艾草的化学成分和药理作用研究进展
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摘要
艾草为我国传统的中草药,其应用在我国有着悠久的历史和广泛的影响。早在明代李时珍的《本草纲目》中就有记载,称其为"草医"。对艾草的理化性质、提取方法、主要的化学成分、药理学作用和应用进行国内外文献研究总结。艾草主要的化学成分为挥发油类、黄酮类和糖类,具有抑菌、抗虫、抗氧化和提高动物生产性能的作用,开发出了具有抑菌、增强免疫力等功效的产品。基于目前的文献研究,提出仍需深入研究艾草调控的信号转导通路、艾草的药物代谢动力学参数、艾草的安全性评价以及药物间的相互作用等。该综述以期为艾草的药理机制研究和提高艾草的应用价值提供全面的数据支撑。
Artemisia argyi is our traditional herbal medicine,has a centuries old history and widespread influence.It was called "Grass diamond"by Shizhen Li. The accessible literature on Artemisia argyi written in English and Chinese were collected and analyzed. The literatures included physicochemical property,extraction methods,phytochemistry,pharmacology and application that included in NCBI and NCKI. The major extraction methods were decocting,ultrasonic assisted,cold-press,Subcritical extraction and supercritical extraction. The major components were essential oil,flavonoid and polysaccharide. Modern pharmacological studies demonstrated that Artemisia argyi possess wide pharmacological activities that include antimicrobial,insecticidal and antioxidant.Based on the literatures research,the mechanism of signal path were not very clear,further pharmacokinetics,safety assessments and herb-drug/food interaction should be performed before it can be integrated into medicinal.
Artemisia argyi is our traditional herbal medicine,has a centuries old history and widespread influence.It was called "Grass diamond"by Shizhen Li. The accessible literature on Artemisia argyi written in English and Chinese were collected and analyzed. The literatures included physicochemical property,extraction methods,phytochemistry,pharmacology and application that included in NCBI and NCKI. The major extraction methods were decocting,ultrasonic assisted,cold-press,Subcritical extraction and supercritical extraction. The major components were essential oil,flavonoid and polysaccharide. Modern pharmacological studies demonstrated that Artemisia argyi possess wide pharmacological activities that include antimicrobial,insecticidal and antioxidant.Based on the literatures research,the mechanism of signal path were not very clear,further pharmacokinetics,safety assessments and herb-drug/food interaction should be performed before it can be integrated into medicinal.
引文
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[4]Sushil C S,Nitin S,Vivek A,et al.Chemical composition and antifungal activity of Artemisia nilagirica essential oil growing in northern hilly areas of India[J].Natural Product Research,2013,27(1):45-48.
[5]Amri I,De M L,Marandino A,et al.Chemical composition and biological activities of the essential oil from Artemisia herba-alba growing wild in Tunisia.[J].Natural Product Communications,2013,8(3):407-410.
[6]Karandashov V,Nagy R,Wegmüller S,et al.The evaluation of the antibacterial and antioxidant activity of tarragon(Artemisia dracunculus L.)essential oil and its chemical composition[J].Jundishapur Journal of Microbiology,2013,6(9):463-468.
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[20]廖延智.超临界萃取野生艾草挥发油的GC-MS分析[J].食品工程,2013,(4):46-49.Liao Y Z,Analysis of volatile oil of wild artemisia capiliaris in anhui by supercritical carbondioxide extraction[J].Food Engineering,2013,(4):46-49.
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[23]Corrêaferreira M L,Ferreira D M,Dallazen J L,et al.Gastroprotective effects and structural characterization of a pectic fraction isolated from Artemisia campestris subsp maritima.[J].International Journal of Biological Macromolecules,2017,107(Pt B):2395.
[24]Sonker N,Pandey A K,Singh P.Efficiency of Artemisia nilagirica(Clarke)Pamp.essential oil as a mycotoxicant against postharvest mycobiota of table grapes[J].J Sci Food Agric,2015,95(9):1932-1939.
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[26]Stappen I,Wanner J,Tabanca N,et al.Chemical composition and biological effects of Artemisia maritima and Artemisia nilagirica essential oils from wild plants of western Himalaya[J].Planta Medica,2014,80(13):1079-1087.
[27]Hwang Y C,Jenkins E M.Effect of acupuncture on young pigs with induced enteropathogenic Escherichia coli diarrhea.[J].American Journal of Veterinary Research,1988,49(9):1641.
[28]Kumudini M M,George S,David E W.Antifungal constituents of the essential oil fraction of Artemisia dracunculus L.Var.dracunculus[J].J Agric Food Chem,2002,50(24):6989-6992.
