玻璃酸钠联合中药外敷治疗膝关节骨性关节炎的临床研究
摘要
目的探讨玻璃酸钠关节腔注射联合中药外敷在膝关节骨性关节炎(knee osteoarthritis,KOA)治疗中的临床疗效。方法 2016年9月～2017年12月,门诊共收集68例单侧膝骨性关节炎患者随机分为对照组和治疗组,对照组33例行单纯玻璃酸钠膝关节腔内注射治疗,治疗组35例行玻璃酸钠联合中药外敷治疗,根据治疗前、治疗后及治疗后6个月VAS疼痛评分,膝关节功能HSS评分及临床治愈率对比评估两组治疗效果。结果治疗组和对照组VAS评分、膝关节功能HSS评分治疗后及治疗后6个月与治疗前比较差异均显著(P <0. 05)。治疗后6个月治疗组VAS评分及HSS评分改善程度与对照组比较差异均显著(P <0. 05),治疗后治疗组临床有效率96. 2%,对照组92. 5%,两组有效率具有显著性差异(P <0. 05)。结论运用中药外敷配合膝关节腔内注射玻璃酸钠治疗膝关节骨性关节炎,具有中西医结合疗效优势,临床效果满意,能更好改善早期症状及巩固远期疗效。
引文
[1]蒋泰媛,刘伟军,邹波,等.中药湿热敷联合玻璃酸钠、臭氧治疗膝关节骨性关节炎效果评价[J].亚太传统医药,2016,12(12):110-111.
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[2]黄斌.中西医结合治疗老年膝关节骨性关节炎价值分析[J].中医临床研究,2016,8(20):86-87.
[3]武纪玲,石瑞芳,王想福等.解毒消瘀膏联合玻璃酸钠治疗膝关节骨性关节炎疗效观察与护理[J].中国临床研究,2015,28(1):116-118.
[4]黄坚汉,蒙诗景,孟林,等.关节镜下清理术联合中西医治疗膝关节骨性关节炎的临床研究[J].微创医学,2016,11(3):371-374.
[5]廖烨纯.中西医结合治疗膝关节骨性关节炎36例[J].中医外治杂志,2015,24(1):18-19.
[6]孙维强.膝关节骨性关节炎中西医治疗概况[J].中国民族民间医药,2017,26(1):38-40.
[7]高志.膝关节骨关节炎经中西医不同疗法的对比研究[J].世界中医药,2017,12(8):1767-1770.
[8]赵朝清,焦丽,马凯,等.臭氧结合中西医治疗膝骨性关节炎的临床研究[J].光明中医,2016,31(20):2996-2997.
[9]杨明.膝关节炎的中西医治疗疗效分析[J].中国保健营养,2018,28(30):358.
[10]吴俊杰.改良海桐皮汤熏洗联合玻璃酸钠关节腔注射治疗早中期的膝关节骨性关节炎的临床研究[D].南京:南京中医药大学,2016.
[11]Mantripragada VP,Bova WA,Boehm C,etal.Primary Cells Isolated from Human Knee Cartilage Reveal Decreased Prevalence of Progenitor Cells but Comparable Biological Potential During Osteoarthritic Disease Progression[J].J Bone Joint Surg Am.2018;100(20):1771-1780.
[12]Lamplot JD,Bansal A,Nguyen JT,etal.Risk of Subsequent Joint Arthroplasty in Contralateral or Different Joint After Index Shoulder,Hip,or Knee Arthroplasty:Association with Index Joint,Demographics,and Patient-Specific Factors[J].J Bone Joint Surg Am.2018;100(20):1750-1756.
[13]Gay C,Guiguet-Auclair C,Pereira B,etal.Efficacy of self-management exercise program with spa therapy for behavioral management of knee osteoarthritis:research protocol for a quasi-randomized controlled trial(GEETone)[J].BMC Complement Altern Med.2018;18(1):279.
[14]Draper DO,Klyve D,Ortiz R,etal.Effect of low-intensity long-duration ultrasound on the symptomatic relief of knee osteoarthritis:a randomized,placebo-controlled double-blind study[J].J Orthop Surg Res,2018,13(1):257.
[15]Kim D,Park G,Kuo LT,etal.The effects of pain on quadriceps strength,joint proprioception and dynamic balance among women aged 65 to 75 years with knee osteoarthritis[J].BMC Geriatr,2018,18(1):245.