中药提取工艺的超分子“印迹模板”作用规律探讨
|
摘要
选用适宜的中药提取工艺是中药制剂制备过程的关键环节,也是行业人员关注的热点。近年来,中药提取原理不断创新,技术不断完善发展,新思路与新方法不断涌现,面对着各式各样的中药提取方法,如何针对中药多成分群的特点,选择或创新适宜的提取方法高效提取中药有效成分是经常遇到的难题。因此亟需对目前中药提取工艺的研究现状进行梳理,对中药多成分间相互作用特征进行探讨,并提出一套适应多成分目标优化提取方法。基于此,引进超分子化学,结合超分子"印迹模板"理论,从"分子社会"间作用层面上提出适宜中药有效成分特点的中药定性定量提取的理论、方法与技术,旨在推动中药提取工艺研究的发展,促进中药制剂生产工艺的进步,加快实现中药制药现代化进程。
The selection of appropriate extraction technology of Chinese materia medica(CMM) is the key phase in the preparation process of CMM preparation, and it is also the hot spot the industry personnel concerned about. In recent years, the extraction principle of CMM has been innovated, the technology has been improved and new ideas and methods have emerged. In the face of different kinds of extraction methods of CMM, how to select or innovate the appropriate extraction method to extract the effective components of CMM is a common difficult problem in accordance with the characteristics of multi-component groups of CMM.Therefore, it is urgent to sort out the extant situation of CMM, discuss the characteristics of interaction between multi-components of CMM and propose a set of optimization extraction methods adapted to multi-component objectives. Based on the above discussion,this paper firstly summarizes the present situation of CMM extraction, and introduces supramolecular chemistry, combined with supramolecular imprinting templates theory to put forward the theory, the method and the technology of qualitative and quantitative extraction of Chinese medicines which is suitable for the characteristics of active ingredients of Chinese medicines from the perspective of molecular social interaction. The aim is to promote the development of the extraction technology of CMM,make progress in the production technology of CMM preparations, and accelerate the process of modernization of CMM pharmaceuticals.
The selection of appropriate extraction technology of Chinese materia medica(CMM) is the key phase in the preparation process of CMM preparation, and it is also the hot spot the industry personnel concerned about. In recent years, the extraction principle of CMM has been innovated, the technology has been improved and new ideas and methods have emerged. In the face of different kinds of extraction methods of CMM, how to select or innovate the appropriate extraction method to extract the effective components of CMM is a common difficult problem in accordance with the characteristics of multi-component groups of CMM.Therefore, it is urgent to sort out the extant situation of CMM, discuss the characteristics of interaction between multi-components of CMM and propose a set of optimization extraction methods adapted to multi-component objectives. Based on the above discussion,this paper firstly summarizes the present situation of CMM extraction, and introduces supramolecular chemistry, combined with supramolecular imprinting templates theory to put forward the theory, the method and the technology of qualitative and quantitative extraction of Chinese medicines which is suitable for the characteristics of active ingredients of Chinese medicines from the perspective of molecular social interaction. The aim is to promote the development of the extraction technology of CMM,make progress in the production technology of CMM preparations, and accelerate the process of modernization of CMM pharmaceuticals.
引文
[1]袁亚男,姜廷良,周兴,等.青蒿素的发现和发展[J].科学通报,2017,62(18):1914-1927.
[2]杨明,伍振峰,林环玉,等.中药复方制剂工艺研究问题、模式与策略[J].中草药,2018,49(12):2735-2741.
[3]朱安运,夏嫱,李小波,等.栀子与西红花中西红花苷纯化、分析及构效关系研究进展[J].药物分析杂志,2018,38(5):735-747.
[4]殷明阳,刘素香,张铁军,等.复方中药提取工艺研究概况[J].中草药,2015,46(21):3279-3283.
[5]叶陈丽,贺帅,曹伟灵,等.中药提取分离新技术的研究进展[J].中草药,2015,46(3):457-464.
[6]张效嘉,胡良平.试验设计类型之可以考察部分交互作用的多因素设计:正交设计与均匀设计[J].四川精神卫生,2017,30(3):205-210.
[7]Long V D.Aqueous extraction of black leaf tea.Experiments with a stirred column[J].Int J Food Sci Technol,1979,14(5):449-462.
[8]Spiro M,Siddique S.Kinetics and equilibria of tea infusion:Kinetics of extraction of theaflavins,thearubigins and caffeine from Koonsong Broken Pekoe[J].J Sci Food Agric,1981,32(11):1135-1139.
[9]储茂泉,古宏晨.中草药浸提过程的动力学模型[J].中草药,2000,31(7):504-506.
