肝素联合疏血通注射液治疗肺栓塞患者的临床疗效及对血清TNI Hcy D-二聚体水平的影响
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摘要
目的:探讨肝素联合疏血通注射液治疗肺栓塞患者的临床疗效及对血清肌钙蛋白I(TNI)、血同型半胱氨酸(Hcy)、D-二聚体(D-Dimer)水平的影响。方法:选择2015年4月至2018年4月90例肺栓塞患者作为研究对象,简单随机分组法分为对照组和观察组,每组各45例。两组患者检查完毕后均按照常规的西医治疗方式进行诊治,对照组患者给予疏血通注射液进行治疗,观察组在对照组基础上增服肝素。观察分析两组患者的临床疗效以及治疗前后肌钙蛋白I(TNI)、血同型半胱氨酸(Hcy)、D-二聚体(D-Dimer)水平的变化。结果:治疗后,观察组患者临床总有效率显著高于对照组(P<0.05);两组患者血二氧化碳分压(PCO2)以及氧分压(PO2)均较治疗前明显上升,且观察组PO2明显高于对照组;两组患者治疗后血清TNI、Hcy和D-二聚体水平均较治疗前明显下降,且观察组血清TNI、Hcy和D-二聚体水平明显低于对照组;治疗后,两组患者均出现不良反应,两组不良反应发生情况无明显差异(P>0.05)。结论:针对肺栓塞患者,肝素联合疏血通注射液治疗肺栓塞患者可有效提高临床疗效,且显著降低血清肌钙蛋白I、血同型半胱氨酸和D-二聚体水平。
Objective: To investigate the clinical efficacy of heparin combined with Shuxuetong injection in the treatment of pulmonary embolism and its influence on serum troponin I(TNI),homocysteine(Hcy)and D-dimer levels. Methods: 90 patients with pulmonary embolism admitted to our hospital from April 2015 to April 2018 were selected as study objects. All the patients were randomly divided into control group and observation group,with 45 cases in each group. After the examination,the patients in both groups were diagnosed and treated according to the conventional western medical treatment. The patients in the control group were treated with shuxuetong injection,and the observation group was treated with heparin on the basis of the control group. The clinical efficacy of the two groups and the changes of troponin I(TNI),homocysteine(Hcy) and d-dimer levels before and after treatment were observed and analyzed. Results: After treatment,the total clinical efficiency of the observation group was significantly higher than that of the control group(P <0.05). PCO2 and PO2 in both groups were significantly higher than before treatment,and PO2 in the observation group was significantly higher than that in the control group. The serum TNI,Hcy and d-dimer levels of the two groups were significantly decreased after treatment compared with those before treatment,and the serum TNI,Hcy and d-dimer levels of the observation group were significantly lower than those of the control group. There was no significant difference in the occurrence of adverse reactions between the two groups(P >0.05). Conclusion: For patients with pulmonary embolism,the treatment of patients with pulmonary embolism with heparin combined with dredge injection can effectively improve the clinical efficacy and significantly reduce the levels of serum troponin I,homocysteine and d-dimer.
Objective: To investigate the clinical efficacy of heparin combined with Shuxuetong injection in the treatment of pulmonary embolism and its influence on serum troponin I(TNI),homocysteine(Hcy)and D-dimer levels. Methods: 90 patients with pulmonary embolism admitted to our hospital from April 2015 to April 2018 were selected as study objects. All the patients were randomly divided into control group and observation group,with 45 cases in each group. After the examination,the patients in both groups were diagnosed and treated according to the conventional western medical treatment. The patients in the control group were treated with shuxuetong injection,and the observation group was treated with heparin on the basis of the control group. The clinical efficacy of the two groups and the changes of troponin I(TNI),homocysteine(Hcy) and d-dimer levels before and after treatment were observed and analyzed. Results: After treatment,the total clinical efficiency of the observation group was significantly higher than that of the control group(P <0.05). PCO2 and PO2 in both groups were significantly higher than before treatment,and PO2 in the observation group was significantly higher than that in the control group. The serum TNI,Hcy and d-dimer levels of the two groups were significantly decreased after treatment compared with those before treatment,and the serum TNI,Hcy and d-dimer levels of the observation group were significantly lower than those of the control group. There was no significant difference in the occurrence of adverse reactions between the two groups(P >0.05). Conclusion: For patients with pulmonary embolism,the treatment of patients with pulmonary embolism with heparin combined with dredge injection can effectively improve the clinical efficacy and significantly reduce the levels of serum troponin I,homocysteine and d-dimer.
引文
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[4]孙塑伦,高颖,孙建宁,等.疏血通注射液治疗缺血性脑血管病临床应用专家共识[J].中医杂志,2018,59(2):175~180.
[5]许坤,赵弘卿,冯金萍,等.低分子肝素钙和利伐沙班联合阿托伐他汀对急性肺栓塞患者相关指标的影响[J].中国药房,2017,28(21):2940~2943.
[6]李伦红.低分子量肝素联合华法林治疗晚期肺癌合并急性非大面积肺栓塞临床研究及护理分析[J].重庆医学,2017(A03):424~426.