厄贝沙坦联合氨氯地平治疗高血压左室肥厚临床效果探讨
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摘要
目的探讨厄贝沙坦联合氨氯地平治疗高血压左室肥厚的临床效果。方法将我院2017年3月—2018年3月收治的高血压左室肥厚患者98例作为探讨对象,按入院顺序将其分成对照组和观察组各49例,对照组患者在治疗中应用氨氯地平进行治疗,观察组患者则应用厄贝沙坦联合氨氯地平进行治疗,观察两组患者治疗效果。结果观察组患者的临床治疗效果以及SBP、DBP评分明显优于对照组,组间数据差异存在统计学意义(P <0.05)。结论针对高血压左室肥厚患者给予厄贝沙坦与氨氯地平联用治疗,可有效提高临床治疗效果,改善患者临床症状。
Objective To discuss the clinical effect of irbesartan combined with amlodipine in the treatment of hypertensive with left ventricular hypertrophy. Methods 98 hypertensive patients with left ventricular hypertrophy admitted from March 2017 and March 2018 in our hospital were investigated. According to the order of admission, 49 patients were divided into control group and observation group. The control group was under treatment. Amlodipine was used for treatment. The patients in the observation group were treated with irbesartan combined with amlodipine, and the treatment effects of the two groups were observed. Results The clinical treatment effect and SBP and DBP scores in the observation group were significantly better than those in the control group. There was a statistically significant difference in the data between the groups(P < 0.05). Conclusion The combination of irbesartan with amlodipine in the treatment of hypertension in patients with left ventricular hypertrophy can effectively improve the clinical effect and improve the clinical symptoms of patients.
Objective To discuss the clinical effect of irbesartan combined with amlodipine in the treatment of hypertensive with left ventricular hypertrophy. Methods 98 hypertensive patients with left ventricular hypertrophy admitted from March 2017 and March 2018 in our hospital were investigated. According to the order of admission, 49 patients were divided into control group and observation group. The control group was under treatment. Amlodipine was used for treatment. The patients in the observation group were treated with irbesartan combined with amlodipine, and the treatment effects of the two groups were observed. Results The clinical treatment effect and SBP and DBP scores in the observation group were significantly better than those in the control group. There was a statistically significant difference in the data between the groups(P < 0.05). Conclusion The combination of irbesartan with amlodipine in the treatment of hypertension in patients with left ventricular hypertrophy can effectively improve the clinical effect and improve the clinical symptoms of patients.
引文
[1]肖秋玉.厄贝沙坦与氨氯地平治疗高血压病的临床疗效观察[J].中国药物经济学,2013(1):241-242.
[2]马鑫.厄贝沙坦与氨氯地平治疗高血压的临床疗效[J].中国保健营养,2016,26(10):110.
[3]Gaudio C,Ferri FM,Giovannini M,et al.Comparative effects of irbesartan versus amlodipine on left ventricular mass index in hypertensive patients with left ventricular hypertrophy[J].Journal of Cardiovascular Pharmacology,2003,42(5):622-628.
[4]张强.厄贝沙坦联合氨氯地平治疗高血压左室肥厚临床分析[J].中国现代药物应用,2014,8(9):121-122.
[5]张陶莉,张春晓.厄贝沙坦联合苯磺酸氨氯地平治疗老年糖尿病合并高血压伴高尿酸血症[J].中国临床医生,2011,39(12):25-27.
[6]胡海强,於华敏,孙金栋,等.厄贝沙坦联合氨氯地平治疗高血压合并糖尿病肾病的疗效观察[J].中国生化药物杂志,2015,35(4):141-143.
[7]张晓,马琳,郑乐民.厄贝沙坦联合苯磺酸氨氯地平对老年糖尿病高血压合并高尿酸血症患者的疗效研究[J].中国生化药物杂志,2014,34(8):157-158,161.
[8]王又省.厄贝沙坦与氨氯地平联用治疗高血压左室肥厚的临床疗效评价[J].当代医学,2013,19(10):6-7.
[9]YASUNARI MATSUNO,SHINYA MINATOGUCHI,HISAYOSHI FUJIWARA,et al.Effects of candesartan versus amlodipine on home-measured blood pressure,QT dispersion and left ventricular hypertrophy in high-risk hypertensive patients[J].Blood pressure,2011(Suppl 1):12-19.
[10]潘宏华,边平达.厄贝沙坦联合氨氯地平或氢氯噻嗪在老年高血压患者中的疗效[J].中国临床药理学杂志,2013,29(4):246-248.
[11]雷强,董玉会,严丹.左旋氨氯地平与厄贝沙坦联合治疗糖尿病并发肾病及高血压[J].四川医学,2009,30(6):854-855.
[12]李菊琴.厄贝沙坦联合氨氯地平治疗老年高血压并2型糖尿病效果[J].中国继续医学教育,2018,10(2):123-125.
[13]张硕,马静,张赛丹.左旋氨氯地平联合厄贝沙坦或阿罗洛尔对原发性高血压患者左心室舒张功能的影响[J].中华高血压杂志,2015,23(3):276-279.
[2]马鑫.厄贝沙坦与氨氯地平治疗高血压的临床疗效[J].中国保健营养,2016,26(10):110.
[3]Gaudio C,Ferri FM,Giovannini M,et al.Comparative effects of irbesartan versus amlodipine on left ventricular mass index in hypertensive patients with left ventricular hypertrophy[J].Journal of Cardiovascular Pharmacology,2003,42(5):622-628.
[4]张强.厄贝沙坦联合氨氯地平治疗高血压左室肥厚临床分析[J].中国现代药物应用,2014,8(9):121-122.
[5]张陶莉,张春晓.厄贝沙坦联合苯磺酸氨氯地平治疗老年糖尿病合并高血压伴高尿酸血症[J].中国临床医生,2011,39(12):25-27.
[6]胡海强,於华敏,孙金栋,等.厄贝沙坦联合氨氯地平治疗高血压合并糖尿病肾病的疗效观察[J].中国生化药物杂志,2015,35(4):141-143.
[7]张晓,马琳,郑乐民.厄贝沙坦联合苯磺酸氨氯地平对老年糖尿病高血压合并高尿酸血症患者的疗效研究[J].中国生化药物杂志,2014,34(8):157-158,161.
[8]王又省.厄贝沙坦与氨氯地平联用治疗高血压左室肥厚的临床疗效评价[J].当代医学,2013,19(10):6-7.
[9]YASUNARI MATSUNO,SHINYA MINATOGUCHI,HISAYOSHI FUJIWARA,et al.Effects of candesartan versus amlodipine on home-measured blood pressure,QT dispersion and left ventricular hypertrophy in high-risk hypertensive patients[J].Blood pressure,2011(Suppl 1):12-19.
[10]潘宏华,边平达.厄贝沙坦联合氨氯地平或氢氯噻嗪在老年高血压患者中的疗效[J].中国临床药理学杂志,2013,29(4):246-248.
[11]雷强,董玉会,严丹.左旋氨氯地平与厄贝沙坦联合治疗糖尿病并发肾病及高血压[J].四川医学,2009,30(6):854-855.
[12]李菊琴.厄贝沙坦联合氨氯地平治疗老年高血压并2型糖尿病效果[J].中国继续医学教育,2018,10(2):123-125.
[13]张硕,马静,张赛丹.左旋氨氯地平联合厄贝沙坦或阿罗洛尔对原发性高血压患者左心室舒张功能的影响[J].中华高血压杂志,2015,23(3):276-279.