[10]储茂泉,古宏晨.中草药浸提温度对有效成分浸出浓度的影响[J].中草药,2001,32(1):22-23.
[11]李有润,郑青.中草药提取过程数学模拟与优化[J].中草药,1997,28(7):399-401.
[12]Hou K,Zheng Q,Li Y,et al.Modeling and optimization of herb leaching processes[J].Comp Chem Eng,2000,24(2):1343-1348.
[13]柯仁怀.混合溶剂提取水葫芦叶绿素动力学模型[J].科学技术与工程,2007,7(19):4944-4946.
[14]赵平,宋学娟,张月萍,等.葡萄籽原花青素提取动力学研究[J].食品科学,2010,31(1):110-112.
[15]边名鸿,左勇,宗绪岩,等.黄连提取动力学模型研究[J].四川理工学院学报:自然科学版,2012,25(4):26-29.
[16]雒羽,李稳宏,刘庆超,等.飞天蜈蚣七皂苷提取动力学研究[J].化学工程,2011,39(12):81-84.
[17]苏辉,王伯初,刘玮琦,等.天然药物提取过程的动力学数学模型[J].中草药,2011,42(2):384-391.
[18]韩泳平,向永臣,王曙宾,等.挥发油提取过程动力学数学模型研究[J].中成药,2001,23(1):11-13.
[19]王振斌,姜美花,曲文娟.蜂巢中多酚的提取动力学[J].食品工业科技,2013,34(15):793-798.
[20]赵文英,朱庆书,岳莉,等.苍耳子油提取动力学研究及模型建立[J].林产化学与工业,2012,32(4):63-66.
[21]汝绍刚,赵文英,朱庆书,等.苍耳子油回流提取工艺优化及其动力学研究[J].化学工业与工程,2012,29(1):34-38.
[22]赵文英,公衍玲,黄山,等.薏苡仁油回流提取工艺参数优化及其动力学研究[J].生物加工过程,2010,8(3):1-5.
[23]贺福元,邓凯文,罗杰英,等.中药复方成分提取动力学数学模型的初步研究[J].中国中药杂志,2007,32(6):490-495.
[24]贺福元,周宏灏,邓凯文,等.指纹图谱的一种定性定量研究新方法:总量统计矩分析法[J].药学学报,2008,43(2):195-201.
[25]谢相贵,贺福元,石继连,等.总量统计矩法与主成分分析对红花HPLC指纹图谱的考察[J].中国实验方剂学杂志,2012,18(18):64-69.
[26]黄胜,贺福元,刘文龙,等.总量统计矩相似度法对左金缓释片多成分释放相似度的评价研究[J].中成药,2009,31(1):35-39.
[27]刘红宇,贺福元,罗杰英.中药(复方)成分提取动力学数学模型的建立及对六味地黄汤梓醇的验证试验[J].中国药业,2007,16(3):1-3.
[28]刘文龙,贺福元,张喜利,等.鱼腥草挥发油中甲基正壬酮的提取动力学参数测定及分析[J].中医药导报,2008,14(11):10-12.
[29]贺福元,邓凯文,吴德智,等.左金方与黄连中小檗碱型生物碱提取动力学差异性的研究[J].中成药,2009,31(9):1354-1359.
[30]刘文龙,贺福元,张喜利,等.IGC法测定苦杏仁苷溶度参数的方法学研究[J].中成药,2008,30(3):415-418.
[31]刘文龙.补阳还五汤有效成分及部位配伍溶度参数法的研究[D].长沙:湖南中医药大学,2006.
[32]贺福元,刘文龙,扶瑾,等.HPLC测定中药多成分总量溶度参数的理论及实验研究[J].中国中药杂志,2010,35(8):977-983.
[33]贺福元,周宏灏,罗杰英,等.HPLC测定中药成分溶度参数的理论与实验研究[J].中国中药杂志,2008,33(6):642-648.
[34]邹欢.补阳还五汤总苷类成分提取分离过程中溶解迁移规律的研究[D].长沙:湖南中医药大学,2010.
[35]贺福元,周宏灏,罗杰英,等.生物遗传多态性规律揭示中药材质量稳定性规律的探讨[J].中草药,2008,39(1):2-6.
[36]贺福元,邓凯文,黄胜,等.中药群体指纹图谱信息量和一次投料量数学模型的建立及对大黄和鱼腥草实验研究[J].中成药,2011,33(8):1292-1298.
[37]廖琼.补阳还五汤提取谱动学的研究[D].长沙:湖南中医药大学,2015.
