百事乐加味方抗抑郁作用的实验研究
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摘要
目的:考察百事乐加味方(MBD)的抗抑郁作用。方法:采用小鼠模型和卒中后抑郁大鼠模型(PSD)等方法进行研究。观察MBD对小鼠的抗抑郁作用。结果:小鼠抑郁实验中,MBD能明显对抗利血平引起的小鼠眼睑关闭程度,体温下降,差异有统计学意义(P<0.05);MBD动物活动数明显增多,悬尾不动、游泳不动时间明显缩短,差异有统计学意义(P<0.05~0.01);PSD实验中,MBD增加大鼠体重,糖水消耗,改善旷野实验水平活动得分和垂直活动得分。结论:MBD具有一定的抗抑郁作用,能够改善抑郁模型的抑郁状态。
Objective: To investigate the antidepressant effect of Modified Baishile Decoction.Methods: Reserpine-antagonism test,the tail suspension and foceed swimming tests and PSD mode1 to evaluate the antidepressant effect of Modified Baishile Decoction. Result: The group of Modified Baishile Decoction significantly ptosis in mice induced by reserpine,increased the times of Locomotor activity tests and shortened the duration of immobily in tail suspension test and forced swimming tests( P<0.05 ~ 0.01) Compared with PSD group,on the 14,21 th day after CUMS,the Modified Baishile Decoction group showed significantly increase weights,horizontal and vertical activities and sugar-water consumption( P<0.05~0.01). Conclusion: the Modified Baishile Decoction is effective for the treatment of Depression.
Objective: To investigate the antidepressant effect of Modified Baishile Decoction.Methods: Reserpine-antagonism test,the tail suspension and foceed swimming tests and PSD mode1 to evaluate the antidepressant effect of Modified Baishile Decoction. Result: The group of Modified Baishile Decoction significantly ptosis in mice induced by reserpine,increased the times of Locomotor activity tests and shortened the duration of immobily in tail suspension test and forced swimming tests( P<0.05 ~ 0.01) Compared with PSD group,on the 14,21 th day after CUMS,the Modified Baishile Decoction group showed significantly increase weights,horizontal and vertical activities and sugar-water consumption( P<0.05~0.01). Conclusion: the Modified Baishile Decoction is effective for the treatment of Depression.
引文
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[2]原红霞,韦彩柳,程遥.小柴胡汤抗抑郁作用研究[J].中国实验方剂学杂志,2012,18(15):190-191.
[3]赵威,黄国钧.抑郁康制剂的抗抑郁作用研究[J].中药新药与临床药理,2006,17(6):432-434.
[4]陈奇.中药药效研究思路与方法[M].北京:人民卫生出版社,2010:246.
[5]Koizumi J,Yoshida Y,Nakazawa T,et al.Experimental studies of ischemic brain edema:A new experimental model of cerebral embolism in rats in which recirculation can be in troduced in the ischemic area[J].Jpn J Stroke,1986,8:1-8.
[6]Longa EZ,Weistein PR,Carlson S.Reversible middle cerebral artery occlusion without craniectomy in rats[J].Stroke,1989,20:84-89.
[7]Seo HJ,Wang SM,Han C,et al.Curcumin as a putative antidepressant[J].Expert Rev Neurother,2015(Feb3):1-12.
[8]王瑞,李学军.姜黄素抗抑郁作用可能机制的研究[J].中国药理通讯,2007,24(3):47.
[9]时等,刘妍如,杨建云,等.贯叶连翘治疗脑卒中后抑郁对照研究的Meta分析[J].时珍国医国药,2012,23(9):2133-2136.