预后营养指数与乳腺癌临床病理关系研究
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摘要
目的:研究预后营养指数(PNI)与乳腺癌的预后及临床病理之间的关系。方法:回顾性分析2014年1月至2017年1月肿瘤外科收治的乳腺癌病人90例的临床资料与随访资料,分析PNI与其临床病理及术后并发症的关系。结果:PNI评分较高的病人术后近期并发症发生率较低(P<0.01);PNI与乳腺癌的免疫组化指标Her-2、Ki-67均有关,PNI≥45组病人的Her-2和Ki-67阳性率均低于PNI<45组(P<0.05);PNI≥45组病人肿瘤直径小于PNI<45组(P<0.01);PNI≥45组乳腺癌局部复发率为3.33%,与PNI<45组复发率13.3%差异无统计学意义(P>0.05),PNI≥45组全身转移率为5%,低于PNI<45组全身转移率20%(P<0.05)。结论:PNI是乳腺癌的一种预后预测指标,具有简单、易行的特点。
Objective:To explore the relationship between prognosis nutritional index(PNI),prognosis and clinicopathology of breast cancer.Methods:The clinical data and following-up data of breast cancer patients from January 2014 to January 2017 were retrospectively analyzed.The relationships between PNI,and pathology and postoperative complications were analyzed.Results:The incidence rate of postoperative complications in patients with high PNI score was lower(P<0.01),and PNI was related to Her-2 and Ki-67.The positive rates of Her-2 and Ki-67 in patients with PNI more than or equal to 45 were less than those in patients with PNI less than 45(P<0.05).The tumor size in patients with PNI more than or equal to 45 was less than that in patients with PNI less than 45(P<0.01).The local recurrence rates of breast cancer in patients with PNI more than or equal to 45 and PNI less than 45 were 3.33% and 13.3%,respectively,and the difference of which was not statistically significant(P>0.05),and the systemic metastasis rate in patients with PNI more than or equal to 45(5%) was lower than that in patients with PNI less than 45(20%)(P<0.05).Conclusions:PNI is a prognostic index of breast cancer,which is simple and easy to perform.
Objective:To explore the relationship between prognosis nutritional index(PNI),prognosis and clinicopathology of breast cancer.Methods:The clinical data and following-up data of breast cancer patients from January 2014 to January 2017 were retrospectively analyzed.The relationships between PNI,and pathology and postoperative complications were analyzed.Results:The incidence rate of postoperative complications in patients with high PNI score was lower(P<0.01),and PNI was related to Her-2 and Ki-67.The positive rates of Her-2 and Ki-67 in patients with PNI more than or equal to 45 were less than those in patients with PNI less than 45(P<0.05).The tumor size in patients with PNI more than or equal to 45 was less than that in patients with PNI less than 45(P<0.01).The local recurrence rates of breast cancer in patients with PNI more than or equal to 45 and PNI less than 45 were 3.33% and 13.3%,respectively,and the difference of which was not statistically significant(P>0.05),and the systemic metastasis rate in patients with PNI more than or equal to 45(5%) was lower than that in patients with PNI less than 45(20%)(P<0.05).Conclusions:PNI is a prognostic index of breast cancer,which is simple and easy to perform.
引文
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[2] 张保宁,陈万青,张希,等.中国乳腺癌防控形势面临挑战[J].中华肿瘤杂志,2016,38(190):798.
[3] 许文娟,康妍萌,周玲,等.预后营养指数在评估中、晚期非小细胞肺癌病人预后的临床应用价值[J].中华肿瘤杂志,2017,39(2):146.
[4] 常颖智,曹杰,谭卫民,等.小野寺预后营养指数在老年结直肠癌病人预后评估中的应用[J].中华胃肠外科杂志,2013,16(6):561.
[5] 宋书彬,刘宏刚,薛英威.进展期胃部患者预后营养指数的临床意义[J].中华胃肠外科杂志,2018,21(2):180.
[6] 罗雯,王佾,周智勇,等.小野寺预后营养指数对胃肠择期手术病人营养风险的预测价值[J].中华胃肠外科杂志,2016,19(5):575.
[7] 黄海,彭健.小野寺预后营养指数对胆囊癌病人生存的影响[J].中国肿瘤临床,2014,41(22):1450.
[8] 方军,余阳,许涛,等.小野寺预后营养指数在胃癌病人预后评估中的价值[J].临床外科杂志,2016,24(11):831.
[9] 杨海源,江一舟,邵志敏.精准医学时代的乳腺癌研究[J].中华肿瘤杂志,2016,38(6):798.