皮肤衰老表现及相关标志物研究及应用
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摘要
皮肤衰老是由多因素引起的皮肤老化,是机体衰老的外在体现。目前抗衰老化妆品作用途径单一,为实现高效抗衰老就需要对衰老表现及相关标志物进行研究。总结了衰老的表现和衰老标志物两方面的内容。按部位对衰老现象进行概括,重点阐述了衰老标志物的研究进展及应用现状,为衰老标志物在抗衰老化妆品功效评价中的应用提供理论依据。
Skin aging induced by multi-factor is the external manifestation of body aging. Now the most of anti-aging cosmetics acted in a single pathway. To achieve effective anti-aging, it is necessary to study the aging mechanism and related biomarkers. The phenotype, mechanism and the biomarkers of aging were summarized. The mechanism of senescence was introduced in endogenous and exogenous aspects, and the phenomenon of senescence was described according to the position focusing on the research progress and application. It provided theoretical basis for the application of aging markers in the evaluation of the efficacy of anti-aging cosmetics.
Skin aging induced by multi-factor is the external manifestation of body aging. Now the most of anti-aging cosmetics acted in a single pathway. To achieve effective anti-aging, it is necessary to study the aging mechanism and related biomarkers. The phenotype, mechanism and the biomarkers of aging were summarized. The mechanism of senescence was introduced in endogenous and exogenous aspects, and the phenomenon of senescence was described according to the position focusing on the research progress and application. It provided theoretical basis for the application of aging markers in the evaluation of the efficacy of anti-aging cosmetics.
引文
[1]郭莉.皮肤衰老的机理和影响因素[J].中国美容医学杂志,2001(5):438-440.
[2]李想,胡君姣,李琼,等.抗衰老化妆品及其功效评价[J].香料香精化妆品,2013(5):58-62.
[3]KANAKI T,MAKRANTONAKI E,ZOUBOULIS C C.Biomarkers of skin aging[J].Reviews in Endocrine and Metabolic Disorders,2016,17(3):1-10.
[4]蔄茂强,胡立志.老年人表皮通透屏障功能的改变及其临床意义[J].皮肤科学通报,2017(4):388-391.
[5]SEXTIUS P,BERNARD B,BERNERD F,et al.Molecular signature representing a dysfunctional epidermal homeostasis:EP 2147982[P].2017-03-08.
[6]黄珊珊,李利.人表皮厚度与皮肤衰老[J].中华医学美学美容杂志,2011,17(1):34-36.
[7]ELENA R M,ABDALLAH M A,ZOUBOULIS C C.Ageassociated skin changes in innate immunity markers reflect a complex interaction between aging mechanisms in the sebaceous gland[J].Journal of Dermatology,2015,42(5):467-76.
[8]张丽丽,李贤玉,穆荣,等.皮肤中基底膜的结构与功能[J].中国美容医学,2016,25(10):113-117.
[9]DELOCHE C,MINONDO A M,BERNARD B A,et al.Effect of C-xyloside on morphogenesis of the dermal epidermal junction in aged female skin.An ultrastuctural pilot study[J].European Journal of Dermatology,2011,21(2):191-196.
[10]刘大旭,高晓波,祁永华,等.杜仲有效成分β-萘黄酮对UVB诱导人皮肤成纤维细胞光老化保护作用研究[J].中医药学报,2016,44(3):41-43.
[11]KIM J,JEONG I H,KIM C S,et al.Chlorogenic acid inhibits the formation of advanced glycation end products and associated protein cross-linking[J].Archives of Pharmacal Research,2011,34(3):495-500.
[12]陈婷,江智茂,于波,等.绿原酸抗人皮肤成纤维细胞衰老的研究[J].中华皮肤科杂志,2015(12):849-852.
[13]唐桦.AQP3在不同年龄段正常人皮肤组织及角质形成细胞、成纤维细胞中的表达[D].长沙:中南大学,2008.
[14]INOUE Y,SHIBASAKI M,HIRATA K,et al.Relationship between skin blood flow and sweating rate,and age related regional differences[J].European journal of applied physiology and occupational physiology,1998,79(1):17-23.
