1780例泌尿生殖道标本支原体培养与药敏结果分析
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摘要
目的分析惠州市第一人民医院解脲支原体(UU)和人型支原体(MH)的感染情况以及抗生素的耐药性。方法收集2017年1月～2018年7月到惠州市第一人民医院就诊患者的泌尿生殖道标本1780例,分析支原体感染及耐药情况。结果 1780例标本中支原体感染者1286例(72.25%),单纯UU阳性1053例,占81.88%,单纯MH阳性30例,占2.33%,UU+MH双感染203例,占12.39%。支原体感染具有性别差异,女性感染率(77.53%)明显高于男性(11.27%),差异有统计学意义(P<0.05)。药敏实验结果显示,支原体对强力霉素、美满霉素、交沙霉素的敏感率较高,MH、UU+MH对克拉霉素、罗红霉素、阿奇霉素与氧氟沙星的耐药率较高。结论泌尿生殖道支原体感染主要由UU引起,且多发于女性,建议选用敏感性高的药物如强力霉素、美满霉素、交沙霉素进行治疗。
Objective To analyze the infection of Ureaplasma urealyticum(UU)and Mycoplasma hominis(MH)and drug resistance of antibiotics in the First Peopole′ s Hospital of Huizhou City. Methods All of 1780 urogenital tract specimens from the patients treated in the First Peopole′s Hospital of Huizhou City from January 2017 to July 2018 were collected. Mycoplasma infection and drug resistance were analyzed. Results In 1780 specimens, 1286(72.25%)were Mycoplasma infection, 1053 cases(81.88%) were UU-positive, 30 cases(2.33%) were MH-positive, 203 cases(12.39%) were UU+MH-positive. The infection rate of Mycoplasma in women(77.53%) was significantly higher than that in men(11.27%) and the difference was statistically significant(P<0.05). Drug susceptibility test showed that Mycoplasma was more susceptible to Doxycycline, Minocycline and Josamycin, while MH, UU+MH were more resistant to Clarithromycin, Roxithromycin, Azithromycin and Ofloxacin. Conclusion Mycoplasma infection in urogenital tract is major caused by UU, that mostly occurs in female. It is recommended to use high sensitive antibiotices such as Doxycycline, Minocycline, and Josamycin to treat.
Objective To analyze the infection of Ureaplasma urealyticum(UU)and Mycoplasma hominis(MH)and drug resistance of antibiotics in the First Peopole′ s Hospital of Huizhou City. Methods All of 1780 urogenital tract specimens from the patients treated in the First Peopole′s Hospital of Huizhou City from January 2017 to July 2018 were collected. Mycoplasma infection and drug resistance were analyzed. Results In 1780 specimens, 1286(72.25%)were Mycoplasma infection, 1053 cases(81.88%) were UU-positive, 30 cases(2.33%) were MH-positive, 203 cases(12.39%) were UU+MH-positive. The infection rate of Mycoplasma in women(77.53%) was significantly higher than that in men(11.27%) and the difference was statistically significant(P<0.05). Drug susceptibility test showed that Mycoplasma was more susceptible to Doxycycline, Minocycline and Josamycin, while MH, UU+MH were more resistant to Clarithromycin, Roxithromycin, Azithromycin and Ofloxacin. Conclusion Mycoplasma infection in urogenital tract is major caused by UU, that mostly occurs in female. It is recommended to use high sensitive antibiotices such as Doxycycline, Minocycline, and Josamycin to treat.
引文
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[2]王家雄.支原体和衣原体感染对男性生殖的影响[J].中华男科学杂志,2017,23(2):183-188.
[3]方菊,曹正英,吉文倩,等.医院非淋球菌性尿道炎患者支原体感染和耐药状况研究[J].中华医院感染学杂志,2017,27(3):510-513.
[4]陈浩宇,郭海波,吴晓蔓,等.2744例泌尿生殖道感染患者解脲支原体和人型支原体分布及耐药率分析[J].中华实用诊断与治疗杂志,2016,30(4):415-416.
[5]周琼艳,赵敬军,许素玲,等.13181例疑似生殖道支原体感染患者支原体分布及耐药率分析[J].中华临床感染病杂志,2016,9(2):186-189.
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[7]贾双荣,胡萌,蒋琳华,等.重庆地区4414例泌尿生殖道支原体检测及药敏分析[J].重庆医学,2017,46(5):609-611.
[8]王鹏,泰淑红,徐豪,等.10734例女性泌尿生殖道支原体感染及耐药性分析[J].现代预防医学,2014,41(22):4073-4076.
[9]郑新,李岸英,刘忠,等.5640例门诊患者生殖道支原体属感染状况及耐药率分析[J].中国药房,2016,27(5):622-624.
[10]龚娅,段德令,何宗忠,等.19530例泌尿生殖道感染患者支原体感染及药敏结果分析[J].重庆医学,2015,44(25):3539-3541.
