动物性食品中青霉素类药物残留色谱与质谱检测技术研究进展
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摘要
<正>近年来,随着人们生活水平的提高,动物性食品在满足人类需求的同时,也面临着诸多问题和挑战,其中兽药残留问题尤为突出,为保障畜产品的高品质,需对食品卫生安全提出更高的要求。畜牧养殖业是畜产品的主要供给部门,尤其需要加强对其兽药的使用和残留监控。其中青霉素类药物常被用于防治动物性疾病,企业为获取高额利润,使用较多,滥用现象普遍,所以在动物性食品中的兽药残留现象也日趋严重~([1])。青霉素类药物既属于广谱类抗生素,也属于窄谱类抗生素,主要用于治疗由病原体微
引文
[1] 邢浩春,陈建中,葛水莲,等.动物源性食品中β-内酰胺类抗生素前处理及检测方法研究进展[J].食品与发酵工业,2016,42(3):268-274.
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[2] CHEN C,YAN H,SHEN B H,et al.A Research on detection and application of penicillin antibiotics[J].Chin J Forensic Sci,2010,25(9):1055-1059.
[3] KARDOS N,DEMAIN A L.Penicillin:the medicine with the greatest impact on therapeutic outcomes[J].Appl Microbiol Biotechnol,2011,92(4):677-687.
[4] SACCO K A,BATES A,BRIGHAM T J,et al.Clinical outcomes following inpatient penicillin allergy testing:a systematic review and meta-analysis[J].Allergy,2017,72(9):1288-1296.
[5] 邓斌,邓春来,张曦.高效液相色谱法检测牛奶中青霉素残留的研究进展[J].中国兽药杂志,2003,37(6):36-40.
[6] 郎友,单艺,满朝新,等.超高效液相色谱-串联质谱法测定乳及乳制品中青霉素类药物残留量[J].中国乳品工业,2013,41(5):48-51.
[7] 陈聪,严慧,沈保华,等.青霉素类抗生素分析研究进展及其应用[J].中国司法鉴定,2010(6):36-40.
[8] 张兴艳,王霆,李苌清,等.青霉素类抗生素高分子聚合物的研究进展[J].中南药学,2011,9(7):520-524.
[9] MEETSCHEN U,PETZ M.Gas chromatographic method for the analysis of residues of seven penicillins in food of animal origin[J].Z Lebensm Untersd Forsch,1991,193(4):337-343.
[10] PETRA L,MARIE-CLAUDE SAVOY-PERROU D,ESTHER CAMPOS-GIMENE Z,et al.Screening and confirmatory methods for the determination of melamine in cow’s milk and milk-based powdered infant formula:Validation and proficiency-tests of ELISA,HPLC-UV,GC-MS and LC-MS/MS[J].Food Control,2011,22(6):903-913.
[11] KUKUSAMUDE C,BURAKHAM R,CHAILAPAKUL O,et al.High performance liquid chromatography for the simultaneous analysis of penicillin residues in beef and milk using ion-paired extraction and binary water-acetonitrile mixture.[J].Talanta,2012,92(92):38-44.
[12] 王昕.高效液相色谱研究进展[J].光明中医,2011,26(1):56-58.
[13] XIE K,JIA L,XU D,et al.Simultaneous determination of amoxicillin and ampicillin in eggs by reversed-phase high-performance liquid chromatography with fluorescence detection using pre-column derivatization[J].J Chromatogr Sci,2012,50(7):620.
[14] 孙礼瑞,赵敏,谢恺舟,等.高效液相色谱荧光检测法同时检测鸡血浆中阿莫西林和氨苄西林残留[J].中国兽医学报,2014,34(9):82-85.
[15] 崔璐璐,谢星,谢恺舟,等.高效液相色谱荧光检测法同时检测鸡组织中阿莫西林和氨苄西林残留[J].中国兽医杂志,2015,51(8):82-85.
[16] 王超,王星.柱前衍生高效液相色谱法测定猪肉中5种青霉素残留量[J].分析化学,2001,29(7):779-781.
[17] 阮祥春,曾明华,陶小平.高效液相色谱法检测猪血浆和肌肉组织中的氨苄青霉素残留[J].中国兽药杂志,2007,41(5):14-17.
[18] 王超,李淑娟.测定牛奶中5种青霉素残留量的高效液相色谱柱前衍生法[J].分析测试学报,2000,19(6):72-74.
[19] 古丽曼·木哈买提拜.高效液相色谱法测定生鲜乳中氨苄青霉素的残留量[J].新疆畜牧业,2015(12):30-31.
[20] 王成龙,岳治光,刘海林,等.高效液相色谱法测定绵羊血浆内阿莫西林的含量[J].畜牧与兽医,2016,48(4):148-149.
[21] 李雷霆,刘均华,刘宝涛,等.高效液相色谱紫外法同时检测鸡蛋中5种青霉素类药物残留的研究[J].中国畜牧兽医,2017,44(8):2483-2488.
