不同CT成像方法对脑内胶质瘤的边界确定效果比较
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摘要
目的分析不同CT成像方法在脑胶质瘤边界确定中的差异性。方法分析2012年6月~2016年12月于我院就诊的43例脑胶质瘤患者的CT灌注与普通增强CT的数据资料,根据所获得的图像分别勾勒并测量脑胶质瘤面积,比较两种成像方法所获得的病灶截面面积。结果术前胶质瘤患者CT灌注成像中胶质瘤勾勒的面积为(11.63±2.25)cm~2,明显大于常规增强CT中胶质瘤勾勒的面积(10.06±2.13)cm~2,差异具有统计学意义(P<0.05);术后残留或复发患者中CT灌注成像中胶质瘤勾勒的面积为(11.14±2.12)cm~2,明显大于常规增强CT中胶质瘤勾勒的面积(9.78±2.03)cm~2,差异具有统计学意义(P<0.05)。结论 CT灌注成像所确定的肿瘤范围更能反映出胶质瘤的浸润范围,有助于指导胶质瘤的治疗,值得在临床上推广。
Objective To analyze the difference of different CT imaging methods in the determination of brain glioma boundary. Methods The data of CT perfusion and generally enhanced CT in 43 patients with brain glioma who were admitted to our hospital from June 2012 to December 2016 were analyzed. According to the obtained images, the brain glioma area was outlined and measured. The obtained lesion cross-sectional area was compared between the two imaging methods. Results The outlined area of glioma in CT perfusion imaging was(11.63±2.25) cm~2 in preoperative glioma patients, significantly higher than that of(10.06±2.13) cm~2 in conventional enhanced CT, the difference was statistically significant(P<0.05); the outlined area of glioma in CT perfusion imaging was(11.14±2.12) cm~2 in postoperative residual or relapsed patients, significantly higher than that of(9.78±2.03) cm~2 in the conventional enhanced CT, the difference was statistically significant(P<0.05). Conclusion The range of tumor determined by CT perfusion imaging can reflect the infiltration range of glioma, and it can help to guide the treatment of glioma, which is worthy to be popularized in clinical practice.
Objective To analyze the difference of different CT imaging methods in the determination of brain glioma boundary. Methods The data of CT perfusion and generally enhanced CT in 43 patients with brain glioma who were admitted to our hospital from June 2012 to December 2016 were analyzed. According to the obtained images, the brain glioma area was outlined and measured. The obtained lesion cross-sectional area was compared between the two imaging methods. Results The outlined area of glioma in CT perfusion imaging was(11.63±2.25) cm~2 in preoperative glioma patients, significantly higher than that of(10.06±2.13) cm~2 in conventional enhanced CT, the difference was statistically significant(P<0.05); the outlined area of glioma in CT perfusion imaging was(11.14±2.12) cm~2 in postoperative residual or relapsed patients, significantly higher than that of(9.78±2.03) cm~2 in the conventional enhanced CT, the difference was statistically significant(P<0.05). Conclusion The range of tumor determined by CT perfusion imaging can reflect the infiltration range of glioma, and it can help to guide the treatment of glioma, which is worthy to be popularized in clinical practice.
引文
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[16]卢庆刚,牟安娜,朱礼.不同放疗法对脑胶质瘤的疗效比较[J].航空航天医学杂志,2015,26(9):1067-1069.
[17]韩松.CT灌注成像技术在脑胶质瘤术前分级诊断中的价值分析[J].中国现代药物应用,2017,11(4):34-36.
[18]向清国,郭鹏,陈林.CT灌注成像在脑胶质瘤手术中的应用价值分析[J].当代医学,2015,21(16):91-92.
[19]苏杭,梁新强,宾静文,等.全脑灌注在脑胶质瘤边界区分中的应用价值[J].中国实用神经疾病杂志,2016,19(13):1-2.
[20]杜成利,梁新强,梁亮,等.128层CT全脑灌注成像在脑胶质瘤术前分级中的应用价值研究[J].广西医学,2015,37(1):31-33.
