颈动脉斑块超声与血清中血脂、C-反应蛋白水平的关系
|
摘要
目的探讨颈动脉粥样硬化超声结果与患者血脂、CRP水平及心血管事件的关系。方法回顾性分析本院2016年5月-2017年5月收治的颈动脉斑块患者90例作为研究对象,根据颈动脉彩超结果将患者分为软斑块、混合斑块、硬斑块组各30例,所有患者均行颈动脉超声检测,全自动生化仪检测血脂、CRP水平,并采用Logistic回归分析患者心血管事件发生的危险因素。结果软斑块组TC、TG、LDL-C均较混合斑、硬斑块组高,HDL-C较混合斑、硬斑块组低。软斑块患者CRP水平高于混合斑块、硬斑块患者(P<0.05)。Logistic回归分析结果证实,软斑块、TG、CRP是患者心血管事件发生的独立危险因素(P<0.05)。结论劲动脉斑块类型与患者血脂、CRP水平密切相关。
Objective To investigate the relationship of carotid atherosclerotic ultrasound with blood lipid, CRP level and cardiovascular events. Methods A retrospective analysis was carried out on 90 patients with carotid artery plaque collected from our hospital during May 2016-May 2017. According to the results of carotid artery color Doppler ultrasound, the patients were divided into soft plaque group, mixed plaque group, and hard plaque group, with 30 cases in each group. All patients underwent carotid ultrasound detection. Automatic biochemical analyzer was used to detect blood lipids, CRP levels, and logistic regression was used to analyze the risk factors for cardiovascular events. Results The levels of TC, TG and LDL-C in the soft plaque group were higher than those in the mixed plaque and hard plaque group, and HDL-C was lower than that in the mixed plaque group and hard plaque group. The CRP level in patients with soft plaque was higher than that in patients with mixed plaque and hard plaque(P<0.05). Logistic regression analysis confirmed that soft plaque, TG and CRP were independent risk factors for cardiovascular events(P<0.05). Conclusion Carotid artery plaque type is closely related to blood lipids, CRP levels.
Objective To investigate the relationship of carotid atherosclerotic ultrasound with blood lipid, CRP level and cardiovascular events. Methods A retrospective analysis was carried out on 90 patients with carotid artery plaque collected from our hospital during May 2016-May 2017. According to the results of carotid artery color Doppler ultrasound, the patients were divided into soft plaque group, mixed plaque group, and hard plaque group, with 30 cases in each group. All patients underwent carotid ultrasound detection. Automatic biochemical analyzer was used to detect blood lipids, CRP levels, and logistic regression was used to analyze the risk factors for cardiovascular events. Results The levels of TC, TG and LDL-C in the soft plaque group were higher than those in the mixed plaque and hard plaque group, and HDL-C was lower than that in the mixed plaque group and hard plaque group. The CRP level in patients with soft plaque was higher than that in patients with mixed plaque and hard plaque(P<0.05). Logistic regression analysis confirmed that soft plaque, TG and CRP were independent risk factors for cardiovascular events(P<0.05). Conclusion Carotid artery plaque type is closely related to blood lipids, CRP levels.
引文
[1] 申春云,梁洁,岑磊,等.氯吡格雷联合强化阿托伐他汀治疗脑梗死患者颈动脉粥样硬化斑块的效果观察[J].中国医药科学,2016,6(18):50-53.
[2] 周宇,苏本利,张宇虹.超声评价2型糖尿病患者内脏脂肪厚度及其与颈动脉粥样硬化的相关性研究[J].临床超声医学杂志,2015,17(7):491-493.
[3] 曲明卫,吴慧君,张福波,等.脑梗死患者血清胱抑素C,hs-CRP及D-二聚体与颈动脉斑块稳定性的研究[J].中国医药导刊,2017,19(8):764-767.
[4] 王迎霞,王欣,孟素敏,等.普罗布考联合瑞舒伐他汀治疗对脑梗死伴颈动脉斑块患者颈动脑内膜中层厚度及血清hs-CRP、脂蛋白水平的影响[J].临床合理用药杂志,2016,9(11):40-41.
[5] 谭安隽,李天荣,李红.老年2型糖尿病、糖耐量减低患者CRP、TNF-α与颈动脉粥样硬化及胰岛素抵抗的相关性[J].中国老年学杂志,2015,12(14):3878-3880.
[6] 曾庆范,卢红.急性脑梗死患者颈动脉粥样硬化斑块与IL-6及CRP的关系[J].中国实用神经疾病杂志,2016,19(7):17-19.
[7] 王晓琳,陆宁,朱宁,等.中老年高血压患者颈动脉斑块与hs-CRP的相关性分析[J].浙江临床医学,2017,19(8):1467-1468.
