知柏地黄丸联合盐酸克林霉素治疗牙周炎的临床疗效及对血清IL-8、TNF-α、IL-10水平的影响
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摘要
目的探讨知柏地黄丸联合盐酸克林霉素对牙周炎的临床疗效及对血清白介素-8(interleukin-8,IL-8)、肿瘤坏死因子α(tumor necrosis factorα,TNF-α)、白介素-10(IL-10)水平的影响。方法回顾性选取绍兴市人民医院口腔科确诊为牙周炎患者98例作研究对象,按随机数字表法进行分组,对照组49例在基础治疗上予以盐酸克林霉素治疗;研究组49例在基础治疗上予以盐酸克林霉素联合知柏地黄丸治疗,治疗前后检查牙周袋深度、菌斑指数、牙龈指数及探针出血阳性率,采血测定血清IL-8、TNF-α、IL-10水平,同时对比临床疗效。结果研究组治疗有效率(93.88%)高于对照组治疗有效率(79.59%),差异具有统计学意义(P<0.05)。观察组探诊出血阳性率(38.78%)显著低于对照组为(59.18%),差异具有统计学意义(P<0.05)。研究组治疗后牙周袋深度、菌斑指数、牙龈指数低于对照组,研究组治疗后TNF-α和IL-8水平低于对照组,IL-10高于对照组,差异具有统计学意义(P<0.05)。结论采用盐酸克林霉素联合知柏地黄丸治疗牙周炎疗效更好,能降低牙周炎血清IL-8、TNF-α水平,提高IL-10水平。
Objective To investigate the effect of Zhibaidihuangwan combined with clindamycin hydrochloride on serum IL-8,TNF-α,IL-10 levels in periodontitis and its clinical efficacy. Methods A total of 98 patients with periodontitis from our hospital were collected and randomly divided into the control group and the experimental group,49 cases each group. Patients in the control group were treated on the basis of the foundation therapy with clindamycin hydrochloride,patients in the experimental group were treated with Zhibaidihuangwan on the basis of control group. The periodontal pocket depth,plaque index,gingival index and positive rate of probe bleeding,serum IL-8,TNF-a,IL-10 levels were measured,and the clinical efficacy were compared. Results The effective rate of the experimental group( 93. 88%) was higher than the control group( 79. 59%),with statistical significance( P < 0. 05). The positive rate of probe bleeding in experimental group( 38. 78%) was lower than control group of two groups( 59. 18%),with statistical significance( P < 0. 05). The periodontal pocket depth,plaque index,gingival index in experimental group were lower than the control group after treatment,the TNF-α and IL-8 levels in experimental group were lower than the control group,IL-10 was higher than the control group after treatment,with statistical significance( P < 0. 05). Conclusion Zhibaidihuangwan combined with clindamycin hydrochloride could reduce periodontitis serum IL-8 and TNF-α levels,improve the level of IL-10.
Objective To investigate the effect of Zhibaidihuangwan combined with clindamycin hydrochloride on serum IL-8,TNF-α,IL-10 levels in periodontitis and its clinical efficacy. Methods A total of 98 patients with periodontitis from our hospital were collected and randomly divided into the control group and the experimental group,49 cases each group. Patients in the control group were treated on the basis of the foundation therapy with clindamycin hydrochloride,patients in the experimental group were treated with Zhibaidihuangwan on the basis of control group. The periodontal pocket depth,plaque index,gingival index and positive rate of probe bleeding,serum IL-8,TNF-a,IL-10 levels were measured,and the clinical efficacy were compared. Results The effective rate of the experimental group( 93. 88%) was higher than the control group( 79. 59%),with statistical significance( P < 0. 05). The positive rate of probe bleeding in experimental group( 38. 78%) was lower than control group of two groups( 59. 18%),with statistical significance( P < 0. 05). The periodontal pocket depth,plaque index,gingival index in experimental group were lower than the control group after treatment,the TNF-α and IL-8 levels in experimental group were lower than the control group,IL-10 was higher than the control group after treatment,with statistical significance( P < 0. 05). Conclusion Zhibaidihuangwan combined with clindamycin hydrochloride could reduce periodontitis serum IL-8 and TNF-α levels,improve the level of IL-10.
引文
[1]何英慧,苑士清,吴丹,等.人工牛黄甲硝唑胶囊、阿莫西林联合西帕依固龈液治疗单纯性牙周炎对患者血清IFN-γ、SAA(淀粉样蛋白A)及IL-14水平的影响分析[J].医疗装备,2015,28(9):132-133.
