中药调节免疫细胞治疗支气管哮喘机制研究进展
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摘要
综述中药调节免疫细胞治疗支气管哮喘机制研究进展。支气管哮喘主要以慢性气道炎症为特征,发病机制涉及多种免疫细胞(嗜酸性粒细胞、嗜中性粒细胞、辅助性T细胞、肥大细胞、树突状细胞、先天淋巴细胞等)以及相应的细胞因子。平喘方、射干麻黄重楼汤等中药复方及黄芪甲苷、黄芪多糖等中药提取物可通过调节免疫细胞缓解支气管哮喘的气道炎症与气道重塑状态。
This paper reviews the research progress on the mechanism of traditional Chinese medicine regulating immune cells in the treatment of bronchial asthma. Bronchial asthma is mainly characterized by chronic airway inflammation, and its pathogenesis involves a variety of immune cells(eosinophils, neutrophils, helper T cells, mast cells, dendritic cells and innate lymphocytes, etc.) and corresponding cytokines. Compound Chinese traditional medicine(Pingchuan Formula and Shegan Mahuang Chonglou Decoction etc.) and Chinese medicine extract(astragaloside and astragalus polysaccharide etc.) relieve airway inflammation and airway remodeling state in bronchial asthma by regulating immune cells.
This paper reviews the research progress on the mechanism of traditional Chinese medicine regulating immune cells in the treatment of bronchial asthma. Bronchial asthma is mainly characterized by chronic airway inflammation, and its pathogenesis involves a variety of immune cells(eosinophils, neutrophils, helper T cells, mast cells, dendritic cells and innate lymphocytes, etc.) and corresponding cytokines. Compound Chinese traditional medicine(Pingchuan Formula and Shegan Mahuang Chonglou Decoction etc.) and Chinese medicine extract(astragaloside and astragalus polysaccharide etc.) relieve airway inflammation and airway remodeling state in bronchial asthma by regulating immune cells.
引文
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[21] 何飞,徐俭朴,杨明华,等.芍药甘草汤对哮喘大鼠Treg/Th17比例失衡的影响[J].中华中医药杂志,2016,31(11):4477- 4479.
[22] 张业清,苏克雷,庞中化,等.宣肺平喘方对哮喘小鼠气道炎症及Th17/Treg平衡的影响[J].中国实验方剂学杂志,2016,22(6):119- 123.
[23] LU Y,CAI S,NIE J,et al.The natural compound nujiangexanthone A suppresses mast cell activation and allergic asthma[J].Biochem Pharmacol,2016,100(1):61- 72.
[24] DONG K J,KIM D K,SOON K H,et al.Morus bombycis extract suppresses mast cell activation and IgE- mediated allergic reaction in mice[J].J Ethnopharmacol,2013,146(1):287- 293.
[25] 尹航,马淑骅,任映,等哮喘宁颗粒含药血清对致敏肥大细胞脱颗粒的作用[J].中国实验方剂学杂志,2013,19(3):257- 260.
[26] QIAN C,CAO X.Dendritic cells in the regulation of immunity and inflammation[J].Semin Immunol,2018,35(2):3- 11.
[27] LIN C L,HSIAO G,WANG C C,et al.Imperatorin exerts antiallergic effects in Th2- mediated allergic asthma via induction of IL- 10- producing regulatory T cells by modulating the function of dendritic cells[J].Pharmacol Res,2016,110(8):111- 121.
[28] 刘亚尊,虞坚尔,薛征,等平喘方及拆方对哮喘模型小鼠pDC/cDC免疫失衡的影响[J].中华中医药杂志,2018,33(6):2349- 2352.
[29] HURRELL BP, SHAFIEI JAHANI P, AKBARI O.Social Networking of Group Two Innate Lymphoid Cells in Allergy and Asthma[J].Front Immunol,2018(9):2694.
[30] PENG G,LIU Z,WANG Y,et al.Da cheng qi decoction ameliorates allergic lung inflammation in mice via influencing the interaction between intestinal microbiota and ILC2[J].Pathophysiology,2018,25(3):237.
[31] LEE Y G,JEONG J J,NYENHUIS S,et al.Recruited Alveolar Macrophages,in Response to Airway Epithelial–Derived Monocyte Chemoattractant Protein 1/CCL2,Regulate Airway Inflammation and Remodeling in Allergic Asthma[J].Am J Resp Cell Mol,2015,52(6):772- 784.
[32] SONG Y,WU Y,LI X,et al.Protostemonine attenuates alternatively activated macrophage and DRA- induced asthmatic inflammation[J].Biochem Pharmacol,2018,155(9):198- 206.
