葛根素及其衍生物抗炎、抗痛风作用研究进展
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摘要
该文综述了葛根素及其衍生物在抗炎、抗痛风方面的研究进展。葛根素可通过影响免疫细胞、炎性因子、信号通路等方式起到抗炎作用;同时可通过抑制黄嘌呤氧化酶、促进尿酸排泄降低血清尿酸水平,达到抗痛风作用。虽然与临床使用的别嘌醇相比,其体内降尿酸水平活性较低,但葛根素能增强机体总抗氧化和清除氧自由基的能力,且抗炎作用较强,因此预测,以葛根素为先导化合物,对其结构进行修饰或改造以期寻找活性好、副作用小的新型抗痛风药物将是一个有一定前景的研究方向。
The research progress of puerarin and its derivatives in anti-inflammatory and anti-gout activities was reviewed in this paper. Puerarin possesses anti-inflammatory activity by affecting immunocyte,inflammation cytokines and signaling pathway. Puerarin also has anti-gout activity through inhibition of xanthine oxidase,promoting the excretion of uric acid to reduce serum uric acid level. Although its ability in reducing uric acid level was lower than that of allopurinol in clinical application,puerarin can also enhance the total antioxidant and free radical scavenging with stronger anti-inflammatory effect,so it will be a promising research direction to find new drugs with better anti-gout activity and less side effects by modifying the chemical structure of puerarin.
The research progress of puerarin and its derivatives in anti-inflammatory and anti-gout activities was reviewed in this paper. Puerarin possesses anti-inflammatory activity by affecting immunocyte,inflammation cytokines and signaling pathway. Puerarin also has anti-gout activity through inhibition of xanthine oxidase,promoting the excretion of uric acid to reduce serum uric acid level. Although its ability in reducing uric acid level was lower than that of allopurinol in clinical application,puerarin can also enhance the total antioxidant and free radical scavenging with stronger anti-inflammatory effect,so it will be a promising research direction to find new drugs with better anti-gout activity and less side effects by modifying the chemical structure of puerarin.
引文
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[35]Qin S,Deng F,Wu W,et al.Baicalein modulates Nrf2/Keap1system in both Keap1-dependent and Keap-independent mechanisms[J].Arch Biochem Biophys,2014,559(10):53.
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[41]王勇.杨梅素、葛根素对高尿酸血症的影响及其意义[J].内蒙古中医药,2010,29(19):9.
[42]Woodward O M,Kottgen A,Coresh J,et al.Identification of a urate transporter,ABCG2,with a common functional polymorphism causing gout[J].Proc Natl Acad Sci USA,2009,106(25):10338.
[43]张洪长,张莹,律广富,等.葛根素对人肾近曲小管上皮细胞ABCG2表达影响[J].上海中医药杂志,2016(3):74.
[44]史坤,张荣涛,尚小玉,等.葛根提取物对高尿酸血症大鼠血尿酸的影响[J].食品科技,2014,39(2):216.
[45]马越,吕圭源,陈素红.葛根提取物抗痛风性关节炎作用及机制初探[J].中药新药与临床药理,2011,22(3):241.
[46]刘丽娟,张卓.葛根治疗痛风的临床疗效[J].吉林大学学报:医学版,2005,31(5):670.
[47]王钰宁,姜琪,张扩,等.葛根素-锗配合物的合成及其抗炎活性研究[J].哈尔滨商业大学学报:自然科学版,2015,31(2):149.
[48]张毅,李恒华,江兵,等.葛根素衍生物抗炎作用及对环氧化酶活性的影响[J].中国现代应用药学,2011,28(1):8.
[49]董鑫鑫,高书亮,肖诚,等.葛根素衍生物4ac对胶原诱导性关节炎大鼠血液流变学的影响[J].中国中医基础医学杂志,2010,16(4):295.
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[2]吕慧娟,朱路文,唐强.炎症反应在多发性硬化中作用机制研究进展[J].中国医学创新,2015,12(12):129.
