阻塞性睡眠呼吸暂停低通气综合征与颈动脉内膜中层厚度关系的研究进展
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摘要
阻塞性睡眠呼吸暂停低通气综合征(OSAHS)以夜间反复低氧血症、高碳酸血症为特点。近年来发现OSAHS与中风、心力衰竭等动脉粥样硬化性心血管疾病(ASCVD)发病密切相关。而颈动脉内膜中层厚度(CIMT)可预测ASCVD。故研究OSAHS与CIMT对于预防OSAHS患者动脉粥样硬化(As),甚至ASCVD意义重大。本文介绍了OSAHS的流行病学、OSAHS导致IMT增厚的机制及相关治疗,为干预OSAHS患者的动脉粥样硬化进展提供参考和依据。
Obstructive sleep apnea hypopnea syndrome(OSAHS) is characterized by recurrent hypoxemia and hypercapnia at night. Recent fingdings show that OSAHS is closely associated with atherosclerosis cardiovascular disease(ASCVD)such as stroke,heart failure. And carotid intima-media thickness(CIMT)can predict ASCVD. So it is significant for preventing atherosclerosis(As) in OSAHS patients to study the relationship between IMT and OSAHS. This review summarized the recent research progress on the relationship between obstructive sleep apnea hypopnea syndrome and carotid intima-media thickness, including human epidemiological and related mechanism studies and related treatments. It can provide a background reference for interrupting the progress of As in OSAHS patients.
Obstructive sleep apnea hypopnea syndrome(OSAHS) is characterized by recurrent hypoxemia and hypercapnia at night. Recent fingdings show that OSAHS is closely associated with atherosclerosis cardiovascular disease(ASCVD)such as stroke,heart failure. And carotid intima-media thickness(CIMT)can predict ASCVD. So it is significant for preventing atherosclerosis(As) in OSAHS patients to study the relationship between IMT and OSAHS. This review summarized the recent research progress on the relationship between obstructive sleep apnea hypopnea syndrome and carotid intima-media thickness, including human epidemiological and related mechanism studies and related treatments. It can provide a background reference for interrupting the progress of As in OSAHS patients.
引文
[1]Zaidi FN,Meadows P,Jacobowitz O,et al.Tongue anatomy and physiology,the scientific basis for a novel targeted neurostimulation system designed for the treatment of obstructive sleep apnea[J].Neuromodulation,2013,16(4):376-386.
[2]Yaggi HK,Concato J,Kernan WN,et al.Obstructive sleep apnea as a risk factor for stroke and death[J].N Engl J Med,2005,353(19):2034-2041.
[3]杨秀平,赵尧辉,冯玉婧,等.阻塞性睡眠呼吸暂停低通气综合征与脑梗死的关系[J].中国动脉硬化杂志,2015,23(7):713-716.
[4]Bouloukaki I,Mermigkis C,Kallergis EM,et al.Obstructive sleep apnea syndrome and cardiovascular disease:the influence of C-reactive protein[J].World J Exp Med,2015,5(2):77-83.
[5]Gottlieb DJ,Yenokyan G,Newman AB,et al.Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure:the sleep heart health study[J].Circulation,2010,122(4):352-360.
[6]王钊,姚晓光,汪迎春,等.冠状动脉狭窄<50%的夜间胸痛与阻塞性睡眠呼吸暂停低通气综合征的关系[J].中国动脉硬化杂志,2014,22(2):143-146.
[7]Young T,Palta M,Dempsey J,et al.The occurrence of sleep-disordered breathing among middle-aged adults[J].N Engl J Med,1993,328(17):1230-1235.
[8]Peppard PE,Young T,Barnet JH,et al.Increased prevalence of sleep-disordered breathing in adults[J].Am J Epidemiol,2013,177(9):1006-1014.
[9]Peppard PE,Young T,Palta M,et al.Prospective study of the association between sleep-disordered breathing and hypertension[J].N Engl J Med,2000,342(19):1378-1384.
[10]Adedayo AM,Olafiranye O,Smith D,et al.Obstructive sleep apnea and dyslipidemia:evidence and underlying mechanism[J].Sleep Breath,2014,18(1):13-18.
[11]Grobbee DE,Bots ML.Carotid artery intima-media thickness as an indicator of generalized atherosclerosis[J].J Intern Med,1994,236(5):567-573.
[12]Stumpf MJ,Schaefer CA,Krycki J,et al.Impairment of vascular strain in patients with obstructive sleep apnea[J].PLoS One,2018,13(2):e0193397.
[13]Lorenz MW,Kegler S,Steinmetz H,et al.Carotid intima-media thickening indicates a higher vascular risk across a wide age range:prospective data from the Carotid Atherosclerosis Progression Study(CAPS)[J].Stroke,2006,37(1):87-92.
