三叉神经带状疱疹罕见并发症颌骨坏死回顾分析
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摘要
目的通过回顾分析,总结三叉神经带状疱疹罕见并发症颌骨坏死的发病特点及临床表现,以期为该病的正确诊治提供科学依据。方法收集上海交通大学医学院附属第九人民医院口腔外科在2011年5月至2016年12月间诊治的4例由三叉神经带状疱疹引发的颌骨坏死,结合52例以往文献报道的病例进行回顾分析。结果本病多发生于中老年患者,年龄范围6～86岁,平均年龄54岁;男性28例,女性19例;病变单独累及三叉神经第二支或第三支者23例,同时累及第二、三支者7例;合并HIV感染者6例,合并恶性肿瘤者8例。结论三叉神经带状疱疹合并颌骨坏死发病率较低,综合考虑其发病特点及临床表现有助于该病的诊治。对于面颊部带状疱疹患者宜尽早治疗,控制病情,同时检查是否存在全身性疾病,预防严重口腔并发症的发生。
Objective To summarize the pathogenesis features and clinical manifestations of osteonecrosis of the jaw associated with trigeminal herpes zoster and to provide scientific basis for the correct diagnosis and treatment through retrospective analysis. Methods Four cases were collected in the Department of Oral Surgery,Shanghai Ninth People's Hospital from 2011 to 2016 and 52 cases were collected from literatures. Then the retrospective analysis was conducted. Results The complication occurred mostly in middle-aged and elderly patients,with an age range of 6 to 86 and an average age of 54. These cases included 28 males and 19 females. The lesion could affect either the second( 23 cases) or the third branch( 23 cases) of the trigeminal nerve,or both( 7 cases). 6 cases were complicated by HIV,8 by malignant tumors. Conclusion Osteonecrosis of the jaw associated with trigeminal herpes zoster has a low incidence. Comprehensive consideration of its pathogenesis features and clinical manifestations can help to diagnose and treat it. For patients with cheek herpes zoster,it is advisable to treat them as soon as possible and to check for the presence of systemic diseases in order to prevent serious oral complications.
Objective To summarize the pathogenesis features and clinical manifestations of osteonecrosis of the jaw associated with trigeminal herpes zoster and to provide scientific basis for the correct diagnosis and treatment through retrospective analysis. Methods Four cases were collected in the Department of Oral Surgery,Shanghai Ninth People's Hospital from 2011 to 2016 and 52 cases were collected from literatures. Then the retrospective analysis was conducted. Results The complication occurred mostly in middle-aged and elderly patients,with an age range of 6 to 86 and an average age of 54. These cases included 28 males and 19 females. The lesion could affect either the second( 23 cases) or the third branch( 23 cases) of the trigeminal nerve,or both( 7 cases). 6 cases were complicated by HIV,8 by malignant tumors. Conclusion Osteonecrosis of the jaw associated with trigeminal herpes zoster has a low incidence. Comprehensive consideration of its pathogenesis features and clinical manifestations can help to diagnose and treat it. For patients with cheek herpes zoster,it is advisable to treat them as soon as possible and to check for the presence of systemic diseases in order to prevent serious oral complications.
引文
[1]孟宪芙.三叉神经带状疱疹临床分析[J].中国实用神经疾病杂志,2015,18(6):34-36.
[2]黄春子.1例无环鸟苷静脉滴注治疗带状疱疹的护理[J].中华临床医学研究杂志,2017,13(21):3109-3110.
[3]Roxas M.Herpes zoster and postherpetic neuralgia:diagnosis and therapeutic considerations.[J].Altern Med Rev,2006,11(2):102-113.
[4]Jain MK,Manjunath KS,Jagadish SN.Unusual oral complications of herpes zoster infection:Report of a case and review of literature[J].Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol,2010,110(5):e37-e41.
[5]Ramchandani PL,Mellor TK.Herpes zoster associated with tooth resorption and periapicallesions[J].Br J Oral Maxillofac Surg,2007,45(1):71-73.