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[13]Bayraktar MR,Ozerol IH,Gucluer N,et al.Prevalence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in pregnant women[J].Int J infect Dis,2010,14(2):1271-1275.
[14]Zhou Y,Ma H,Shi X,et al.Prevalence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum coinfection[J].J Infect Chemother,2014,14(1):11-14.
[15]刘思宇,朱艳,张晓梅,等.不孕不育患者宫颈解脲支原体感染情况分析及耐药监测[J].中华全科医学,2017,15(10):1748-1751.
[16]潘长清,王丹,齐成秋,等.不孕妇女支原体感染调查与药物敏感性研究[J].中华医院感染学杂志,2017,27(11):2583-2586.
[17]何涛,孙宗立,袁红英,等.高危型人乳头状瘤病毒阳性患者支原体属感染与宫颈癌发生的相关性研究[J].中华医院感染学杂志,2014,24(9):2094-2098.
[18]王顺德,王澍弘,李行,等.男性泌尿生殖道支原体感染特征及耐药性分析[J].中国病原生物学杂志,2017(7):680-684.
[19]Wang QY,Li RH,Zheng LQ,et al.Prevalence and antimicrobial susceptibility of Ureaplasma urealyticum and Mycoplasma hominis in female outpatients,2009-2013[J].J Microbiol Immunol Infect,2016,49(3):359-362.
[20]邱静,佟志刚,裘晓华.孕期抗菌药物对孕妇妊娠结局影响分析[J].中华医院感染学杂志,2017,27(1):175-178.
[2]王家雄.支原体和衣原体感染对男性生殖的影响[J].中华男科学杂志,2017,23(2):183-188.
[3]方菊,曹正英,吉文倩,等.医院非淋球菌性尿道炎患者支原体感染和耐药状况研究[J].中华医院感染学杂志,2017,27(3):510-513.
[4]陈浩宇,郭海波,吴晓蔓,等.2744例泌尿生殖道感染患者解脲支原体和人型支原体分布及耐药率分析[J].中华实用诊断与治疗杂志,2016,30(4):415-416.
[5]周琼艳,赵敬军,许素玲,等.13181例疑似生殖道支原体感染患者支原体分布及耐药率分析[J].中华临床感染病杂志,2016,9(2):186-189.
[6]张妹,许琦,张丽,等.女性生殖道感染支原体的情况及耐药性分析[J].中国当代医药,2016,23(3):108-110.
[7]贾双荣,胡萌,蒋琳华,等.重庆地区4414例泌尿生殖道支原体检测及药敏分析[J].重庆医学,2017,46(5):609-611.
[8]王鹏,泰淑红,徐豪,等.10734例女性泌尿生殖道支原体感染及耐药性分析[J].现代预防医学,2014,41(22):4073-4076.
[9]郑新,李岸英,刘忠,等.5640例门诊患者生殖道支原体属感染状况及耐药率分析[J].中国药房,2016,27(5):622-624.
[10]龚娅,段德令,何宗忠,等.19530例泌尿生殖道感染患者支原体感染及药敏结果分析[J].重庆医学,2015,44(25):3539-3541.
[11]Hunjak B,Sabol I,Vojnovic G,et al.Ureaplasma urealyticum,and Ureaplasma parvum,in women of reproductive age[J].Arch Gynecol Obste,2014,289(2):407-412.
[12]曾义斌,权哲,梅莉红,等.孕妇生殖道支原体属感染的调查与药敏分析[J].中华医院感染学杂志,2014,24(3):730-731.
[13]Bayraktar MR,Ozerol IH,Gucluer N,et al.Prevalence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in pregnant women[J].Int J infect Dis,2010,14(2):1271-1275.
[14]Zhou Y,Ma H,Shi X,et al.Prevalence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum coinfection[J].J Infect Chemother,2014,14(1):11-14.
[15]刘思宇,朱艳,张晓梅,等.不孕不育患者宫颈解脲支原体感染情况分析及耐药监测[J].中华全科医学,2017,15(10):1748-1751.
[16]潘长清,王丹,齐成秋,等.不孕妇女支原体感染调查与药物敏感性研究[J].中华医院感染学杂志,2017,27(11):2583-2586.
[17]何涛,孙宗立,袁红英,等.高危型人乳头状瘤病毒阳性患者支原体属感染与宫颈癌发生的相关性研究[J].中华医院感染学杂志,2014,24(9):2094-2098.
[18]王顺德,王澍弘,李行,等.男性泌尿生殖道支原体感染特征及耐药性分析[J].中国病原生物学杂志,2017(7):680-684.
[19]Wang QY,Li RH,Zheng LQ,et al.Prevalence and antimicrobial susceptibility of Ureaplasma urealyticum and Mycoplasma hominis in female outpatients,2009-2013[J].J Microbiol Immunol Infect,2016,49(3):359-362.
[20]邱静,佟志刚,裘晓华.孕期抗菌药物对孕妇妊娠结局影响分析[J].中华医院感染学杂志,2017,27(1):175-178.