千金胶囊联合金刚藤胶囊治疗慢性盆腔炎的临床效果观察
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摘要
目的:分析千金胶囊联合金刚藤胶囊治疗慢性盆腔炎的临床效果。方法:选取2015年3月至2016年5月河北省保定市第二医院收治的慢性盆腔炎患者96例,随机分为对照组与观察组,每组48例。其中对对照组患者给予千金胶囊口服,观察组在对照组治疗基础上联合金刚藤胶囊口服,比较2组患者的治疗总有效率、各项临床症状消失时间、血清细胞因子变化情况、不良反应情况等。结果:经过临床治疗后,观察组与对照组的治疗总有效率分别为95.83%与79.17%,差异有统计学意义(P<0.05);观察组患者盆腔肿块消失时间、腹痛缓解时间、白带恢复正常时间、下腹坠胀缓解时间比较对照组均明显较短,差异有统计学意义(P<0.05);治疗前2组患者的血清细胞因子检测水平无明显差异,差异无统计学意义(P>0.05),治疗后观察组患者检测水平比较对照组明显较优,差异有统计学意义(P<0.05),2组患者治疗后均未出现较为明显的不良反应现象。结论:对慢性盆腔炎患者采取千金胶囊联合金刚藤胶囊进行治疗的疗效显著,可明显改善患者腹痛、下腹坠胀等临床症状,改善血清细胞因子水平,药物安全性高,值得在今后的临床工作中实践推广。
Objective: To analyze the clinical effects of Qianjin Capsule combined with Jingang Capsule in the treatment of chronic pelvic inflammation disease. Methods: A total of 96 cases of chronic pelvic inflammatory disease who were treated in Baoding Second Hospital from March 2015 to May 2016 were selected and divided into the normal group and the experimental group,with 48 cases in each group. Patients in the conventional group were given Qianjin capsule orally,and the experimental group was added with Jingang Capsule orally. The total effective rate,the clinical symptoms disappeared time,the change of the serum levels of cytokines,adverse reactions,etc. of 2 groups were compared. Results: After clinical treatment,the total effective rates of experimental group and normal group were 95. 83% and 79. 17% respectively( P < 0. 05). The pelvic lumps disappear time,abdominal pain relief time,the time of leucorrhea returning to normal,time of belly bulge relief of experimental group were significantly shorter compared with the normal group( P < 0. 05); The serum cytokine levels in patients of 2 groups before treatment had no significant difference( P > 0. 05). After treatment,the levels of experimental group were significantly better than the normal group( P <0. 05). No evident adverse reactions occurred in both groups after treatment. Conclusion: Qianjin Capsule combined with Jingang Capsule in treating patients with chronic pelvic inflammatory disease had significant clinical efficacy,can significantly improve the patients clinical symptoms such as abdominal pain,distention and bulge,improve the serum levels of cytokines,with high drug safety,which is worthy of promotion in the future clinical work practice.
Objective: To analyze the clinical effects of Qianjin Capsule combined with Jingang Capsule in the treatment of chronic pelvic inflammation disease. Methods: A total of 96 cases of chronic pelvic inflammatory disease who were treated in Baoding Second Hospital from March 2015 to May 2016 were selected and divided into the normal group and the experimental group,with 48 cases in each group. Patients in the conventional group were given Qianjin capsule orally,and the experimental group was added with Jingang Capsule orally. The total effective rate,the clinical symptoms disappeared time,the change of the serum levels of cytokines,adverse reactions,etc. of 2 groups were compared. Results: After clinical treatment,the total effective rates of experimental group and normal group were 95. 83% and 79. 17% respectively( P < 0. 05). The pelvic lumps disappear time,abdominal pain relief time,the time of leucorrhea returning to normal,time of belly bulge relief of experimental group were significantly shorter compared with the normal group( P < 0. 05); The serum cytokine levels in patients of 2 groups before treatment had no significant difference( P > 0. 05). After treatment,the levels of experimental group were significantly better than the normal group( P <0. 05). No evident adverse reactions occurred in both groups after treatment. Conclusion: Qianjin Capsule combined with Jingang Capsule in treating patients with chronic pelvic inflammatory disease had significant clinical efficacy,can significantly improve the patients clinical symptoms such as abdominal pain,distention and bulge,improve the serum levels of cytokines,with high drug safety,which is worthy of promotion in the future clinical work practice.
