缺氧诱导因子1α在急性心肌梗死中的研究进展
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摘要
<正>急性心肌梗死(acute myocardial infarction,AMI)是临床上常见的高危心血管病急症,具有发病急、进展迅速、并发症多、病死率及致残率高等特点,严重危害人类健康。冠脉内粥样斑块形成、破裂,继而血小板黏附、聚集,在此基础上血栓形成,血管急性闭塞引起的急性心肌缺血、缺氧和坏死是AMI发生发展的主要病理机制。据统计,约1/3的AMI患者临床症状并不典型,从而延误最佳诊疗时机,引发一系列严重的心血管终点事件,因此,对AMI
引文
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[8] 李建勇,王彬尧,王长谦,等.HIF-1基因治疗促进缺血心肌血管新生的实验研究[J].中国心血管病研究杂志,2005,3(9):709-711.
[9] 王琼.急性心肌梗死患者急诊PCI治疗前后HIF-1α的表达变化与意义[J].临床医学,2015,35(2):31-32.
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[12] 李玲萍.急性心梗患者血清低氧诱导因子-1α与心肌标志物的相关性研究[D].太原:山西医科大学,2016.
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[15] 孔宏亮,侯爱洁,陈晓明,等.HIF-1α介导人参皂甙Rb1对缺氧心肌细胞葡萄糖代谢的调节[J].中国病理生理杂志,2016,32(9):1621-1626.
[16] 王东,薛守斌,曹明嫄,等.HIF-1α、BNP表达在缺氧性肺动脉高压中的研究进展[J].临床肺杂志,2015,20(2):321-323.
[17] MALHOTRA R,TYSON D W,ROSEVEAR H M.et al.Hypoxia-inducible factor-1alpha is a critical mediator of hypoxia-induced apoptosis in cardiacH9c2 and kidney epithelial HK-2 cells[J].BMC Cardiovasc Disord,2008,8:9.
[18] 林美玲,余伟,王伟,等.线粒体应激蛋白沉默信息调节因子2相关酶3通过缺氧诱导因子-1α和核转录因子-κB信号通保护心肌缺血损伤[J].中国血液流变学杂志,2016,26(4):397-402.
[19] SANTINI D,ABBATE A,SCRAP S,et al.Surviving acute myocardial infarction:survivin expression in viable cardiomyocytes after infarction[J].J Clin Pathol,2004,57(12):1321-1324.
[20] 窦梦怡,秦富忠,李保.缺氧诱导因子在心脏重构和心力衰竭中的作用[J].中国循环杂志,2015,30(11):1125-1127.
[2] 李大伟,董频.缺氧诱导因子-1α在头颈肿瘤中的研究进展[J].现代肿瘤医学,2010,18(8):1650-1652.
[3] SHOULDERS M D,RAINES R T.Collagen structure and stability[J].Annu Rev Biochem,2009,78:929-958.
[4] YANG P W,REECEE A.Role of HIF-1α in maternal hyperglycemia-induced embryonic vasculopathy[J].Am J Obstet Gynecol,2011,204(4):332.e1-7.
[5] JIU W,WANG S J,LIN Q D.Study on the expressions of PHD and HIF in placentas from normal pregnant women and patients with preeclampsia[J].Int J Biol Sei,2014,10(3):278-284.
[6] KIDO M,DU L,SULIiVAN C C,et al.Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse[J].J Am Coll Cardiol,2005,46(11):2116-2124.
[7] 刘静.低氧诱导因子-1α在良性气道狭窄肉芽组织成纤维细胞的表达[D].石家庄:河北医科大学,2016.
[8] 李建勇,王彬尧,王长谦,等.HIF-1基因治疗促进缺血心肌血管新生的实验研究[J].中国心血管病研究杂志,2005,3(9):709-711.
[9] 王琼.急性心肌梗死患者急诊PCI治疗前后HIF-1α的表达变化与意义[J].临床医学,2015,35(2):31-32.
[10] AL-SALAM S,HASHMI S.Galectin-1 in acute myocardial infarction[J].PLoS One,2014,9(1):e86994.
[11] CLEE S H,WOLF P L,ESCUDERO R,et al.Early expression of angiogenesis factor in acute myocardial ischemia and infarction[J].N Engl J Med,2000,342(9):626-633.
[12] 李玲萍.急性心梗患者血清低氧诱导因子-1α与心肌标志物的相关性研究[D].太原:山西医科大学,2016.
[13] KAMURA T,SATO S,IWAI K.Activation of HIF-1a ubiquitination by a reconstituted von Hippel-Lindu(VHL)tumor suppressor complex[J].Pro Natl Acad Sci USA,2000,97(19):10430-10435.
[14] CHEN S M,LI Y G,ZHANG H X,et al.Hypoxia-inducible factor-1alpha induces the coronary collaterals for coronary artery disease[J].Coron Artery Dis,2008,19(3):1732-1739.
[15] 孔宏亮,侯爱洁,陈晓明,等.HIF-1α介导人参皂甙Rb1对缺氧心肌细胞葡萄糖代谢的调节[J].中国病理生理杂志,2016,32(9):1621-1626.
[16] 王东,薛守斌,曹明嫄,等.HIF-1α、BNP表达在缺氧性肺动脉高压中的研究进展[J].临床肺杂志,2015,20(2):321-323.
[17] MALHOTRA R,TYSON D W,ROSEVEAR H M.et al.Hypoxia-inducible factor-1alpha is a critical mediator of hypoxia-induced apoptosis in cardiacH9c2 and kidney epithelial HK-2 cells[J].BMC Cardiovasc Disord,2008,8:9.
[18] 林美玲,余伟,王伟,等.线粒体应激蛋白沉默信息调节因子2相关酶3通过缺氧诱导因子-1α和核转录因子-κB信号通保护心肌缺血损伤[J].中国血液流变学杂志,2016,26(4):397-402.
[19] SANTINI D,ABBATE A,SCRAP S,et al.Surviving acute myocardial infarction:survivin expression in viable cardiomyocytes after infarction[J].J Clin Pathol,2004,57(12):1321-1324.
[20] 窦梦怡,秦富忠,李保.缺氧诱导因子在心脏重构和心力衰竭中的作用[J].中国循环杂志,2015,30(11):1125-1127.