儿科重症监护病房侵袭性真菌感染临床研究进展
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摘要
<正>侵袭性真菌感染(invasive fungal infection,IFI)通常是指侵袭深部组织和内脏以及全身的真菌感染。近年来,随着广谱抗生素、免疫抑制剂和糖皮质激素的大量应用以及侵入性诊疗技术的增多,IFI正呈逐年上升之势。2005—2013年国外的一项统计数据显示,IFI在免疫缺陷儿童中的发生率为24%~([1])。虽然目前关于儿童真菌感染病原菌方面的流行病学数据有限,但在儿童真菌感染的病
引文
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[13]段玲.儿童重症监护病房侵袭性真菌感染情况分析[J].河南医学研究,2015,24(12):106.
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[22]赵醴.血浆1,3-β-葡聚糖检测儿童侵袭性真菌感染早期诊断价值探究[J].中国当代儿科杂志,2009,11(11):905-908.
[23]曹凤娥,韦丹.儿科重症监护病房侵袭性肺部真菌感染93例临床分析[J].广西医学杂志,2013,35(8):1049-1051.
[24]Liu Y,Chen F,Zhu X,et,al.Evaluation of a novel plasma(1,3-β)-D-glucan detection assay for diagnosis of candidemia in pediatric patients[J].J Clin Microbiol,2015,53(9):3017-3020.
[25]孙丹.血清1,3β-D葡聚糖检测对深部真菌感染患者的诊断价值[J].科学技术与工程,2010,10(13):3197-3200.
[26]席丽艳.重视侵袭性真菌感染加强早期诊断研究[J].中华检验医学杂志,2007,1(30):9-11.
[27]Conde-RosaA,AmadorR,Prez-TorresD,et al.Candidemia distribution,associated risk factors,and attributed mortality at a university-based medical center[J].PR Health Sci,2010,29(1):26-29.
[28]王丽杰,刘春峰.儿童真菌感染的高危因素[J].中国实用儿科杂志,2010,25(8):586-588.
[29]隗佳,韩平阳.151例侵袭性真菌感染的临床特点分析[J].临床内科杂志,2010,27(5):307-310.
[30]Takuma T,Shoji H,Niki Y.Terminal-stage prognostic analysis in candidemia[J].J Infect Chemother,2015,21(5):376-380.
[31]杨雪梅,赵谦谦,尚丽新.未足月胎膜早破残余羊水量对妊娠结局的影响[J].中国实用妇科与产科杂志,2017,33(5):512-516
[32]Kollef M,Micek S,Hampton N,et al.Septic shock attributed to Candida infection:importance of empiric therapy source control[J].Clin Infect Dis,2012,54(12):1739-1746.
[33]陈丽燕.危重患者导管相关性血流感染危险评估的应用研究[J].中华医院感染学杂志,2015,25(4):845-846.
[2]Calandra T,Roberts JA,Antonelli M,et al.Diagnosis and management of invasive candidiasis in the ICU:an updated approach to an old enemy[J].Crit Care,2016,20(1):125.
[3]Leroy O,Gangneux JP,Montravers P,et al.Epidemiology,management,and risk factors for death of invasive Candida infections in critical care:a multicenter,prospective,observational study in France(2005-2006)[J].Crit Care Med,2009,37(5):1612-1618.
[4]Christopher B,Palasanthiran P,O’Brien TA.Antifungal therapy in children with invasive fungal infections:a systematic review[J].Pediatrics,2007,119(4):772-784.
[5]Conde-Rosa A,Amador R,Perez-Torres D,et al.Candidemia distribution,associated risk factors,and attributed mortality at a university-based medical center[J].PR Health Sci J,2010,29(1):26-29.
[6]Arendrup MC,Sulims S,Holm A,et al.Diagnostic issues,clinical characteristics,and outcomes for patients with fungemia[J].Clin Microbiol,2011,49(9):3300-3308.
[7]Gilbert RE,Mok Q,Dwan K,et al.Impregnated central venous catheters for prevention of blood stream infection in children(the CATCH trial):a randomised controlled trial[J].Lancet,2016,387(10029):1732-1742.
[8]Ostrosky-Zeichner L,Sable C,Sobel J,et al.Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting[J].Eur J Clin Microbiol Infect Dis,2007,26(4):271-276.
[9]Yang SP,Chen YY,Hsu HS,et al.A risk factor analysis of healthcare-associated fungal infections in an intensive care unit:a retrospective cohort study[J].BMC Infect Dis,2013,13:1-10.