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[5]邓泽亚,卢俊慧,黎秀珍.牙周治疗对冠心病伴牙周炎患者血清Hs CRP、TNF-α、IL-1β、IL-6水平的影响[J].中国医学创新,2014,11(22):65-67.
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[8]陈国均.局部应用奥硝唑对老年牙周炎患者血清及龈沟液骨代谢炎性指标的影响[J].现代实用医学,2014,26(9):1148-1149.
[9]严寒.阿莫西林联合甲硝唑治疗牙周炎的临床疗效观察[J].中国医药指南,2013,11(33):356-357.
[10]洪达.盐酸克林霉素治疗慢性牙周炎的临床效果分析[J].当代医学,2014,20(4):82.
[11]夏承鉴.知柏地黄丸加减对慢性牙周炎的炎症因子的影响[J].中药药理与临床,2015,31(1):277-278.
[12]刘柳芳,黄文荣,李雪飞.奥硝唑对牙周炎患者疗效以及炎症因子影响的临床价值分析[J].医学综述,2014,20(9):1703-1705.
[13]罗振华,郭淑娟,贾岳,等.CD4+T淋巴细胞亚型在牙周炎免疫机制中作用的研究进展[J].中华口腔医学杂志,2013,48(6):41-42.
[14]江剑彬,区凤玲.牙周炎治疗对龈沟液IL-8水平的影响分析[J].吉林医学,2015,36(14):3012-3013.
[15]张艳,张振海,廖湘凌.牙周基础治疗对冠心病伴牙周炎患者血清hs CRP、IL-1β和TNF-α水平的影响[J].中国临床医生,2013,41(12):65-66.
[16]陈晓涛.Th亚群细胞及其特征性细胞因子与慢性牙周炎相关性的研究[D].杭州:浙江大学,2015.
[2]王一敏,陈贵敏,许建华,等.老年人糖尿病与牙周炎的临床分析[J].东南国防医药,2006,8(4):275-276.
[3]梁自立.阿莫西林、奥美拉唑联合奥硝唑治疗牙周病的疗效研究[J].现代诊断与治疗,2015,26(22):5120-5122.
[4]王学明,徐敏.知柏地黄丸加减联合牙周基础治疗对慢性牙周炎的炎症因子影响[J].中国地方病防治杂志,2014,29(S1):45-46.
[5]邓泽亚,卢俊慧,黎秀珍.牙周治疗对冠心病伴牙周炎患者血清Hs CRP、TNF-α、IL-1β、IL-6水平的影响[J].中国医学创新,2014,11(22):65-67.
[6]中华人民共和国卫生部办公厅.中国居民口腔健康指南[J].广东牙病防治,2010,18(1):4-10.
[7]翁旭,王友山.氯己定龈下冲洗辅助牙周基础治疗对冠心病伴牙周炎患者血清IL-10和TNF-α水平的影响[J].中国当代医药,2015,22(20):84-86.
[8]陈国均.局部应用奥硝唑对老年牙周炎患者血清及龈沟液骨代谢炎性指标的影响[J].现代实用医学,2014,26(9):1148-1149.
[9]严寒.阿莫西林联合甲硝唑治疗牙周炎的临床疗效观察[J].中国医药指南,2013,11(33):356-357.
[10]洪达.盐酸克林霉素治疗慢性牙周炎的临床效果分析[J].当代医学,2014,20(4):82.
[11]夏承鉴.知柏地黄丸加减对慢性牙周炎的炎症因子的影响[J].中药药理与临床,2015,31(1):277-278.
[12]刘柳芳,黄文荣,李雪飞.奥硝唑对牙周炎患者疗效以及炎症因子影响的临床价值分析[J].医学综述,2014,20(9):1703-1705.
[13]罗振华,郭淑娟,贾岳,等.CD4+T淋巴细胞亚型在牙周炎免疫机制中作用的研究进展[J].中华口腔医学杂志,2013,48(6):41-42.
[14]江剑彬,区凤玲.牙周炎治疗对龈沟液IL-8水平的影响分析[J].吉林医学,2015,36(14):3012-3013.
[15]张艳,张振海,廖湘凌.牙周基础治疗对冠心病伴牙周炎患者血清hs CRP、IL-1β和TNF-α水平的影响[J].中国临床医生,2013,41(12):65-66.
[16]陈晓涛.Th亚群细胞及其特征性细胞因子与慢性牙周炎相关性的研究[D].杭州:浙江大学,2015.