引文
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[4]朱慧芳,陈素芳,彭海平,等.中药灌肠联合阿奇霉素治疗慢性盆腔炎临床疗效分析[J].亚太传统医药,2015,11(3):135-136.
[5]衡丽娜,柴淑慧,索世云,等.中药康盆汤灌肠联合微波热疗治疗慢性盆腔炎临床疗效观察[J].河北医学,2016,22(6):1017-1019.
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[11]张晓颖.金刚藤胶囊治疗湿热瘀结型盆腔炎、附件炎的临床观察[J].中国现代药物应用,2016,10(10):159-160.
[12]杨晓庆.乳酸左氧氟沙星联合金刚藤胶囊治疗盆腔炎的临床疗效观察[J].医药前沿,2016,6(6):126-127.
[13]张晓慧.金刚藤胶囊治疗湿热瘀结型盆腔炎、附件炎的临床疗效[J].医药前沿,2016,6(2):322-323.
[14]杨晓辉.金刚藤胶囊治疗慢性盆腔炎临床研究[J].河南中医,2014,34(5):886-887.
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[16]苏筱俐.金刚藤胶囊配伍康妇消炎栓治疗盆腔炎性包块80例临床疗效观察[J].亚太传统医药,2014,10(7):118-119.
[17]Corr TE,Sullivan J,Frazer LC,et al.Steroids Alone or as Adjunctive Therapy with Doxycycline Fail To Improve Oviduct Damage in Mice Infected with Chlamydia muridarum[J].Clinical and vaccine immunology CVI,2014,21(6):824-830.
[18]胡琳.金刚藤胶囊治疗湿热瘀结型盆腔炎、附件炎的临床疗效和安全性分析[J].内蒙古中医药,2016,35(2):26-27.
[19]王秀华.金刚藤胶囊治疗慢性盆腔炎患者的临床研究[J].中外医疗,2015,34(32):131-132.
[20]陈爱珠.金刚藤胶囊配伍康妇消炎栓治疗盆腔炎性包块的效果观察[J].福建医药杂志,2014,36(6):109-111.
[21]曹俊娟.联用康妇消炎栓和金刚藤胶囊治疗慢性盆腔炎的效果分析[J].当代医药论丛,2016,14(11):95-96.
[22]彭淼.金刚藤胶囊联合抗生素治疗慢性盆腔炎的临床疗效观察[J].湖北中医杂志,2016,38(8):47-48.
[23]何瑰玉.金刚藤软胶囊和金刚藤糖浆两种剂型治疗慢性盆腔炎疗效对比观察[J].亚太传统医药,2014,10(12):118-119.
[24]Parker RM,Bell A,Currie MJ,et al.Catching chlamydia:combining cash incentives and community pharmacy access for increased chlamydia screening,the view of young people[J].Australian journal of primary health,2015,21(1):79-83.
[25]赵保荣.金刚藤胶囊联合抗生素治疗慢性盆腔炎的临床疗效[J].海峡药学,2012,24(11):90-91.
[26]李海英.金刚藤胶囊联合西药治疗慢性盆腔炎随机平行对照研究[J].实用中医内科杂志,2014,11(4):89-91.
[27]左玲.金刚藤胶囊联合抗生素治疗慢性盆腔炎的疗效分析[J].吉林医学,2015,36(14):3131.
[28]孙雅平.抗宫炎软胶囊联合金刚藤颗粒应用于治疗慢性盆腔炎疗效观察[J].新中医,2014,46(6):133-134.
[29]卢葱茏.抗生素联合妇科千金胶囊治疗50例慢性盆腔炎的临床效果观察[J].中国伤残医学,2016,24(7):83-84.
[30]吴君兰,吴建华,贾雪梅.抗生素联合妇科千金软胶囊治疗盆腔炎的效果分析[J].中国当代医药,2014,21(20):115-116.
