加味四妙汤辅助治疗宫颈HPV感染疗效观察
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摘要
目的:观察加味四妙汤辅助常规疗法治疗宫颈人乳头瘤病毒(HPV)感染的临床疗效。方法:将宫颈HPV感染患者84例采用随机数字表法分为中医组和常规组各42例,2组患者均予重组人干扰素治疗,中医组加用加味四妙汤辅助治疗,3个月经周期为1个疗程,治疗1个疗程后观察2组患者症状积分变化情况及HPV-DNA、HPV转阴率。结果:治疗后中医组患者接触性出血、外阴瘙痒、带下异常、小腹疼痛、腰骶酸痛积分及HPV-DNA病毒载量低于常规组(P<0.05),中医组患者HPV转阴率高于常规组(P<0.05);中医组治愈率为54.8%,高于常规组的31.0%,2组比较差异具有统计学意义(P<0.05)。结论:加味四妙汤辅助治疗宫颈HPV感染能改善患者的临床症状,降低HPV-DNA病毒载量,提高HPV转阴率。
Objective: To observe clinical effects of modified SiMiao decoction as adjunctive therapy(AT) in treating cervical human papillomavirus(HPV) infection. Methods: All 84 patients were allocated into TCM group and the conventional group according to random number table method, 42 cases each group, both groups were treated with recombinant human interferon. The TCM group accepted modified SiMiao decoction as AT. Three menstrual cycles were one course, after treating for one course, HPV-DNA and HPV negative-conversion rates and the changes of symptom scores of both groups were observed. Results: After treating, TCM group was lower than the conventional group in contact bleeding, pruritus vulvae, vaginal discharge diseases, lower abdominal pain, the scores of lumbosacral ache and HPV-DNA virus load(P<0.05), TCM group was higher than the conventional group in HPV negative-conversion rate(P<0.05); the cure rate of TCM group was 54.8%, higher than 31.0% of the conventional group, and the difference showed statistical meaning(P<0.05). Conclusion: Modified SiMiao decoction as AT in treating cervical HPV infection could improve clinical symptoms, lower HPV-DNA virus load and raise HPV negative-conversion rate.
Objective: To observe clinical effects of modified SiMiao decoction as adjunctive therapy(AT) in treating cervical human papillomavirus(HPV) infection. Methods: All 84 patients were allocated into TCM group and the conventional group according to random number table method, 42 cases each group, both groups were treated with recombinant human interferon. The TCM group accepted modified SiMiao decoction as AT. Three menstrual cycles were one course, after treating for one course, HPV-DNA and HPV negative-conversion rates and the changes of symptom scores of both groups were observed. Results: After treating, TCM group was lower than the conventional group in contact bleeding, pruritus vulvae, vaginal discharge diseases, lower abdominal pain, the scores of lumbosacral ache and HPV-DNA virus load(P<0.05), TCM group was higher than the conventional group in HPV negative-conversion rate(P<0.05); the cure rate of TCM group was 54.8%, higher than 31.0% of the conventional group, and the difference showed statistical meaning(P<0.05). Conclusion: Modified SiMiao decoction as AT in treating cervical HPV infection could improve clinical symptoms, lower HPV-DNA virus load and raise HPV negative-conversion rate.
引文
[1]朱怡,吴旭,杨蓉,等.上海市育龄妇女HPV感染情况调查及感染因素分析[J].现代仪器与医疗,2015,21(3):119-120.
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[10]Stevanovic S,Draper LM,Langhan MM,et al.Complete regression of metastatic cervical cancer after treatment with human papillomavirus-targeted tumorinfiltrating T cells[J].J Clin Oncol,2015,33(14):1543-1550.
[11]程锦梅,童燕,陈书辰,等.加味四妙汤在宫颈人乳头瘤病毒感染的临床效果[J].中药药理与临床,2015,26(3):149-150.
[12]Poltorak A,Kurmyshkina O,Volkova T.Stimulator of interferon genes(STING):a"new chapter"in virusassociated cancer research.Lessons from wild-derived mouse models of innate immunity[J].Cytokine Growth Factor Rev,2016,29(6):83-91.
[13]Mora-Garcia ML,Monroy-Garcia A.Immune response in cervical cancer.Strategies for the development of therapeutic vaccines[J].Rev Med Inst Mex Seguro Soc,2015,53(Supple 2):206-211.
[14]Chopjitt P,Pientong C,Bumrungthai S,et al.Activities of E6protein of human papillomavirus 16asian variant on mi R-21 up-regulation and expression of human immune response genes[J].Asian Pac JCancer Prev,2015,16(9):3961-3968.
[15]朱玉丽.加味四妙汤治疗宫颈人乳头瘤病毒感染临床观察[J].亚太传统医药,2015,11(7):109-110.
[2]张宜群,叶利群.宫颈病变中IFN-γ、IL-10的表达与高危型HPV感染的关系及中药清热扶正法对其表达的影响[J].中华中医药学刊,2015,33(9):2180-2184.
[3]熊翡,叶银利,桑晓庆.宫颈高危型人乳头状瘤病毒感染中药配合保妇康治疗效果的临床研究[J].中华医院感染学杂志,2015,25(3):678-680.
[4]周璐,叶利群.中药扶正解毒法治疗宫颈高危型人乳头状病毒感染120例临床观察[J].中国中西医结合杂志,2014,34(3):366-368.
[5]徐又先,袁林,陈静,等.中药二黄散对伴有HPV感染的CIN I患者宫颈局部微环境的影响[J].时珍国医国药,2013,24(10):2318-2320.
[6]岑苏,杨晓慧,王伟行.加味四妙汤治疗宫颈人乳头瘤病毒感染的临床研究[J].中国现代医生,2014,52(9):110-112.
[7]岳明明,葛崇华,洪玉.子宫丸治疗新疆维族妇女HPV亚临床感染宫颈病变患者的临床研究[J].中国妇幼保健,2013,28(26):4391-4393.
[8]刘平,许俐,孙源,等.妊娠期妇女宫颈人乳头瘤病毒感染率及型别分布[J].山东大学学报:医学版,2014,52(4):107-112.
[9]徐又先,袁林,陈静,等.中药二黄散对伴有HPV感染的CINI患者宫颈局部微环境的影响[J].时珍国医国药,2013,24(10):2318-2320.
[10]Stevanovic S,Draper LM,Langhan MM,et al.Complete regression of metastatic cervical cancer after treatment with human papillomavirus-targeted tumorinfiltrating T cells[J].J Clin Oncol,2015,33(14):1543-1550.
[11]程锦梅,童燕,陈书辰,等.加味四妙汤在宫颈人乳头瘤病毒感染的临床效果[J].中药药理与临床,2015,26(3):149-150.
[12]Poltorak A,Kurmyshkina O,Volkova T.Stimulator of interferon genes(STING):a"new chapter"in virusassociated cancer research.Lessons from wild-derived mouse models of innate immunity[J].Cytokine Growth Factor Rev,2016,29(6):83-91.
[13]Mora-Garcia ML,Monroy-Garcia A.Immune response in cervical cancer.Strategies for the development of therapeutic vaccines[J].Rev Med Inst Mex Seguro Soc,2015,53(Supple 2):206-211.
[14]Chopjitt P,Pientong C,Bumrungthai S,et al.Activities of E6protein of human papillomavirus 16asian variant on mi R-21 up-regulation and expression of human immune response genes[J].Asian Pac JCancer Prev,2015,16(9):3961-3968.
[15]朱玉丽.加味四妙汤治疗宫颈人乳头瘤病毒感染临床观察[J].亚太传统医药,2015,11(7):109-110.