[33] LIU C,YANG N,SONG Y,et al.Ganoderic acid C1 isolated from the anti- asthma formula,ASHMI? suppresses TNF- α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients[J].Int Immunopharmacol,2015,27(2):224- 231.
[34] KAO S T,WANG S D,LIN C C,et al.Jin Gui Shen Qi Wan,a Traditional Chinese Medicine,Alleviated Allergic Airway Hypersensitivity and Inflammatory Cell Infiltration in a Chronic Asthma Mouse Model[J].J Ethnopharmacol ,2018,227(12):181- 190.
[35] SHERGIS J L,WU L,ZHANG A L,et al.Herbal medicine for adults with asthma:a systematic review[J].J Asthma,2016,53(6):650- 659.
[36] ZHANG H P,WANG L,WANG Z,et al.Chinese herbal medicine formula for acute asthma:A multi- center,randomized,double- blind,proof- of- concept trial[J].Respir Med,2018,140(7):42- 49.
[2] BUENO S B,ROSALEN P L,ALENCAR S M,et al.Anti- inflammatory mechanisms of neovestitol from Brazilian red propolis in LPS- activated macrophages[J].J Funct Foods,2017,36(7):440- 447.
[3] DUVALL M G,BARNIG C,CERNADAS M,et al.Natural killer cell- mediated inflammation resolution is disabled in severe asthma[J].Sci Immunol,2017,2(9):eaam5446.
[4] MARCO C,LE P D,DIEGO B,et al.Type 2 immunity in asthma[J].WAO J,2018,11(1):13- 22.
[5] RAY A,RAUNDHAL M,ORISS T B,et al.Current concepts of severe asthma[J].J Clin Invest,2016,126(7):2394- 2403.
[6] 王嵩,郤庆,李国文,等.黄芪甲苷对OVA诱导哮喘小鼠Th细胞亚群的影响[J].上海中医药杂志,2017,51(12):67- 70.
[7] XIONG G H,LIU S Y,GAO J L,et al.Naringin protects ovalbumin- induced airway inflammation in a mouse model of asthma[J].Inflammation,2016,39(2):891- 899.
[8] LEE C C,LEE Y L,WANG C N,et al.Polygonum multiflorum Decreases Airway Allergic Symptoms in a Murine Model of Asthma[J].Am J Chin Med,2016,44(1):133- 147.
[9] XU W,HU M,ZHANG Q,et al.Effects of anthraquinones from Cassia occidentalis L.on ovalbumin- induced airways inflammation in a mouse model of allergic asthma[J].J Ethnopharmacol,2018,221(7):1- 9.
[10] I?IK S,KARAMAN M,MICILI S C,et al.Sinomenine ameliorates the airway remodelling,apoptosis of airway epithelial cells,and Th2 immune response in a murine model of chronic asthma[J].Allergol Immunopathol,2018,46(1):67- 75.
[11] XU L,LI J,ZHANG Y,et al.Regulatory effect of baicalin on the imbalance of Th17/Treg responses in mice with allergic asthma[J].J Ethnopharmacol,2017,208(8):199- 206.
[12] Sunga Y Y,Kimb S H,Yuka H J,et al.Siraitia grosvenorii residual extract attenuates ovalbumin- induced lung inflammation by down- regulating IL- 4,IL- 5,IL- 13,IL- 17,and MUC5AC expression in mice[J/OL].Phytomedicine,[2019- 01- 16].https://doi.org/10.1016/j.phymed.2019.152835.
[13] LU Y,XING Q Q,XU J Y,et al.Astragalus polysaccharide modulates ER stress response in an OVA- LPS induced murine model of severe asthma[J].Int J Biol Macromol,2016,93(Pt A):995- 1006.
[14] JING W,FENGSEN L,NANNAN P,et al.Inhibition of Asthma in OVA Sensitized Mice Model by a Traditional Uygur Herb Nepeta bracteata Benth[J].Evid Based Complement Alternat Med,2016(2016):1- 8.
[15] BUI T T,PIAO C H,SONG C H,et al.Bupleurum chinense extract ameliorates an OVA- induced murine allergic asthma through the reduction of the Th2 and Th17 cytokines production by inactivation of NFκB pathway[J].Biomed Pharmacother,2017,91(7):1085- 1095.
[16] WEI Y,LIU J,ZHANG H,et al.Ligustrazine attenuates inflammation and the associated chemokines and receptors in ovalbumine- induced mouse asthma model[J].Environ Toxicol Phar,2016,46(9):55- 61.