[22] NAGATA T,ASHIZAWA E,HASHIMOTO H.Simultaneous determination of residual fourteen kinds of beta-lactam and macrolide antibiotics in bovine muscles by high-performance liquid chromatography with a diode array detector[J].Shokuhin Eiseigaku Zasshi,2004,45(45):161-164.
[23] SAMANIDOU V F,GIANNAKIS D E,PAPADAKI A.Development and validation of an HPLC method for the determination of seven penicillin antibiotics in veterinary drugs and bovine blood plasma[J].J Sep Sci,2009,32(9):1302.
[24] KARAGEORGOU E G,SAMANIDOU V F,PAPADOYANNIS I N.Ultrasound-assisted matrix solid phase dispersive extraction for the simultaneous analysis of β-lactams (four penicillins and eight cephalosporins) in milk by high performance liquid chromatography with photodiode array detection[J].J Sep Sci,2012,35(19):2599-2607.
[25] YAHAYA N,SANAGI M M,MITOME T,et al.Dispersive micro-solid phase extraction combined with high-performance liquid chromatography for the determination of three penicillins in milk samples[J].Food Anal Methods,2015,8(5):1079-1087.
[26] SOKOLOVA L I,CHERNYAEV A P.Determination of benzylpenicillin,levomycetin (chloramphenicol),and tetracycline in food products by high-performance liquid chromatography[J].J Anal Chem,2001,56(11):1032-1034.
[27] LUO W,ANG C Y W,JR H C T.Rapid method for the determination of ampicillin residues in animal muscle tissues by high-performance liquid chromatography with fluorescence detection[J].J Chromatogr B Biomed Sci Appl,1997,694(2):401-407.
[28] MOATS W A,ROMANOWSKI R D.Determination of penicillin G in beef and pork tissues using an automated LC cleanup[J].J Agric Food Chem,1998,46(4):1410-1413.
[29] S?RENSEN L K,RASMUSSEN B M,BOISON J O,et al.Simultaneous determination of six penicillins in cows' raw milk by a multiresidue high-performance liquid chromatographic method.[J].J Chromatogr B Biomed Sci Appl,1997,694(2):383-391.
[30] S?RENSEN L K,SNOR L K,ELKAER T,et al.Simultaneous determination of seven penicillins in muscle,liver and kidney tissues from cattle and pigs by a multiresidue high-performance liquid chromatographic method[J].J Chromatogr B Biomed Sci Appl,1999,734(2):307-318.
[31] WANG C,WANG X.Determination of 5 penicillin residues in pork by high performance liquid chromatography with pre-column derivatization[J].Chin J Anal Chemy,2001,29(7):779-781.
[32] ITO Y,IKAI Y,OKA H,et al.Application of ion-exchange cartridge clean-up in food analysis:Ⅲ.Determination of benzylpenicillin,phenoxymethyl-penicillin,oxacillin,cloxacillin,nafcillin and dicloxacillin in bovine liver and kidney by liquid chromatography with ultraviolet detection[J].J Chromatogr A,2000,880(1/2):85-91.
[33] 冯月超,范筱京,贾丽,等.液相色谱-质谱联用法测定牛奶中14种青霉素及相应青霉噻唑酸残留量[J].分析试验室,2012(9):67-70.
[34] 肖惠贞,刘红河,尹江伟,等.高效液相色谱-串联质谱法测定乳制品中青霉素类药物及其主要代谢产物[J].卫生研究,2015,44(4):641-646.
[35] LIU Y N,PANG M D,XIE X,et al.Residue depletion of amoxicillin and its major metabolites in eggs[J].J Vet Pharmacol Ther,2017,40(4):383-391.
[36] 赵敏.鸡组织中阿莫西林、主要代谢物和氨苄西林多残留检测法及其消除规律的研究[D].江苏扬州:扬州大学,2014.
[37] 范莹莹,其鲁,杨树民.高效液相色谱-质谱联用法检测猪肉中5种青霉素的残留量[J].分析试验室,2007(12):76-79.
[38] 孙雷,张骊,汪霞,等.超高效液相色谱-串联质谱法对动物源性食品中13种β-内酰胺类药物残留的检测[J].分析测试学报,2009,28(5):576-580.
[39] 李玮,艾连峰,郭春海,等.高效液相色谱-串联质谱法同时测定牛奶和奶粉中的青霉素类药物及其主要酶解代谢产物[J].色谱,2013,31(10):946-953.
[40] 刘创基,王海,杜振霞,等.超高效液相色谱-串联质谱法同时测定牛肉中青霉素类药物及其代谢产物[J].分析化学,2011,39(5):617-622.
[41] 许蔚,张晓燕,吴斌,等.高效液相色谱-串联质谱法测定蜂蜜中的阿莫西林残留量[J].色谱,2012,30(10):1089-1092.
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