生命信息安全控制体系整体结构性构建与分析
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摘要
在前期生命信息安全控制原理探讨的基础上,基于整体论的思考,旨在构思能表述生命信息安全控制体系实质内涵的几何图形。所作图呈圆台形,自上而下依次为2大部分(内在部分和外延部分),5个层次(特异性识别系统、泛特异性识别系统、皮肤黏膜、共生微生物及外环境开放接触面)。在圆台形生命信息安全控制体系中,圆台形的中心轴为生命信息安全控制轴;特异性识别系统、泛特异性识别系统、皮肤、黏膜和共生微生物组成内在部分;外延部分即外环境开放接触面;内在部分各部间以及与外延部分之间存在物质、能量、信息交流沟通传递的空间界面。特异性识别系统建立在泛特异性识别系统基础上,置于最顶端,寓意着生物进化高级发展的一种客观结局,泛特异性识别系统与特异性识别系统作为一个整体和共生微生物层次联系,其中安插皮肤、黏膜组织层次,符合宏生物与微生物之间存在的完全不可分割的相关关系客观事实。共生微生物层次举足轻重,所占份额最大,主导整个体系的稳定性,成为整个体系的基座。就上述5个层次及其相互关系的解析归纳,证明构建的圆台形几何图能真实客观反映出生命信息安全控制体系各层次之间完全不可分割、相互依存影响的关系。
Based on the previous theory of life information security control and the idea of holism, we intended to construct a geometric figure that can express the real connotation of the life information security control system. The figure is a circular truncated cone figure with two main parts(the inner and extension part) and five levels(specific recognition system, pan-specific recognition system, skin and mucous membranes, symbiotic microbes, and external environment open contact surface). The circular truncated cone figure is completely in compliance with the actual relationship between various levels. The central axis of the truncated cone is the life information security control axis, which contains the specific recognition system, pan-specific recognition system, skin and mucous membranes, and symbiotic microbes, while the extension is the environment open contact surface. Space interface exists between the inner part and the external environment, where material, energy, and information can exchange. The specific recognition system is constructed based on the pan-specific recognition system and located on the top position of the specific recognition system, which implies an objective outcome of the advanced development of biological evolution. As a whole, the specific recognition system and the pan-specific recognition system interact with symbiotic microbes through skin and mucous membranes, which is in accord with the truth that organisms can not be segmented from microorganisms.By nature, symbiotic microbes account for the biggest share among all the 5 levels, play an important role in the stability of the entire system, and are the base of this system. We used subjective specific regulation to symbolize abstractive information to reach the essence. Results indicate that the circular truncated cone figure can truly reflect the inseparable and interdependent interaction of the levels in life information security control system.
Based on the previous theory of life information security control and the idea of holism, we intended to construct a geometric figure that can express the real connotation of the life information security control system. The figure is a circular truncated cone figure with two main parts(the inner and extension part) and five levels(specific recognition system, pan-specific recognition system, skin and mucous membranes, symbiotic microbes, and external environment open contact surface). The circular truncated cone figure is completely in compliance with the actual relationship between various levels. The central axis of the truncated cone is the life information security control axis, which contains the specific recognition system, pan-specific recognition system, skin and mucous membranes, and symbiotic microbes, while the extension is the environment open contact surface. Space interface exists between the inner part and the external environment, where material, energy, and information can exchange. The specific recognition system is constructed based on the pan-specific recognition system and located on the top position of the specific recognition system, which implies an objective outcome of the advanced development of biological evolution. As a whole, the specific recognition system and the pan-specific recognition system interact with symbiotic microbes through skin and mucous membranes, which is in accord with the truth that organisms can not be segmented from microorganisms.By nature, symbiotic microbes account for the biggest share among all the 5 levels, play an important role in the stability of the entire system, and are the base of this system. We used subjective specific regulation to symbolize abstractive information to reach the essence. Results indicate that the circular truncated cone figure can truly reflect the inseparable and interdependent interaction of the levels in life information security control system.
