热毒宁注射液不良反应文献计量研究
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摘要
目的分析热毒宁注射液所致药品不良反应(Adverse drug reaction,ADR)发生的特点和一般规律。方法应用文献计量分析方法,以"热毒宁"、"热毒宁注射液"、"不良反应"、"过敏反应"、"Reduning"、"Reduning injection"、"Adverse reaction"、"Naphylaxis"等为关键词,检索万方数据库、维普中文科技期刊数据库、中国知网(CNKI)和PubMed数据库截至2018年4月的相关文献,经EndNoteX7软件去重和人工排除后,针对患者的信息(性别、年龄、过敏史、用法用量、不良反应发生时间、临床表现、转归等)进行统计分析。结果共纳入39篇文献,2 188例患者。男性多于女性,18岁以下的患者多见。3岁以下婴幼儿每日给予2、4、5、6、8、10 ml剂量都有发生ADR的报道; ADR发生时间最长为7 d,最短为2 min,以30 min内发生最多见;临床表现以皮肤及其附件损害发生率最高;转归一般为痊愈和好转。结论热毒宁注射液所致ADR与多种因素相关,临床应重点关注18岁以下患者,尽量避免3岁以下婴幼儿使用,规范联合用药行为,保障患者的用药安全。
Objective To analyze the characteristics and general rules of adverse drug reactions (ADR) induced by Reduning injection. Methods Literatures were searched from Wanfang database,VIP,CNKI and PubMed up to April 2018 by bibliometric analysis method."Reduning","Reduning Injection","Adverse Reaction"and "Naphylaxis"were selected as key words. After filtering out the repetitive ones by End NoteX7 software and excluding manually,the information,such as gender,age,allergy history,usage and dosage,occurrence time and clinical manifestation of adverse reactions and prognosis,was statistically analyzed. Results A total of 39 articles (n = 2 188) were included.Male patients were more than females,and patients aged less than 18 years old were more frequently seen; ADR has been reported in different doses of 2 ml,4 ml,5 ml,6 ml,8 ml and 10 ml for children aged less than 3 years old. The frequently longest time of ADR occurrence was 7 d,and the shortest was 2 min. The ADR occurred most frequently with in 30 min after treatment. The incidence rate of damage of skin and its appendages was the highest in the aspects of clinical manifestations,and the ADR usually recovered and turned better after disease onset. Conclusion The ADR induced by Reduning injection is related to many factors; clinical attention should be paid to the patients aged less than 18 years old; avoid its use in infants below 3 years old; standardize the combined drug use to ensure the safe use of drugs.
Objective To analyze the characteristics and general rules of adverse drug reactions (ADR) induced by Reduning injection. Methods Literatures were searched from Wanfang database,VIP,CNKI and PubMed up to April 2018 by bibliometric analysis method."Reduning","Reduning Injection","Adverse Reaction"and "Naphylaxis"were selected as key words. After filtering out the repetitive ones by End NoteX7 software and excluding manually,the information,such as gender,age,allergy history,usage and dosage,occurrence time and clinical manifestation of adverse reactions and prognosis,was statistically analyzed. Results A total of 39 articles (n = 2 188) were included.Male patients were more than females,and patients aged less than 18 years old were more frequently seen; ADR has been reported in different doses of 2 ml,4 ml,5 ml,6 ml,8 ml and 10 ml for children aged less than 3 years old. The frequently longest time of ADR occurrence was 7 d,and the shortest was 2 min. The ADR occurred most frequently with in 30 min after treatment. The incidence rate of damage of skin and its appendages was the highest in the aspects of clinical manifestations,and the ADR usually recovered and turned better after disease onset. Conclusion The ADR induced by Reduning injection is related to many factors; clinical attention should be paid to the patients aged less than 18 years old; avoid its use in infants below 3 years old; standardize the combined drug use to ensure the safe use of drugs.
引文
[1]登革热诊疗指南(2014年第2版)[J].中药新药与临床药理,2016,27(1):138-142.