[6]Gupta S,Sreenivasan V,Patil P.Dental complications of herpes zoster:Two case reports and review of literature[J].Indian J Dent Res,2015,26(2):214.
[7]Hall HD,Jacobs JS.Necrosis of maxilla in patient with herpes zoster.Report of a case[J].Oral Surg Oral Med Oral Pathol,1974,37(5):657-662.
[8]Chenitz JE.Herpes zoster in Hodgkin's disease:unusual oral sequelae[J].ASDC J Dent Child,1976,43(3):184-186.
[9]Vickery IM,Midda M.Dental complications of cytotoxic therapy in Hodgkin's disease-a case report[J].Br J Oral Surg,1976,13(3):282-288.
[10]Cooper JC.Tooth exfoliation and osteonecrosis of the jaw following herpes zoster[J].Br Dent J,1977,143(9):297-300.
[11]Dielert E.Clinical aspect of herpes zoster and the pathogenesis of symptomatic cranial nerve zoster[J].SSO Schweiz Monatsschr Zahnheilkd,1979,89(2):135-145.
[12]Delbrouck-Poot F,Reginster JP.Trigeminal zona with necrosis of theupper jaw[J].Dermatologica,1979,158(3):210-213.
[13]Schwartz O,Kvorning SA.Tooth exfoliation,osteonecrosis of the jaw and neuralgia following herpes zoster of the trigeminal nerve[J].Int J Oral Surg,1982,11:364-371.
[14]Rodrigues JB,Poiares Baptista A,Leitao A,et al.Alveolar necrosis of the maxillary bone following trigeminal zona[J].Ann Dermatol Venereol,1982,109(12):1057-1059.
[15]Wright WE,Davis ML.Alveolar bone necrosis and tooth loss.Arare complication associated with herpes zoster infection of the fifth cranial nerve[J].Oral Surg Oral Med Oral Pathol,1983,56:39-46.
[16]Garty BZ,Dinari G,Sarnat H,et al.Tooth exfoliation and osteonecrosis of the maxilla after trigeminal herpes zoster[J].J Pediatr,1985,106(1):71-73.
[17]De Biscop J,Wackens G.Alveolar bone necrosis as a complication of herpes zoster infection[J].Acta Stomatol Belg,1985,82(3):183-188.
[18]Manz HJ,Canter HG,Melton J.Trigeminal herpes zoster causing mandibular osteonecrosis and spontaneous tooth exfoliation[J].South Med J,1986,79(8):1026-1028.
[19]Mostofi R,Marchmont-Robinson H,Freije S.Spontaneous tooth exfoliation and osteonecrosis following a herpes zoster infection of the fifth cranial nerve[J].J Oral Maxillofac Surg,1987,45(3):264-266.
[20]张来虎.带状疱疹引起牙槽骨坏死及牙齿自然脱落1例[J].国外医学口腔医学分册,1990(6):362.
[21]Schwartz O,Pindborg JJ,Svenningsen A.Tooth exfoliation and necrosis of the alveolar bone following trigeminal herpes zoster in HIV-infected patient[J].Tandlaegebladet,1989,93(16):623-627.
[22]Muto T,Tsuchiya H.Tooth exfoliation and necrosis of the mandible-a rare complication following trigeminal herpes zoster:report of a case[J].J Oral Maxillofac Surg,1990,48(9):1000-1003.
[23]Mc Kenzie CD,Gobetti JP.Diagnosis and treatment of orofacial herpes zoster:report of cases[J].J Am Dent Assoc,1990,120(6):679-81.
[24]Consolaro A,Oliveira DT.Simultaneous oral and skin manifestations of herpes zoster.Report of a case[J].Rev Odontol Univ Sao Paulo,1990,4(4):349-352.
[25]Pe1arrocha M,Alfaro A.Idiopathic trigeminal sensory neuropathy[J].J Oral Maxillofac Surg,1992,50(5):472-476.
