基于模型的蓝藻生物钟昼夜节律的非线性特性研究
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摘要
依据蓝藻生物钟昼夜节律的生理实验结果和非线性动力学理论,构建了其非线性动力学模型,并利用Matlab软件求出其核心振荡器调控蛋白KaiABC等的相互作用关系,获得各蛋白分泌随时间变化的数值解,且与已有实验数据结果一致,说明理论模型是合理的.
On the basis of the physiological experiment results of biological clock circadian rhythm of cyanobacteria and the theory of nonlinear dynamics,it's nonlinear dynamic model was constructed for the first time.And the interaction relationships between KaiABC proteins was computed by Matlab.The numerical solutions of each protein secretion quantity with time was obtained,and the simulation results were consistent with the experimental data in references.Therefore,this nonlinear dynamics model is rationality.
On the basis of the physiological experiment results of biological clock circadian rhythm of cyanobacteria and the theory of nonlinear dynamics,it's nonlinear dynamic model was constructed for the first time.And the interaction relationships between KaiABC proteins was computed by Matlab.The numerical solutions of each protein secretion quantity with time was obtained,and the simulation results were consistent with the experimental data in references.Therefore,this nonlinear dynamics model is rationality.
引文
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[2]安扬,徐璎.哺乳动物昼夜节律机制研究进展[J].生命科学,2015,27(10):1373-1379.
[3]王春燕,廖萍,刘晓黎,等.生物钟紊乱与相关疾病关系的研究进展[J].临床与病理杂志,2015,35(4):676-680.
[4]秦冰,李刚,杨树利.生物节律及其基因研究进展[J].中国疗养医学,2016,28(6):563-566.
[5]徐淑云.浅谈生物节律与优生遗传的关系[J].医学检验,2017,17(39):116-117.
[6]MITCHELL S D,RONALD J K,DOMINIC O,et al.Phenotypic and genetic analysis of clock,a new circadian rhythm mutant in drosophila melanogaster[J].The Genetics Society of America,1990,125:557-578.
[7]PATRICK E,VENUS SO W,MAKI K,et al.CRY,aDrosophilaclock and light-regulated cryptochrome,is a major contributor to circadian rhythm resetting and photosensitivity[J].Cell Press,1998,95(25):670-679.
[8]LALCHHANDAMA K.The path to the 2017Nobel Prize in physiology or medicine[J].Science,2017,17(Suppl.):1-13.
[9]袁力,李艺柔,徐小冬.时间生物学:2017年诺贝尔生理或医学奖解读[J].遗传,2018,40(1):1-11.
[10]胡鸿钧.水华蓝藻生物学[M].北京:科学出版社,2011:1-3.
[11]林少苑,李淑彬.蓝藻生物钟分子机理的研究进展[J].生物化学与生物物理进展,2006,33(8):719-723.
[12]陈立群,刘延柱.非线性动力学[M].上海:上海交通大学出版社,1999:50-150.
[13]HAO BAI-LIN.ChaosⅡ[M].Singapore:World Scientific,1984:430-540.
[14]CVITANOVIC P.University in chaos[M].2nd ed.Bristol:Adam Hilger,1989:35-70.
[15]ABRAHAM R,MARSDEN JE.Foundations of mechanics[M].Massachusetts:Benjamin,1978:90-120.
[16]王颖,孙迎春,佟倜.下丘脑-胰岛轴血糖调节的非线性动力学模型[J].东北师大学报(自然科学版),2010,42(1):133-136.
[17]佟倜,巴合提古丽·阿斯里别克,孙迎春.下丘脑-垂体-肾上腺轴激素分泌的周期振荡及混沌现象[J].东北师大学报(自然科学版),2011,43(4):76-80.
[18]王森,蔡理,张斌,等.量子细胞神经网络的混沌函数投影同步[J].微纳电子技术,2016,53(1):7-12.
[19]刘剑钊,董朝轶,冯丽斐.生物神经网络的建模与仿真[J].生物学杂志,2016,33(3):104-106.
[20]来盼.蓝藻prx基因抗氧化功能及其与Kai生物种关联关系研究[D].西安:西北大学,2016.
[21]ISHIURA M,KUTSUNA S,AOKI S,et al.Expression of a gene cluster kaiABC as a circadian feedback process in cyanobacteria[J].Science,1998,281(5382):1519-1523.
[22]IWASAKI H,NISHIWAKI T,KITAYAMA Y,et al.KaiA-stimulated KaiC phosphorylation in circadian timing loops in cyanobacteria[J].Proc Natl Acad Sci USA,2002,99(24):15788-15793.
[23]KITAYAMA Y,IWASAKI H,NISHIWAKI T,et al.KaiB functions as an attenuator of KaiC phosphorylation in the cyanobacterial circadian clock system[J].EMBO J,2003,22(9):2127-2134.
[24]NAKAJIMA M,IMAI K,ITO H,et al.Reconstitution of circadian oscillation of cyanobacterial KaiC phosphorylation in vitro[J].Science,2005,308(5720):414-415.
[25]刘松,刘森.蓝藻生物钟核心振荡器KaiB-KaiC相互作用机制[J].生物化学与生物物理进展,2015,42(3):220-227.
[26]陈为群,刘松,刘森.蓝藻生物钟核心振荡器的分子机制研究进展[J].生物物理学报,2013,29(11):801-810.
[27]程牛亮.生物化学[M].第2版.北京:高等教育出版社,2011:46-64.
[28]刘秉正,彭建华.非线性动力学[M].北京:高等教育出版社,2005:14-15.