local advanced nasopharyngeal carcinoma.Methods 102 patients were randomly divided into the group C(n = 50) and the group P(n = 52).The group C was used venous with 40 mg/m2 Cisplatin once a week.The P group was received Paclitaxel by 60 mg/m2 via intravenous infusion,every 7 days for 7 times in the radiotherapy duration.All patients were received conventional radiotherapy.Results Complete tumor remission,regional recurrence rate and survive rate were no significant difference between the two groups.The metastasis rate in the group C(52.0%) was significantly higher than in the group P(28.8%)(P < 0.05).Oral cavity mucositis in grade 2 and 3,leukopenia in the group P were more frequent than in the group C(P < 0.01).Conclusion Cisplatin is similar to Paclitaxel in radio-sensitization efficiency for local advanced nasopharyngeal carcinoma,but the side effect of Paclitaxel is more severe than Cisplatin.
Objective To evaluate the radio-sensitization effect and side effect of Cisplatin versus Paclitaxel in local advanced nasopharyngeal carcinoma.Methods 102 patients were randomly divided into the group C(n = 50) and the group P(n = 52).The group C was used venous with 40 mg/m2 Cisplatin once a week.The P group was received Paclitaxel by 60 mg/m2 via intravenous infusion,every 7 days for 7 times in the radiotherapy duration.All patients were received conventional radiotherapy.Results Complete tumor remission,regional recurrence rate and survive rate were no significant difference between the two groups.The metastasis rate in the group C(52.0%) was significantly higher than in the group P(28.8%)(P < 0.05).Oral cavity mucositis in grade 2 and 3,leukopenia in the group P were more frequent than in the group C(P < 0.01).Conclusion Cisplatin is similar to Paclitaxel in radio-sensitization efficiency for local advanced nasopharyngeal carcinoma,but the side effect of Paclitaxel is more severe than Cisplatin.
引文
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[2]陆亚梅,吴建亭,倪赛楠.鼻咽癌调强放疗和常规放疗急性反应观察及护理[J].护理实践与研究,2011,8(20):46-48.
[3]贺冬林,魏来.甘氨双唑钠与顺铂在鼻咽癌放疗中增敏作用的比较[J].中国药房,2011,22(44):4165-4166.
[4]陈龙,王湘辉.紫杉醇、顺铂及卡培他滨联合放疗治疗晚期鼻咽癌的疗效观[J].临床肿瘤学杂志,2012,17(5):459-462.
[5]朱彩梅.优质护理在鼻咽癌放射治疗病人中的应用效果[J].护理实践与研究,2012,9(13):83-85.
[6]原雨灵.临床护理路径在鼻咽癌放化疗患者中的应用[J].护理实践与研究,2012,9(16):42-43.
[7]Sia KJ,Tang IP.Nasolacrimal relapse of nasopharyngeal carcinoma[J].The Journal of laryngology and otology,2012,126(8):847-850.
[8]赖振南,梁荣.紫杉醇与甘氨双唑钠在局部晚期鼻咽癌放疗中的增敏作用比较[J].山东大学学报:医学版,2011,49(11):131-134.
[9]付喜秀,屈元姣.紫杉醇联合顺铂化疗的毒副反应观察与护理[J].护理实践与研究,2011,8(5):63-64.
[10]莫志文,邵汛帆.顺铂单药方案同期放疗治疗鼻咽癌的疗效观察[J].药物与临床,2012,2(4):99-100.
[11]瞿美霞,徐金中.抗肿瘤药物的不良反应分析与防治[J].医药导报,2009,29(3):394-396.