[21]付伟,朱玉芳,王贵生,等.CT灌注成像与普通增强CT成像对胶质瘤边界确定的对比分析[J].中国煤炭工业医学杂志,2015,18(11):1785-1788.
[2]Jain R,Griffith B,Alotaibi F,et al.Glioma angiogenesis and perfusion imaging:Understanding the relationship between tumor blood volume and leakiness with increasing glioma grade[J].AJNR Am J Neuroradiol,2015,36(11):2030-2035.
[3]于慧芳.脑胶质瘤应用CT灌注成像的诊断价值观察[J].中国实用医药,2014,9(34):130-131.
[4]申旭东,沈桂权,高波.脑胶质瘤浸润程度的扩散张量成像研究进展[J].磁共振成像,2015,6(3):221-224.
[5]刘刚,崔国胜,孙宝山,等.多层螺旋CT灌注成像在脑胶质瘤病理分级中的应用[J].中外医学研究,2016,14(6):61-62.
[6]胡粟,王希明,郝光宇,等.基于组织相似度图谱的MR灌注成像评价脑胶质瘤的价值探讨[J].临床放射学杂志,2016,35(3):320-322.
[7]Lu N,Di Y,Feng XY,et al.CT perfusion with acetazolamide challenge in C6 gliomas and angiogenesis[J].PLo S One.2015,10(3):e0121631.
[8]兰华.多层螺旋CT灌注成像在脑胶质瘤中的应用价值[J].中国实用神经疾病杂志,2014,17(11):55-57.
[9]洪建斌,许乃滔,侯志雄.多层螺旋CT灌注成像在脑胶质瘤分级中的价值与微血管密度的相关性研究[J].检验医学与临床,2014,11(9):1169-1170.
[10]陆娜,冯晓源,邸悦,等.CT灌注成像评价人脑胶质瘤肿瘤血管生成[J].中国医学计算机成像杂志,2014,20(6):481-484.
[11]周开甲,张鸣,刘伯伟,等.利用光学投影无接触性、简易、快速定位颅内病变、重要血管及功能区的临床研究[J].现代肿瘤医学,2017,25(14):2231-2233.
[12]何永跃,陈礼刚.胶质瘤免疫治疗与血脑屏障[J].国际神经病学神经外科学杂志,2017,44(1):68-70.
[13]段天鹏,尹建军.全脑CT灌注成像诊断邻近大血管颅内肿瘤[J].现代肿瘤医学,2017,25(3):456-458.
[14]李玲玲.多层螺旋CT灌注成像在脑胶质瘤分级中的临床应用价值[J].当代医学,2014,20(29):17-18.
[15]杜成利,梁新强,刘克勤,等.128层CT灌注成像在脑胶质瘤分级的应用价值[J].中国微侵袭神经外科杂志,2015,20(4):150-151.
[16]卢庆刚,牟安娜,朱礼.不同放疗法对脑胶质瘤的疗效比较[J].航空航天医学杂志,2015,26(9):1067-1069.
[17]韩松.CT灌注成像技术在脑胶质瘤术前分级诊断中的价值分析[J].中国现代药物应用,2017,11(4):34-36.
[18]向清国,郭鹏,陈林.CT灌注成像在脑胶质瘤手术中的应用价值分析[J].当代医学,2015,21(16):91-92.
[19]苏杭,梁新强,宾静文,等.全脑灌注在脑胶质瘤边界区分中的应用价值[J].中国实用神经疾病杂志,2016,19(13):1-2.
[20]杜成利,梁新强,梁亮,等.128层CT全脑灌注成像在脑胶质瘤术前分级中的应用价值研究[J].广西医学,2015,37(1):31-33.
[21]付伟,朱玉芳,王贵生,等.CT灌注成像与普通增强CT成像对胶质瘤边界确定的对比分析[J].中国煤炭工业医学杂志,2015,18(11):1785-1788.