[2]Wilkes FA,Akram H,Hyam JA,et al.Publication productivity of neurosurgeons in Great Britain and Ireland[J].J Neurosurg,2015,122(4):948-954.
[3]Khan MS,Ullah W,Riaz IB,et al.Top 100 cited articles in cardiovascular magnetic resonance:a bibliometric analysis[J].J Cardiovasc M agn Reson,2016,18(1):87.
[4]张玉梅,宁慧雪.93例热毒宁注射液的不良反应报告分析[J].中国卫生产业,2014,12(30):189-190.
[5]田文颖.93例热毒宁注射液的不良反应报告分析[J].中医药导报,2012,18(11):84-86.
[6]张莉.50例热毒宁注射液不良反应分析[J].北方药学,2016,13(8):139,114.
[7]张雷.热毒宁注射液不良反应9例分析[J].河北中医,2013,35(9):1380.
[8]瞿艳红.热毒宁注射剂不良反应三例报告[J].临床合理用药杂志,2012,5(9):40.
[9]皇甫建新.热毒宁注射液不良反应2例[J].医学信息,2012,25(2):413.
[10]施长城,张鹏飞,祁天寿.我院患儿使用热毒宁注射液致不良反应的影响因素分析[J].中国药房,2016,27(26):3636-3640.
[11]常艳鹏,萧伟,杨伟,等.热毒宁注射液医院集中监测不良反应特征分析[J].中医杂志,2014,55(9):791-794.
[12]田晓华.热毒宁注射液不良反应25例分析[J].中国医药指南,2015,13(16):1-2.
[13]王强.热毒宁注射液致不良反应40例分析[J].临床合理用药杂志,2012,5(20):69.
[14]陈静,王蓓蓓.66例热毒宁注射液的不良反应报告分析[J].世界最新医学信息文摘,2017,17(A4):193-194.
[15]杨雪,杨玉涛,李文武,等.182例热毒宁注射液药品不良反应报告分析[J].光明中医,2012,27(6):1250-1252.
[16]柯萌,张叶,张程亮,等.588例热毒宁注射液不良反应分析[J].时珍国医国药,2017,28(11):2682-2683.
[17]施长城.儿科使用热毒宁注射液致26例不良反应及分析[J].药学与临床研究,2015,23(5):501-502.
[18]冯辉.分析热毒宁注射液的不良反应及其相关因素[J].中国卫生标准管理,2017,8(3):111-112.
[19]黎明全,萧伟,谢雁鸣,等.基于巢式设计的热毒宁注射液不良反应特征及影响因素分析[J].中医杂志,2014,55(9):786-790.
[20]丁霞.几种清热解毒类中药注射剂的不良反应及处理办法[J].中国现代药物应用,2015,9(21):254-255.
[21]郑桂香,方草.静滴热毒宁注射液致严重不良反应一例[J].海南医学,2012,23(3):103.
[22]王绚,张永,王珊珊,等.南京医科大学附属南京儿童医院104例热毒宁注射液致不良反应报告分析[J].药物评价研究,2016,39(6):1066-1069.
[23]周永红,吴涤心,李郁,等.热毒宁注射剂不良反应6例报告[J].新疆中医药,2013,31(2):44-47.
[24]李蓉,董志,路晓钦,等.热毒宁注射液不良反应/事件监测及安全性评价[J].中国新药与临床杂志,2014,33(3):233-236.
[25]钱桂英,顾利芳.34例患者热毒宁注射液所致不良反应报告分析[J].抗感染药学,2015,12(3):388-390.
[26]徐梦雪,刘彬,王刚.热毒宁注射液不良反应46例报告分析[J].儿科药学杂志,2012,18(11):27-29.
[27]孙卫峰.热毒宁注射液不良反应情况的临床分析[J].中国继续医学教育,2016,8(13):193-194.
[28]安立澌.热毒宁注射液的不良反应发生因素的分析[D].长春中医药大学,2014.
