山奈酚功能及提取工艺研究进展
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摘要
介绍了黄酮类物质山奈酚在体内的代谢及功能,简述了山奈酚从各类植物中被提取的有效方法及其含量测定,并对山奈酚的开发前景进行了展望。
The metabolism in vivo and function of flavonoids kaempferol were introduced. The effective extraction method from a variety of plants about kaempferol and the content determination were described. And the later development prospects about kaempferol were discussed.
The metabolism in vivo and function of flavonoids kaempferol were introduced. The effective extraction method from a variety of plants about kaempferol and the content determination were described. And the later development prospects about kaempferol were discussed.
引文
[1]BANDYOPADHYAY S,ROMERO J R,CHATTOPADHYAY N.Kaempferol and quercetin stimulate granulocyte-macrophage colony-stimulating factor secretion in human prostate cancer cells[J].Molecular and Cellular Endocrinology,2008,287(1/2):57-64.
[2]SHARMA V,JOSEPH C,GHOSH S,et al.Kaempferol induces apoptosis in glioblastoma cells through oxidative stress[J].Molecular Cancer Therapeutics,2007,6(9):2544-2553.
[3]CHOI E J,AHN W S.Kaempferol induced the apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells[J].Nutrition Research&Practice,2008,2(4):322-325.
[4]陶世冰,田浩明.糖尿病颈动脉病变的诊断和现状[J].中国糖尿病杂志,2009,17(10):724-726.
[5]王玲玲,陈立英,付春华,等.糖尿病健康教育研究进展[J].中国误诊学杂志,2011,11(8):1782-1783.
[6]丁淑琴,杨风琴,张玮,等.山奈酚治疗去卵巢大鼠骨质疏松的实验研究[J].中国新药杂志,2014,23(24):2925-2929.
[7]郭媛媛.山奈酚对急性肝衰竭模型的作用及对内质网应激诱导肝细胞凋亡的研究[D].太原:山西医科大学,2015.
[8]王铮华,梁统,李涛,等.山奈酚对人肝癌细胞Huh7生长及凋亡的影响[J].广东医学,2014,35(2):192-194.
[9]曾玲.山奈酚对小鼠黑色素瘤自杀基因系统的增效作用[D].广州:广州中医药大学,2014.
[10]蔡云朗,高永星,任慕兰,等.山奈酚对子宫肌瘤体外抑制作用的实验研究[J].实用妇产科杂志,2014,30(5):350-353.
[11]HUANG W W,TSAI S C,PENG S F,et al.Kaempferol induces autophagy through AMPK and AKT signaling molecules and causes G2/M arrest via downregulation of CDKl/cyclin B in SKHEP-1 human hepatic cancer cells[J].International Journal of Oncology,2013,42(6):2069-2077.
[12]LUO H,RANKIN G O,LI Z L,et a1.Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway[J].Food Chemistry,2011,128(2):513-519.
[13]LUO H,DADDYSMAN M K,RANKIN G O,et a1.Kaempferol enhances cisplatin's effect on ovarian cancer cells through promoting apoptosis caused by down regulation of c Myc[J].Cancer Cell International,2009,10(1):1-9.
[14]杜标炎,周瑶,谭宇蕙,等.山奈酚对人胃癌MGC-803细胞的生长抑制及诱导凋亡作用[J].肿瘤,2010,30(6):477-480.
[15]TU L Y,PI J,JIN H,et al.Synthesis,characterization and anticancer activity of kaempferol-zinc(II)complex[J].Bioorganic&Medicinal Chemistry Letters,2016,26(11):2730-2734.
[16]张家瑞.槲皮苷和山奈酚对糖尿病小鼠血糖及血脂水平的影响[J].现代食品科技,2013,29(3):459-462.
[17]陈磊,李秋红,韦庆益,等.山奈酚抑制α-淀粉酶作用的研究[J].食品工业科技,2013,34(22):88-90.
[18]PENG X,ZHANG G W,LIAO Y J,et al.Inhibitory kinetics and mechanism of kaempferol onα-glucosidase[J].Food Chemistry,2016,190:207-215.
[19]童方念,罗超,罗丹,等.山奈酚对四氯化碳致小鼠急性肝损伤的保护作用[J].西安交通大学学报(医学版),2014,35(6):816-819.
[20]连立芳.山奈酚抑制Ba P致HTR8-SVneo细胞氧化损伤的研究[D].石家庄:河北医科大学,2014.
[21]LIAO W Z,CHEN L Y,MA X,et al.Protective effects of kaempferol against reactive oxygen species-induced hemolysis and its antiproliferative activity on human cancer cells[J].European Journal of Medicinal Chemistry,2016,114(23):24-32.
[22]丁淑琴,杨风琴,张玮,等.山奈酚治疗去卵巢大鼠骨质疏松的实验研究[J].中国新药杂志,2014,23(24):2925-2929.
[23]方贺,张雅,李佳,等.黄花柳花总黄酮对心肌缺血再灌注损伤的保护作用机制[J].中国新药杂志,2016,25(8):949-953.
