客家地区≥80岁乳腺癌患者的临床病理特点及治疗情况
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摘要
目的:探索客家地区≥80岁乳腺癌患者的临床病理特点及治疗情况。方法:收治高龄乳腺癌患者44例,对其临床病理资料及治疗情况进行回顾性分析。结果:浸润性导管癌86.4%(38/44),黏液癌9.1%(4/44),Luminal型74.3%(26/35),三阴性20.0%(7/35),HER-2阳性型5.7%(2/35)。TNM分期ⅡB～ⅢC期52.3%(23/44),合并≥1种基础疾病患者34.1%(15/44)。手术和内分泌治疗是主要治疗手段,但近5年接受乳房切除术和腋窝淋巴结清扫比例降低,内分泌治疗以来曲唑为主。结论:客家地区高龄乳腺癌患者的病期偏晚,多为激素受体阳性,手术和内分泌治疗是主要治疗手段。
Objective:To investigate the clinicopathological features and treatment of elderly breast cancer patients aged over 80 years in Hakka area.Methods:The clinicopathological data and treatment plan of 44 elderly breast cancer patients were retrospectively analyzed.Results:Invasive ductal carcinoma and mucinous adenocarcinoma accounted for 86.4%(38/44)and 9.1%(4/44),respectively.Luminal,triple negative and HER-2 positive subtype accounted for 74.3%(26/35),20.0%(7/35)and 5.7%(2/35),respectively.52.3%(23/44)had a TNM stage of Ⅱ B～Ⅲ C,and 34.1%(15/44)had at least one underlying disease.Surgery and endocrine therapy were the main treatments.Patients who underwent mastectomy and axillary lymph node dissection have been declining in the recent 5 years.Letrozole was the main choice for hormone therapy.Conclusions:In the Hakka area,elderly breast cancer patients had a relatively late stage and were mostly hormone receptor positive.Surgery and endocrine therapy are the main treatment options.
Objective:To investigate the clinicopathological features and treatment of elderly breast cancer patients aged over 80 years in Hakka area.Methods:The clinicopathological data and treatment plan of 44 elderly breast cancer patients were retrospectively analyzed.Results:Invasive ductal carcinoma and mucinous adenocarcinoma accounted for 86.4%(38/44)and 9.1%(4/44),respectively.Luminal,triple negative and HER-2 positive subtype accounted for 74.3%(26/35),20.0%(7/35)and 5.7%(2/35),respectively.52.3%(23/44)had a TNM stage of Ⅱ B～Ⅲ C,and 34.1%(15/44)had at least one underlying disease.Surgery and endocrine therapy were the main treatments.Patients who underwent mastectomy and axillary lymph node dissection have been declining in the recent 5 years.Letrozole was the main choice for hormone therapy.Conclusions:In the Hakka area,elderly breast cancer patients had a relatively late stage and were mostly hormone receptor positive.Surgery and endocrine therapy are the main treatment options.
引文
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[8]陈鑫.老年不同分子分型乳腺癌的临床特点、预后及影响预后的相关因素[J].中国老年学杂志,2016,36(8):1910-1912.
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[11]吴勤祥.不同手术方式在70岁以上老年女性乳腺癌患者中的应用对比[J].中国老年学杂志,2015(14):3928-3929.
[12]Freedman,Rachel A.Treatment of Breast Cancer in the Elderly[J].Current Oncology Reports,2015,17(11):51.
[2]Chen W,Zheng R,Baade PD,et al.Cancer Statistics in China,2015[J].CA A Cancer Journal for Clinicians,2016,66(2):115-132.
[3]林燕.中国老年乳腺癌治疗专家共识(2018)[J].协和医学杂志,2018,9(4)307-312.
[4]吕庆,金琳芳,孟东.58例年龄大于80岁乳腺癌的临床病理分析及诊治体会[J]中华内分泌外科杂志,2015,9(5):385-389.
[5]牛司华,姜玉新,朱庆莉,等.80岁以上乳腺癌的临床及超声特点[J].中国医学科学院学报,2014,36(1):57-60.
[6]闫宇,任予,范金虎,等.65岁以上中国老年女性原发性乳腺癌临床病理特征及治疗分析:多中心10年回顾性研究[J].中国肿瘤,2017,26(7):561-566.
[7]李聪,娄春,任延律,等.70岁以上女性乳腺癌临床病理特征及预后分析[J].中国普通外科杂志,2015,24(11):1547-1552.
[8]陈鑫.老年不同分子分型乳腺癌的临床特点、预后及影响预后的相关因素[J].中国老年学杂志,2016,36(8):1910-1912.
[9]修萌,张频.老年乳腺癌特点及内科辅助治疗现状[J].中国肿瘤临床,2017,44(15)733-738.
[10]丁清清,唐金海.老年乳腺癌的诊治进展[J].中华老年医学杂志,2017,36(12)1386-1389.
[11]吴勤祥.不同手术方式在70岁以上老年女性乳腺癌患者中的应用对比[J].中国老年学杂志,2015(14):3928-3929.
[12]Freedman,Rachel A.Treatment of Breast Cancer in the Elderly[J].Current Oncology Reports,2015,17(11):51.