[26]Mintz SM,Anavi Y.Maxillary osteomyelitis and spontaneous tooth exfoliation after herpes zoster[J].Oral Surg Oral Med Oral Pathol,1992,73(6):664-666.
[27]Eury J,Gilain L,Peynegre R.Oral manifestations of zona.Apropos of a case[J].Ann Otolaryngol Chir Cervicofac,1993,110(3):170-172.
[28]Lin JR,Huang CC.Oral complications following a herpes zoster infection of trigeminal nerve[J].Changgeng Yi Xue Za Zhi,1993,16(1):75-80.
[29]Chindia ML.HIV-associated fulminating herpes zoster infection with alveolar necrosis and tooth exfoliation:a case report[J].Dent Update,1997,24(3):126-128.
[30]Owotade FJ,Ugboko VI,Kolude B.Herpes zoster infection of the maxilla:case report[J].J Oral Maxillofac Surg,1999,57(10):1249-1251.
[31]Tidwell E,Hutson B.Herpes zoster of the trigeminal nerve third branch:a case report and review of the literature[J].Int Endod J,1999,32(1):61-6.
[32]Volvoikar P,Patil S.Tooth exfoliation,osteonecrosis and neuralgia following herpes zoster of trigeminal nerve[J].Indian J Dent Res,2002,13(1):11-14.
[33]Arikawa J,Mizushima J.Mandibular alveolar bone necrosis after trigeminal herpes zoster[J].Int J Dermatol,2004,43:136-137.
[34]Mendieta C,Miranda J,Brunet L,et al.Alveolar bone necrosis and tooth exfoliation following herpes zoster infection:a review of the literature and case report[J].J Periodontol,2005,76(1):148-153.
[35]Pillai KG,Nayar K,Rawal YB.Spontaneous tooth exfoliation,maxillary osteomyelitis and facial scarring following trigeminal herpes zoster infection[J].Prim Dent Care,2006,13(3):114-116.
[36]Siwamogstham P,Kuansuwan C,Reichart PA.Herpes zoster in HIV infection with osteonecrosis of the jaw and tooth exfoliation[J].Oral Dis,2006,12(5):500-505.
[37]Meer S,Coleman H.Mandibular osteomyelitis and tooth exfoliation following zoster-CMV co-infection[J].Oral Surg Oral Med Oral Pathol Oral Radiol Endod,2006,101(1):70-75.
[38]Badjate SJ,Cariappa KM.Ramsay-Hunt syndrome complicating osteonecrosis of edentulous maxilla and mandible:report of a rare case[J].J Maxillofac Oral Surg,2009,8(2):188-191.
[39]Kamarthi N,Narasimha GE,Lingappa A.An unusual case of osteonecrosis and spontaneous tooth exfoliation following trigeminal herpes zoster in a HIV seropositive patient[J].Int J Oral Med Sci,2009,8:52-59.
[40]Bandral MR,Chidambar YS.Oral complications of herpes zoster infection-Report of 3 cases[J].Int J Dent Clin,2010,2:70-73.
[41]Kashinath KR,Chandra Shekar L.Case report:Herpes zoster along maxillary nerve with osteonecrosis[J].J Dent Res,2011,2:12-17.
[42]Lambade P,Lambade D,Pandilwar PK.Maxillary osteonecrosis and spontaneous teeth exfoliation following herpes zoster[J].Oral Maxillofac Surg,2012,16:369-372.
[43]姜涛,张学锋,孙鹏.三叉神经带状疱疹造成骨坏死1例[J].现代口腔医学杂志,2015,29(6):178.
[44]Kaur R,Rani P.A rare case report and appraisal of the literature on spontaneous tooth exfoliation associated with trigeminal herpes zoster[J].Oral Maxillofac Surg,2016,20(3):331-336.
[45]Gholami M,Shahakbari R.Herpes zoster induced alveolar bone necrosis in immunocompromised patients,two case reports[J].Iran J Otorhinolaryngol,2016,28(88):369-373.