[3]徐伟,王俊栋,邬俊峰,等.冠心病与炎症反应的中西医临床研究进展[J].中西医结合心脑血管病杂志,2013,11(6):741.
[4]段乐,白利群,田苗苗,等.炎症反应在脑缺血中作用机制研究进展[J].中华实用诊断与治疗杂志,2013,27(9):837.
[5]邱世翠,韩兆东,刘学东.葛根对小鼠淋巴细胞增殖、IL-2和抗体产生的影响[J].中国中医药科技,2002,9(4):211.
[6]李凤菊,张建英.葛根素对T淋巴细胞核仁区嗜银蛋白的影响[J].中国现代医药杂志,2004,6(6):39.
[7]久保道德.葛根的药理作用研究进展[J].国外医学·中医中药分册,1993,15(3):23.
[8]刘云波,邱世翠,邸大琳.葛根对小白鼠免疫功能的影响[J].中国现代医学志,2002,12(15):62.
[9]张仲海,王长海,王胜春.柴葛颗粒剂的降温作用与免疫调节功能[J].广州医药大学学报,1999,16(3):217.
[10]姜晓晓,李勇,吴永宾,等.葛根素预处理对体外循环围手术期细胞因子的影响[J].中国中西医结合杂志,2009,29(12):1089.
[11]Wan H,Zhu H,Tian M,et al.Protective effect of chuanxiongzine-puerarin in a rat model of transient middle cerebral artery occlusion-induced focal cerebral ischemia[J].Nucl Med Commun,2008,29(12):1113.
[12]王明智,梅志刚,曾永保,等.葛根素通过激活胆碱能抗炎通路抑制大鼠脑缺血再灌注损伤[J].中国老年学杂志,2012,32(12):2563.
[13]孙琦,汤仁仙,范兴丽,等.葛根素对炎症反应综合征大鼠的治疗作用[J].中华急诊医学杂志,2008,17(2):158.
[14]夏肖萍,费春荣,叶爱青.葛根素对SD大鼠全身炎症反应综合征的治疗作用及其机制研究[J].浙江检验医学,2008,6(2):12.
[15]郝雪娜.葛根素对血管炎性损伤的影响[D].北京:中国协和医科大学,2007.
[16]姚定固,罗苏生,倪海祥,等.葛根素对2型糖尿病血管并发症患者血浆内皮素和血清肿瘤坏死因子的影响[J].中国自然医学杂志,2002,4(2):71.
[17]Blake G J,Ridker P M.C-reactive protein and other inflammatory risk markers in acute coronary syndromes[J].J Am Coll Cardiol,2003,41:37S.
[18]Ferroni P,Basili S,Martini F,et al.Serum metalloproteinase-9levels in patients with coronary artery disease:a novel marker of inflammation[J].J Invest Med,2003,51:295.
[19]肖立中,黄志,马绍椿,等.葛根素对急性心肌梗死患者梗死面积的影响及其机制探讨[J].中国中西医结合杂志,2004,24(9):790.
[20]盛宏光,邱凌,黄薇,等.葛根素对2型糖尿病v WF、t-PA及PAI-1含量的影响[J].浙江中西医结合杂志,2009,19(9):559.
[21]胡文婷.基于特异性敲除技术的葛根素与葛根解热与降糖作用相关性的研究[D].北京:北京中医药大学,2015.
[22]唐瑜.葛根素对脑缺血再灌注损伤保护机制的研究现状[J].四川生理科学杂志,2006,28(4):177.
[23]李强翔,钟惠菊,周敏,等.葛根素对糖尿病大鼠血脂和主动脉细胞间粘附分子-1表达的调控[J].中国行为医学科学,2006,15(11):981.
[24]Hu W,Zhang Q,Yang X,et al.Puerarin inhibits adhesion molecule expression in tnf-alpha-stimulated human endothelial cells via modulation of the nuclear factor kappa B pathway[J].Pharmacology,2010,85(1):27.
