基于数据挖掘的中药复方保健食品功能评价研究
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摘要
"药食同源"是中医药的重要内容,也是指导中药复方保健食品研制的基础。历代本草中的上品、补品、养生方与药膳等,是中药复方保健品的理论宝库。国家"健康中国2030"的实施,我国大健康产业面临巨大机遇。开发一批具有中医药特点的中药复方保健食品,符合国家及社会需求。国内对于中药保健食品研究多集中在功能成分提取、制剂成型工艺、质量标准、功效评价等,但在中药保健食品的中医药理论与功能关联特点、功效评价及安全性评价规范、新产品研发评价体系和研发平台方面存在不足。该文基于实验室前期大量研究,提出的性效关联观点,基于建立的中药功能-药理-临床应用数据库系统、中药配伍数据库系统、中药性味现代研究数据库系统等,及中医药动物模型评价平台,建立中药复方保健食品功效研究、安全性评价、新产品研发评价体系和研发平台,为开发及评价中药复方保健食品提供了基础,阐释中药复方保健食品核心功效的现代科学内涵,有助于促进中药复方保健品的研发,在大健康中发挥重要的作用。
Homology of medicine and food is an important content in Chinese medicine and also works as the basis for guiding the development of compound health food containing Chinese materia medica. The top products,supplements,health care prescriptions,and medicinal meals in traditional herbal texts are the theoretical treasures of Chinese medicine compound health foods. With the implementation of the National Healthy China 2030,China's major health industry faces with tremendous opportunities. It is necessary to develop a batch of compound health food containing Chinese materia medica with Chinese medicine characteristics,in line with the needs of the country and society. Domestic research on compound health food containing Chinese materia medica mainly focuses on the extraction of functional components,preparation molding processes,quality standards,and efficacy evaluation. However,there are still some deficiencies in the related characteristics of traditional Chinese medicine(TCM) theory and function,evaluation criteria of efficacy and safety,new product R&D evaluation system and R&D platform. Based on a large number of previous studies by this laboratory,the views in nature,flavor and efficacy relationship were put forward in this paper. Based on the establishment of the Chinese medicine function-pharmacology-clinical application database system,the Chinese medicine compatibility database system,the Chinese medicine nature and flavor modern research database system,and the evaluation platform for animal models of Chinese medicine; the efficacy study,safety evaluation system,new product research and development evaluation system as well as research and development platform were established,providing a basis for the development and evaluation of compound health food containing Chinese materia medica. The modern scientific connotation of the core efficacy of compound health food containing Chinese materia medica was explained as well,helpful to promote the research and development of compound health food containing Chinese materia medica and play an important role in general health.
Homology of medicine and food is an important content in Chinese medicine and also works as the basis for guiding the development of compound health food containing Chinese materia medica. The top products,supplements,health care prescriptions,and medicinal meals in traditional herbal texts are the theoretical treasures of Chinese medicine compound health foods. With the implementation of the National Healthy China 2030,China's major health industry faces with tremendous opportunities. It is necessary to develop a batch of compound health food containing Chinese materia medica with Chinese medicine characteristics,in line with the needs of the country and society. Domestic research on compound health food containing Chinese materia medica mainly focuses on the extraction of functional components,preparation molding processes,quality standards,and efficacy evaluation. However,there are still some deficiencies in the related characteristics of traditional Chinese medicine(TCM) theory and function,evaluation criteria of efficacy and safety,new product R&D evaluation system and R&D platform. Based on a large number of previous studies by this laboratory,the views in nature,flavor and efficacy relationship were put forward in this paper. Based on the establishment of the Chinese medicine function-pharmacology-clinical application database system,the Chinese medicine compatibility database system,the Chinese medicine nature and flavor modern research database system,and the evaluation platform for animal models of Chinese medicine; the efficacy study,safety evaluation system,new product research and development evaluation system as well as research and development platform were established,providing a basis for the development and evaluation of compound health food containing Chinese materia medica. The modern scientific connotation of the core efficacy of compound health food containing Chinese materia medica was explained as well,helpful to promote the research and development of compound health food containing Chinese materia medica and play an important role in general health.
引文
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[28]田硕,曹利华,苗明三,等.基于临床中西医病症特点的中医药动物模型评价新方法[J].中药药理与临床,2017,33(6):165.
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[30]任泽明,童晔玲,陈璇,等.蜂胶姜黄软胶囊辅助降血脂功能人体试食试验研究[J].中国预防医学杂志,2017,18(11):819.
[31]黄妍,李小莉,张勋力,等.纳豆银杏紫苏软胶囊辅助降血脂人体试食试验研究[J].湖北工业大学学报,2017,32(5):54.