[14]Lorenz MW,Gao l,Ziegelbauer K,et al.Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk-Results from the PROG-IMT collaboration[J].PLoS One,2018,13(4):e0191172.
[15]Sarioglu N,Demirpolat G,Erel F,et al.Which is the ideal marker for early atherosclerosis in obstructive sleep apnea(OSA)-carotid intima-media thickness or mean platelet volume?[J].Med Sci Monit,2017,23:1674-1681.
[16]Gorzewska A,Specjalski K,Drozdowski J,et al.Intima-media thickness in patients with obstructive sleep apnea without comorbidities[J].Lung,2013,191(4):397-404.
[17]Oktay B,Rice TB,Atwood CW,et al.Evaluation of a single-channel portable monitor for the diagnosis of obstructive sleep apnea[J].J Clin Sleep Med,2011,7(4):384-390.
[18]Zou JY,Meng LL,Liu YP,et al.Evaluation of a 2-channel portable device and a predictive model to screen for obstructive sleep apnea in a laboratory environment[J].Respir Care,2015,60(3):356-362.
[19]Rosen CL,Auckley D,Benca R,et al.A multisite randomized trial of portable sleep studies and positive airway pressure autotitration versus laboratory-based polysomnography for the diagnosis and treatment of obstructive sleep apnea:the Home PAP study[J].Sleep,2012,35(6):757-767.
[20]Wilson PW,Agostino RB,Levy D,et al.Prediction of coronary heart disease using risk factor categories[J].Circulation,1998,97(18):1837-1847.
[21]Ozdemir C,Conkbayir I,Kuru A,et al.Correlation between the intima-media thickness and Framingham risk score in patients with sleep apnea syndrome[J].J Thorac Dis,2013,5(6):751-757.
[22]Suzuki M,Shimamoto K,Sekiguchi H,et al.Arousal index as a marker of carotid artery atherosclerosis in patients with obstructive sleep apnea syndrome[J].Sleep Breath,2019,23(1):87-94.
[23]Gamez BJ,Marin MC,Chaparro JL,et al.Relationship of oxidative stress and endothelial dysfunction in sleep apnoea[J].Eur Respir J,2011,37(4):873-879.
[24]Carreras A,Zhang SX,Peris E,et al.Chronic sleep fragmentation induces endothelial dysfunction and structural vascular changes in mice[J].Sleep,2014,37(11):1817-1824.
[25]Lee YH,Kweon SS,Choi BY,et al.Self-reported snoring and carotid atherosclerosis in middle-aged and older adults:the Korean Multi-Rural Communities Cohort Study[J].J Epidemiol,2014,24(4):281-286.
[26]Kim J,Pack A,Maislin G,et al.Prospective observation on the association of snoring with subclinical changes in carotid atherosclerosis over four years[J].Sleep Med,2014,15(7):769-775.
[27]Lee GS,Lee LA,Wang CY,et al.The frequency and energy of snoring sounds are associated with common carotid artery intimamedia thickness in obstructive sleep apnea patients[J].Sci Rep,2016,6:30559.
[28]Peppard PE,Young T,Palta M,et al.Longitudinal study of moderate weight change and sleep-disordered breathing[J].JAMA,2000,284(23):3015-3021.
[29]Mc Evoy RD,Antic NA,Heeley E,et al.CPAP for prevention of cardiovascular events in obstructive sleep apnea[J].N Engl JMed,2016,375(10):919-931.
[30]Horwood F,Gruber A,Sithole J,et al.Cardiovascular disease risk assessment in patients with obstructive sleep apnoea:clinical utility of the Framingham risk equation for initiating statins[J].Diabetes Obes Metab,2008,10(2):181-182.
[2]Yaggi HK,Concato J,Kernan WN,et al.Obstructive sleep apnea as a risk factor for stroke and death[J].N Engl J Med,2005,353(19):2034-2041.
[3]杨秀平,赵尧辉,冯玉婧,等.阻塞性睡眠呼吸暂停低通气综合征与脑梗死的关系[J].中国动脉硬化杂志,2015,23(7):713-716.
[4]Bouloukaki I,Mermigkis C,Kallergis EM,et al.Obstructive sleep apnea syndrome and cardiovascular disease:the influence of C-reactive protein[J].World J Exp Med,2015,5(2):77-83.
[5]Gottlieb DJ,Yenokyan G,Newman AB,et al.Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure:the sleep heart health study[J].Circulation,2010,122(4):352-360.
[6]王钊,姚晓光,汪迎春,等.冠状动脉狭窄<50%的夜间胸痛与阻塞性睡眠呼吸暂停低通气综合征的关系[J].中国动脉硬化杂志,2014,22(2):143-146.
[7]Young T,Palta M,Dempsey J,et al.The occurrence of sleep-disordered breathing among middle-aged adults[J].N Engl J Med,1993,328(17):1230-1235.
