血清维生素D水平对子宫内膜异位症的评估价值
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摘要
目的探究血清维生素D水平对子宫内膜异位症的评估价值。方法选取本院2016年1月至2017年10月收治的198例子宫内膜异位症和卵巢其他肿瘤患者为研究对象,根据病理结果不同将其分为观察组(子宫内膜异位症,102例)和对照组(卵巢其他肿瘤,96例),比较两组患者血清维生素D水平,分析其对子宫内膜异位症的评估价值。结果两组患者Ca~(2+)、25-羟维生素D_2[25-hydroxyvitaminD_2,25-(OH)D_2]水平比较均无显著差异(P_均> 0.05)。观察组患者25-羟维生素D_3[25-hydroxyvitaminD_3,25-(OH)D_3]和维生素D水平均显著低于对照组(P_均<0.05)。观察组中美国生殖医学学会(American Society for Reproductive Medicine,ASRM)分期Ⅰ～Ⅱ期和Ⅲ～Ⅳ期患者Ca~(2+)、25-(OH)D_2水平比较均无显著差异(P_均> 0.05);ASRM分期Ⅰ～Ⅱ期患者25-(OH)D_3和维生素D水平均显著高于Ⅲ～Ⅳ期患者(P_均<0.05)。观察组中痛经患者与无痛经患者Ca~(2+)、25-(OH)D_2、25-(OH)D_3、维生素D水平比较均无显著差异(P_均> 0.05)。结论子宫内膜异位症患者维生素D水平明显低于卵巢其他肿瘤患者,ASRM不同分期的子宫内膜异位症患者维生素D水平亦不同,可根据维生素D水平评估子宫内膜异位症及其病情严重程度。
Objective To explore the value of serum vitamin D level in the evaluation of endometriosis. Method 198 patients with endometriosis and other ovarian tumors in our hospital from January 2016 to October 2017 were selected as the subjects of the study. According to the different pathological results, they were divided into observation group(endometriosis, 102 cases) and control group(other ovarian tumors, 96 cases), analysis of its evaluation value in endometriosis. Result There were no significant differences in the levels of Ca~(2+) and 25-hydroxyvitamin D_2[25-(OH)D_2] between the two groups(P_(all)> 0.05). The levels of 25-hydroxyvitamin D_3[25-(OH)D_3] and vitamin D in observation group were significantly lower than those in control group(P_(all)< 0.05). There were no significant differences in the levels of Ca~(2+) and 25-(OH)D_2 between stage Ⅰ～Ⅱ and stage Ⅲ～Ⅳ of American Society of Reproductive Medicine(ASRM) in observation group(P_(all)> 0.05). The levels of 25-(OH)D_3 and vitamin D in patients with ASRM stage Ⅰ～Ⅱ were significantly higher than those in patients with stage Ⅲ～Ⅳ(P_(all)< 0.05). There were no significant differences in Ca~(2+), 25-(OH)D_2, 25-(OH)D_3 and vitamin D levels between dysmenorrhea patients and non-dysmenorrhea patients in observation group(P_(all)> 0.05). Conclusion The levels of vitamin D in patients with endometriosis were significantly lower than those in patients with other ovarian tumors, and the levels of vitamin D in patients with endometriosis in different stages of ASRM were also different. Endometriosis and its severity can be evaluated according to vitamin D levels.