[38]刘文龙,张喜利,贺福元,等.稳态提取工艺中平衡群体的研究及对鱼腥草的实验验证[J].中国中药杂志,2011,36(21):2950-2955.
[39]王海琴,刘文龙,贺福元,等.基于鱼腥草ISSR扩增条带信息熵的一次投料量研究[J].中国中药杂志,2012,37(3):288-292.
[40]贺福元,贺红,邓凯文,等.借超分子“印迹模板”的自主作用解开金(山)银花纷争[J].中国中药杂志,2016,41(6):1152-1160.
[41]张艳斌,崔元璐,何永志.分子印迹技术与中药研究[J].中药材,2008,31(4):616-619.
[42]贺福元,周逸群,邓凯文,等.超分子化学对中医药理论的特殊影响[J].中国中药杂志,2014,39(8):1534-1543.
[43]杨姣,贺福元,刘惠,等.金银花与山银花绿原酸提取动力学比较研究[J].中国中医药信息杂志,2018,25(4):91-95.
[44]陶叶琴.金(山)银花超分子客体“印迹模板”特征及其代谢研究[D].长沙:湖南中医药大学,2017.
[45]贺福元,罗杰英,邓凯文,等.中药(复方)药动学研究现状及研究方法探讨[J].中草药,2005,36(10):146-150.
[46]Zhang Y T,Liu W L,Tang Y,et al.A novel kinetic model for dissolution of herbal medicine[J].Dissolut Technol,2018,25(4):28-38.
[47]Zhang Y T,Xiao M F,Deng K W,et al.Novel mathematic models for quantitative transitivity of quality-markers in extraction process of the Buyanghuanwu Decoction[J].Phytomedicine,2018,45(3):68-75.
[2]杨明,伍振峰,林环玉,等.中药复方制剂工艺研究问题、模式与策略[J].中草药,2018,49(12):2735-2741.
[3]朱安运,夏嫱,李小波,等.栀子与西红花中西红花苷纯化、分析及构效关系研究进展[J].药物分析杂志,2018,38(5):735-747.
[4]殷明阳,刘素香,张铁军,等.复方中药提取工艺研究概况[J].中草药,2015,46(21):3279-3283.
[5]叶陈丽,贺帅,曹伟灵,等.中药提取分离新技术的研究进展[J].中草药,2015,46(3):457-464.
[6]张效嘉,胡良平.试验设计类型之可以考察部分交互作用的多因素设计:正交设计与均匀设计[J].四川精神卫生,2017,30(3):205-210.
[7]Long V D.Aqueous extraction of black leaf tea.Experiments with a stirred column[J].Int J Food Sci Technol,1979,14(5):449-462.
[8]Spiro M,Siddique S.Kinetics and equilibria of tea infusion:Kinetics of extraction of theaflavins,thearubigins and caffeine from Koonsong Broken Pekoe[J].J Sci Food Agric,1981,32(11):1135-1139.
[9]储茂泉,古宏晨.中草药浸提过程的动力学模型[J].中草药,2000,31(7):504-506.
[10]储茂泉,古宏晨.中草药浸提温度对有效成分浸出浓度的影响[J].中草药,2001,32(1):22-23.
[11]李有润,郑青.中草药提取过程数学模拟与优化[J].中草药,1997,28(7):399-401.
[12]Hou K,Zheng Q,Li Y,et al.Modeling and optimization of herb leaching processes[J].Comp Chem Eng,2000,24(2):1343-1348.
[13]柯仁怀.混合溶剂提取水葫芦叶绿素动力学模型[J].科学技术与工程,2007,7(19):4944-4946.
[14]赵平,宋学娟,张月萍,等.葡萄籽原花青素提取动力学研究[J].食品科学,2010,31(1):110-112.
[15]边名鸿,左勇,宗绪岩,等.黄连提取动力学模型研究[J].四川理工学院学报:自然科学版,2012,25(4):26-29.
[16]雒羽,李稳宏,刘庆超,等.飞天蜈蚣七皂苷提取动力学研究[J].化学工程,2011,39(12):81-84.
[17]苏辉,王伯初,刘玮琦,等.天然药物提取过程的动力学数学模型[J].中草药,2011,42(2):384-391.
[18]韩泳平,向永臣,王曙宾,等.挥发油提取过程动力学数学模型研究[J].中成药,2001,23(1):11-13.
[19]王振斌,姜美花,曲文娟.蜂巢中多酚的提取动力学[J].食品工业科技,2013,34(15):793-798.
[20]赵文英,朱庆书,岳莉,等.苍耳子油提取动力学研究及模型建立[J].林产化学与工业,2012,32(4):63-66.