引文
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[15]王涛,胡旭,吴晓丽.肠道共生微生物与免疫[J].中国微生态学杂志,2015,27(8):980-986. DOI: 10.13381/j.cnki.cjm.201508032. WANG Tao,HU Xu,WU Xiaoli. Gut microbiota and immunity[J]. Chinese Journal of Microecology,2015,27(8):980-986. DOI: 10.13381/j.cnki.cjm.201508032.
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[18]名倉宏,小野克彦,川内秀之,等. 医学の あゆみ[M].東京都:医歯薬出版株式会社,2001.
[19]祁珊珊,郑红星.动物肠道黏膜免疫系统研究进展[J].黑龙江畜牧兽医(科技版),2014,7:46-49. DOI:10.13881/j.cnki.hljxmsy.2014.0550. QI Shanshan,ZHENG Hongxing. Research progress on intestinal mucosal immune system in animals[J].Heilongjiang Animal Science and Veterinary Medicine,2014,7:46-49. DOI:10.13881/j.cnki.hljxmsy.2014.0550.
[20]范骏.肠道黏膜免疫[J].国际免疫学杂志,2006,29(2):111-115. FAN Jun. Intestinal mucosal immunity[J].International Journal of Immunology,2006,29 (2):111-115.
[21]赵雪,张辉,刘禹.分泌型IgA对肠道黏膜免疫的研究进展[J].中国畜牧兽医,2013,40(6):96-99. ZHAO Xue,ZHANG Hui,LIU Yu. Research advances on secretory IgA roles in intestinal mucosal immunity[J]. China Animal Husbandry & Veterinary Medicine,2013,40(6):96-99.
[22]胡艳艳,刘小伟. 肠道杯状细胞结构和功能的研究进展[J].国防病理科学与临床杂志,2013,33(5):424-430. DOI:10.3969/j.issn.1673-2588.2013.05.013. HU Yanyan,LIU Xiaowei. Research advance in structure and function of intestinal goblet cell[J]. Journal of Pathology and Clinical Medicine in National Defense,2013,33(5):424-430. DOI:10.3969/j.issn.1673-2588.2013.05.013.
[23]高明,敖越,栾新红.Toll样受体信号转导的负调控机制研究进展[J].动物医学进展,2015,36(1):99-101. DOI:10.16437/j.cnki.1007-5038.2015.01.023. GAO Ming,AO Yue,LUAN Xinhong. Progress on negative regulatory mechanism of Toll-like receptor signal transduction[J]. Progress in Veterinary Medicine,2015,36(1):99-101. DOI:10.16437/j.cnki.1007-5038.2015.01.023.
[24]郑松,高兴华.皮肤的免疫功能[J].实用医院临床杂志,2015,12(2):3-7. ZHENG Song,GAO Xinghua. Skin immune sentinels in health and disease[J]. Journal of Practical Hospital Clinical,2015,12(2):3-7.
[25]张长琳.看不见的彩虹:人体的耗散结构[M].杭州:浙江科学技术出版社,2013. ZHANG Changlin.An invisible rainbow: the dissipative structure of the human body[M]. Hangzhou:Zhejiang Science and Technology Press,2013.
[26]羅廣英. 破解東方神秘主義《道德經》真注 [M].中国香港:東方出版社,2014. LUO Guangying. Cracking oriental mysticism: a true annotation of the Tao Te Chin[M]. China Hongkong: Hongkong Oriental Publishing House,2014.
[2]宋德平,谌南辉.生命信息安全控制原理的再探讨[J].生物信息学,2016,14(50):49-55. DOI: 10.3969/J.ISSN.1672-5565.2016.01.09. SONG Deping, CHEN Nanhui. Re-discussion on the life information security control theory [J]. Chinese Journal of Bioinformatics, 2016, 14 (1): 49-55. DOI:10.3969/J.ISSN.1672-5565.2016.01.09.