[29]Tian J,Ban X,Zeng H,et al.The mechanism of antifungal action of essential oil from dill(Anethum graveolens L.)on Aspergillus flavus[J].Plos One,2012,7(1):e30147.
[30]Bouzenna H,Krichen L.Pelargonium graveolens L'Her.and Artemisia arborescens L.essential oils:chemical composition,antifungal activity against Rhizoctonia solani and insecticidal activity against Rhysopertha dominica.[J].Natural Product Research,2013,27(9):841-846.
[31]Negahban M,Moharramipour S,Sefidkon F.Fumigant toxicity of essential oil from Artemisia sieberi Besser against three storedproduct insects[J].Journal of Stored Products Research,2007,43(2):123-128.
[32]Wang J,Zhu F,Zhou X M,et al.Repellent and fumigant activity of essential oil from Artemisia vulgaris,to Tribolium castaneum,(Herbst)(Coleoptera:Tenebrionidae)[J].Journal of Stored Products Research,2006,42(3):339-347.
[33]Liu X C,Li Y P,Li H Q,et al.Identification of repellent and insecticidal constituents of the essential oil of Artemisia rupestris L.aerial parts against Liposcelis bostrychophila Badonnel.[J].Journal of Chemistry,2013,(2013-12-16),2013,18(5):10733-46.
[34]Singh P,Sonker N,Pandey A K.Chemical composition and antioxidant activity of essential oil of Artemisia nilagirica Linn.from eastern uttar pradesh,India[J].2015,18(3):247-262.
[35]Sandip S,Reena P,Santilata S,et al.High radical scavenging activity of camphor rich Artemisia nilagirica essential oil growing in Eastern plain areas of India[J].Research Journal of Biotechnology,2014,9(1):63-65.
[36]Kordali S,Cakir A,Mavi A,et al.Screening of chemical composition and antifungal and antioxidant activities of the essential oils from three Turkish artemisia species[J].Journal of Agricultural&Food Chemistry,2005,53(5):1408-16.
[37]徐红蕊,陈小连,时建青,等.艾叶对热应激蛋鸡抗氧化功能、产蛋性能和蛋品质的影响[J].浙江大学学报(农业与生命科学版),2017,43(1):113-119.Xu H R,Chen X L,Shi J Q,et al.Effect of Artemisia Argyi on the antioxidant activity,laying performance and egg quality in laying hens under heat stress.Journal of Zhejiang University(Agric.&Life Sci.)2017,43(1):113-119.
[38]刘平,潘秀颉,韩丽,等.长期艾烟干预对Wistar大鼠外周血T淋巴细胞亚群及CD4+CD25+Treg的影响[J].中国针灸,2013,33(2):145-148.Liu P,Pan X Z,Han L,et al.Effects of long-term intervention of moxa smoke on T lymphocyte subsets and CD4+CD25+Treg in peripheral blood of Wistar rats.Chinese Acupuncture&Moxibustion,2013,33(2):145-148.
[39]唐照亮,宋小鸽,章复清,等.艾灸治疗类风湿性关节炎抗炎免疫作用机理的研究[J].针刺研究,2003,28(4):292-298.Tang Z L,Song X G,Zhang F Q,et al.Study on action mechanism of moxibustion in anti-inflammation and immunoregulation in rheumatoid arthritis rats[J].Acupuncture Research,2003,28(4):292-298.
[40]马明云,姜劲峰,周小云,等.艾灸对高脂血症患者血脂、血糖的影响[J].上海针灸杂志,2012,31(8):535-536.Ma M Y,Jiang J F,Zhou X Y,et al.Effect of moxibustion on blood fat and glucose in hyperlipemia patients[J].Shanghai Journal of Acupuncture and Moxibustion,2012,31(8):535-536.
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[2]Sharopov F S,Wink M,Gulmurodov I S,et al.Composition and bioactivity of the essential oil of Anethum graveolens L.from Tajikistan.[J].International Journal of Medicinal&Aromatic Plants,2013(3):2249-4340.
[3]Judzentiene A,Budiene J,Gircyte R,et al.Toxic activity and chemical composition of lithuanian wormwood(Artemisia absinthium L.)essential oils[J].Records of Natural Products,2012,6(2).
[4]Sushil C S,Nitin S,Vivek A,et al.Chemical composition and antifungal activity of Artemisia nilagirica essential oil growing in northern hilly areas of India[J].Natural Product Research,2013,27(1):45-48.
[5]Amri I,De M L,Marandino A,et al.Chemical composition and biological activities of the essential oil from Artemisia herba-alba growing wild in Tunisia.[J].Natural Product Communications,2013,8(3):407-410.
[6]Karandashov V,Nagy R,Wegmüller S,et al.The evaluation of the antibacterial and antioxidant activity of tarragon(Artemisia dracunculus L.)essential oil and its chemical composition[J].Jundishapur Journal of Microbiology,2013,6(9):463-468.