[46]Francis M,Subramanian K,Sankari SL.Herpes Zoster with post herpetic neuralgia involving the right maxillary branch of trigeminal nerve:A case report and review of literature[J].J Clin Diagn Res,2017,11(1):40-42.
[47]Cloarec N,Zaegel-Faucher O,Bregigeon S.Mandibular osteonecrosis and dental exfoliation after trigeminal zoster in an HIV-infected patient[J].AIDS,2014,28(3):448-450.
[48]张更建,张信江,罗显华,等.HIV感染并发带状疱疹12例临床分析[J].中国皮肤性病学杂志,2013,27(3):281-282.
[49]Volpi A.Severe complications of herpes zoster[J].Herpes,2007,14(2):35-39.
[50]王福东,曹慧.27例带状疱疹患者血清特异性Ig A、Ig G和Ig M抗体的测定[J].中国医药指南,2008,14(6):92-93.
[51]郑绍同,唐朝贵.带状疱疹患者血清白细胞介素及病毒抗体检测的意义[J].检验医学与临床,2016,5(22):1347-1348.
[52]张志愿.口腔颌面外科学[M].7版.北京:人民卫生出版社,2015:200-208.
[53]陈启文,陶静,魏培迪,等.免疫调节剂的应用对带状疱疹患者的病程及后遗神经痛的影响[J].中国医药导刊,2012,14(10):1179-1182.
[54]汤江林,徐新颜,彭济勇,等.晚期癌症患者化疗后带状疱疹病毒感染状况分析[J].中华医院感染学杂志,2018,28(3):380-383.
[55]翟志超,刘思同,李慧莹,等.带状疱疹后神经痛治疗研究进展[J].中国疼痛医学杂志,2016,22(1):55-58.
[2]黄春子.1例无环鸟苷静脉滴注治疗带状疱疹的护理[J].中华临床医学研究杂志,2017,13(21):3109-3110.
[3]Roxas M.Herpes zoster and postherpetic neuralgia:diagnosis and therapeutic considerations.[J].Altern Med Rev,2006,11(2):102-113.
[4]Jain MK,Manjunath KS,Jagadish SN.Unusual oral complications of herpes zoster infection:Report of a case and review of literature[J].Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol,2010,110(5):e37-e41.
[5]Ramchandani PL,Mellor TK.Herpes zoster associated with tooth resorption and periapicallesions[J].Br J Oral Maxillofac Surg,2007,45(1):71-73.
[6]Gupta S,Sreenivasan V,Patil P.Dental complications of herpes zoster:Two case reports and review of literature[J].Indian J Dent Res,2015,26(2):214.
[7]Hall HD,Jacobs JS.Necrosis of maxilla in patient with herpes zoster.Report of a case[J].Oral Surg Oral Med Oral Pathol,1974,37(5):657-662.
[8]Chenitz JE.Herpes zoster in Hodgkin's disease:unusual oral sequelae[J].ASDC J Dent Child,1976,43(3):184-186.
[9]Vickery IM,Midda M.Dental complications of cytotoxic therapy in Hodgkin's disease-a case report[J].Br J Oral Surg,1976,13(3):282-288.
[10]Cooper JC.Tooth exfoliation and osteonecrosis of the jaw following herpes zoster[J].Br Dent J,1977,143(9):297-300.
[11]Dielert E.Clinical aspect of herpes zoster and the pathogenesis of symptomatic cranial nerve zoster[J].SSO Schweiz Monatsschr Zahnheilkd,1979,89(2):135-145.
[12]Delbrouck-Poot F,Reginster JP.Trigeminal zona with necrosis of theupper jaw[J].Dermatologica,1979,158(3):210-213.
[13]Schwartz O,Kvorning SA.Tooth exfoliation,osteonecrosis of the jaw and neuralgia following herpes zoster of the trigeminal nerve[J].Int J Oral Surg,1982,11:364-371.
[14]Rodrigues JB,Poiares Baptista A,Leitao A,et al.Alveolar necrosis of the maxillary bone following trigeminal zona[J].Ann Dermatol Venereol,1982,109(12):1057-1059.
