数字化X射线摄影检查对乳腺癌患者的诊断价值及与临床病理关系分析
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摘要
目的:探究数字化X射线摄影(DR)对乳腺癌患者的诊断价值研究及与其临床病理关系分析。方法:回顾性选取在医院就诊的170例乳腺癌患者资料,按照免疫组织化学法结果分为三阴性乳腺癌(TNBC)组(33例)、雌激素受体(ER)阳性组(91例)及人表皮生长因子2(HER2)阳性组(46例)。分析3组患者临床特征、病理特征以及DR特征。结果:3组间相比,TNBC组和HER2阳性组肿块较大,ER阳性组较小,其差异有统计学意义(x~2=9.327,P<0.05);TNBC组患者淋巴结转移率高于ER阳性组和HER2阳性组,其差异有统计学意义(x~2=9.431,P<0.05);ER阳性组患者肿瘤边缘毛刺数多于TNBC组和HER2组,其差异有统计学意义(x~2=4.272,P<0.05);HER2阳性组和ER阳性组患者肿瘤内部微钙化灶数高于TNBC组,其差异有统计学意义(x~2=44.332,P<0.05)。结论:采用DR检查能够为乳腺癌的早期诊断提供有效证据。
Objective: To investigate the diagnostic value of DR examination for patients with breast cancer and an analysis on relationship between it and clinical pathology. Methods: 170 patients with breast cancer were prospectively selected and were divided into triple negative breast cancer group(TNBC) group(33 cases), estrogen receptor(ER) positive group(91 cases) and human epidermal growth factor receptor 2(HER2) positive group(46 cases) according to the results of immunohistochemical method. The clinical features, pathological features and DR features of the patients of three groups were further analyzed. Results: The lumps of TNBC group and HER2 positive group were larger and one of ER positive group was smaller, and the differences among three groups were significant(x~2=9.327, P<0.05). The lymph node metastasis rate in patients of TNBC group was significantly higher than that of ER positive group and HER2 positive group(x~2=9.431, P<0.05). The number of tumor marginal burrs in patients of ER positive group was significantly higher than that of TNBC group and HER2 group(x~2=4.272, P<0.05). The number of patients with microcalcifications inside the tumor of HER2 positive group and ER positive group were significantly higher than that of TNBC group(x~2=44.332, P<0.05). Conclusion: DR examination can provide effective evidence for early diagnosis of breast cancer.
Objective: To investigate the diagnostic value of DR examination for patients with breast cancer and an analysis on relationship between it and clinical pathology. Methods: 170 patients with breast cancer were prospectively selected and were divided into triple negative breast cancer group(TNBC) group(33 cases), estrogen receptor(ER) positive group(91 cases) and human epidermal growth factor receptor 2(HER2) positive group(46 cases) according to the results of immunohistochemical method. The clinical features, pathological features and DR features of the patients of three groups were further analyzed. Results: The lumps of TNBC group and HER2 positive group were larger and one of ER positive group was smaller, and the differences among three groups were significant(x~2=9.327, P<0.05). The lymph node metastasis rate in patients of TNBC group was significantly higher than that of ER positive group and HER2 positive group(x~2=9.431, P<0.05). The number of tumor marginal burrs in patients of ER positive group was significantly higher than that of TNBC group and HER2 group(x~2=4.272, P<0.05). The number of patients with microcalcifications inside the tumor of HER2 positive group and ER positive group were significantly higher than that of TNBC group(x~2=44.332, P<0.05). Conclusion: DR examination can provide effective evidence for early diagnosis of breast cancer.
引文
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[14]吕涛,吕晓玉,汪湍,等.超声与钼靶摄片对乳腺癌早期诊断的意义[J].中国普通外科杂志,2013,22(11):1414-1419.
[2]Ganz PA.Understanding the impact of breast cancer adjuvant endocrine therapy on cognitive function:a work in progress[J].Br J Cancer,2016,114(9):953-955.
[3]Mackenzie A,Warren LM,Wallis MG,et al.Breast cancer detection rates using four different types of mammography detectors[J].Eur Radiol,2016,26(3):874-883.
[4]Park MM,Ebel JJ,Zhao W,et al.ER and PRimmunohistochemistry and HER2 FISH versus oncotype DX:implications for breast cancer treatment[J].Breast J,2014,20(1):37-45.
[5]Dodd GD.Present status of thermography,ultrasound and mammography in breast cancer detection[J].Cancer,2015,39(6):2796-2805.
[6]李大强,王刚,杨超,等.超声与MRI联合检查对乳腺癌的临床价值分析[J].医学影像学杂志,2016,26(9):1744-1747.
[7]Bickelhaupt S,Laun FB,Tesdorff J,et al.Fast and noninvasive characterization of suspicious lesions detected at breast cancer x-ray screening:capability of diffusionweighted mr imaging with mips[J].Radiology,2016,278(3):689-697.
[8]杨彩仙,李建民,赵宏光.钙化性乳腺癌数字化X线特征与分子生物学指标表达的相关性研究[J].肿瘤研究与临床,2016,28(8):543-545.
[9]牟广华,吕鹏威,薛宝军,等.三阴性与非三阴性乳腺癌临床特征、治疗方案及预后的对比分析[J].实用肿瘤杂志,2018,33(3):234-237.
[10]徐乐,何琳,陈涛,等.乳腺癌超声图像特征与ER、PR、CerbB-2的相关性研究[J].第三军医大学学报,2016,38(2):182-186.
[11]万静,吴蓉,姚明华,等.乳腺癌免疫组化亚型的超声、临床和病理分析[J].影像诊断与介入放射学,2016,25(3):210-214.
[12]《中国肿瘤临床》编辑部.乳腺癌微钙化灶的研究新进展[J].中国肿瘤临床,2016,43(6):239-239.
[13]韦彩琴,江丽莎.乳腺钼靶、彩超联合MRI检查在乳腺癌早期诊断中的应用价值[J].中国当代医药,2017,24(30):70-72.
[14]吕涛,吕晓玉,汪湍,等.超声与钼靶摄片对乳腺癌早期诊断的意义[J].中国普通外科杂志,2013,22(11):1414-1419.