[25]杨彬,扈友庄,刘东彪.葛根素对急性脑梗死患者血清s ICAM-1和TNF-α的影响[J].中国康复,2004,19(6):363.
[26]涂强,林捷,谭小平,等.葛根素对大鼠脑缺血/再灌注损伤缺血区细胞粘附分子ICAM-1的影响[J].慢性病学杂志,2010,12(8):782.
[27]任婷婷,张东君,朱丽萍,等.葛根素对奶牛乳腺上皮细胞炎症模型中NF-κB信号通路的影响[J].农业生物技术学报,2016,24(1):44.
[28]汪亮.葛根素对大鼠局灶性脑缺血再灌注损伤后TLR4/NF-κB信号通路的影响[D].宁波:宁波大学,2012.
[29]胡建军,张丹丹,陈俊杰,等.葛根素预处理对LPS诱导RAW264.7细胞活化的影响[J].中国中药杂志,2012,37(20):3112.
[30]Kurosaka M,Machida S.Interleukin-6-induced satellite cell proliferation is regulated by induction of the JAK2/STAT3 signalling pathway through cyclin D1 targeting[J].Cell Prolif,2013,46:365.
[31]徐志红,白永愉,黄新策,等.垂盆草提取物经JAK2/STAT3信号通路途径改善大鼠重症急性胰腺炎肺损伤的研究[J].肝胆胰外科杂志,2014,26(5):398.
[32]Yu X,Kensler T.Nrf2 as a target for cancer chemoprevention[J].Mutat Res,2005(591):93.
[33]Dinkova-Kostova A T,Holtzclaw W D,Cole R N,et al.Direct evi-dence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants[J].Proc Natl Acad Sci USA,2002,99(18):11908.
[34]Li L,Yang N,Nin L,et al.Chinese herbal medicine formula Tao Hong Si Wu decoction protects against cerebral ischemia-reper-fusion injury via PI3K/Akt and the Nrf2 signaling pathway[J].J Nat Med,2014,68(4):798.
[35]Qin S,Deng F,Wu W,et al.Baicalein modulates Nrf2/Keap1system in both Keap1-dependent and Keap-independent mechanisms[J].Arch Biochem Biophys,2014,559(10):53.
[36]陈超.葛根素抗炎作用研究进展[J].宁德师专学报:自然科学版,2010,22(3):225.
[37]杨澍,高秀清,高杉.抗痛风药不良反应文献分析[J].中国药房,2016(5):624.
[38]杨会军,陈艳林,彭江云.抗高尿酸血症天然产物的药理研究进展[J].天然产物研究与开发,2015,27:1483.
[39]张艳梅,王越,董大伟,等.葛根的解肌作用及药理学研究[J].黑龙江医药,2010,23(3):416.
[40]申启荣.中药黄嘌呤氧化酶抑制剂的筛选及抑制动力学研究[D].南昌:南昌大学,2015.
[41]王勇.杨梅素、葛根素对高尿酸血症的影响及其意义[J].内蒙古中医药,2010,29(19):9.
[42]Woodward O M,Kottgen A,Coresh J,et al.Identification of a urate transporter,ABCG2,with a common functional polymorphism causing gout[J].Proc Natl Acad Sci USA,2009,106(25):10338.
[43]张洪长,张莹,律广富,等.葛根素对人肾近曲小管上皮细胞ABCG2表达影响[J].上海中医药杂志,2016(3):74.
[44]史坤,张荣涛,尚小玉,等.葛根提取物对高尿酸血症大鼠血尿酸的影响[J].食品科技,2014,39(2):216.
[45]马越,吕圭源,陈素红.葛根提取物抗痛风性关节炎作用及机制初探[J].中药新药与临床药理,2011,22(3):241.
[46]刘丽娟,张卓.葛根治疗痛风的临床疗效[J].吉林大学学报:医学版,2005,31(5):670.
[47]王钰宁,姜琪,张扩,等.葛根素-锗配合物的合成及其抗炎活性研究[J].哈尔滨商业大学学报:自然科学版,2015,31(2):149.
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