[7]Joshi R K.Volatile composition and antimicrobial activity of the essential oil of Artemisia absinthium growing in Western Ghats region of North West Karnataka,India.[J].Pharmaceutical Biology,2013,51(7):888-892.
[8]Niko S R,Pavle J R,Nikola M S,et al.Toxic essential oils.Part II:Chemical,toxicological,pharmacological and microbiological profiles of Artemisia annua,L.volatiles[J].Food&Chemical Toxicology An International Journal Published for the British Industrial Biological Research Association,2013,58(3):37-49.
[9]Ben H A,Ben H N,Abdelkafi S,et al.Essential oil from Artemisia phaeolepis:chemical composition and antimicrobial activities[J].Journal of Oleo Science,2013,62(12):973.
[10]Rashid S,Rather M A,Shah W A,et al.Chemical composition,antimicrobial,cytotoxic and antioxidant activities of the essential oil of Artemisia indica Willd[J].Food Chemistry,2013,138(1):693-700.
[11]Belhattab R,Amor L,Barroso J G,et al.Essential oil from Artemisia herba-alba,Asso grown wild in Algeria:Variability assessment and comparison with an updated literature survey[J].Arabian Journal of Chemistry,2014,7(2):243-251.
[12]Liu X C,Li Y,Wang T,et al.Chemical composition and insecticidal activity of essential oil of Artemisia frigida Willd(Compositae)against two grain storage insects[J].Tropical Journal of Pharmaceutical Research,2014,13(4):587-592.
[13]Zhang W J,You C X,Yang K,et al.Bioactivity of essential oil of Artemisia argyi Lévl.et Van.and its main compounds against lasioderma serricorne[J].Journal of Oleo Science,2014,63(8):829.
[14]Liu X C,Li Y P,Li H Q,et al.Identification of repellent and insecticidal constituents of the essential oil of Artemisia rupestris L.aerial parts against Liposcelis bostrychophila Badonnel[J].Molecules,2013,18(9):10733-10746.
[15]Kumlay A M,Yildirim B A,Ekici K,et al.Screening biological activity of essential oils from Artemisia dracunculus L[J].Oxidation Communications,2015,38(3):1320-1328.
[16]Zhang W J,Yang K,You C X,et al.Bioactivity of essential oil from Artemisia stolonifera(Maxim.)Komar.and its main compounds against two stored-product insects.[J].Journal of Oleo Science,2015,64(3):299.
[17]Lohani H,Gwari G,Bhandari U,et al.Variability in the essential oils from aerial parts of Artemisia vulgaris L.grown in Uttarakhand(India)[J].Journal of Essential Oil Bearing Plants,2016,19(1):103-107.
[18]Vieira T M,Dias H J,Medeiros T C T,et al.Chemical composition and antimicrobial activity of the essential oil of Artemisia absinthium asteraceae leaves[J].Journal of Essential Oil Bearing Plants,2017,20(1):123-131.
[19]Pelkonen O,Abass K,Wiesner J.Thujone and thujone-containing herbal medicinal and botanical products:toxicological assessment.[J].Regul Toxicol Pharmacol,2013,65(1):100-107.
[20]廖延智.超临界萃取野生艾草挥发油的GC-MS分析[J].食品工程,2013,(4):46-49.Liao Y Z,Analysis of volatile oil of wild artemisia capiliaris in anhui by supercritical carbondioxide extraction[J].Food Engineering,2013,(4):46-49.
[21]Yim S H,Tabassum N,Kim W H,et al.Isolation and characterization of isofraxidin 7-O-(6'-O-p-Coumaroyl)-β-glucopyranoside from Artemisia capillaris thunberg:a novel,nontoxic hyperpigmentation agent that is effective in vivo.[J].EvidenceBased Complementray and Alternative Medicine,2017,2017:1401279.
[22]Lee Y K,Hong E Y,Wan K W.Inhibitory Effect of Chemical Constituents Isolated from Artemisia iwayomogi on Polyol Pathway and Simultaneous Quantification of Major Bioactive Compounds[J].BioMed Research International,2017,(2017-4-23),2017,2017(4):1-12.
[23]Corrêaferreira M L,Ferreira D M,Dallazen J L,et al.Gastroprotective effects and structural characterization of a pectic fraction isolated from Artemisia campestris subsp maritima.[J].International Journal of Biological Macromolecules,2017,107(Pt B):2395.
[24]Sonker N,Pandey A K,Singh P.Efficiency of Artemisia nilagirica(Clarke)Pamp.essential oil as a mycotoxicant against postharvest mycobiota of table grapes[J].J Sci Food Agric,2015,95(9):1932-1939.
