番茄红素蜂胶胶囊改善大鼠前列腺增生的实验研究
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摘要
目的:探究番茄红素蜂胶胶囊对去势雄性大鼠前列腺增生的改善作用。方法:雄性去势SD大鼠,皮下注射丙酸睾丸素建立前列腺增生模型,灌胃给予番茄红素蜂胶胶囊,考察其对大鼠前列腺湿质量、前列腺体积、SOD、MDA水平及前列腺组织结构的影响。结果:高剂量番茄红素蜂胶胶囊能降低前列腺增生大鼠的前列腺指数(PI)及前列腺增生率(P<0.05),并提高组织中SOD活力(P<0.05)。结论:番茄红素蜂胶胶囊具有改善实验性前列腺增生的作用。
Objective: To investigate whether Lycopene compound possess a protective effect on benign prostatic hyperplasia(BPH) induced by testosterone propionate in male castrated SD rats. Methods: BPH was induced by subcutaneous administration of testosterone propionate in male castrated SD rats. We evaluated the efficacy of Lycopene compound against BPH by detecting the volume of prostate, weighting the prostate tissue,measuring SOD and MDA level of prostate tissue and performing histopathological studies. Results: Administration of Lycopene compound prohibited significant inhibition of prostate enlargement and reduction the PI and the volume growth rate of prostate(P<0.05). Moreover, the activity of SOD was also enhanced(P<0.05). Conclusion:Present study showed that the Lycopene compound has protective effect on BPH.
Objective: To investigate whether Lycopene compound possess a protective effect on benign prostatic hyperplasia(BPH) induced by testosterone propionate in male castrated SD rats. Methods: BPH was induced by subcutaneous administration of testosterone propionate in male castrated SD rats. We evaluated the efficacy of Lycopene compound against BPH by detecting the volume of prostate, weighting the prostate tissue,measuring SOD and MDA level of prostate tissue and performing histopathological studies. Results: Administration of Lycopene compound prohibited significant inhibition of prostate enlargement and reduction the PI and the volume growth rate of prostate(P<0.05). Moreover, the activity of SOD was also enhanced(P<0.05). Conclusion:Present study showed that the Lycopene compound has protective effect on BPH.
引文
[1]时浩清,孙立江.肥胖与良性前列腺增生[J].临床泌尿外科杂志,2015,30(1):87-91.
[2]周岩,程静,王瑾,等.良性前列腺增生症与勃起功能障碍的流行病学及治疗方案研究进展[J].中国新药杂志,2015,21(21):2437-2447,2466.
[3]Pan J G,Jiang C,Luo R,et al.Association of metabolic syndrome and benign prostatic hyperplasia in Chinese patients of different age decades[J].Urologia internationalis,2014,93(1):10-16.
[4]Mucci LA,Tamimi R,Lagiou P,et al.Are dietary influences on the risk of prostate cancer mediated through the insulin-like growth factor system?[J].BJU international,2001,87(9):814-820.
[5]Obermuller-Jevic U C,Olano-Martin E,Corbacho A M,et al.Lycopene inhibits the growth of normal human prostate epithelial cells in vitro[J].The Journal of nutrition,2003,133(11):3356-3360.
[6]楚元奎,杨文,冉林武,等.前列腺增生大鼠模型的建立[J].贵阳医学院学报,2014,39(5):657-659,663.
[7]田少鹏,梁海清,倪依东,等.前列通片对前列腺增生的抑制作用[J].中草药,2005,36(10):102-103,132.
[8]孙自学,陈建设,王德军,等.前列安对良性前列腺增生症大鼠模型前列腺组织碱性成纤维生长因子的影响[J].中国实验方剂学杂志,2010,16(15):101-104.
[9]刘绍龑,佐艇,白明,等.乌鸡白凤丸对小鼠前列腺增生模型的影响[J].中国实验方剂学杂志,2012,18(9):180-183.
[10]Forbes K,Gillette K,Sehgal I.Lycopene increases urokinase receptor and fails to inhibit growth or connexin expression in a metastatically passaged prostate cancer cell line:a brief communication[J].Experimental biology and medicine(Maywood,NJ),2003,228(8):967-971.
