同期放化疗治疗晚期鼻咽癌的疗效分析
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摘要
目的分析同期放化疗对晚期鼻咽癌患者的治疗效果及不良反应。方法 2002年9月—2005年7月收治符合入选条件的鼻咽癌初诊患者79例,随机分为观察组和对照组,观察组接受同期放化疗治疗,对照组接受单纯放射治疗,收集2组患者疗效和不良反应数据并分析统计。结果观察组鼻咽缓解率(87.2%)优于对照组(67.5%),颈部淋巴结缓解率(87.2%)亦优于对照组(65.0%),2组比较差异均有统计学意义(P<0.05)。5年生存率和无瘤生存率观察组均优于对照组(P<0.05)。2组远处转移率无显著性差异(P>0.05),而在转移时间上,观察组晚于对照组(P<0.05)。观察组在恶心呕吐、血液毒性、口腔黏膜不良反应方面重于对组照(P<0.01),而皮肤反应基本相同(P>0.05)。结论对于晚期鼻咽癌,同期放化疗治疗较单纯放射治疗具有更佳的治疗效果,极大地延迟患者的转移时间,但其增加了一定的不良反应,仍需进一步改进。
Objective To study the concurrent chemoradiotherapy to improve the role of treatment effects and side effects in patients with advanced nasopharyngeal.Methods 9 cases of nasopharyngeal carcinoma patients who were recently diagnosed met the inclusion criteria were collected from September 2002 to July 2005.All the patients were randomly divided into observation group and control group.The observation group received concurrent chemoradiation therapy,the control group received radiotherapy alone.And then collected and analyzed efficacy and toxicity data.Results In the observation group, nasopharyngeal complete remission rate of 87.2%,67.5%in the control group;the neck lymph observation group complete remission rate was 87.2%,65.0%in the control group,two indicators were significant differences(P <0.05).5 years survival rate and disease free survival rate indicators were better in the observation group than the control group(P < 0.05 ). Nausea and vomiting indicators of the observation group were serious than control group(P <0.01 ).Hematologic toxicity indicators of the observation group were serious than control group(P <0.01).Oral mucosa indicators of the observation group were worse than control group(P <0.01 ).The two groups in the reaction of the skin are basically the same(P >0.05). Conclusion Concurrent chemotherapy and radiotherapy compared with radiotherapy alone has a better therapeutic effect, greatly reduces the time of transfer of patients with nasopharyngeal carcinoma,but its enhanced certain side effects is needed to be further improved.
Objective To study the concurrent chemoradiotherapy to improve the role of treatment effects and side effects in patients with advanced nasopharyngeal.Methods 9 cases of nasopharyngeal carcinoma patients who were recently diagnosed met the inclusion criteria were collected from September 2002 to July 2005.All the patients were randomly divided into observation group and control group.The observation group received concurrent chemoradiation therapy,the control group received radiotherapy alone.And then collected and analyzed efficacy and toxicity data.Results In the observation group, nasopharyngeal complete remission rate of 87.2%,67.5%in the control group;the neck lymph observation group complete remission rate was 87.2%,65.0%in the control group,two indicators were significant differences(P <0.05).5 years survival rate and disease free survival rate indicators were better in the observation group than the control group(P < 0.05 ). Nausea and vomiting indicators of the observation group were serious than control group(P <0.01 ).Hematologic toxicity indicators of the observation group were serious than control group(P <0.01).Oral mucosa indicators of the observation group were worse than control group(P <0.01 ).The two groups in the reaction of the skin are basically the same(P >0.05). Conclusion Concurrent chemotherapy and radiotherapy compared with radiotherapy alone has a better therapeutic effect, greatly reduces the time of transfer of patients with nasopharyngeal carcinoma,but its enhanced certain side effects is needed to be further improved.
引文
1费新雄,蒋中君,王刚胜,等.复方苦参注射液配合同期放化疗治疗局部晚期鼻咽癌的临床观察[J].天津医药,2012,40(12):1256- ??1258.
2宣莹,张振勇,曾越灿,等.同步放化疗治疗局部晚期鼻咽癌的Meta分析[J].中国医科大学学报,2013,42(3):204-208.
3马静静,张云波,赵美红,等.TPF、PF方案诱导化疗联合同期放化疗治疗局部晚期鼻咽癌的近期疗效分析[J].安徽医药,2011,15 (10):1291-1293.
4Zhuang M,Zhang T,Chen Z,et al.Advanced nasopharyngeal carcinoma radiotherapy with volumetric modulated arcs and the potential role of flattening filter-free beams[J].Radial Oncol,2013,8(1 ):120.
5汪晓洁,寿涛,刁宪民,等.长春瑞滨诱导化疗联合同期放化疗治疗局部晚期鼻咽癌[J].实用医学杂志,2011,27(24):4451-4453.
6宁雪坚,于洪波,冯献斌,等.改良同期放化疗联合辅助化疗治疗局部晚期鼻咽癌临床观察[J].山东医药,2011,51(30):82-83.
7 Leung SW,Lee TF.Treatment of nasopharyngeal carcinoma by tomotherapy: five-year experienc[J].Radiat Oncol,2013,8(1):107.
8 Wang D.Wang S.Liu Q,et al.SZ-685C exhibits potent anticancer activity in both radiosensitive and radioresistant NPC cells through the miR- 205-PTEN-Akt pathway[J].Oncol Rep,2013,29(6):2341-2347.
9张福正,邹勤舟,黄剑峰,等.鼻咽癌调强放射治疗与常规放疗的剂量学比较[J].中国医药,2010,5(12):1182.
10刘化科.鼻咽癌放疗中顺铂增敏作用和紫杉醇增敏作用的比较[J].中国医药导报,2013,10(7):54-56.
2宣莹,张振勇,曾越灿,等.同步放化疗治疗局部晚期鼻咽癌的Meta分析[J].中国医科大学学报,2013,42(3):204-208.
3马静静,张云波,赵美红,等.TPF、PF方案诱导化疗联合同期放化疗治疗局部晚期鼻咽癌的近期疗效分析[J].安徽医药,2011,15 (10):1291-1293.
4Zhuang M,Zhang T,Chen Z,et al.Advanced nasopharyngeal carcinoma radiotherapy with volumetric modulated arcs and the potential role of flattening filter-free beams[J].Radial Oncol,2013,8(1 ):120.
5汪晓洁,寿涛,刁宪民,等.长春瑞滨诱导化疗联合同期放化疗治疗局部晚期鼻咽癌[J].实用医学杂志,2011,27(24):4451-4453.
6宁雪坚,于洪波,冯献斌,等.改良同期放化疗联合辅助化疗治疗局部晚期鼻咽癌临床观察[J].山东医药,2011,51(30):82-83.
7 Leung SW,Lee TF.Treatment of nasopharyngeal carcinoma by tomotherapy: five-year experienc[J].Radiat Oncol,2013,8(1):107.
8 Wang D.Wang S.Liu Q,et al.SZ-685C exhibits potent anticancer activity in both radiosensitive and radioresistant NPC cells through the miR- 205-PTEN-Akt pathway[J].Oncol Rep,2013,29(6):2341-2347.
9张福正,邹勤舟,黄剑峰,等.鼻咽癌调强放射治疗与常规放疗的剂量学比较[J].中国医药,2010,5(12):1182.
10刘化科.鼻咽癌放疗中顺铂增敏作用和紫杉醇增敏作用的比较[J].中国医药导报,2013,10(7):54-56.