Objective To explore the value of serum vitamin D level in the evaluation of endometriosis. Method 198 patients with endometriosis and other ovarian tumors in our hospital from January 2016 to October 2017 were selected as the subjects of the study. According to the different pathological results, they were divided into observation group(endometriosis, 102 cases) and control group(other ovarian tumors, 96 cases), analysis of its evaluation value in endometriosis. Result There were no significant differences in the levels of Ca~(2+) and 25-hydroxyvitamin D_2[25-(OH)D_2] between the two groups(P_(all)> 0.05). The levels of 25-hydroxyvitamin D_3[25-(OH)D_3] and vitamin D in observation group were significantly lower than those in control group(P_(all)< 0.05). There were no significant differences in the levels of Ca~(2+) and 25-(OH)D_2 between stage Ⅰ～Ⅱ and stage Ⅲ～Ⅳ of American Society of Reproductive Medicine(ASRM) in observation group(P_(all)> 0.05). The levels of 25-(OH)D_3 and vitamin D in patients with ASRM stage Ⅰ～Ⅱ were significantly higher than those in patients with stage Ⅲ～Ⅳ(P_(all)< 0.05). There were no significant differences in Ca~(2+), 25-(OH)D_2, 25-(OH)D_3 and vitamin D levels between dysmenorrhea patients and non-dysmenorrhea patients in observation group(P_(all)> 0.05). Conclusion The levels of vitamin D in patients with endometriosis were significantly lower than those in patients with other ovarian tumors, and the levels of vitamin D in patients with endometriosis in different stages of ASRM were also different. Endometriosis and its severity can be evaluated according to vitamin D levels.
引文
[1]何政星,王姝,冷金花,等.子宫内膜异位症恶变的临床风险分析[J].中华妇产科杂志,2018,53(4):282-284.
[2]范素鸿,林开清,马俊彦,等.195例青春期盆腔子宫内膜异位症临床病例分析[J].现代妇产科进展,2017,26(1):19-22.
[3]沈春晖,张婷婷,曹阳.子宫内膜异位症中西医病因学研究进展[J].中国中医基础医学杂志,2012,18(12):1398-1401.
[4]王丁然,迟洪滨,乔杰.子宫内膜异位症与自身免疫性甲状腺炎的相关性及对生殖功能影响的研究进展[J].中华医学杂志,2017,97(3):238-240.
[5]孙梅,陈子江.子宫内膜异位症对妇女生育力的影响[J].实用妇产科杂志,2012,28(8):609-611
[6]岳静,靳镭.子宫内膜异位症对女性生育力的影响及评估方法[J].实用妇产科杂志,2015,31(1):7-9.
[7]张丽凤,张信美.维生素D在子宫内膜异位症中的作用研究进展[J].浙江大学学报(医学版),2018,47(4):90-95.
[8]杜旭园,顾林.维生素D与多囊卵巢综合征[J].国际生殖健康/计划生育杂志,2014,33(2):128-130,143.
[9]刘利芝.维生素D对恶性转化的小鼠卵巢表面上皮细胞肿瘤干细胞样细胞特性的影响[D].苏州:苏州大学,2016.
[10]滕爱兰,麻瑞芹,黄国英,等.维生素D与免疫的关系[J].中国临床研究,2013,26(6):606-608.
[11]皮洁,闫文杰,洛若愚.维生素D与子宫内膜异位症相关性研究进展[J].中华实用诊断与治疗杂志,2015,29(12):1148-1150.
[12]曹华斌,涂灵.维生素D受体基因多态性与多囊卵巢综合征的相关性研究[J].实用临床医学,2016,17(2):40-42.
[13]黄天福,刘宪福,王芳,等.维生素D抗炎机制对糖尿病大鼠骨代谢的影响[J].中华糖尿病杂志,2014,6(8):594-597.
[14]祁珊珊,王永吉.维生素D的代谢及调控研究新进展[J].中国骨质疏松杂志,2015,21(10):1267-1271.
[15]吴芳芳,阙守红,谢杰,等.维生素D及类似物与皮肤病相关性研究[J].临床皮肤科杂志,2018,47(1):56-58.
[16]金小岚.钙剂和维生素D在骨质疏松症中的应用[J].中国临床医生杂志,2013,41(6):3-5.
[17]毕新岭,顾军.维生素D类似物在银屑病治疗中的应用[J].皮肤科学通报,2018,35(1):30-42.
[18]吴怡玲,邵洁.哮喘儿童血清25羟维生素D及其免疫相关因素分析[J].中国实用儿科杂志,2013,28(12):917-920.
[19]林岚,彭静宜,谭美珍,等.69例维生素D过量病例的血清维生素D与钙及钙磷乘积的关系[J].国际医药卫生导报,2017,23(12):1862-1865.