[31]康喜梅.妇科千金胶囊联合金刚藤胶囊治疗盆腔炎的效果分析[J].中国卫生标准管理,2013(19):17-18.
[32]王红梅.金刚藤胶囊联合康妇消炎栓治疗慢性盆腔炎的临床疗效分析[J].海峡药学,2013,25(4):58-59.
[33]吴艳红.盆腔炎应用妇科千金胶囊联合金刚藤胶囊治疗的疗效观察[J].生物技术世界,2014(11):132.
[34]邬芳.妇科千金胶囊与金刚藤胶囊联合治疗盆腔炎的效果研究[J].中国保健营养(旬刊),2013(12):7320.
[35]黄兰.金刚藤胶囊治疗慢性盆腔炎90例疗效观察[J].临床医学研究与实践,2017,2(7):115-116.
[36]李海霞.金刚藤软胶囊联合常规抗菌药物治疗慢性盆腔炎35例[J].中国药业,2015,24(12):88-89.
[37]屈云芳.妇科千金胶囊联合抗生素治疗60例慢性盆腔炎的临床疗效[J].医疗装备,2016,29(5):146-147.
[38]郑守辉,李华,郑海霞.妇科千金胶囊联合康妇消炎栓治疗慢性盆腔炎效果观察[J].中国卫生产业,2013(2):165.
[2]张军会,王永辉,周文静,等.中医辨治慢性盆腔炎经验[J].河北中医,2015,37(3):429-430.
[3]赵莹.补肾疏肝法治疗慢性盆腔炎临床疗效观察[J].亚太传统医药,2015,11(1):84-85.
[4]朱慧芳,陈素芳,彭海平,等.中药灌肠联合阿奇霉素治疗慢性盆腔炎临床疗效分析[J].亚太传统医药,2015,11(3):135-136.
[5]衡丽娜,柴淑慧,索世云,等.中药康盆汤灌肠联合微波热疗治疗慢性盆腔炎临床疗效观察[J].河北医学,2016,22(6):1017-1019.
[6]Choe HS,Lee SJ,Han CH,et al.Clinical efficacy of roxithromycin in men with chronic prostatitis/chronic pelvic pain syndrome in comparison with ciprofloxacin and aceclofenac:A prospective,randomized,multicenter pilot trial[J].Journal of infection and chemotherapy:fficial journal of the Japan Society of Chemotherapy,2014,20(1):20-25.
[7]柴淑慧,沈静,于亚波,等.针灸与穴注相结合治疗慢性盆腔炎临床疗效观察[J].河北医学,2016,22(5):839-840.
[8]鞠秀丽.康妇炎胶囊联合丹红注射液治疗慢性盆腔炎的疗效及对患者炎症因子水平的影响[J].医学临床研究,2016,33(4):647-649.
[9]崔美英.金刚藤胶囊治疗湿热瘀结型盆腔炎、附件炎的临床疗效和安全性分析[J].中国现代医生,2014,52(28):97-99.
[10]Neziri AY,Bersinger NA,Andersen OK,et al.Correlation between altered central pain processing and concentration of peritoneal fluid inflammatory cytokines in endometriosis patients with chronic pelvic pain[J].Regional anesthesia and pain medicine,2014,39(3):181-184.
[11]张晓颖.金刚藤胶囊治疗湿热瘀结型盆腔炎、附件炎的临床观察[J].中国现代药物应用,2016,10(10):159-160.
[12]杨晓庆.乳酸左氧氟沙星联合金刚藤胶囊治疗盆腔炎的临床疗效观察[J].医药前沿,2016,6(6):126-127.
[13]张晓慧.金刚藤胶囊治疗湿热瘀结型盆腔炎、附件炎的临床疗效[J].医药前沿,2016,6(2):322-323.
[14]杨晓辉.金刚藤胶囊治疗慢性盆腔炎临床研究[J].河南中医,2014,34(5):886-887.
[15]Mccallum CA,Oman KS,Makic MB.Improving the assessment and treatment of pelvic inflammatory disease among adolescents in an urban children's hospital emergency department[J].Journal of emergency nursing,2014,40(6):579-585.