[3]谌南辉,宋德平.生命机体危险因子信息特征分析[J].生物信息学,2017, 15 (2): 69-77. DOI:10.3969/j.issn.1672-5565. 20160907001. CHEN Nanhui, SONG Deping. Analyses on the information characteristics of risk factors in living organisms[J]. Chinese Journal of Bioinformatics, 2017, 15 (2): 69-77. DOI:10. 3969 /j. issn. 1672-5565. 20160907001 .
[4]吴克复.免疫的细胞社会生态学原理[M].北京:科学出版社,2012. WU Kefu. The theory of social ecology of immune cells [M]. Beijing:Science Press,2012.
[5]庞广昌.食品免疫论 [M].北京:科学出版社,2008. PANG Guangchang. The theory of food immunity[M]. Beijing:Science Press,2008.
[6]李方舟,胡海峰. 人cathelicidin抗菌肽LL-37在宿主防御系统中的作用[J]. 世界临床药物,2011,32(4):243-246. LI Fangzhou, HU Haifeng. Function of LL-37 in the host defense system[J]. World Clinical Drugs,2011,32(4):243-246.
[7]赵亚华,徐来祥,黄蓬亮. 人类防御素的结构与功能研究进展[J]. 中国比较医学杂志,2006,16(7):436-441. DOI:10.3969/j.issn.1671-7856.2006.07.015. ZHAO Yahua,XU Laixiang,HUANG Pengliang. Function progress and structure of human defensin[J]. Chinese Journal of Comparative Medicine,2006,16(7):436-441. DOI:10.3969/j.issn.1671-7856.2006.07.015.
[8]周光炎. 免疫学原理(第三版)[M]. 北京:科学出版社,2013. ZHOU Guangyan. Principles of immunology (Third edition)[M]. Beijing: Science Press,2013.
[9]舒红兵. 抗病毒天然免疫[M].北京:科学出版社,2009. SHU Hongbing. Antiviral natural immunity[M]. Beijing: Science Press, 2009.
[10]孙东明,井丽娟,尹建英. 脂多糖结合蛋白与脂多糖受体的研究进展[J]. 国外医学儿科学分册,2003,30(5):245-247. SUN Dongming,JING Lijiuan,YIN Jianying. Research progress on lipopolysaccharide binding protein and lipopolysaccharide receptor[J]. Foreign Medical Pediatrics Section,2003,30(5):245-247.
[11]曹雪涛. 免疫学前沿进展第3版[M].北京:人民出版社,2014. CAO Xuetao. Advances in immunology (Third edition) [M]. Beijing: People’s Health Publishing House, 2014.
[12]徐明,郭宁.甘露糖受体在免疫调节中的作用[J].细胞与分子免疫学杂志,2002,18(6):673-675. DOI: 10.13423/j.cnki.cjcmi.002617. XU Ming,GUO Ning. The role of mannose receptor in immune regulation [J]. Chinese Journal of Cellular and Molecular Immunology, 2002,18(6):673-675. DOI: 10.13423/j.cnki.cjcmi.002617.
[13]彭海英,朱家勇.杀菌/通透性增加蛋白的研究现状及展望[J]. 医学综述,2006,12(1):1-3. PENG Haiying,ZHU Jiayong. Present status and prospect of the research on bactericidal permeability increasing protein[J]. Medical Recapitulate,2006,12(1):1-3.
[14]肖晶,李晓莉,童亮,等. 杀菌/通透性增加蛋白研究进展[J].中国畜牧兽医,2009,38(11):41-43. DOI: 10.3969/j.issn.1006-2084.2006.01.001. XIAO Jing, LI Xiaoli, TONG Liang, et al. Study progress in bactericidal/permeability increasing protein[J]. Chinese Journal of Animal Husbandry and Veterinary Medicine,2009,38(11):41-43. DOI: 10.3969/j.issn.1006-2084.2006.01.001.