[15]Wright WE,Davis ML.Alveolar bone necrosis and tooth loss.Arare complication associated with herpes zoster infection of the fifth cranial nerve[J].Oral Surg Oral Med Oral Pathol,1983,56:39-46.
[16]Garty BZ,Dinari G,Sarnat H,et al.Tooth exfoliation and osteonecrosis of the maxilla after trigeminal herpes zoster[J].J Pediatr,1985,106(1):71-73.
[17]De Biscop J,Wackens G.Alveolar bone necrosis as a complication of herpes zoster infection[J].Acta Stomatol Belg,1985,82(3):183-188.
[18]Manz HJ,Canter HG,Melton J.Trigeminal herpes zoster causing mandibular osteonecrosis and spontaneous tooth exfoliation[J].South Med J,1986,79(8):1026-1028.
[19]Mostofi R,Marchmont-Robinson H,Freije S.Spontaneous tooth exfoliation and osteonecrosis following a herpes zoster infection of the fifth cranial nerve[J].J Oral Maxillofac Surg,1987,45(3):264-266.
[20]张来虎.带状疱疹引起牙槽骨坏死及牙齿自然脱落1例[J].国外医学口腔医学分册,1990(6):362.
[21]Schwartz O,Pindborg JJ,Svenningsen A.Tooth exfoliation and necrosis of the alveolar bone following trigeminal herpes zoster in HIV-infected patient[J].Tandlaegebladet,1989,93(16):623-627.
[22]Muto T,Tsuchiya H.Tooth exfoliation and necrosis of the mandible-a rare complication following trigeminal herpes zoster:report of a case[J].J Oral Maxillofac Surg,1990,48(9):1000-1003.
[23]Mc Kenzie CD,Gobetti JP.Diagnosis and treatment of orofacial herpes zoster:report of cases[J].J Am Dent Assoc,1990,120(6):679-81.
[24]Consolaro A,Oliveira DT.Simultaneous oral and skin manifestations of herpes zoster.Report of a case[J].Rev Odontol Univ Sao Paulo,1990,4(4):349-352.
[25]Pe1arrocha M,Alfaro A.Idiopathic trigeminal sensory neuropathy[J].J Oral Maxillofac Surg,1992,50(5):472-476.
[26]Mintz SM,Anavi Y.Maxillary osteomyelitis and spontaneous tooth exfoliation after herpes zoster[J].Oral Surg Oral Med Oral Pathol,1992,73(6):664-666.
[27]Eury J,Gilain L,Peynegre R.Oral manifestations of zona.Apropos of a case[J].Ann Otolaryngol Chir Cervicofac,1993,110(3):170-172.
[28]Lin JR,Huang CC.Oral complications following a herpes zoster infection of trigeminal nerve[J].Changgeng Yi Xue Za Zhi,1993,16(1):75-80.
[29]Chindia ML.HIV-associated fulminating herpes zoster infection with alveolar necrosis and tooth exfoliation:a case report[J].Dent Update,1997,24(3):126-128.
[30]Owotade FJ,Ugboko VI,Kolude B.Herpes zoster infection of the maxilla:case report[J].J Oral Maxillofac Surg,1999,57(10):1249-1251.
[31]Tidwell E,Hutson B.Herpes zoster of the trigeminal nerve third branch:a case report and review of the literature[J].Int Endod J,1999,32(1):61-6.
[32]Volvoikar P,Patil S.Tooth exfoliation,osteonecrosis and neuralgia following herpes zoster of trigeminal nerve[J].Indian J Dent Res,2002,13(1):11-14.
[33]Arikawa J,Mizushima J.Mandibular alveolar bone necrosis after trigeminal herpes zoster[J].Int J Dermatol,2004,43:136-137.
[34]Mendieta C,Miranda J,Brunet L,et al.Alveolar bone necrosis and tooth exfoliation following herpes zoster infection:a review of the literature and case report[J].J Periodontol,2005,76(1):148-153.
