白癜风胶囊联合卤米松乳膏治疗白癜风患者免疫功能相关指标分析
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摘要
目的探讨白癜风患者白癜风胶囊联合卤米松乳膏治疗前后血清干扰素-γ(IFN-γ)、白介素-17(IL-17)、粒细胞-巨噬细胞集落刺激因子(GM-CSF)的水平变化。方法采用双抗夹心酶联免疫吸附法(ELISA)和放射免疫法测定110例白癜风患者治疗前后血清IFN-γ、IL-17、GM-CSF水平,并与65例健康体检者进行比较。结果白癜风组血清IFN-γ、IL-17、GM-CSF水平显著高于对照组(P <0. 05),进展期患者显著高于稳定期患者(P <0. 05),白斑面积≥5%患者显著高于白斑面积<5%患者(P <0. 05)。白癜风患者治疗后上述指标均显著降低(P <0. 05)。白癜风患者血清IFN-γ、IL-17、GM-CSF水平具有显著相关性(P <0. 05)。结论白癜风患者血清IFN-γ、IL-17、GM-CSF与病情密切相关。
Objective To explore the changes of serum interferon-γ(IFN-γ),interleukin-17(IL-17) and granulocyte macrophage-colony stimulating factor(GM-CSF) levels before and after treatment in patients with vitiligo treated by Vitiligo Capsule and Halometasone Ointment. Methods The levels of serum IFN-γ,IL-17 and GM-CSF before and after treatment in 110 patients with vitiligo were measured by double-antibody sandwich enzyme-linked immunosorbent assay(ELISA) and radioimmunoassay,and the results were compared with 65 healthy people. Results Serum IFN-γ,IL-17,GM-CSF levels were significantly higher in vitiligo group than control group(P < 0. 05),in advanced patients than stable patients(P < 0. 05),and in patients with leukoplakia area ≥5% than those with leukoplakia area < 5%(P < 0. 05). After treatment,the above indexes significantly decreased in vitiligo group(P < 0. 05). There were significant correlations among IFN-γ,IL-17 and GM-CSF in vitiligo group(P < 0. 05). Conclusion In patients with vitiligo,the serum levelsof IFN-γ,IL-17 and GM-CSF are closely related with the condition of disease.
Objective To explore the changes of serum interferon-γ(IFN-γ),interleukin-17(IL-17) and granulocyte macrophage-colony stimulating factor(GM-CSF) levels before and after treatment in patients with vitiligo treated by Vitiligo Capsule and Halometasone Ointment. Methods The levels of serum IFN-γ,IL-17 and GM-CSF before and after treatment in 110 patients with vitiligo were measured by double-antibody sandwich enzyme-linked immunosorbent assay(ELISA) and radioimmunoassay,and the results were compared with 65 healthy people. Results Serum IFN-γ,IL-17,GM-CSF levels were significantly higher in vitiligo group than control group(P < 0. 05),in advanced patients than stable patients(P < 0. 05),and in patients with leukoplakia area ≥5% than those with leukoplakia area < 5%(P < 0. 05). After treatment,the above indexes significantly decreased in vitiligo group(P < 0. 05). There were significant correlations among IFN-γ,IL-17 and GM-CSF in vitiligo group(P < 0. 05). Conclusion In patients with vitiligo,the serum levelsof IFN-γ,IL-17 and GM-CSF are closely related with the condition of disease.
引文
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[9]尚智伟,冯海瑕,崔利莎,等.他克莫司联合308 nm准分子激光治疗白癜风的效果及作用机制[J].山东医药,2016,56(21):90-91.
[10]刘哲,曲生明,巫毅,等.白癜风的免疫学发病机制及吡美莫司治疗白癜风的研究进展[J].中国老年学杂志,2017,37(10):2588-2592.
[11]司鹤南,钟淑霞,周俊峰,等. 271例儿童白癜风患者的临床特点及危险因素分析[J].吉林大学学报:医学版,2017,43(1):147-150.
[12]王华清.黑素细胞自噬与老年白癜风患者临床类型的关系[J].中国老年学杂志,2017,37(23):5912-5914.
[13]孔珍珍,陆江涛,刘春保,等.中西医结合治疗白癜风疗效的Meta分析[J].中国现代医学杂志,2017,27(7):121-124.
[14]黄骏,林福全,洪为松,等.白癜风黑素细胞移植供皮区同形反应严重程度与疗效的关系[J].中华皮肤科杂志,2017,50(10):751-753.