[8] 朱卫华.急性脑梗死患者颈动脉斑块与血清CRP 脂蛋白(a)水平的关系[J].中国实用神经疾病杂志,2014,17(12):25-26.
[9] 苏少慧,刘颖娇,郭兆霞,等.慢性丙型肝炎患者颈动脉内膜和血清内脏脂肪素的变化[J].实用肝脏病杂志,2015,7(6):674-675.
[10] 朱娜,叶桦.高尿酸血症与非酒精性脂肪性肝病及颈动脉粥样硬化的关系研究[J].浙江医学,2017,39(17):1421-1424.
[11] 许育伟,何文贞.部分缺血性脑卒中患者颈动脉斑块稳定性与血清CRP相关性分析[C].2015临床急重症经验交流高峰论坛,2015:59-60.
[12] 马文娟,杨佳,赵世刚.普罗布考联合阿托伐他汀对脑梗死患者血清hs-CRP ox-LDL MMP-9水平及颈动脉斑块的影响[J].河北医学,2017,23(4):620-623.
[13] 高莉洁,李斌,史文珍,等.脂肪因子网膜素与动脉粥样硬化的关系[J].中国动脉硬化杂志,2017,25(11):1179-1183.
[14] 陈社安,张文斌,马婉珍.血清小而密低密度脂蛋白胆固醇和同型半胱氨酸水平与颈动脉斑块的相关性探讨[J].临床检验杂志:电子版,2017,9(4):738-739.
[15] 苑斌,宋成忠,桑艳芳,等.甲壳素治疗颈动脉硬化斑块的疗效及TC、LDC-C、血流变学指标、炎性因子的水平变化[J].菏泽医学专科学校学报,2017,29(3):1-4.
[2] 周宇,苏本利,张宇虹.超声评价2型糖尿病患者内脏脂肪厚度及其与颈动脉粥样硬化的相关性研究[J].临床超声医学杂志,2015,17(7):491-493.
[3] 曲明卫,吴慧君,张福波,等.脑梗死患者血清胱抑素C,hs-CRP及D-二聚体与颈动脉斑块稳定性的研究[J].中国医药导刊,2017,19(8):764-767.
[4] 王迎霞,王欣,孟素敏,等.普罗布考联合瑞舒伐他汀治疗对脑梗死伴颈动脉斑块患者颈动脑内膜中层厚度及血清hs-CRP、脂蛋白水平的影响[J].临床合理用药杂志,2016,9(11):40-41.
[5] 谭安隽,李天荣,李红.老年2型糖尿病、糖耐量减低患者CRP、TNF-α与颈动脉粥样硬化及胰岛素抵抗的相关性[J].中国老年学杂志,2015,12(14):3878-3880.
[6] 曾庆范,卢红.急性脑梗死患者颈动脉粥样硬化斑块与IL-6及CRP的关系[J].中国实用神经疾病杂志,2016,19(7):17-19.
[7] 王晓琳,陆宁,朱宁,等.中老年高血压患者颈动脉斑块与hs-CRP的相关性分析[J].浙江临床医学,2017,19(8):1467-1468.
[8] 朱卫华.急性脑梗死患者颈动脉斑块与血清CRP 脂蛋白(a)水平的关系[J].中国实用神经疾病杂志,2014,17(12):25-26.
[9] 苏少慧,刘颖娇,郭兆霞,等.慢性丙型肝炎患者颈动脉内膜和血清内脏脂肪素的变化[J].实用肝脏病杂志,2015,7(6):674-675.
[10] 朱娜,叶桦.高尿酸血症与非酒精性脂肪性肝病及颈动脉粥样硬化的关系研究[J].浙江医学,2017,39(17):1421-1424.
[11] 许育伟,何文贞.部分缺血性脑卒中患者颈动脉斑块稳定性与血清CRP相关性分析[C].2015临床急重症经验交流高峰论坛,2015:59-60.
[12] 马文娟,杨佳,赵世刚.普罗布考联合阿托伐他汀对脑梗死患者血清hs-CRP ox-LDL MMP-9水平及颈动脉斑块的影响[J].河北医学,2017,23(4):620-623.
[13] 高莉洁,李斌,史文珍,等.脂肪因子网膜素与动脉粥样硬化的关系[J].中国动脉硬化杂志,2017,25(11):1179-1183.
[14] 陈社安,张文斌,马婉珍.血清小而密低密度脂蛋白胆固醇和同型半胱氨酸水平与颈动脉斑块的相关性探讨[J].临床检验杂志:电子版,2017,9(4):738-739.
[15] 苑斌,宋成忠,桑艳芳,等.甲壳素治疗颈动脉硬化斑块的疗效及TC、LDC-C、血流变学指标、炎性因子的水平变化[J].菏泽医学专科学校学报,2017,29(3):1-4.