[35]Pillai KG,Nayar K,Rawal YB.Spontaneous tooth exfoliation,maxillary osteomyelitis and facial scarring following trigeminal herpes zoster infection[J].Prim Dent Care,2006,13(3):114-116.
[36]Siwamogstham P,Kuansuwan C,Reichart PA.Herpes zoster in HIV infection with osteonecrosis of the jaw and tooth exfoliation[J].Oral Dis,2006,12(5):500-505.
[37]Meer S,Coleman H.Mandibular osteomyelitis and tooth exfoliation following zoster-CMV co-infection[J].Oral Surg Oral Med Oral Pathol Oral Radiol Endod,2006,101(1):70-75.
[38]Badjate SJ,Cariappa KM.Ramsay-Hunt syndrome complicating osteonecrosis of edentulous maxilla and mandible:report of a rare case[J].J Maxillofac Oral Surg,2009,8(2):188-191.
[39]Kamarthi N,Narasimha GE,Lingappa A.An unusual case of osteonecrosis and spontaneous tooth exfoliation following trigeminal herpes zoster in a HIV seropositive patient[J].Int J Oral Med Sci,2009,8:52-59.
[40]Bandral MR,Chidambar YS.Oral complications of herpes zoster infection-Report of 3 cases[J].Int J Dent Clin,2010,2:70-73.
[41]Kashinath KR,Chandra Shekar L.Case report:Herpes zoster along maxillary nerve with osteonecrosis[J].J Dent Res,2011,2:12-17.
[42]Lambade P,Lambade D,Pandilwar PK.Maxillary osteonecrosis and spontaneous teeth exfoliation following herpes zoster[J].Oral Maxillofac Surg,2012,16:369-372.
[43]姜涛,张学锋,孙鹏.三叉神经带状疱疹造成骨坏死1例[J].现代口腔医学杂志,2015,29(6):178.
[44]Kaur R,Rani P.A rare case report and appraisal of the literature on spontaneous tooth exfoliation associated with trigeminal herpes zoster[J].Oral Maxillofac Surg,2016,20(3):331-336.
[45]Gholami M,Shahakbari R.Herpes zoster induced alveolar bone necrosis in immunocompromised patients,two case reports[J].Iran J Otorhinolaryngol,2016,28(88):369-373.
[46]Francis M,Subramanian K,Sankari SL.Herpes Zoster with post herpetic neuralgia involving the right maxillary branch of trigeminal nerve:A case report and review of literature[J].J Clin Diagn Res,2017,11(1):40-42.
[47]Cloarec N,Zaegel-Faucher O,Bregigeon S.Mandibular osteonecrosis and dental exfoliation after trigeminal zoster in an HIV-infected patient[J].AIDS,2014,28(3):448-450.
[48]张更建,张信江,罗显华,等.HIV感染并发带状疱疹12例临床分析[J].中国皮肤性病学杂志,2013,27(3):281-282.
[49]Volpi A.Severe complications of herpes zoster[J].Herpes,2007,14(2):35-39.
[50]王福东,曹慧.27例带状疱疹患者血清特异性Ig A、Ig G和Ig M抗体的测定[J].中国医药指南,2008,14(6):92-93.
[51]郑绍同,唐朝贵.带状疱疹患者血清白细胞介素及病毒抗体检测的意义[J].检验医学与临床,2016,5(22):1347-1348.
[52]张志愿.口腔颌面外科学[M].7版.北京:人民卫生出版社,2015:200-208.
[53]陈启文,陶静,魏培迪,等.免疫调节剂的应用对带状疱疹患者的病程及后遗神经痛的影响[J].中国医药导刊,2012,14(10):1179-1182.
[54]汤江林,徐新颜,彭济勇,等.晚期癌症患者化疗后带状疱疹病毒感染状况分析[J].中华医院感染学杂志,2018,28(3):380-383.
[55]翟志超,刘思同,李慧莹,等.带状疱疹后神经痛治疗研究进展[J].中国疼痛医学杂志,2016,22(1):55-58.