[17] 陆城华,孟凯,徐倍琪,等.蝎蜈胶囊联合川芎平喘合剂对痰瘀互结型发作期支气管哮喘肺功能及细胞因子的影响[J].上海中医药杂志,2018,52(4):62- 65.
[18] 罗登攀,戴凌云,何雪云,等.射干麻黄重楼汤加减对老年过敏性哮喘冬季发作患者血清 Th1/Th2 因子影响的研究[J].新中医,2018,50(9):153- 156.
[19] 邢琼琼,赵霞,杨睿雪,等.固本防哮饮对哮喘缓解期小鼠 T- bet,IFN- γ 和 IL- 2 的影响[J].中华中医药杂志,2018,33(2):517- 520.
[20] CHENG B H,HU T Y,MO L H,et al.Yan- Hou- Qing formula attenuates attenuates allergic airway inflammation via up- regulation of Treg and suppressing Th2 responses in Ovalbumin- inducedasthmatic mice[J].J Ethnopharmacol,2019,231(3):275- 282.
[21] 何飞,徐俭朴,杨明华,等.芍药甘草汤对哮喘大鼠Treg/Th17比例失衡的影响[J].中华中医药杂志,2016,31(11):4477- 4479.
[22] 张业清,苏克雷,庞中化,等.宣肺平喘方对哮喘小鼠气道炎症及Th17/Treg平衡的影响[J].中国实验方剂学杂志,2016,22(6):119- 123.
[23] LU Y,CAI S,NIE J,et al.The natural compound nujiangexanthone A suppresses mast cell activation and allergic asthma[J].Biochem Pharmacol,2016,100(1):61- 72.
[24] DONG K J,KIM D K,SOON K H,et al.Morus bombycis extract suppresses mast cell activation and IgE- mediated allergic reaction in mice[J].J Ethnopharmacol,2013,146(1):287- 293.
[25] 尹航,马淑骅,任映,等哮喘宁颗粒含药血清对致敏肥大细胞脱颗粒的作用[J].中国实验方剂学杂志,2013,19(3):257- 260.
[26] QIAN C,CAO X.Dendritic cells in the regulation of immunity and inflammation[J].Semin Immunol,2018,35(2):3- 11.
[27] LIN C L,HSIAO G,WANG C C,et al.Imperatorin exerts antiallergic effects in Th2- mediated allergic asthma via induction of IL- 10- producing regulatory T cells by modulating the function of dendritic cells[J].Pharmacol Res,2016,110(8):111- 121.
[28] 刘亚尊,虞坚尔,薛征,等平喘方及拆方对哮喘模型小鼠pDC/cDC免疫失衡的影响[J].中华中医药杂志,2018,33(6):2349- 2352.
[29] HURRELL BP, SHAFIEI JAHANI P, AKBARI O.Social Networking of Group Two Innate Lymphoid Cells in Allergy and Asthma[J].Front Immunol,2018(9):2694.
[30] PENG G,LIU Z,WANG Y,et al.Da cheng qi decoction ameliorates allergic lung inflammation in mice via influencing the interaction between intestinal microbiota and ILC2[J].Pathophysiology,2018,25(3):237.
[31] LEE Y G,JEONG J J,NYENHUIS S,et al.Recruited Alveolar Macrophages,in Response to Airway Epithelial–Derived Monocyte Chemoattractant Protein 1/CCL2,Regulate Airway Inflammation and Remodeling in Allergic Asthma[J].Am J Resp Cell Mol,2015,52(6):772- 784.
[32] SONG Y,WU Y,LI X,et al.Protostemonine attenuates alternatively activated macrophage and DRA- induced asthmatic inflammation[J].Biochem Pharmacol,2018,155(9):198- 206.
[33] LIU C,YANG N,SONG Y,et al.Ganoderic acid C1 isolated from the anti- asthma formula,ASHMI? suppresses TNF- α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients[J].Int Immunopharmacol,2015,27(2):224- 231.
[34] KAO S T,WANG S D,LIN C C,et al.Jin Gui Shen Qi Wan,a Traditional Chinese Medicine,Alleviated Allergic Airway Hypersensitivity and Inflammatory Cell Infiltration in a Chronic Asthma Mouse Model[J].J Ethnopharmacol ,2018,227(12):181- 190.
[35] SHERGIS J L,WU L,ZHANG A L,et al.Herbal medicine for adults with asthma:a systematic review[J].J Asthma,2016,53(6):650- 659.
[36] ZHANG H P,WANG L,WANG Z,et al.Chinese herbal medicine formula for acute asthma:A multi- center,randomized,double- blind,proof- of- concept trial[J].Respir Med,2018,140(7):42- 49.