温阳通络方、针灸联合西药治疗糖尿病周围神经病变疗效及对糖代谢的影响
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摘要
目的:观察糖尿病周围神经病变(Diabetic Peripherat Heuropathy,DPN)经温阳通络方、针灸联合西药治疗前后实验室相关指标及糖代谢变化情况及临床疗效。方法:将2015年10月-2017年10月我社区服务中心诊治50例DPN(均经影像学检查和生化检验后确诊)患者依据治疗方案分为两组[对照组(25例)和中医组(25例)],两组均采取西药常规治疗(未抗氧化等相关药物),后者同时口服温阳通络方和针灸治疗,疗程为3个月,检测并观察临床指标变化,统计治疗效果,并记录不良反应。结果:疗效比较:中医组总有效率高于对照组(P <0.05),且治疗过程中无明显不良反应;血生化指标:空腹血糖、餐后两小时血糖及糖化血红蛋白经治疗后,两组三项指标均较治疗前改善(P <0.05),且中医组优于对照组(P <0.05);临床症状指标:运动神经、感觉神经传导速度经治疗后,两组两项指标均较治疗前改善(P <0.05),且中医组优于对照组(P <0.05)。结论:温阳通络方、针灸联合西药治疗DPN明显较单纯西药效果更佳,不仅能改善SCV、MCV等相关症状,且利于糖代谢改善。
Objective: To observe the changes of laboratory indicators and clinical efficacy on DPN patients. 50 patients were divided into the control group and the TCM group according to the treatment plan. Both groups were treated with western medicine. The TCM group was given the Wenyang Tongluo prescription and acupuncture more. The clinical indicators(SCV, MCV, GLU, 2 h PG and HbA1 c)changes, effects, and adverse reactions were recorded. Results: The total effective rate in the TCM group was higher(P<0.05), and there was no obvious adverse reaction. The GLU, 2 h PG and HbA1 c in 2 groups were improved after treatment(P<0.05), and those in the TCM group was superior(P<0.05). The SCV and MCV were better after treatment(P<0.05), and those in the TCM group was better(P<0.05).Conclusion: The Wenyang Tongluo prescription, acupuncture plus western medicine is more effective than western medicine on DPN. It can not only improve SCV, MCV and other related symptoms, but also improve glucose metabolism.
Objective: To observe the changes of laboratory indicators and clinical efficacy on DPN patients. 50 patients were divided into the control group and the TCM group according to the treatment plan. Both groups were treated with western medicine. The TCM group was given the Wenyang Tongluo prescription and acupuncture more. The clinical indicators(SCV, MCV, GLU, 2 h PG and HbA1 c)changes, effects, and adverse reactions were recorded. Results: The total effective rate in the TCM group was higher(P<0.05), and there was no obvious adverse reaction. The GLU, 2 h PG and HbA1 c in 2 groups were improved after treatment(P<0.05), and those in the TCM group was superior(P<0.05). The SCV and MCV were better after treatment(P<0.05), and those in the TCM group was better(P<0.05).Conclusion: The Wenyang Tongluo prescription, acupuncture plus western medicine is more effective than western medicine on DPN. It can not only improve SCV, MCV and other related symptoms, but also improve glucose metabolism.
引文
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[3]桂伟,胡霞,唐宏图,等.中西医结合治疗糖尿病周围神经病变的临床研究[J].辽宁中医杂志,2016,43(01):101-103.
[4]方朝晖,吴以岭,赵进东.糖尿病周围神经病变中医临床诊疗指南(2016年版)[J].中医杂志,2017,58(07):625-630.
[5]刘瑶霞,陈树,周晋,等.糖尿病患者周围神经病变早期筛查的临床意义及危险因素分析[J].中国糖尿病杂志,2016,24(06):536-539.
[6]崔家玉,纪立伟,陈哲,等.糖尿病周围神经病变治疗药物使用合理性评价[J].中国新药杂志,2017,26(08):960-964.
[7]李光善,黄达,李鸣镝,等.温阳活血通痹方对糖尿病性周围神经病变阳虚寒凝血瘀证神经传导速度及血浆Hcy的影响[J].中医杂志,2016,57(17):1486-1489.