[29]杨胜斌,舒娟,徐晓芳.热毒宁注射液的不良反应发生原因与预防措施[J].临床合理用药杂志,2016,9(3):167-168.
[30]岳惠玲.热毒宁注射液的不良反应分析[J].中国医药指南,2016,14(6):229-230.
[31]周悦.热毒宁注射液的临床不良反应[J].今日健康杂志,2014,13(4):274.
[32]于红权.热毒宁注射液的临床不良反应分析[J].中国实用医药,2015,10(27):141-142.
[33]叶浩昌.热毒宁注射液的药品不良反应分析与防治[J].临床医药文献电子杂志,2017,4(40):7871.
[34]张文远.热毒宁注射液应用于儿童人群的不良反应发生特征及风险因素分析[J].中国处方药,2017,15(12):66-67.
[35]杜兴,尚菊,林荣强.热毒宁注射液致变态反应2例[J].医药导报,2012,31(1):37.
[36]郁鑫霖.热毒宁注射液致不良反应1例的护理[J].中国误诊学杂志,2011,11(34):8533.
[37]蔺秀香,方海丽.热毒宁注射液致不良反应的原因分析及预防[J].内蒙古中医药,2014,33(29):75-76.
[38]方岚峰,叶佩雯,司徒淑贤.热毒宁注射液致不良反应七例报告[J].临床合理用药杂志,2013,6(6):146-147.
[39]郑勋.热毒宁注射液致过敏性休克一例并不良反应文献复习[J].临床合理用药杂志,2013,6(12):147-148.
[40]邵艳.我院热毒宁注射液致不良反应65例分析[J].中国药房,2015,26(8):1096-1098.
[41]吴燕,吴安林.热毒宁42例不良反应分析[J].世界最新医学信息文摘,2015,15(11):162.
[42]詹云丽,杨小瑶,罗东丽.41例热毒宁注射液不良反应分析[J].药物流行病学杂志,2015,24(10):602-604.
[2]Wilkes FA,Akram H,Hyam JA,et al.Publication productivity of neurosurgeons in Great Britain and Ireland[J].J Neurosurg,2015,122(4):948-954.
[3]Khan MS,Ullah W,Riaz IB,et al.Top 100 cited articles in cardiovascular magnetic resonance:a bibliometric analysis[J].J Cardiovasc M agn Reson,2016,18(1):87.
[4]张玉梅,宁慧雪.93例热毒宁注射液的不良反应报告分析[J].中国卫生产业,2014,12(30):189-190.
[5]田文颖.93例热毒宁注射液的不良反应报告分析[J].中医药导报,2012,18(11):84-86.
[6]张莉.50例热毒宁注射液不良反应分析[J].北方药学,2016,13(8):139,114.
[7]张雷.热毒宁注射液不良反应9例分析[J].河北中医,2013,35(9):1380.
[8]瞿艳红.热毒宁注射剂不良反应三例报告[J].临床合理用药杂志,2012,5(9):40.
[9]皇甫建新.热毒宁注射液不良反应2例[J].医学信息,2012,25(2):413.
[10]施长城,张鹏飞,祁天寿.我院患儿使用热毒宁注射液致不良反应的影响因素分析[J].中国药房,2016,27(26):3636-3640.
[11]常艳鹏,萧伟,杨伟,等.热毒宁注射液医院集中监测不良反应特征分析[J].中医杂志,2014,55(9):791-794.
[12]田晓华.热毒宁注射液不良反应25例分析[J].中国医药指南,2015,13(16):1-2.
[13]王强.热毒宁注射液致不良反应40例分析[J].临床合理用药杂志,2012,5(20):69.
[14]陈静,王蓓蓓.66例热毒宁注射液的不良反应报告分析[J].世界最新医学信息文摘,2017,17(A4):193-194.
[15]杨雪,杨玉涛,李文武,等.182例热毒宁注射液药品不良反应报告分析[J].光明中医,2012,27(6):1250-1252.