[20]闫震.子宫内膜异位症治疗研究现状[J].中国医刊,2005,40(12):45-47.
[21]赵水苗,路莉,王德莹,等.维生素D结合蛋白与子宫内膜异位症的研究进展[J].实用妇产科杂志,2015,31(5):342-344.
[22]李卓莉,郝敏,赵卫红.免疫细胞在子宫内膜异位症发病机制中的作用[J].国际妇产科学杂志,2014,41(3):260-262.
[2]范素鸿,林开清,马俊彦,等.195例青春期盆腔子宫内膜异位症临床病例分析[J].现代妇产科进展,2017,26(1):19-22.
[3]沈春晖,张婷婷,曹阳.子宫内膜异位症中西医病因学研究进展[J].中国中医基础医学杂志,2012,18(12):1398-1401.
[4]王丁然,迟洪滨,乔杰.子宫内膜异位症与自身免疫性甲状腺炎的相关性及对生殖功能影响的研究进展[J].中华医学杂志,2017,97(3):238-240.
[5]孙梅,陈子江.子宫内膜异位症对妇女生育力的影响[J].实用妇产科杂志,2012,28(8):609-611
[6]岳静,靳镭.子宫内膜异位症对女性生育力的影响及评估方法[J].实用妇产科杂志,2015,31(1):7-9.
[7]张丽凤,张信美.维生素D在子宫内膜异位症中的作用研究进展[J].浙江大学学报(医学版),2018,47(4):90-95.
[8]杜旭园,顾林.维生素D与多囊卵巢综合征[J].国际生殖健康/计划生育杂志,2014,33(2):128-130,143.
[9]刘利芝.维生素D对恶性转化的小鼠卵巢表面上皮细胞肿瘤干细胞样细胞特性的影响[D].苏州:苏州大学,2016.
[10]滕爱兰,麻瑞芹,黄国英,等.维生素D与免疫的关系[J].中国临床研究,2013,26(6):606-608.
[11]皮洁,闫文杰,洛若愚.维生素D与子宫内膜异位症相关性研究进展[J].中华实用诊断与治疗杂志,2015,29(12):1148-1150.
[12]曹华斌,涂灵.维生素D受体基因多态性与多囊卵巢综合征的相关性研究[J].实用临床医学,2016,17(2):40-42.
[13]黄天福,刘宪福,王芳,等.维生素D抗炎机制对糖尿病大鼠骨代谢的影响[J].中华糖尿病杂志,2014,6(8):594-597.
[14]祁珊珊,王永吉.维生素D的代谢及调控研究新进展[J].中国骨质疏松杂志,2015,21(10):1267-1271.
[15]吴芳芳,阙守红,谢杰,等.维生素D及类似物与皮肤病相关性研究[J].临床皮肤科杂志,2018,47(1):56-58.
[16]金小岚.钙剂和维生素D在骨质疏松症中的应用[J].中国临床医生杂志,2013,41(6):3-5.
[17]毕新岭,顾军.维生素D类似物在银屑病治疗中的应用[J].皮肤科学通报,2018,35(1):30-42.
[18]吴怡玲,邵洁.哮喘儿童血清25羟维生素D及其免疫相关因素分析[J].中国实用儿科杂志,2013,28(12):917-920.
[19]林岚,彭静宜,谭美珍,等.69例维生素D过量病例的血清维生素D与钙及钙磷乘积的关系[J].国际医药卫生导报,2017,23(12):1862-1865.
[20]闫震.子宫内膜异位症治疗研究现状[J].中国医刊,2005,40(12):45-47.
[21]赵水苗,路莉,王德莹,等.维生素D结合蛋白与子宫内膜异位症的研究进展[J].实用妇产科杂志,2015,31(5):342-344.
[22]李卓莉,郝敏,赵卫红.免疫细胞在子宫内膜异位症发病机制中的作用[J].国际妇产科学杂志,2014,41(3):260-262.