[15]宋贾玲,周萍,杨璐,等.白癜风患者微量元素及细胞因子水平观察[J].重庆医学,2017,46(9):1191-1192,1195.
[16]甄昱,李珊山.进展期非节段型白癜风患者外周血CD4+T细胞亚群分析[J].中华皮肤科杂志,2018,51(1):39-42.
[17]何振晶.疏肝活血法联合窄谱中波紫外光治疗气滞血瘀型白癜风的疗效观察[J].中国现代医学杂志,2017,27(29):66-70.
[18]胡文婷,黄骏,许爱娥,等.不同治疗方法对晕痣疗效的影响因素分析[J].中华皮肤科杂志,2018,51(2):121-125.
[19]商干伟,周敏,孙菊,等.供皮区308nm准分子光照射后自体表皮移植治疗白癜风的效果评价[J].实用临床医药杂志,2016,20(21):128-129.
[20]丁敏,张建中,杜鹃.进展期白癜风患者治疗后血清中s ICAM-1、IFN-γ的变化[J].中国中西医结合皮肤性病学杂志,2016,15(1):34-36.
[2]王丽莉. NB-UVB治疗对寻常型白癜风患者外周血IL-17、IL-22和Fox P3的影响[J].医学临床研究,2017,34(2):397-399.
[3]中国中西医结合学会皮肤性病专业委员会色素病学组.白癜风临床分型及疗效标准(2003年修定稿)[J].中国中西医结合皮肤性病学杂志,2004,3(1):65.
[4]田军,周进科,李强.白癜风免疫发病机制研究新进展[J].医学综述,2016,22(18):3541-3545.
[5]张倩,坚哲,刘玲,等.白癜风细胞免疫学发病机制研究进展[J].中国麻风皮肤病杂志,2018,34(1):50-52.
[6]雷勇,王晶晶,张少光.中西医结合治疗对白癜风的临床疗效和血清炎性因子的影响[J].世界中医药,2016,11(6):1016-1019.
[7]王文影,毕桂姣,朱辉,等.卡泊三醇对白癜风患者血清和皮肤组织中IL-18及IFN-γ水平的影响[J].现代生物医学进展,2016,16(6):1150-1152,1130.
[8]蒋丽,盛国荣,赵婧.退白颗粒联合NB-UVB对白癜风患者T细胞亚群及GM-CSF的调节作用[J].中国皮肤性病学杂志,2016,30(7):744-747.
[9]尚智伟,冯海瑕,崔利莎,等.他克莫司联合308 nm准分子激光治疗白癜风的效果及作用机制[J].山东医药,2016,56(21):90-91.
[10]刘哲,曲生明,巫毅,等.白癜风的免疫学发病机制及吡美莫司治疗白癜风的研究进展[J].中国老年学杂志,2017,37(10):2588-2592.
[11]司鹤南,钟淑霞,周俊峰,等. 271例儿童白癜风患者的临床特点及危险因素分析[J].吉林大学学报:医学版,2017,43(1):147-150.
[12]王华清.黑素细胞自噬与老年白癜风患者临床类型的关系[J].中国老年学杂志,2017,37(23):5912-5914.
[13]孔珍珍,陆江涛,刘春保,等.中西医结合治疗白癜风疗效的Meta分析[J].中国现代医学杂志,2017,27(7):121-124.
[14]黄骏,林福全,洪为松,等.白癜风黑素细胞移植供皮区同形反应严重程度与疗效的关系[J].中华皮肤科杂志,2017,50(10):751-753.
[15]宋贾玲,周萍,杨璐,等.白癜风患者微量元素及细胞因子水平观察[J].重庆医学,2017,46(9):1191-1192,1195.
[16]甄昱,李珊山.进展期非节段型白癜风患者外周血CD4+T细胞亚群分析[J].中华皮肤科杂志,2018,51(1):39-42.
[17]何振晶.疏肝活血法联合窄谱中波紫外光治疗气滞血瘀型白癜风的疗效观察[J].中国现代医学杂志,2017,27(29):66-70.
[18]胡文婷,黄骏,许爱娥,等.不同治疗方法对晕痣疗效的影响因素分析[J].中华皮肤科杂志,2018,51(2):121-125.
[19]商干伟,周敏,孙菊,等.供皮区308nm准分子光照射后自体表皮移植治疗白癜风的效果评价[J].实用临床医药杂志,2016,20(21):128-129.
[20]丁敏,张建中,杜鹃.进展期白癜风患者治疗后血清中s ICAM-1、IFN-γ的变化[J].中国中西医结合皮肤性病学杂志,2016,15(1):34-36.