[24]CORREIA M,RODRIGUES A S,PERESTRELO T,et al.Different concentrations of kaempferol distinctly modulate murine embryonic stem cell function[J].Food and Chemical Toxicology,2016,87:148-156.
[25]LIN F,LUO X R,TSUN A,et al.Kaempferol enhances the suppressive function of Treg cells by inhibiting FOXP3phosphorylation[J].International Immunopharmacology,2015,28(2):859-865.
[26]肖骁,张慧娟,庞思平.光谱法研究山奈酚与小牛胸腺DNA的相互作用[J].光谱实验室,2009,26(5):1211-1213.
[27]张敏,孔令希,罗成,等.山奈酚在家兔体内的药动学研究[J].中国药房,2014,25(43):4040-4042.
[28]刘慧燕,方海田,张光弟,等.HPLC法测定宁夏红葱中槲皮素与山奈酚的含量[J].食品研究与开发,2015,36(18):141-144.
[29]高意,周光明木,陈军华,等.高效液相色谱法同时测定仙鹤草中6种黄酮[J].食品科学,2015,36(18):93-96.
[30]LI B,XU Y,JIN Y X,et al.Response surface optimization of supercritical fluid extraction of kaempferol glycosides from tea seed cake[J].Industrial Crops and Products,2010,32(2):123-128.
[31]MITRA P,CHANG K S,YOO D S.Kaempferol extraction from Cuscuta refl exa using supercritical carbon dioxide and separation of kaempferol from the Extracts[J].International Journal of Food Engineering,2011,7(4):457-461.
[32]王昌涛,张佳婵,孙啸涛,等.鼠李糖脂/蔗糖酯辅助乙醇提取沙棘籽黄酮的工艺条件及初步鉴定[J].食品科学,2014,35(2):62-68.
[33]张丽贤,周光明,姜兰芳,等.非离子表面活性剂萃取-高效液相色谱法测定枇杷叶中的绿原酸、槲皮素和山奈酚[J].食品科学,2012,33(6):150-153.
[34]刘慧燕,方海田,张光弟,等.HPLC法测定宁夏红葱中槲皮素与山奈酚的含量[J].食品研究与开发,2015,36(18):141-144.
[35]张禄捷,李荣,姜子涛.茼蒿叶中总黄酮的提取纯化及抗氧化活性分析[J].食品科学,2015,36(24):40-45.
[36]林贵兵,罗光明,许燕萍,等.HPLC法对细梗香草中槲皮素和山奈酚含量的测定[J].湖北农业科学,2014,53(23):5848-5850.
[37]卫亚丽,吕昱,杨琼,等.HPLC法同时测定地桃花的槲皮素和山奈酚[J].贵州农业科学,2014,42(12):66-69.
[38]高意,周光明,陈军华,等.高效液相色谱法同时测定仙鹤草中6种黄酮[J].食品科学,2015,36(18):93-96.
[39]GUPTAV K,YOLA M L,ATAR N.A novel molecular imprinted nanosensor based quartz crystal microbalance for determination of kaempferol[J].Sensors&Actuators B Chemical,2014,194:79-85.
[2]SHARMA V,JOSEPH C,GHOSH S,et al.Kaempferol induces apoptosis in glioblastoma cells through oxidative stress[J].Molecular Cancer Therapeutics,2007,6(9):2544-2553.
[3]CHOI E J,AHN W S.Kaempferol induced the apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells[J].Nutrition Research&Practice,2008,2(4):322-325.
[4]陶世冰,田浩明.糖尿病颈动脉病变的诊断和现状[J].中国糖尿病杂志,2009,17(10):724-726.
[5]王玲玲,陈立英,付春华,等.糖尿病健康教育研究进展[J].中国误诊学杂志,2011,11(8):1782-1783.
[6]丁淑琴,杨风琴,张玮,等.山奈酚治疗去卵巢大鼠骨质疏松的实验研究[J].中国新药杂志,2014,23(24):2925-2929.
[7]郭媛媛.山奈酚对急性肝衰竭模型的作用及对内质网应激诱导肝细胞凋亡的研究[D].太原:山西医科大学,2015.
[8]王铮华,梁统,李涛,等.山奈酚对人肝癌细胞Huh7生长及凋亡的影响[J].广东医学,2014,35(2):192-194.
[9]曾玲.山奈酚对小鼠黑色素瘤自杀基因系统的增效作用[D].广州:广州中医药大学,2014.
[10]蔡云朗,高永星,任慕兰,等.山奈酚对子宫肌瘤体外抑制作用的实验研究[J].实用妇产科杂志,2014,30(5):350-353.
[11]HUANG W W,TSAI S C,PENG S F,et al.Kaempferol induces autophagy through AMPK and AKT signaling molecules and causes G2/M arrest via downregulation of CDKl/cyclin B in SKHEP-1 human hepatic cancer cells[J].International Journal of Oncology,2013,42(6):2069-2077.
[12]LUO H,RANKIN G O,LI Z L,et a1.Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway[J].Food Chemistry,2011,128(2):513-519.
[13]LUO H,DADDYSMAN M K,RANKIN G O,et a1.Kaempferol enhances cisplatin's effect on ovarian cancer cells through promoting apoptosis caused by down regulation of c Myc[J].Cancer Cell International,2009,10(1):1-9.