[15]李利,MARY S M,St HILLIER J M,等.不同年龄和部位女性皮肤微循环变化[J].中国微循环,2004,8(1):43-46.
[16]Biomarkers Definitions Working Group.Biomarkers and surrogate endpoints:Preferred definitions and conceptual framework[J].Clin Pharmacol Ther,2001,69:89-95.
[17]National Heart,Lung,and Blood Institute of U.S.Department of Health and Human Services.Guidelines for the Diagnosis&Management of Asthma[M].Washington:HHS,2007.
[18]MILLER E J,MARTIN G R,PIAZ K A.The utilization of lysine in the biosynthesis of elastin crosslinks[J].Biochemical and Biophysical Research Communications,1964,17(3):248-253.
[19]EDWARDS C A,O'BRIEN W D J.Modified assay for determination of hydroxyproline in a tissue hydrolyzate[J].Clinica Chimica Acta,1980,104(2):161-167.
[20]孙程,王冬东,张辉靠,等.茶树提取物经皮给药对衰老小鼠皮肤的影响[J].中成药,2017,39(8):1690-1694.
[21]詹雪芬,司鹤南,姚海舟,等.槲皮素对人成纤维细胞增殖及胶原合成的影响[J].中国老年学,2017,37(8):1845-1846.
[22]倪庆纯,郭健敏,肖百全,等.两种中药组方对D-半乳糖诱导的衰老模型裸鼠皮肤的影响[J].中草药,2012,43(9):1808-1813.
[23]陈迪,章漳,蒋耀权,等.冰川水和五脉绿绒蒿提取物的美容功效研究[J].日用化学工业,2017,47(4):207-211.
[24]李文芝.ADMA对人皮肤成纤维细胞衰老的作用及机制研究[D].长沙:中南大学,2012.
[25]DR?GE W.Free radicals in the physiological control of cell function[J].Physiological Reviews,2002,82(1):47-95.
[26]KONG L,WANG S,WU X,et al.Paeoniflorin attenuates ultraviolet B-induced apoptosis in human keratinocytes by inhibiting the ROS-p38-p53 pathway[J].Molecular Medicine Reports,2016,13(4):3553-3558.
[27]OHTANI N,ZEBEDEE Z,HUOT T J,et al.Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence[J].Nature,2001,409(6823):1067-1070.
[28]欧芹,王雅丽,魏晓东,等.山茱萸多糖对HDF细胞β-半乳糖苷酶及p16表达的影响[J].中国老年学,2007,27(4):325-327.
[29]KUWANA T,MACKEY M R,PERKINS G,et al.Bid,Bax,and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane[J].Cell,2002,111(3):331-342.
[30]姚媛媛.皮肤老化小鼠皮肤衰老的发病机制及核桃仁水提物的治疗作用[D].合肥:安徽大学,2012.
[2]李想,胡君姣,李琼,等.抗衰老化妆品及其功效评价[J].香料香精化妆品,2013(5):58-62.
[3]KANAKI T,MAKRANTONAKI E,ZOUBOULIS C C.Biomarkers of skin aging[J].Reviews in Endocrine and Metabolic Disorders,2016,17(3):1-10.
[4]蔄茂强,胡立志.老年人表皮通透屏障功能的改变及其临床意义[J].皮肤科学通报,2017(4):388-391.
[5]SEXTIUS P,BERNARD B,BERNERD F,et al.Molecular signature representing a dysfunctional epidermal homeostasis:EP 2147982[P].2017-03-08.
[6]黄珊珊,李利.人表皮厚度与皮肤衰老[J].中华医学美学美容杂志,2011,17(1):34-36.
[7]ELENA R M,ABDALLAH M A,ZOUBOULIS C C.Ageassociated skin changes in innate immunity markers reflect a complex interaction between aging mechanisms in the sebaceous gland[J].Journal of Dermatology,2015,42(5):467-76.
[8]张丽丽,李贤玉,穆荣,等.皮肤中基底膜的结构与功能[J].中国美容医学,2016,25(10):113-117.