[15]王涛,胡旭,吴晓丽.肠道共生微生物与免疫[J].中国微生态学杂志,2015,27(8):980-986. DOI: 10.13381/j.cnki.cjm.201508032. WANG Tao,HU Xu,WU Xiaoli. Gut microbiota and immunity[J]. Chinese Journal of Microecology,2015,27(8):980-986. DOI: 10.13381/j.cnki.cjm.201508032.
[16]王自强. 实验动物学[M]. 兰州:甘肃民族出版社,1993. WANG Ziqiang.Laboratory zoology[M]. Lan zhou:Gansu Nationalities Publishing House,1993.
[17]TYING S K.黏膜免疫学与病毒学[M]. 国泰,王军志,等译.北京:科学出版社,2013. TYING S K. Mucosal immunology and virology [M]. GUO Tai,WANG Junzhi,et al. trans. Beijing: Science Press, 2013.
[18]名倉宏,小野克彦,川内秀之,等. 医学の あゆみ[M].東京都:医歯薬出版株式会社,2001.
[19]祁珊珊,郑红星.动物肠道黏膜免疫系统研究进展[J].黑龙江畜牧兽医(科技版),2014,7:46-49. DOI:10.13881/j.cnki.hljxmsy.2014.0550. QI Shanshan,ZHENG Hongxing. Research progress on intestinal mucosal immune system in animals[J].Heilongjiang Animal Science and Veterinary Medicine,2014,7:46-49. DOI:10.13881/j.cnki.hljxmsy.2014.0550.
[20]范骏.肠道黏膜免疫[J].国际免疫学杂志,2006,29(2):111-115. FAN Jun. Intestinal mucosal immunity[J].International Journal of Immunology,2006,29 (2):111-115.
[21]赵雪,张辉,刘禹.分泌型IgA对肠道黏膜免疫的研究进展[J].中国畜牧兽医,2013,40(6):96-99. ZHAO Xue,ZHANG Hui,LIU Yu. Research advances on secretory IgA roles in intestinal mucosal immunity[J]. China Animal Husbandry & Veterinary Medicine,2013,40(6):96-99.
[22]胡艳艳,刘小伟. 肠道杯状细胞结构和功能的研究进展[J].国防病理科学与临床杂志,2013,33(5):424-430. DOI:10.3969/j.issn.1673-2588.2013.05.013. HU Yanyan,LIU Xiaowei. Research advance in structure and function of intestinal goblet cell[J]. Journal of Pathology and Clinical Medicine in National Defense,2013,33(5):424-430. DOI:10.3969/j.issn.1673-2588.2013.05.013.
[23]高明,敖越,栾新红.Toll样受体信号转导的负调控机制研究进展[J].动物医学进展,2015,36(1):99-101. DOI:10.16437/j.cnki.1007-5038.2015.01.023. GAO Ming,AO Yue,LUAN Xinhong. Progress on negative regulatory mechanism of Toll-like receptor signal transduction[J]. Progress in Veterinary Medicine,2015,36(1):99-101. DOI:10.16437/j.cnki.1007-5038.2015.01.023.
[24]郑松,高兴华.皮肤的免疫功能[J].实用医院临床杂志,2015,12(2):3-7. ZHENG Song,GAO Xinghua. Skin immune sentinels in health and disease[J]. Journal of Practical Hospital Clinical,2015,12(2):3-7.
[25]张长琳.看不见的彩虹:人体的耗散结构[M].杭州:浙江科学技术出版社,2013. ZHANG Changlin.An invisible rainbow: the dissipative structure of the human body[M]. Hangzhou:Zhejiang Science and Technology Press,2013.
[26]羅廣英. 破解東方神秘主義《道德經》真注 [M].中国香港:東方出版社,2014. LUO Guangying. Cracking oriental mysticism: a true annotation of the Tao Te Chin[M]. China Hongkong: Hongkong Oriental Publishing House,2014.