[8]Peppard PE,Young T,Barnet JH,et al.Increased prevalence of sleep-disordered breathing in adults[J].Am J Epidemiol,2013,177(9):1006-1014.
[9]Peppard PE,Young T,Palta M,et al.Prospective study of the association between sleep-disordered breathing and hypertension[J].N Engl J Med,2000,342(19):1378-1384.
[10]Adedayo AM,Olafiranye O,Smith D,et al.Obstructive sleep apnea and dyslipidemia:evidence and underlying mechanism[J].Sleep Breath,2014,18(1):13-18.
[11]Grobbee DE,Bots ML.Carotid artery intima-media thickness as an indicator of generalized atherosclerosis[J].J Intern Med,1994,236(5):567-573.
[12]Stumpf MJ,Schaefer CA,Krycki J,et al.Impairment of vascular strain in patients with obstructive sleep apnea[J].PLoS One,2018,13(2):e0193397.
[13]Lorenz MW,Kegler S,Steinmetz H,et al.Carotid intima-media thickening indicates a higher vascular risk across a wide age range:prospective data from the Carotid Atherosclerosis Progression Study(CAPS)[J].Stroke,2006,37(1):87-92.
[14]Lorenz MW,Gao l,Ziegelbauer K,et al.Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk-Results from the PROG-IMT collaboration[J].PLoS One,2018,13(4):e0191172.
[15]Sarioglu N,Demirpolat G,Erel F,et al.Which is the ideal marker for early atherosclerosis in obstructive sleep apnea(OSA)-carotid intima-media thickness or mean platelet volume?[J].Med Sci Monit,2017,23:1674-1681.
[16]Gorzewska A,Specjalski K,Drozdowski J,et al.Intima-media thickness in patients with obstructive sleep apnea without comorbidities[J].Lung,2013,191(4):397-404.
[17]Oktay B,Rice TB,Atwood CW,et al.Evaluation of a single-channel portable monitor for the diagnosis of obstructive sleep apnea[J].J Clin Sleep Med,2011,7(4):384-390.
[18]Zou JY,Meng LL,Liu YP,et al.Evaluation of a 2-channel portable device and a predictive model to screen for obstructive sleep apnea in a laboratory environment[J].Respir Care,2015,60(3):356-362.
[19]Rosen CL,Auckley D,Benca R,et al.A multisite randomized trial of portable sleep studies and positive airway pressure autotitration versus laboratory-based polysomnography for the diagnosis and treatment of obstructive sleep apnea:the Home PAP study[J].Sleep,2012,35(6):757-767.
[20]Wilson PW,Agostino RB,Levy D,et al.Prediction of coronary heart disease using risk factor categories[J].Circulation,1998,97(18):1837-1847.
[21]Ozdemir C,Conkbayir I,Kuru A,et al.Correlation between the intima-media thickness and Framingham risk score in patients with sleep apnea syndrome[J].J Thorac Dis,2013,5(6):751-757.
[22]Suzuki M,Shimamoto K,Sekiguchi H,et al.Arousal index as a marker of carotid artery atherosclerosis in patients with obstructive sleep apnea syndrome[J].Sleep Breath,2019,23(1):87-94.
[23]Gamez BJ,Marin MC,Chaparro JL,et al.Relationship of oxidative stress and endothelial dysfunction in sleep apnoea[J].Eur Respir J,2011,37(4):873-879.
[24]Carreras A,Zhang SX,Peris E,et al.Chronic sleep fragmentation induces endothelial dysfunction and structural vascular changes in mice[J].Sleep,2014,37(11):1817-1824.
[25]Lee YH,Kweon SS,Choi BY,et al.Self-reported snoring and carotid atherosclerosis in middle-aged and older adults:the Korean Multi-Rural Communities Cohort Study[J].J Epidemiol,2014,24(4):281-286.
[26]Kim J,Pack A,Maislin G,et al.Prospective observation on the association of snoring with subclinical changes in carotid atherosclerosis over four years[J].Sleep Med,2014,15(7):769-775.
[27]Lee GS,Lee LA,Wang CY,et al.The frequency and energy of snoring sounds are associated with common carotid artery intimamedia thickness in obstructive sleep apnea patients[J].Sci Rep,2016,6:30559.
[28]Peppard PE,Young T,Palta M,et al.Longitudinal study of moderate weight change and sleep-disordered breathing[J].JAMA,2000,284(23):3015-3021.
[29]Mc Evoy RD,Antic NA,Heeley E,et al.CPAP for prevention of cardiovascular events in obstructive sleep apnea[J].N Engl JMed,2016,375(10):919-931.
[30]Horwood F,Gruber A,Sithole J,et al.Cardiovascular disease risk assessment in patients with obstructive sleep apnoea:clinical utility of the Framingham risk equation for initiating statins[J].Diabetes Obes Metab,2008,10(2):181-182.