梅州地区川崎病临床特征分析
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摘要
目的探讨梅州地区川崎病(KD)的临床特征,为治疗及预后评估提供依据。方法选取梅州市人民医院2015年1月—2018年12月收治的206例KD住院患儿,对其临床特点进行回顾性分析。结果 206例KD患儿中典型KD 120例,不完全KD 86例,男135例,女71例,男女比例1.9∶1,平均年龄为2.13岁。实验室检查中红细胞沉降率升高,CRP升高发生率分别为97.3%和83.5%,204例进行丙种球蛋白治疗,有36例存在冠脉损伤。结论本组80%以上的川崎病患儿红细胞沉降率及CRP升高,提示红细胞沉降率及CRP可作为KD尤其是不完全性KD的参考指标;KD发病10 d内用丙种球蛋白效果好。
Objective To investigate the clinical characteristics of Kawasaki disease(KD)in Meizhou area,and to provide evidence for its treatment and prognosis. Methods 206 cases of KD hospitalized children in Meizhou People's Hospital from January 2015 to December 2018 were selected and their clinical characteristics were retrospectively analyzed and summarized. Results Typical KD 120 cases,incomplete KD 86 cases,male 135 cases,female 71 cases,male to female ratio:1.9∶1,average age is 2.13 years old. The incidence of elevated erythrocyte sedimentation rate(ESR)and CRP was 97.3% and 83.5% respectively in laboratory examinations. 204 cases were treated with gamma globulin and 36 cases had coronary artery injury. Conclusion More than 80% of children with Kawasaki disease have elevated erythrocyte sedimentation rate and CRP,suggesting that erythrocyte sedimentation rate and CRP can be used as a reference index for KD,especially incomplete KD. The effect of gamma globulin was good within 10 days after KD onset.
Objective To investigate the clinical characteristics of Kawasaki disease(KD)in Meizhou area,and to provide evidence for its treatment and prognosis. Methods 206 cases of KD hospitalized children in Meizhou People's Hospital from January 2015 to December 2018 were selected and their clinical characteristics were retrospectively analyzed and summarized. Results Typical KD 120 cases,incomplete KD 86 cases,male 135 cases,female 71 cases,male to female ratio:1.9∶1,average age is 2.13 years old. The incidence of elevated erythrocyte sedimentation rate(ESR)and CRP was 97.3% and 83.5% respectively in laboratory examinations. 204 cases were treated with gamma globulin and 36 cases had coronary artery injury. Conclusion More than 80% of children with Kawasaki disease have elevated erythrocyte sedimentation rate and CRP,suggesting that erythrocyte sedimentation rate and CRP can be used as a reference index for KD,especially incomplete KD. The effect of gamma globulin was good within 10 days after KD onset.
引文
[1]SELAMET TIERNEY E S,GAL D,GAUVREAU K,et al.Vascular health in Kawasaki disease[J].Jam Coll Cardiol,2013,62(12):1114-1121.
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[3]NEWBURGER J W,TAKAHASHI M,GERBER M A,et al.Diagnosis treatment,and long-term management of Kawasaki disease:a statement for health professionals from the committee on Rheumatic Fever.Endocarditis and Kawasaki Disease,Council on Cardiovascular Disease in the Young.American Heart Association[J].Pediatrics,2004,114(6):1708-1733.
[4]郑琳,杜忠东,金兰中,等.超声心动图评价儿童冠状动脉内径正常参考值范围及其临床意义[J].中华儿科杂志,2013,51(5):371-376.
[5]YAHATA T,SUZUKI C,YOSHIOKA A,et al.Platelet activation dynamics evaluated using platelet-derived microparticles in Kawasaki disease[J].Circulation journal,2014,78(1):188-193..
[6]张永兰,杜忠东,赵地,等.2000-2004年北京川崎病住院患儿流行病学调查[J].实用儿科临床杂志,2007,22(1):12-15.
[7]张晓梅,张宇,张圳,等.吉林省1999-2008年小儿川崎病流行病学调查[J].实用儿科临床杂志,2010,25(1):28-30.
[8]NAKAMURA Y,YASHIRO M,UEHARA R,et al.Epidemiologic features of Kawasaki disease in Japan:Results of the 2007-2008nationwide survey[J].J Epidemiol,2010,20(4):302-307.
[9]LI J J,WU Y J,QIN X W.Shold slow coronary flow be considered as a coronary syndrome[J].Med Hypotheses,2006,66(5):953.
[10]张澎.现代儿科学[M].北京:人民军医出版社,1998:575-576.
[2]DAJANI A S,TAUBERT K A,GERBER M A,et al.Diagnosis and therapy of Kawasaki disease in children[J].Circulation,1993(87):1776-1780.
[3]NEWBURGER J W,TAKAHASHI M,GERBER M A,et al.Diagnosis treatment,and long-term management of Kawasaki disease:a statement for health professionals from the committee on Rheumatic Fever.Endocarditis and Kawasaki Disease,Council on Cardiovascular Disease in the Young.American Heart Association[J].Pediatrics,2004,114(6):1708-1733.
[4]郑琳,杜忠东,金兰中,等.超声心动图评价儿童冠状动脉内径正常参考值范围及其临床意义[J].中华儿科杂志,2013,51(5):371-376.
[5]YAHATA T,SUZUKI C,YOSHIOKA A,et al.Platelet activation dynamics evaluated using platelet-derived microparticles in Kawasaki disease[J].Circulation journal,2014,78(1):188-193..
[6]张永兰,杜忠东,赵地,等.2000-2004年北京川崎病住院患儿流行病学调查[J].实用儿科临床杂志,2007,22(1):12-15.
[7]张晓梅,张宇,张圳,等.吉林省1999-2008年小儿川崎病流行病学调查[J].实用儿科临床杂志,2010,25(1):28-30.
[8]NAKAMURA Y,YASHIRO M,UEHARA R,et al.Epidemiologic features of Kawasaki disease in Japan:Results of the 2007-2008nationwide survey[J].J Epidemiol,2010,20(4):302-307.
[9]LI J J,WU Y J,QIN X W.Shold slow coronary flow be considered as a coronary syndrome[J].Med Hypotheses,2006,66(5):953.
[10]张澎.现代儿科学[M].北京:人民军医出版社,1998:575-576.