[10]隗佳,韩平阳.151例侵袭性真菌感染的临床特点分析[J].临床内科杂志,2010,27(5):307-310.
[11]金志鹏,崔利丹,王琪,等.儿童重症监护病房侵袭性真菌感染的临床特点[J].中华实用儿科临床杂志,2012,27(10):758-759.
[12]Fochtmann A,Forstner C,Keck M,et al.Clinical significance of Candida colonization of central vascular catheters in patients with major burns requiring intensive care[J].Intens Care Med,2015,41(6):1143-1144.
[13]段玲.儿童重症监护病房侵袭性真菌感染情况分析[J].河南医学研究,2015,24(12):106.
[14]蔡小芳,孙继民,董宗祈,等.儿童重症监护病房侵袭性真菌感染38例临床分析[J].中国当代儿科杂志,2013,15(8):644-648.
[15]余卫林.呼吸内科患者肺部真菌感染的临床分析[J].中国医学创新,2011,8(17):148-149.
[16]Cerikcio glu N,llki A,Bilgen H,et al.The relationships between candidemia and candidal colonization and virulence factors of the colonizing strains in preterm infants[J].Turk J Pediatr,2004,46(3):245-250.
[17]Ruping MJ,Vehreschild JJ,Comely OA,et al.Patients at high risk of invasive fungal infections:when and how to treat[J].Drugs,2008,68(14):1941-1962.
[18]Clancy CJ,Nguyen MH.Finding the"missing 50%"of invasive candidiasis:how nonculture diagnostics will improve understanding of disease spectrum and transform patient care[J].Clin Infect Dis,2013,56(9):1284-1292.
[19]Prüller F,Wagner J,Raggam RB,et al.Automation of serum(1,3)-β-D-glucan testing allows reliable and rapid discrimination of patients with and without candidemia[J].Med Mycol.Oxford University Press,2014,52(5):455-461.
[20]Obayashi T,Negishi K,Suzuki T,et al.Reappraisal of the serum(1,3)-β-D-glucan assay for the diagnosis of invasive fungal infections-a study based on autopsy eases from 6 years[J].Clin Infect Dis,2008,46(12):1864-1870.
[21]Ostrosky-Zeichner L,Alexander BD,Kett DH.Multicenter clinical evaluation of the(1,3)-β-D-glucan assay a san aid to diagnosis offungal infections in humans[J].Clin Infect Dis,2005,41(5):654-659.
[22]赵醴.血浆1,3-β-葡聚糖检测儿童侵袭性真菌感染早期诊断价值探究[J].中国当代儿科杂志,2009,11(11):905-908.
[23]曹凤娥,韦丹.儿科重症监护病房侵袭性肺部真菌感染93例临床分析[J].广西医学杂志,2013,35(8):1049-1051.
[24]Liu Y,Chen F,Zhu X,et,al.Evaluation of a novel plasma(1,3-β)-D-glucan detection assay for diagnosis of candidemia in pediatric patients[J].J Clin Microbiol,2015,53(9):3017-3020.
[25]孙丹.血清1,3β-D葡聚糖检测对深部真菌感染患者的诊断价值[J].科学技术与工程,2010,10(13):3197-3200.
[26]席丽艳.重视侵袭性真菌感染加强早期诊断研究[J].中华检验医学杂志,2007,1(30):9-11.
[27]Conde-RosaA,AmadorR,Prez-TorresD,et al.Candidemia distribution,associated risk factors,and attributed mortality at a university-based medical center[J].PR Health Sci,2010,29(1):26-29.
[28]王丽杰,刘春峰.儿童真菌感染的高危因素[J].中国实用儿科杂志,2010,25(8):586-588.
[29]隗佳,韩平阳.151例侵袭性真菌感染的临床特点分析[J].临床内科杂志,2010,27(5):307-310.
[30]Takuma T,Shoji H,Niki Y.Terminal-stage prognostic analysis in candidemia[J].J Infect Chemother,2015,21(5):376-380.
[31]杨雪梅,赵谦谦,尚丽新.未足月胎膜早破残余羊水量对妊娠结局的影响[J].中国实用妇科与产科杂志,2017,33(5):512-516
[32]Kollef M,Micek S,Hampton N,et al.Septic shock attributed to Candida infection:importance of empiric therapy source control[J].Clin Infect Dis,2012,54(12):1739-1746.
[33]陈丽燕.危重患者导管相关性血流感染危险评估的应用研究[J].中华医院感染学杂志,2015,25(4):845-846.