[21]汝绍刚,赵文英,朱庆书,等.苍耳子油回流提取工艺优化及其动力学研究[J].化学工业与工程,2012,29(1):34-38.
[22]赵文英,公衍玲,黄山,等.薏苡仁油回流提取工艺参数优化及其动力学研究[J].生物加工过程,2010,8(3):1-5.
[23]贺福元,邓凯文,罗杰英,等.中药复方成分提取动力学数学模型的初步研究[J].中国中药杂志,2007,32(6):490-495.
[24]贺福元,周宏灏,邓凯文,等.指纹图谱的一种定性定量研究新方法:总量统计矩分析法[J].药学学报,2008,43(2):195-201.
[25]谢相贵,贺福元,石继连,等.总量统计矩法与主成分分析对红花HPLC指纹图谱的考察[J].中国实验方剂学杂志,2012,18(18):64-69.
[26]黄胜,贺福元,刘文龙,等.总量统计矩相似度法对左金缓释片多成分释放相似度的评价研究[J].中成药,2009,31(1):35-39.
[27]刘红宇,贺福元,罗杰英.中药(复方)成分提取动力学数学模型的建立及对六味地黄汤梓醇的验证试验[J].中国药业,2007,16(3):1-3.
[28]刘文龙,贺福元,张喜利,等.鱼腥草挥发油中甲基正壬酮的提取动力学参数测定及分析[J].中医药导报,2008,14(11):10-12.
[29]贺福元,邓凯文,吴德智,等.左金方与黄连中小檗碱型生物碱提取动力学差异性的研究[J].中成药,2009,31(9):1354-1359.
[30]刘文龙,贺福元,张喜利,等.IGC法测定苦杏仁苷溶度参数的方法学研究[J].中成药,2008,30(3):415-418.
[31]刘文龙.补阳还五汤有效成分及部位配伍溶度参数法的研究[D].长沙:湖南中医药大学,2006.
[32]贺福元,刘文龙,扶瑾,等.HPLC测定中药多成分总量溶度参数的理论及实验研究[J].中国中药杂志,2010,35(8):977-983.
[33]贺福元,周宏灏,罗杰英,等.HPLC测定中药成分溶度参数的理论与实验研究[J].中国中药杂志,2008,33(6):642-648.
[34]邹欢.补阳还五汤总苷类成分提取分离过程中溶解迁移规律的研究[D].长沙:湖南中医药大学,2010.
[35]贺福元,周宏灏,罗杰英,等.生物遗传多态性规律揭示中药材质量稳定性规律的探讨[J].中草药,2008,39(1):2-6.
[36]贺福元,邓凯文,黄胜,等.中药群体指纹图谱信息量和一次投料量数学模型的建立及对大黄和鱼腥草实验研究[J].中成药,2011,33(8):1292-1298.
[37]廖琼.补阳还五汤提取谱动学的研究[D].长沙:湖南中医药大学,2015.
[38]刘文龙,张喜利,贺福元,等.稳态提取工艺中平衡群体的研究及对鱼腥草的实验验证[J].中国中药杂志,2011,36(21):2950-2955.
[39]王海琴,刘文龙,贺福元,等.基于鱼腥草ISSR扩增条带信息熵的一次投料量研究[J].中国中药杂志,2012,37(3):288-292.
[40]贺福元,贺红,邓凯文,等.借超分子“印迹模板”的自主作用解开金(山)银花纷争[J].中国中药杂志,2016,41(6):1152-1160.
[41]张艳斌,崔元璐,何永志.分子印迹技术与中药研究[J].中药材,2008,31(4):616-619.
[42]贺福元,周逸群,邓凯文,等.超分子化学对中医药理论的特殊影响[J].中国中药杂志,2014,39(8):1534-1543.
[43]杨姣,贺福元,刘惠,等.金银花与山银花绿原酸提取动力学比较研究[J].中国中医药信息杂志,2018,25(4):91-95.
[44]陶叶琴.金(山)银花超分子客体“印迹模板”特征及其代谢研究[D].长沙:湖南中医药大学,2017.
[45]贺福元,罗杰英,邓凯文,等.中药(复方)药动学研究现状及研究方法探讨[J].中草药,2005,36(10):146-150.
[46]Zhang Y T,Liu W L,Tang Y,et al.A novel kinetic model for dissolution of herbal medicine[J].Dissolut Technol,2018,25(4):28-38.
[47]Zhang Y T,Xiao M F,Deng K W,et al.Novel mathematic models for quantitative transitivity of quality-markers in extraction process of the Buyanghuanwu Decoction[J].Phytomedicine,2018,45(3):68-75.