[9]DELOCHE C,MINONDO A M,BERNARD B A,et al.Effect of C-xyloside on morphogenesis of the dermal epidermal junction in aged female skin.An ultrastuctural pilot study[J].European Journal of Dermatology,2011,21(2):191-196.
[10]刘大旭,高晓波,祁永华,等.杜仲有效成分β-萘黄酮对UVB诱导人皮肤成纤维细胞光老化保护作用研究[J].中医药学报,2016,44(3):41-43.
[11]KIM J,JEONG I H,KIM C S,et al.Chlorogenic acid inhibits the formation of advanced glycation end products and associated protein cross-linking[J].Archives of Pharmacal Research,2011,34(3):495-500.
[12]陈婷,江智茂,于波,等.绿原酸抗人皮肤成纤维细胞衰老的研究[J].中华皮肤科杂志,2015(12):849-852.
[13]唐桦.AQP3在不同年龄段正常人皮肤组织及角质形成细胞、成纤维细胞中的表达[D].长沙:中南大学,2008.
[14]INOUE Y,SHIBASAKI M,HIRATA K,et al.Relationship between skin blood flow and sweating rate,and age related regional differences[J].European journal of applied physiology and occupational physiology,1998,79(1):17-23.
[15]李利,MARY S M,St HILLIER J M,等.不同年龄和部位女性皮肤微循环变化[J].中国微循环,2004,8(1):43-46.
[16]Biomarkers Definitions Working Group.Biomarkers and surrogate endpoints:Preferred definitions and conceptual framework[J].Clin Pharmacol Ther,2001,69:89-95.
[17]National Heart,Lung,and Blood Institute of U.S.Department of Health and Human Services.Guidelines for the Diagnosis&Management of Asthma[M].Washington:HHS,2007.
[18]MILLER E J,MARTIN G R,PIAZ K A.The utilization of lysine in the biosynthesis of elastin crosslinks[J].Biochemical and Biophysical Research Communications,1964,17(3):248-253.
[19]EDWARDS C A,O'BRIEN W D J.Modified assay for determination of hydroxyproline in a tissue hydrolyzate[J].Clinica Chimica Acta,1980,104(2):161-167.
[20]孙程,王冬东,张辉靠,等.茶树提取物经皮给药对衰老小鼠皮肤的影响[J].中成药,2017,39(8):1690-1694.
[21]詹雪芬,司鹤南,姚海舟,等.槲皮素对人成纤维细胞增殖及胶原合成的影响[J].中国老年学,2017,37(8):1845-1846.
[22]倪庆纯,郭健敏,肖百全,等.两种中药组方对D-半乳糖诱导的衰老模型裸鼠皮肤的影响[J].中草药,2012,43(9):1808-1813.
[23]陈迪,章漳,蒋耀权,等.冰川水和五脉绿绒蒿提取物的美容功效研究[J].日用化学工业,2017,47(4):207-211.
[24]李文芝.ADMA对人皮肤成纤维细胞衰老的作用及机制研究[D].长沙:中南大学,2012.
[25]DR?GE W.Free radicals in the physiological control of cell function[J].Physiological Reviews,2002,82(1):47-95.
[26]KONG L,WANG S,WU X,et al.Paeoniflorin attenuates ultraviolet B-induced apoptosis in human keratinocytes by inhibiting the ROS-p38-p53 pathway[J].Molecular Medicine Reports,2016,13(4):3553-3558.
[27]OHTANI N,ZEBEDEE Z,HUOT T J,et al.Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence[J].Nature,2001,409(6823):1067-1070.
[28]欧芹,王雅丽,魏晓东,等.山茱萸多糖对HDF细胞β-半乳糖苷酶及p16表达的影响[J].中国老年学,2007,27(4):325-327.
[29]KUWANA T,MACKEY M R,PERKINS G,et al.Bid,Bax,and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane[J].Cell,2002,111(3):331-342.
[30]姚媛媛.皮肤老化小鼠皮肤衰老的发病机制及核桃仁水提物的治疗作用[D].合肥:安徽大学,2012.