调经促孕丸联合克罗米芬对多囊卵巢综合征患者卵泡发育及妊娠情况的影响
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摘要
目的探讨调经促孕丸联合克罗米芬(CC)对多囊卵巢综合征患者(PCOS)卵泡发育及妊娠情况的影响。方法抽选广东省电白区妇幼保健院2010年3月至2017年3月收治的98例PCOS患者作为研究对象,采用随机数字表法分为对照组(n=49例)和观察组(n=49例),两组均采用克罗米芬(CC)促排卵,观察组同时口服调经促孕丸,比较两组患者治疗前后的激素水平及排卵率、妊娠率、卵泡大小、子宫内膜厚度、宫颈黏液评分、妊娠早期流产率。结果两组治疗后卵泡刺激素(FSH)、促黄体生成素(LH)、LH/FSH水平均显著降低,且观察组均明显低于对照组,差异均有统计学意义(均P<0.05)。观察组治疗后子宫内膜厚度、卵泡大小、宫颈黏液评分、排卵率、妊娠率明显高于对照组(t/χ2=13.474、18.477、12.614、5.089、4.991,P<0.05),妊娠早期流产率低于对照组(χ2=4.900,P<0.05)。结论调经促孕丸联合CC治疗PCOS临床疗效显著,能降低性激素水平,促进卵泡发育,改善子宫内膜厚度,提高妊娠率。
Objective To study the effects of Tiaojing Cuyun Pills(调经促孕丸) and clomiphene citrate(CC) on follicular development and pregnancy rate in patients with polycystic ovarian syndrome(PCOS). Methods A total of 98 PCOS patients admitted to Guangdong Maternal and Child Health Hospital of Dianbai District from March 2010 to March 2017 were selected as the research objects. They were randomly divided into control group(n=49) and observation group(n=49). Clomiphene citrate(CC)was used to promote ovulation in both groups. The observation group was given Tiaojing Cuyun Pills orally at the same time. The hormone levels, ovulation rate, pregnancy rate, follicle size, endometrial thickness, cervical mucus score, and abortion rate in early pregnancy of the 2 groups were compared before and after treatment. Results The levels of follicle stimulating hormone(FSH),luteinizing hormone(LH), and LH/FSH in the 2 groups were significantly lowered, and these in the observation group were significantly lower than those in the control group. The differences were statistically significant(P<0.05). After the treatment, the endometrial thickness, follicle size, cervical mucus score, ovulation rate and pregnancy rate in the observation group were significantly higher than those in the control group(t/χ2 =13.474, 18.477, 12.614, 5.089, 4.991, P<0.05), and the abortion rate in early pregnancy was lower than that in the control group(χ2 =4.900, P<0.05). Conclusion Tiaojing Cuyun Pills combined with CC in the treatment of PCOS has remarkable clinical efficacy. It can reduce the level of sex hormones, promote follicular development, improve endometrial thickness and increase pregnancy rate.
Objective To study the effects of Tiaojing Cuyun Pills(调经促孕丸) and clomiphene citrate(CC) on follicular development and pregnancy rate in patients with polycystic ovarian syndrome(PCOS). Methods A total of 98 PCOS patients admitted to Guangdong Maternal and Child Health Hospital of Dianbai District from March 2010 to March 2017 were selected as the research objects. They were randomly divided into control group(n=49) and observation group(n=49). Clomiphene citrate(CC)was used to promote ovulation in both groups. The observation group was given Tiaojing Cuyun Pills orally at the same time. The hormone levels, ovulation rate, pregnancy rate, follicle size, endometrial thickness, cervical mucus score, and abortion rate in early pregnancy of the 2 groups were compared before and after treatment. Results The levels of follicle stimulating hormone(FSH),luteinizing hormone(LH), and LH/FSH in the 2 groups were significantly lowered, and these in the observation group were significantly lower than those in the control group. The differences were statistically significant(P<0.05). After the treatment, the endometrial thickness, follicle size, cervical mucus score, ovulation rate and pregnancy rate in the observation group were significantly higher than those in the control group(t/χ2 =13.474, 18.477, 12.614, 5.089, 4.991, P<0.05), and the abortion rate in early pregnancy was lower than that in the control group(χ2 =4.900, P<0.05). Conclusion Tiaojing Cuyun Pills combined with CC in the treatment of PCOS has remarkable clinical efficacy. It can reduce the level of sex hormones, promote follicular development, improve endometrial thickness and increase pregnancy rate.
引文
[1]陈海庚.调经促孕丸用于脾肾阳虚型多囊卵巢综合征所致不孕症治疗中的价值分析[J].中国现代药物应用,2016,10(18):279-280.
[2]段亚萍.小剂量阿司匹林配伍中成药对多囊卵巢综合征患者卵泡发育及妊娠情况的影响[J].现代中西医结合杂志, 2016, 25(26):2942-2944.
[3]马春霞.调经促孕丸配合克罗米芬治疗多囊卵巢综合征性不孕症的疗效观察[J].内蒙古中医药, 2017(8):96-97.
[4]谢幸,苟文丽.妇产科学[M]. 8版.北京:人民卫生出版社, 2013.
[5]何蕴良,徐晓娟,李宛静,等.肥胖型多囊卵巢综合征中西医研究进展[J].中华中医药学刊, 2015, 33(7):1614-1616.
[6]管海云,张炜.多囊卵巢综合征对子宫内膜容受性的影响[J].生殖医学杂志, 2016, 25(12):1122-1125.
[7]贾七英,张翠肖,彭彩桥.中西医结合治疗多囊卵巢综合征致不孕疗效观察[J].现代中西医结合杂志,2014,23(14):1555-1556.
[8]林淑萍,王金永.戊酸雌二醇片、炔雌醇环丙孕酮片及枸橼酸氯米芬胶囊联合治疗多囊卵巢综合征的疗效观察[J].中国医院用药评价与分析, 2016, 16(11):1517-1519.
[2]段亚萍.小剂量阿司匹林配伍中成药对多囊卵巢综合征患者卵泡发育及妊娠情况的影响[J].现代中西医结合杂志, 2016, 25(26):2942-2944.
[3]马春霞.调经促孕丸配合克罗米芬治疗多囊卵巢综合征性不孕症的疗效观察[J].内蒙古中医药, 2017(8):96-97.
[4]谢幸,苟文丽.妇产科学[M]. 8版.北京:人民卫生出版社, 2013.
[5]何蕴良,徐晓娟,李宛静,等.肥胖型多囊卵巢综合征中西医研究进展[J].中华中医药学刊, 2015, 33(7):1614-1616.
[6]管海云,张炜.多囊卵巢综合征对子宫内膜容受性的影响[J].生殖医学杂志, 2016, 25(12):1122-1125.
[7]贾七英,张翠肖,彭彩桥.中西医结合治疗多囊卵巢综合征致不孕疗效观察[J].现代中西医结合杂志,2014,23(14):1555-1556.
[8]林淑萍,王金永.戊酸雌二醇片、炔雌醇环丙孕酮片及枸橼酸氯米芬胶囊联合治疗多囊卵巢综合征的疗效观察[J].中国医院用药评价与分析, 2016, 16(11):1517-1519.