摘要
目的:考察百事乐加味方(MBD)的抗抑郁作用。方法:采用小鼠模型和卒中后抑郁大鼠模型(PSD)等方法进行研究。观察MBD对小鼠的抗抑郁作用。结果:小鼠抑郁实验中,MBD能明显对抗利血平引起的小鼠眼睑关闭程度,体温下降,差异有统计学意义(P<0.05);MBD动物活动数明显增多,悬尾不动、游泳不动时间明显缩短,差异有统计学意义(P<0.05~0.01);PSD实验中,MBD增加大鼠体重,糖水消耗,改善旷野实验水平活动得分和垂直活动得分。结论:MBD具有一定的抗抑郁作用,能够改善抑郁模型的抑郁状态。
Objective: To investigate the antidepressant effect of Modified Baishile Decoction.Methods: Reserpine-antagonism test,the tail suspension and foceed swimming tests and PSD mode1 to evaluate the antidepressant effect of Modified Baishile Decoction. Result: The group of Modified Baishile Decoction significantly ptosis in mice induced by reserpine,increased the times of Locomotor activity tests and shortened the duration of immobily in tail suspension test and forced swimming tests( P<0.05 ~ 0.01) Compared with PSD group,on the 14,21 th day after CUMS,the Modified Baishile Decoction group showed significantly increase weights,horizontal and vertical activities and sugar-water consumption( P<0.05~0.01). Conclusion: the Modified Baishile Decoction is effective for the treatment of Depression.
引文
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