[16]柯萌,张叶,张程亮,等.588例热毒宁注射液不良反应分析[J].时珍国医国药,2017,28(11):2682-2683.
[17]施长城.儿科使用热毒宁注射液致26例不良反应及分析[J].药学与临床研究,2015,23(5):501-502.
[18]冯辉.分析热毒宁注射液的不良反应及其相关因素[J].中国卫生标准管理,2017,8(3):111-112.
[19]黎明全,萧伟,谢雁鸣,等.基于巢式设计的热毒宁注射液不良反应特征及影响因素分析[J].中医杂志,2014,55(9):786-790.
[20]丁霞.几种清热解毒类中药注射剂的不良反应及处理办法[J].中国现代药物应用,2015,9(21):254-255.
[21]郑桂香,方草.静滴热毒宁注射液致严重不良反应一例[J].海南医学,2012,23(3):103.
[22]王绚,张永,王珊珊,等.南京医科大学附属南京儿童医院104例热毒宁注射液致不良反应报告分析[J].药物评价研究,2016,39(6):1066-1069.
[23]周永红,吴涤心,李郁,等.热毒宁注射剂不良反应6例报告[J].新疆中医药,2013,31(2):44-47.
[24]李蓉,董志,路晓钦,等.热毒宁注射液不良反应/事件监测及安全性评价[J].中国新药与临床杂志,2014,33(3):233-236.
[25]钱桂英,顾利芳.34例患者热毒宁注射液所致不良反应报告分析[J].抗感染药学,2015,12(3):388-390.
[26]徐梦雪,刘彬,王刚.热毒宁注射液不良反应46例报告分析[J].儿科药学杂志,2012,18(11):27-29.
[27]孙卫峰.热毒宁注射液不良反应情况的临床分析[J].中国继续医学教育,2016,8(13):193-194.
[28]安立澌.热毒宁注射液的不良反应发生因素的分析[D].长春中医药大学,2014.
[29]杨胜斌,舒娟,徐晓芳.热毒宁注射液的不良反应发生原因与预防措施[J].临床合理用药杂志,2016,9(3):167-168.
[30]岳惠玲.热毒宁注射液的不良反应分析[J].中国医药指南,2016,14(6):229-230.
[31]周悦.热毒宁注射液的临床不良反应[J].今日健康杂志,2014,13(4):274.
[32]于红权.热毒宁注射液的临床不良反应分析[J].中国实用医药,2015,10(27):141-142.
[33]叶浩昌.热毒宁注射液的药品不良反应分析与防治[J].临床医药文献电子杂志,2017,4(40):7871.
[34]张文远.热毒宁注射液应用于儿童人群的不良反应发生特征及风险因素分析[J].中国处方药,2017,15(12):66-67.
[35]杜兴,尚菊,林荣强.热毒宁注射液致变态反应2例[J].医药导报,2012,31(1):37.
[36]郁鑫霖.热毒宁注射液致不良反应1例的护理[J].中国误诊学杂志,2011,11(34):8533.
[37]蔺秀香,方海丽.热毒宁注射液致不良反应的原因分析及预防[J].内蒙古中医药,2014,33(29):75-76.
[38]方岚峰,叶佩雯,司徒淑贤.热毒宁注射液致不良反应七例报告[J].临床合理用药杂志,2013,6(6):146-147.
[39]郑勋.热毒宁注射液致过敏性休克一例并不良反应文献复习[J].临床合理用药杂志,2013,6(12):147-148.
[40]邵艳.我院热毒宁注射液致不良反应65例分析[J].中国药房,2015,26(8):1096-1098.
[41]吴燕,吴安林.热毒宁42例不良反应分析[J].世界最新医学信息文摘,2015,15(11):162.
[42]詹云丽,杨小瑶,罗东丽.41例热毒宁注射液不良反应分析[J].药物流行病学杂志,2015,24(10):602-604.