[32]常丽影,代玉山,赵毅,等.琦红丸辅助降血脂的人体试食试验研究[J].中成药,2014,36(4):879.
[2]叶永茂.中国食品保健品及其安全问题[J].上海医药情报研究,2005(2):34.
[3]李澎涛.药食同源中药开发保健品安全可靠性的思考[C].北京:第四届第二次中国毒理学会,2008.
[4]钟芳芳.我国中药保健品的发展现状及发展趋势[J].中国卫生产业,2014,11(10):187.
[5]杜晓曦,张象麟.中药保健药品整顿工作的回顾以及中药保健品的展望[J].中国药事,2003(10):3.
[6]高心宇.从食品科学角度看中药保健食品的研发[J].科技风,2018(9):135.
[7]徐梦阳,李笑然.中药保健品的开发应用及市场分析[J].亚太传统医药,2011,7(3):1.
[8]何沂飞.芦荟活性部位及其复方保健品研发[D].海口:海南大学,2015.
[9]郭栋.复方保健产品中总皂苷和红景天苷的检测及质量控制研究[D].广州:华南理工大学,2015.
[10]戈延茹.复方红景天运动保健品的研制[D].延吉:延边大学,2001.
[11]白俊毅.一种复方中药保健品的研制[D].成都:成都中医药大学,2010.
[12]刘霜琪,李冰菲,苏慧,等.中药黄芪在保健品中的应用概述[J].黑龙江科技信息,2016(6):75.
[13]李洋,王俊兰,贾茹.采用偏光显微镜及红外吸收光谱法快速鉴定中药保健品里的西药掺杂[J].广东化工,2013,40(16):197.
[14]徐巧玲,吴学军,姜文清,等.应用高效液相色谱-二极管阵列检测器筛查中药及保健品中糖皮质激素类非法添加剂[J].中国临床保健杂志,2016,19(6):569.
[15]刘飞,柳庆坤,赵莹.UPLC-MS/MS测定中药制剂及保健品中茶碱的含量[J].中国西部科技,2014,13(12):68.
[16]吴俊辉,罗辉泰,沈小玲,等,HPLC-MS/MS检测中药保健品中非法添加成分的研究[J].中药新药与临床药理,2014,25(5):606.
[17]姚晖,贾茹.显微拉曼光谱法快速鉴别保健品中的非法添加物[J].生命科学仪器,2015,13(3):30.
[18]王晶晶,徐方旭,冯叙桥,等.中药类保健食品的研发:从食品科学角度的思考与建议[J].食品安全质量检测学报,2015,6(4):1350.
[19]苗明三,田硕,白明.湿疹动物模型制备规范(草案)[J].中国实验方剂学杂志,2017,23(24):6.
[20]苗明三,闫晓丽,乔靖怡,等.白癜风动物模型制备规范(草案)[J].中国实验方剂学杂志,2017,23(24):1.
[21]苗明三,张旭,白明.皮肤瘢痕动物模型制备规范(草案)[J].中草药,2018,49(1):58.
[22]苗明三,付珍娜,田硕.痤疮动物模型制备规范(草案)[J].中华中医药杂志,2018,33(1):197.
[23]苗明三,项丽玲,白明,等.冻伤动物模型制备规范(草案)[J].中国中药杂志,2018,43(2):410.
[24]苗明三,李欢,苗艳艳,等.斑秃动物模型制备规范(草案)[J].中药新药与临床药理,2018,29(1):42.
[25]苗明三,温亚娟,曹利华.瘙痒动物模型制备规范(草案)[J].中华中医药杂志,2018,33(2):610.
[26]苗明三,田硕,辛卫云,等.围绝经期综合征动物模型制备规范(草案)[J].中华中医药杂志,2018,33(3):996.
[27]苗明三,方晓艳,闫晓丽,等.慢性皮肤疮疡动物模型制备规范(草案)[J].中华中医药杂志,2018,33(1):193.
[28]田硕,曹利华,苗明三,等.基于临床中西医病症特点的中医药动物模型评价新方法[J].中药药理与临床,2017,33(6):165.
[29]中华人民共和国卫生部.保健食品检验与评价技术规范[S]. 2003.
[30]任泽明,童晔玲,陈璇,等.蜂胶姜黄软胶囊辅助降血脂功能人体试食试验研究[J].中国预防医学杂志,2017,18(11):819.
[31]黄妍,李小莉,张勋力,等.纳豆银杏紫苏软胶囊辅助降血脂人体试食试验研究[J].湖北工业大学学报,2017,32(5):54.
[32]常丽影,代玉山,赵毅,等.琦红丸辅助降血脂的人体试食试验研究[J].中成药,2014,36(4):879.