[11]冯霞.氧化应激对实验性前列腺增生的影响及联用抗氧化剂的调整作用[D].广州:暨南大学,2010.
[12]姜伟伟,任国峰,杨爱青,等.大豆异黄酮对良性前列腺增生大鼠抗氧化作用的研究[J].食品科学,2009,30(7):233-235.
[13]刘庆勇,阮喜云.自由基与前列腺[J].现代泌尿外科杂志,1998,3(3):179-182.
[14]Sarbishegi M,Khani M,Salimi S,et al.Antiproliferative and Antioxidant Effects of Withania coagulans Extract on Benign Prostatic Hyperplasia in Rats[J].Nephrourology monthly,2016,8(1):e33180.
[15]Olinski R,Zastawny T H,Foksinski M,et al.DNA base modifications and antioxidant enzyme activities in human benign prostatic hyperplasia[J].Free radical biology&medicine,1995,18(4):807-813.
[16]Minciullo P L,Inferrera A,Navarra M,et al.Oxidative stress in benign prostatic hyperplasia:a systematic review[J].Urologia internationalis,2015,94(3):249-254.
[2]周岩,程静,王瑾,等.良性前列腺增生症与勃起功能障碍的流行病学及治疗方案研究进展[J].中国新药杂志,2015,21(21):2437-2447,2466.
[3]Pan J G,Jiang C,Luo R,et al.Association of metabolic syndrome and benign prostatic hyperplasia in Chinese patients of different age decades[J].Urologia internationalis,2014,93(1):10-16.
[4]Mucci LA,Tamimi R,Lagiou P,et al.Are dietary influences on the risk of prostate cancer mediated through the insulin-like growth factor system?[J].BJU international,2001,87(9):814-820.
[5]Obermuller-Jevic U C,Olano-Martin E,Corbacho A M,et al.Lycopene inhibits the growth of normal human prostate epithelial cells in vitro[J].The Journal of nutrition,2003,133(11):3356-3360.
[6]楚元奎,杨文,冉林武,等.前列腺增生大鼠模型的建立[J].贵阳医学院学报,2014,39(5):657-659,663.
[7]田少鹏,梁海清,倪依东,等.前列通片对前列腺增生的抑制作用[J].中草药,2005,36(10):102-103,132.
[8]孙自学,陈建设,王德军,等.前列安对良性前列腺增生症大鼠模型前列腺组织碱性成纤维生长因子的影响[J].中国实验方剂学杂志,2010,16(15):101-104.
[9]刘绍龑,佐艇,白明,等.乌鸡白凤丸对小鼠前列腺增生模型的影响[J].中国实验方剂学杂志,2012,18(9):180-183.
[10]Forbes K,Gillette K,Sehgal I.Lycopene increases urokinase receptor and fails to inhibit growth or connexin expression in a metastatically passaged prostate cancer cell line:a brief communication[J].Experimental biology and medicine(Maywood,NJ),2003,228(8):967-971.
[11]冯霞.氧化应激对实验性前列腺增生的影响及联用抗氧化剂的调整作用[D].广州:暨南大学,2010.
[12]姜伟伟,任国峰,杨爱青,等.大豆异黄酮对良性前列腺增生大鼠抗氧化作用的研究[J].食品科学,2009,30(7):233-235.
[13]刘庆勇,阮喜云.自由基与前列腺[J].现代泌尿外科杂志,1998,3(3):179-182.
[14]Sarbishegi M,Khani M,Salimi S,et al.Antiproliferative and Antioxidant Effects of Withania coagulans Extract on Benign Prostatic Hyperplasia in Rats[J].Nephrourology monthly,2016,8(1):e33180.
[15]Olinski R,Zastawny T H,Foksinski M,et al.DNA base modifications and antioxidant enzyme activities in human benign prostatic hyperplasia[J].Free radical biology&medicine,1995,18(4):807-813.
[16]Minciullo P L,Inferrera A,Navarra M,et al.Oxidative stress in benign prostatic hyperplasia:a systematic review[J].Urologia internationalis,2015,94(3):249-254.