[16]苏筱俐.金刚藤胶囊配伍康妇消炎栓治疗盆腔炎性包块80例临床疗效观察[J].亚太传统医药,2014,10(7):118-119.
[17]Corr TE,Sullivan J,Frazer LC,et al.Steroids Alone or as Adjunctive Therapy with Doxycycline Fail To Improve Oviduct Damage in Mice Infected with Chlamydia muridarum[J].Clinical and vaccine immunology CVI,2014,21(6):824-830.
[18]胡琳.金刚藤胶囊治疗湿热瘀结型盆腔炎、附件炎的临床疗效和安全性分析[J].内蒙古中医药,2016,35(2):26-27.
[19]王秀华.金刚藤胶囊治疗慢性盆腔炎患者的临床研究[J].中外医疗,2015,34(32):131-132.
[20]陈爱珠.金刚藤胶囊配伍康妇消炎栓治疗盆腔炎性包块的效果观察[J].福建医药杂志,2014,36(6):109-111.
[21]曹俊娟.联用康妇消炎栓和金刚藤胶囊治疗慢性盆腔炎的效果分析[J].当代医药论丛,2016,14(11):95-96.
[22]彭淼.金刚藤胶囊联合抗生素治疗慢性盆腔炎的临床疗效观察[J].湖北中医杂志,2016,38(8):47-48.
[23]何瑰玉.金刚藤软胶囊和金刚藤糖浆两种剂型治疗慢性盆腔炎疗效对比观察[J].亚太传统医药,2014,10(12):118-119.
[24]Parker RM,Bell A,Currie MJ,et al.Catching chlamydia:combining cash incentives and community pharmacy access for increased chlamydia screening,the view of young people[J].Australian journal of primary health,2015,21(1):79-83.
[25]赵保荣.金刚藤胶囊联合抗生素治疗慢性盆腔炎的临床疗效[J].海峡药学,2012,24(11):90-91.
[26]李海英.金刚藤胶囊联合西药治疗慢性盆腔炎随机平行对照研究[J].实用中医内科杂志,2014,11(4):89-91.
[27]左玲.金刚藤胶囊联合抗生素治疗慢性盆腔炎的疗效分析[J].吉林医学,2015,36(14):3131.
[28]孙雅平.抗宫炎软胶囊联合金刚藤颗粒应用于治疗慢性盆腔炎疗效观察[J].新中医,2014,46(6):133-134.
[29]卢葱茏.抗生素联合妇科千金胶囊治疗50例慢性盆腔炎的临床效果观察[J].中国伤残医学,2016,24(7):83-84.
[30]吴君兰,吴建华,贾雪梅.抗生素联合妇科千金软胶囊治疗盆腔炎的效果分析[J].中国当代医药,2014,21(20):115-116.
[31]康喜梅.妇科千金胶囊联合金刚藤胶囊治疗盆腔炎的效果分析[J].中国卫生标准管理,2013(19):17-18.
[32]王红梅.金刚藤胶囊联合康妇消炎栓治疗慢性盆腔炎的临床疗效分析[J].海峡药学,2013,25(4):58-59.
[33]吴艳红.盆腔炎应用妇科千金胶囊联合金刚藤胶囊治疗的疗效观察[J].生物技术世界,2014(11):132.
[34]邬芳.妇科千金胶囊与金刚藤胶囊联合治疗盆腔炎的效果研究[J].中国保健营养(旬刊),2013(12):7320.
[35]黄兰.金刚藤胶囊治疗慢性盆腔炎90例疗效观察[J].临床医学研究与实践,2017,2(7):115-116.
[36]李海霞.金刚藤软胶囊联合常规抗菌药物治疗慢性盆腔炎35例[J].中国药业,2015,24(12):88-89.
[37]屈云芳.妇科千金胶囊联合抗生素治疗60例慢性盆腔炎的临床疗效[J].医疗装备,2016,29(5):146-147.
[38]郑守辉,李华,郑海霞.妇科千金胶囊联合康妇消炎栓治疗慢性盆腔炎效果观察[J].中国卫生产业,2013(2):165.