维生素D水平与2型糖尿病患者周围神经病变的关系
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摘要
目的分析维生素D水平与2型糖尿病患者周围神经病变的关系。方法选取本院收治的65例2型糖尿病患者为研究对象,根据有无周围神经病变分为A组(无周围神经病变,38例)与B组(合并周围神经病变,27例)。比较两组患者的维生素D、血糖相关指标水平及维生素D水平分布情况。结果 B组维生素D水平低于A组(P<0.05);A组空腹血糖、糖化血红蛋白水平低于B组,胰岛素分泌指数高于B组(P<0.05)。两组患者的维生素D水平分布情况有显著差异(P<0.05)。结论 2型糖尿病患者合并周围神经病变与维生素D水平不足具有一定的关联;且与未合并周围神经病变患者相比,其血糖控制效果及胰岛素功能均较差。
Objective To analyze the relationship between vitamin D level and peripheral neuropathy in patients with type 2 diabetes mellitus. Methods Sixty-five patients with type 2 diabetes mellitus admitted in our hospital were divided into group A(without peripheral neuropathy, 38 cases) and group B(with peripheral neuropathy, 27 cases) according to the presence or absence of peripheral neuropathy. The levels of vitamin D, blood sugar related indicators and the distribution of vitamin D levels were compared between the two groups. Results The level of vitamin D in the group B was lower than that in the group A(P<0.05); the levels of fasting blood sugar and glycosylated hemoglobin in the group A were lower than those in the group B, and the insulin secretion index was higher than that in the group B(P <0.05). There was a significant difference in the distribution of vitamin D level between the two groups(P<0.05). Conclusion Patients with type 2 diabetes mellitus complicated with peripheral neuropathy were associated with insufficient vitamin D level, and their blood sugar control effect and insulin function were poorer than those without peripheral neuropathy.
Objective To analyze the relationship between vitamin D level and peripheral neuropathy in patients with type 2 diabetes mellitus. Methods Sixty-five patients with type 2 diabetes mellitus admitted in our hospital were divided into group A(without peripheral neuropathy, 38 cases) and group B(with peripheral neuropathy, 27 cases) according to the presence or absence of peripheral neuropathy. The levels of vitamin D, blood sugar related indicators and the distribution of vitamin D levels were compared between the two groups. Results The level of vitamin D in the group B was lower than that in the group A(P<0.05); the levels of fasting blood sugar and glycosylated hemoglobin in the group A were lower than those in the group B, and the insulin secretion index was higher than that in the group B(P <0.05). There was a significant difference in the distribution of vitamin D level between the two groups(P<0.05). Conclusion Patients with type 2 diabetes mellitus complicated with peripheral neuropathy were associated with insufficient vitamin D level, and their blood sugar control effect and insulin function were poorer than those without peripheral neuropathy.
引文
[1]张楠,吕玉洁,孙飞,等.北京市崔各庄社区2型糖尿病人群代谢综合征的患病率及其分布特征[J].中国全科医学,2009,12(23):2139-2141.
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[6]许桂平,于明香.维生素D与糖尿病[J].复旦学报:医学版,2011,38(1):80-83.
[7]刘冰,洪旭,尹洁,等.维生素D水平与2型糖尿病患者血糖控制关系的分析[J].中华临床医师杂志:电子版,2015,9(13):40-43.
[8]DEL GOBBO LC,SONG Y,DANNENBAUM DA,et al.Serum 25-hydroxyvitamin D is not associated with insulin resistance or beta cell function in Canadian Cree[J].J Nutr,2011,141(2):290-295.
[9]周丽华.血清25-羟维生素D3水平与老年2型糖尿病患者周围神经病变的相关性[J].新乡医学院学报,2017,34(2):136-138.
[10]张吉平,徐宁,尹冬,等.血清维生素D水平与2型糖尿病周围神经病变的关系[J].中华内分泌代谢杂志,2014,30(5):385-387.
[11]佘敦敏,朱妍,冯尚勇,等.血清25羟维生素D3与2型糖尿病周围神经病变的相关性[J].中华骨质疏松和骨矿盐疾病杂志,2014,7(3):240-243.
[2]朱丽颖,宁光.维生素D与2型糖尿病研究进展[J].中国实用内科杂志,2012,32(8):635-637.
[3]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中国糖尿病杂志,2014,30(8):893-942.
[4]ADAMS JS,HEWISON M.Update in vitamin D[J].J Clin Endocrinol Metab,2010,95(2):471-478.
[5]邱云霞,赵桂东,秦建华,等.维生素D与2型糖尿病防治的相关性研究[J].中国骨质疏松杂志,2014,20(1):54-57.
[6]许桂平,于明香.维生素D与糖尿病[J].复旦学报:医学版,2011,38(1):80-83.
[7]刘冰,洪旭,尹洁,等.维生素D水平与2型糖尿病患者血糖控制关系的分析[J].中华临床医师杂志:电子版,2015,9(13):40-43.
[8]DEL GOBBO LC,SONG Y,DANNENBAUM DA,et al.Serum 25-hydroxyvitamin D is not associated with insulin resistance or beta cell function in Canadian Cree[J].J Nutr,2011,141(2):290-295.
[9]周丽华.血清25-羟维生素D3水平与老年2型糖尿病患者周围神经病变的相关性[J].新乡医学院学报,2017,34(2):136-138.
[10]张吉平,徐宁,尹冬,等.血清维生素D水平与2型糖尿病周围神经病变的关系[J].中华内分泌代谢杂志,2014,30(5):385-387.
[11]佘敦敏,朱妍,冯尚勇,等.血清25羟维生素D3与2型糖尿病周围神经病变的相关性[J].中华骨质疏松和骨矿盐疾病杂志,2014,7(3):240-243.