[25]Petretto G L,Chessa M,Piana A,et al.Chemical and biological study on the essential oil of Artemisia caerulescens L.ssp.densiflora(Viv.)[J].Natural Product Research,2013,27(19):1709-1715.
[26]Stappen I,Wanner J,Tabanca N,et al.Chemical composition and biological effects of Artemisia maritima and Artemisia nilagirica essential oils from wild plants of western Himalaya[J].Planta Medica,2014,80(13):1079-1087.
[27]Hwang Y C,Jenkins E M.Effect of acupuncture on young pigs with induced enteropathogenic Escherichia coli diarrhea.[J].American Journal of Veterinary Research,1988,49(9):1641.
[28]Kumudini M M,George S,David E W.Antifungal constituents of the essential oil fraction of Artemisia dracunculus L.Var.dracunculus[J].J Agric Food Chem,2002,50(24):6989-6992.
[29]Tian J,Ban X,Zeng H,et al.The mechanism of antifungal action of essential oil from dill(Anethum graveolens L.)on Aspergillus flavus[J].Plos One,2012,7(1):e30147.
[30]Bouzenna H,Krichen L.Pelargonium graveolens L'Her.and Artemisia arborescens L.essential oils:chemical composition,antifungal activity against Rhizoctonia solani and insecticidal activity against Rhysopertha dominica.[J].Natural Product Research,2013,27(9):841-846.
[31]Negahban M,Moharramipour S,Sefidkon F.Fumigant toxicity of essential oil from Artemisia sieberi Besser against three storedproduct insects[J].Journal of Stored Products Research,2007,43(2):123-128.
[32]Wang J,Zhu F,Zhou X M,et al.Repellent and fumigant activity of essential oil from Artemisia vulgaris,to Tribolium castaneum,(Herbst)(Coleoptera:Tenebrionidae)[J].Journal of Stored Products Research,2006,42(3):339-347.
[33]Liu X C,Li Y P,Li H Q,et al.Identification of repellent and insecticidal constituents of the essential oil of Artemisia rupestris L.aerial parts against Liposcelis bostrychophila Badonnel.[J].Journal of Chemistry,2013,(2013-12-16),2013,18(5):10733-46.
[34]Singh P,Sonker N,Pandey A K.Chemical composition and antioxidant activity of essential oil of Artemisia nilagirica Linn.from eastern uttar pradesh,India[J].2015,18(3):247-262.
[35]Sandip S,Reena P,Santilata S,et al.High radical scavenging activity of camphor rich Artemisia nilagirica essential oil growing in Eastern plain areas of India[J].Research Journal of Biotechnology,2014,9(1):63-65.
[36]Kordali S,Cakir A,Mavi A,et al.Screening of chemical composition and antifungal and antioxidant activities of the essential oils from three Turkish artemisia species[J].Journal of Agricultural&Food Chemistry,2005,53(5):1408-16.
[37]徐红蕊,陈小连,时建青,等.艾叶对热应激蛋鸡抗氧化功能、产蛋性能和蛋品质的影响[J].浙江大学学报(农业与生命科学版),2017,43(1):113-119.Xu H R,Chen X L,Shi J Q,et al.Effect of Artemisia Argyi on the antioxidant activity,laying performance and egg quality in laying hens under heat stress.Journal of Zhejiang University(Agric.&Life Sci.)2017,43(1):113-119.
[38]刘平,潘秀颉,韩丽,等.长期艾烟干预对Wistar大鼠外周血T淋巴细胞亚群及CD4+CD25+Treg的影响[J].中国针灸,2013,33(2):145-148.Liu P,Pan X Z,Han L,et al.Effects of long-term intervention of moxa smoke on T lymphocyte subsets and CD4+CD25+Treg in peripheral blood of Wistar rats.Chinese Acupuncture&Moxibustion,2013,33(2):145-148.
[39]唐照亮,宋小鸽,章复清,等.艾灸治疗类风湿性关节炎抗炎免疫作用机理的研究[J].针刺研究,2003,28(4):292-298.Tang Z L,Song X G,Zhang F Q,et al.Study on action mechanism of moxibustion in anti-inflammation and immunoregulation in rheumatoid arthritis rats[J].Acupuncture Research,2003,28(4):292-298.
[40]马明云,姜劲峰,周小云,等.艾灸对高脂血症患者血脂、血糖的影响[J].上海针灸杂志,2012,31(8):535-536.Ma M Y,Jiang J F,Zhou X Y,et al.Effect of moxibustion on blood fat and glucose in hyperlipemia patients[J].Shanghai Journal of Acupuncture and Moxibustion,2012,31(8):535-536.
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