[14]杜标炎,周瑶,谭宇蕙,等.山奈酚对人胃癌MGC-803细胞的生长抑制及诱导凋亡作用[J].肿瘤,2010,30(6):477-480.
[15]TU L Y,PI J,JIN H,et al.Synthesis,characterization and anticancer activity of kaempferol-zinc(II)complex[J].Bioorganic&Medicinal Chemistry Letters,2016,26(11):2730-2734.
[16]张家瑞.槲皮苷和山奈酚对糖尿病小鼠血糖及血脂水平的影响[J].现代食品科技,2013,29(3):459-462.
[17]陈磊,李秋红,韦庆益,等.山奈酚抑制α-淀粉酶作用的研究[J].食品工业科技,2013,34(22):88-90.
[18]PENG X,ZHANG G W,LIAO Y J,et al.Inhibitory kinetics and mechanism of kaempferol onα-glucosidase[J].Food Chemistry,2016,190:207-215.
[19]童方念,罗超,罗丹,等.山奈酚对四氯化碳致小鼠急性肝损伤的保护作用[J].西安交通大学学报(医学版),2014,35(6):816-819.
[20]连立芳.山奈酚抑制Ba P致HTR8-SVneo细胞氧化损伤的研究[D].石家庄:河北医科大学,2014.
[21]LIAO W Z,CHEN L Y,MA X,et al.Protective effects of kaempferol against reactive oxygen species-induced hemolysis and its antiproliferative activity on human cancer cells[J].European Journal of Medicinal Chemistry,2016,114(23):24-32.
[22]丁淑琴,杨风琴,张玮,等.山奈酚治疗去卵巢大鼠骨质疏松的实验研究[J].中国新药杂志,2014,23(24):2925-2929.
[23]方贺,张雅,李佳,等.黄花柳花总黄酮对心肌缺血再灌注损伤的保护作用机制[J].中国新药杂志,2016,25(8):949-953.
[24]CORREIA M,RODRIGUES A S,PERESTRELO T,et al.Different concentrations of kaempferol distinctly modulate murine embryonic stem cell function[J].Food and Chemical Toxicology,2016,87:148-156.
[25]LIN F,LUO X R,TSUN A,et al.Kaempferol enhances the suppressive function of Treg cells by inhibiting FOXP3phosphorylation[J].International Immunopharmacology,2015,28(2):859-865.
[26]肖骁,张慧娟,庞思平.光谱法研究山奈酚与小牛胸腺DNA的相互作用[J].光谱实验室,2009,26(5):1211-1213.
[27]张敏,孔令希,罗成,等.山奈酚在家兔体内的药动学研究[J].中国药房,2014,25(43):4040-4042.
[28]刘慧燕,方海田,张光弟,等.HPLC法测定宁夏红葱中槲皮素与山奈酚的含量[J].食品研究与开发,2015,36(18):141-144.
[29]高意,周光明木,陈军华,等.高效液相色谱法同时测定仙鹤草中6种黄酮[J].食品科学,2015,36(18):93-96.
[30]LI B,XU Y,JIN Y X,et al.Response surface optimization of supercritical fluid extraction of kaempferol glycosides from tea seed cake[J].Industrial Crops and Products,2010,32(2):123-128.
[31]MITRA P,CHANG K S,YOO D S.Kaempferol extraction from Cuscuta refl exa using supercritical carbon dioxide and separation of kaempferol from the Extracts[J].International Journal of Food Engineering,2011,7(4):457-461.
[32]王昌涛,张佳婵,孙啸涛,等.鼠李糖脂/蔗糖酯辅助乙醇提取沙棘籽黄酮的工艺条件及初步鉴定[J].食品科学,2014,35(2):62-68.
[33]张丽贤,周光明,姜兰芳,等.非离子表面活性剂萃取-高效液相色谱法测定枇杷叶中的绿原酸、槲皮素和山奈酚[J].食品科学,2012,33(6):150-153.
[34]刘慧燕,方海田,张光弟,等.HPLC法测定宁夏红葱中槲皮素与山奈酚的含量[J].食品研究与开发,2015,36(18):141-144.
[35]张禄捷,李荣,姜子涛.茼蒿叶中总黄酮的提取纯化及抗氧化活性分析[J].食品科学,2015,36(24):40-45.
[36]林贵兵,罗光明,许燕萍,等.HPLC法对细梗香草中槲皮素和山奈酚含量的测定[J].湖北农业科学,2014,53(23):5848-5850.
[37]卫亚丽,吕昱,杨琼,等.HPLC法同时测定地桃花的槲皮素和山奈酚[J].贵州农业科学,2014,42(12):66-69.
[38]高意,周光明,陈军华,等.高效液相色谱法同时测定仙鹤草中6种黄酮[J].食品科学,2015,36(18):93-96.
[39]GUPTAV K,YOLA M L,ATAR N.A novel molecular imprinted nanosensor based quartz crystal microbalance for determination of kaempferol[J].Sensors&Actuators B Chemical,2014,194:79-85.